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71.发明申请
公开(公告)号：WO2022263316A1
公开(公告)日：2022-12-22
申请号：PCT/EP2022/065823
申请日：2022-06-10
发明人： SINTON, David , SARGENT, Edward , XIE, Ke , MIAO, Rui Kai
摘要： An electroreduction system for converting carbon oxides selected from CO, CO2 or any mixture thereof into multicarbon (C2+) products, the system comprising a cathodic compartment having a reactant inlet and comprising a cathode, the cathode comprising a catalyst layer that is contactable with a catholyte solution; an anodic compartment having a product outlet to release the C2+ products, the anodic compartment comprising an anode and being configured to accommodate a flowing anolyte solution; and a bipolar membrane being positioned between the cathodic compartment and the anodic compartment, the bipolar membrane comprising an interfacial layer defined between a cation-exchange layer and a anion-exchange layer; wherein the cathodic compartment is configured to accommodate a stationary catholyte layer between the catalyst layer of the cathode and the CEL, the stationary catholyte layer comprising the catholyte solution..
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72.发明申请
公开(公告)号：WO2022246560A1
公开(公告)日：2022-12-01
申请号：PCT/CA2022/050842
申请日：2022-05-26
IPC分类号： B25J9/10
摘要： A magnetic torsion spring for a magnetically actuated mechanism, the spring having first and second links of the mechanism rotatably connected at a joint of the mechanism, the first link provided with a first magnet spaced from the joint and the second link provided with a second magnet spaced from the joint generating a spring effect, the spring defined by a torque curve with respect to spring deflection, the torque curve defined by spring type, dimensionless characteristic length ratio of the spring, and an amplitude constant, and the length ratio has a value between 0 and 1.
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73.发明申请
公开(公告)号：WO2022226647A1
公开(公告)日：2022-11-03
申请号：PCT/CA2022/050642
申请日：2022-04-27
发明人： SUN, Yu , SHAN, Guanqiao , DAI, Changsheng , ZHANG, Zhuoran
摘要： Systems and methods for detecting and 3D imaging of cell junctions on a cell layer of a biological structure, such as a blastocyst, are provided. The method can include operating a microscope to view a portion of the biological structure; rotating the biological structure through a set of orientations; capturing, at each orientation, a respective image of a corresponding one of a set of cell layer regions of the cell layer, wherein each cell layer region partly overlaps with at least another cell layer region, thereby obtaining a set of partially overlapping cell layer images; creating a cell layer texture map containing cell junction information from the set of cell layer images; and constructing a 3D image of the cell junctions based on the cell layer texture map and the cell junction information contained therein.
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74.发明申请
公开(公告)号：WO2022213218A8
公开(公告)日：2022-10-13
申请号：PCT/CA2022/050555
申请日：2022-04-09
IPC分类号： G01N21/25 , G01C11/04 , G06V20/10 , G06T7/00 , G06V20/17 , G06V20/188 , G06V20/194
摘要： Systems and methods for vegetation detection from aerial photogrammetric multispectral data. The method includes: detecting apexes in a height model using Local Maxima (LM) detection; detecting vegetation as detected apexes; performing orthorectification to derive an orthomosaic; generating a fractional map of a vegetation class by applying a Fuzzy classifier on the orthomosaic using the detected vegetation to define the class; generating a binary ridge map using the height model to identify ridges; combining the binary ridge map and the fractional map of the vegetation class to generate a ridge integrated fractional map; performing delineation of individual vegetation on the ridge integrated fractional map on a vegetation class using an active contour algorithm; and outputting the delineated vegetation.
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75.发明申请
公开(公告)号：WO2022213218A1
公开(公告)日：2022-10-13
申请号：PCT/CA2022/050555
申请日：2022-04-09
摘要： Systems and methods for vegetation detection from aerial photogrammetric multispectral data. The method includes: detecting apexes in a height model using Local Maxima (LM) detection; detecting vegetation as detected apexes; performing orthorectification to derive an orthomosaic; generating a fractional map of a vegetation class by applying a Fuzzy classifier on the orthomosaic using the detected vegetation to define the class; generating a binary ridge map using the height model to identify ridges; combining the binary ridge map and the fractional map of the vegetation class to generate a ridge integrated fractional map; performing delineation of individual vegetation on the ridge integrated fractional map on a vegetation class using an active contour algorithm; and outputting the delineated vegetation.
