利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

207 条记录 (耗时 0.024 秒)

    CELLULAR PREDICTIVE MODELS FOR TOXICITIES
    81.
    发明申请
    CELLULAR PREDICTIVE MODELS FOR TOXICITIES 审中-公开
    细胞毒性预测模型

    公开(公告)号：WO2007103406A3

    公开(公告)日：2008-02-28

    申请号：PCT/US2007005767

    申请日：2007-03-07

    申请人： CYTOKINETICS INC ,  VAISBERG EUGENI ,  KUTSYY VADIM

    发明人： VAISBERG EUGENI ,  KUTSYY VADIM

    IPC分类号： G01N33/00 ,  G01N33/53

    CPC分类号： G01N33/5014 ,  C12Q1/6827 ,  G01N33/5026 ,  G01N33/5067 ,  G01N2800/085 ,  G06F19/18 ,  G06F19/24

    摘要： Methods for generating models for predicting biological activity of a stimulus test population of cells are provided. The models may be used to classify or predict the effect of stimuli on cells. In certain embodiments, the methods involve receiving data comprising values for dependent variables associated with stimuli; preparing a set of cell populations based on the data received; identifying a subset of the cell populations to be used in generating a model from data associated with the subset, wherein the model is provided to predict activity of a test population.

    摘要翻译： 提供了产生用于预测刺激测试细胞群生物活性的模型的方法。 这些模型可用于分类或预测刺激对细胞的影响。 在某些实施方案中，所述方法涉及接收包含与刺激相关的因变量的值的数据; 基于所接收的数据准备一组细胞群体; 从与所述子集相关联的数据中识别要用于生成模型的细胞群的子集，其中提供所述模型以预测测试群体的活性。

    DOMAIN SEGMENTATION AND ANALYSIS
    82.
    发明申请
    DOMAIN SEGMENTATION AND ANALYSIS 审中-公开

    公开(公告)号：WO2007081969A3

    公开(公告)日：2007-07-19

    申请号：PCT/US2007/000564

    申请日：2007-01-09

    申请人： CYTOKINETICS, INC. ,  RAO, Aibing ,  VAISBERG, Eugeni, A.

    发明人： RAO, Aibing ,  VAISBERG, Eugeni, A.

    IPC分类号： G06K9/00 ,  G06T5/00

    摘要： Methods and apparatus, including computer program products, implementing and using techniques for analysis of images of cells and extraction of biologically significant features from the cell images, such as features located in cell boundary regions and cell-cell junctions. The extracted features may be correlated with particular conditions induced by biologically-active agents with which cells have been treated, thereby enabling the automated analysis of cells based on features that can be discovered in the cell boundary regions and cell-cell junctions of the images.

    CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
    83.
    发明申请
    CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS 审中-公开
    某些化学实验，组合物和方法

    公开(公告)号：WO2007075377A2

    公开(公告)日：2007-07-05

    申请号：PCT/US2006/047827

    申请日：2006-12-13

    申请人： CYTOKINETICS, INC. ,  MORGAN, Bradley, P. ,  MALIK, Fady ,  MORGANS, David, J., Jr.

    发明人： MORGAN, Bradley, P. ,  MALIK, Fady ,  MORGANS, David, J., Jr.

    IPC分类号： A61K31/195

    CPC分类号： A61K31/195 ,  A61K31/496 ,  A61K31/498 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55

    摘要： Certain substituted urea derivatives modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and are useful in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, cachexia, neuromuscular diseases (e.g., amyotrophic lateral sclerosis, spinal muscular atrophy, familial or acquired myopathies or muscular dystrophies), post-surgical and post-traumatic muscle weakness, and other conditions.

