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    SPIROHYDANTOIN ARYL CGRP RECEPTOR ANTAGONISTS
    71.
    发明申请
    SPIROHYDANTOIN ARYL CGRP RECEPTOR ANTAGONISTS 审中-公开
    螺旋藻降​​钙素受体拮抗剂

    公开(公告)号：WO2007061676A2

    公开(公告)日：2007-05-31

    申请号：PCT/US2006/044086

    申请日：2006-11-14

    Applicant: MERCK & CO., INC. ,  BELL, Ian, M. ,  STUMP, Craig, A. ,  THEBERGE, Cory, R. ,  WOOD, Michael, R. ,  ZARTMAN, C. Blair

    Inventor： BELL, Ian, M. ,  STUMP, Craig, A. ,  THEBERGE, Cory, R. ,  WOOD, Michael, R. ,  ZARTMAN, C. Blair

    IPC: A61K31/55 ,  C07D487/10

    CPC classification number: C07D487/10 ,  C07D471/10 ,  C07D519/00

    Abstract: Compounds of formula (I); (wherein variables A 1 , A 2 . A 3 , A 4 , A 5 , A 6 , A 7 , B 3 E 1 , E 2 , E 3 , E 4 , E 5 , G 1 , G 2 and R. 6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    Abstract translation: 式（I）的化合物; （其中变量A 1，A 2，A 3，A 4，A 5，A 5，A 5，A 5， A 6，A 7，B 3，E 1，E 2，sup E 3，E 4，E 5，G 1，G 2， R 6和R 6如本文所述），它们是CGRP受体的拮抗剂并且可用于治疗或预防其中涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗其中涉及CGRP的此类疾病中的用途。

    MONOCYCLIC ANILIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS
    72.
    发明申请
    MONOCYCLIC ANILIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS 审中-公开
    单克隆抗炎螺旋体CGRP受体拮抗剂

    公开(公告)号：WO2006029153A2

    公开(公告)日：2006-03-16

    申请号：PCT/US2005/031713

    申请日：2005-09-06

    Applicant: MERCK & CO., INC. ,  BELL, Ian, M. ,  STUMP, Craig, A.

    Inventor： BELL, Ian, M. ,  STUMP, Craig, A.

    IPC: C07D487/10

    CPC classification number: C07D471/04 ,  C07D209/96 ,  C07D487/04

    Abstract: The present invention is directed to compounds of Formula I: I (where variables A 1 , A 2 , B, J, K, m, n, R 4 , R 5a , R 5b and R 5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    Abstract translation: 本发明涉及式I的化合物：I（其中变量A 1，A 2，B，J，K，m，n，R 4 R 5c，R 5b和R 5c如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗 或预防CGRP所涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

    BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS
    74.
    发明申请
    BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS 审中-公开
    苯丙胺CGRP受体拮抗剂

    公开(公告)号：WO2005000807A2

    公开(公告)日：2005-01-06

    申请号：PCT/US2004/020206

    申请日：2004-06-24

    Applicant: MERCK & CO., INC. ,  BURGEY, Christopher, S. ,  STUMP, Craig, A. ,  WILLIAMS, Theresa, M.

    Inventor： BURGEY, Christopher, S. ,  STUMP, Craig, A. ,  WILLIAMS, Theresa, M.

    IPC: C07D

    CPC classification number: C07D401/14

    Abstract: The present invention is directed to compounds of Formula I: I (where variables R¿1?, R¿2?, R¿3?, R¿6?, R¿7?, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

    Abstract translation: 本发明涉及式I化合物：I（其中R 1，R 2，R 3，R 6，R 7，G，J，W，X和Y各自为 如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

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