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公开(公告)号：WO2022189978A1
公开(公告)日：2022-09-15
申请号：PCT/IB2022/052070
申请日：2022-03-08
发明人： SIDHU, Sachdev S. , GALLO, Eugenio , ADAMS, Jarrett J. , BLAZER, Levi Lynn , CARDARELLI, Rodilia , KELIL, Abdellali
IPC分类号： C07K16/46 , A61K39/395 , A61K47/68 , A61P35/00 , A61P35/04 , C07K16/28 , C12N15/13 , C12P21/08
摘要： The disclosure provides antibodies that bind human ITGAv/B1 and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an anti-ITGAv/B1 antibody.
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公开(公告)号：WO2022184905A2
公开(公告)日：2022-09-09
申请号：PCT/EP2022/055570
申请日：2022-03-04
IPC分类号： C25B1/23 , C25B3/25 , C25B3/26 , C25B9/19 , C25B9/40 , C25B11/031 , C25B11/032 , C25B11/037 , C25B11/052 , C25B11/053 , C25B11/055 , C25B11/069 , C25B11/071
摘要： The present disclosure relates to an electrode for CO2 electroreduction in an acidic electrolyte comprising cation species, the electrode comprising: a substrate, a metal-based catalyst material, and a cation-augmenting material; wherein the cation-augmenting material comprises an acidic group exchanging protons with the cation species of the acidic electrolyte so as to increase a concentration of the cation species at a surface of the electrode.
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公开(公告)号：WO2022160049A1
公开(公告)日：2022-08-04
申请号：PCT/CA2022/050113
申请日：2022-01-27
发明人： PARDEE, Keith , NOROUZI, Masoud
IPC分类号： C12N15/113 , C12N1/21 , C12N15/11 , C12N15/63 , C12P21/00
摘要： A linear double stranded deoxyribonucleic acid (dsDNA) molecule comprising operatively linked in the 5' to 3' direction: a) one or more Ter sites at the 5' terminus ("5' Ter"); b) a segment comprising a DNA sequence of interest; and c) one or more Ter sites at the 3' terminus ("3' Ter). Also methods of protecting DNA sequences of interest from exonuclease degradation using the DNA constructs of the present disclosure, cells transformed with the DNA construct of the present disclosure and cell-free synthetic biology system comprising a linear dsDNA molecule of the present disclosure.
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79.发明申请
公开(公告)号：WO2022147620A1
公开(公告)日：2022-07-14
申请号：PCT/CA2022/050014
申请日：2022-01-07
申请人： ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , SINAI HEALTH SYSTEM
发明人： AL-AWAR, Rima , ATTISANO, Liliana , ISAAC, Methvin , LIU, Yong , SMIL, David , UEHLING, David , WRANA, Jeff
IPC分类号： C07D409/14 , A61K31/506 , A61K31/551 , A61K31/5383 , A61P35/00 , C07D239/48 , C07D241/36 , C07D409/12 , C07D451/02 , C07D471/10 , C07D487/04 , C07D498/04
摘要： The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting or blocking NUAK kinase, such as cancers and fibrosis.
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80.发明申请
公开(公告)号：WO2022140843A1
公开(公告)日：2022-07-07
申请号：PCT/CA2021/051794
申请日：2021-12-13
摘要： A fully dilutable in aqueous phase self-microemulsifying system for the delivery of one or more polar oil active compounds having a positive characteristic curvature (Cc), comprising: a lecithin compound; a hydrophilic linker or a combination two or more hydrophilic linkers, the hydrophilic linker or the combination of two or more hydrophilic linkers having one having one hydrocarbon group with 6 to 10 carbon atoms, and the hydrophilic linker or the combination of two or more HLs having a Cc of about -5 or more negative than about -5; and a carrier oil.
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