    摘要翻译： 某些取代的脲衍生物调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌，包括其片段和同种型，以及骨骼肌节，并且可用于治疗 肥胖，肌肉减少症，消瘦综合征，虚弱，肌肉痉挛，恶病质，神经肌肉疾病（例如肌萎缩性侧索硬化，脊髓性肌萎缩，家族性或获得性肌病或肌营养不良），手术后和创伤后肌肉无力等条件。

    CELLULAR PHENOTYPE
    85.
    发明申请
    CELLULAR PHENOTYPE 审中-公开
    细胞表型

    公开(公告)号：WO2006031273A3

    公开(公告)日：2006-05-18

    申请号：PCT/US2005021527

    申请日：2005-06-16

    申请人： CYTOKINETICS INC ,  ADAMS CYNTHIA LYNN ,  DE LA ROSA REGINALD NORMAN ,  RAMCHANDANI SHYAMLAL

    发明人： ADAMS CYNTHIA LYNN ,  DE LA ROSA REGINALD NORMAN ,  RAMCHANDANI SHYAMLAL

    IPC分类号： C12N5/00 ,  C12Q1/68 ,  G01N33/50 ,  G06F19/00 ,  G06K9/00

    CPC分类号： G01N33/502 ,  G01N33/5008 ,  G01N2510/00 ,  G06K9/0014

    摘要： Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a "snapshot" of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these "static" and "dynamic" characterizations. The phenotype may be characterized by at least the following features: (a) chromosomes that approach metaphase but fail to separate and maintain alignment compared to a control cell or cell population; (b) a bipolar spindle that is at least about 10% longer than a corresponding metaphase mitotic spindle from the control cell or cell population; and (c) during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.

    摘要翻译： 描述了表型和表现这些表型的细胞。 表型可以被建立为细胞在特定时间的“快照”，或者可以被确定为特征随时间的变化，或者作为这些“静态”和“动态”特征的某种组合。 表型可以至少具有以下特征：（a）与对照细胞或细胞群体相比，接近中期但不能分离并保持比对的染色体; （b）比来自对照细胞或细胞群体的相应中期有丝分裂纺锤体长至少约10％的双极纺锤体; 和（c）在中间期间，细胞或细胞群表现出与对照细胞或细胞群的间期细胞的表型基本相似的表型。

    CELLULAR PHENOTYPE
    87.
    发明申请
    CELLULAR PHENOTYPE 审中-公开
    细胞色谱

    公开(公告)号：WO2006031273A2

    公开(公告)日：2006-03-23

    申请号：PCT/US2005/021527

    申请日：2005-06-16

    申请人： CYTOKINETICS, INC. ,  ADAMS, Cynthia, Lynn ,  DE LA ROSA, Reginald, Norman ,  RAMCHANDANI, Shyamlal

    发明人： ADAMS, Cynthia, Lynn ,  DE LA ROSA, Reginald, Norman ,  RAMCHANDANI, Shyamlal

    IPC分类号： C12N5/00 ,  G01N33/50

    CPC分类号： G01N33/502 ,  G01N33/5008 ,  G01N2510/00 ,  G06K9/0014

    摘要： Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a "snapshot" of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these "static" and "dynamic" characterizations. The phenotype may be characterized by at least the following features: (a) chromosomes that approach metaphase but fail to separate and maintain alignment compared to a control cell or cell population; (b) a bipolar spindle that is at least about 10% longer than a corresponding metaphase mitotic spindle from the control cell or cell population; and (c) during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.

    摘要翻译： 描述了表型和表现出这些表型的细胞。 表型可以在特定时间被建立为细胞的“快照”，或者可以随时间被确定为特征的变化，或者作为这些“静态”和“动态”表征的某种组合。 表型可以至少具有以下特征：（a）与对照细胞或细胞群相比，进入中期但不能分离和保持比对的染色体; （b）双极纺锤体，其比来自对照细胞或细胞群体的相应中期有丝分裂纺锤体长至少约10％; 和（c）在间期期间，细胞或细胞群表现出与对照细胞或细胞群的间期细胞基本相似的表型。