公开(公告)号：WO2008141656A1

公开(公告)日：2008-11-27

申请号：PCT/EP2007/004427

申请日：2007-05-17

Applicant: ELEKTA AB (PUBL) ,  VAN HERK, Marcel ,  SONKE, Jon-Jakob ,  ZIJP, Lambert ,  REMEIJER, Peter

Inventor： VAN HERK, Marcel ,  SONKE, Jon-Jakob ,  ZIJP, Lambert ,  REMEIJER, Peter

IPC: G06T11/00

CPC classification number: G06T11/006 ,  G06T2211/412 ,  G06T2211/421 ,  G06T2211/428

Abstract: An in-line 4D cone beam CT reconstruction algorithm, i.e. one that works in parallel with image acquisition, comprises an imaging system for a object exhibiting internal periodic motion comprising a source of penetrating radiation and a two-dimensional detector for the radiation, the source and the detector being rotateable around an axis lying on the beam path from the source to the detector, a storage means for images obtained from the detector, a control means for initiating rotation of the source and the detector and for obtaining images from the detector at a plurality of rotation angles over time, a processing means for (i) condensing the images in a direction transverse to an axis to produce a one-dimensional image, (ii) collating the one-dimensional images obtained up to that point side-by-side into a two dimensional image, (iii) analysing the two-dimensional image thus obtained to identify periodic patterns, (iv) allocating phase information to the images in the storage means on the basis of that analysis, (v) selecting images in the storage means having like phase information, and (vi) backprojecting the selected images, the control means being adapted to invoke the processing means after a plurality of images have been placed in the storage means, and then place further images in the storage means and further invoke the processing means. Thus, we queue a limited number of projection images such that the phase determination algorithm can look-ahead. At regular intervals, the queue is scanned and those images which have enough look-ahead to obtain phase information are filtered and back-projected. The algorithm thus keeps up with the image acquisition speed and produces a 4D reconstruction within a few seconds of the end of scanning. A local rigid registration algorithm is then used to match the tumor region defined in the mid-ventilation frame of our 4D planning CT with each of the phases of the 4D CBCT. An animation technique provides rapid visual verification; the mean position of the tumor is computed and used for correction, while the amplitude is reviewed to validate the margin.

Abstract translation: 直列4D锥形束CT重建算法，即与图像采集并行工作的一种，包括用于呈现内部周期运动的物体的成像系统，其包括穿透辐射源和用于辐射的二维检测器，源 并且检测器可围绕位于从源到检测器的光束路径上的轴旋转，用于从检测器获得的图像的存储装置，用于启动源和检测器的旋转的控制装置，以及用于从检测器获得图像 随着时间的推移，多个旋转角度，处理装置，用于（i）在垂直于轴线的方向上聚焦图像以产生一维图像，（ii）将直到该点的一维图像对齐 （iii）分析由此获得的二维图像以识别周期性图案，（iv）将相位信息分配给存储装置中的图像 在该分析的基础上，（v）选择具有相似相位信息的存储装置中的图像，以及（vi）反投影所选择的图像，所述控制装置适于在将多个图像放置在所述图像中之后调用所述处理装置 存储装置，然后将更多图像放置在存储装置中，并进一步调用处理装置。 因此，我们排列有限数量的投影图像，使得相位确定算法可以向前看。 定期扫描队列，并对具有足够预先获取相位信息的图像进行过滤和反投影。 因此，该算法保持了图像采集速度，并在扫描结束后几秒钟内产生了4D重建。 然后使用局部刚性配准算法将我们的4D计划CT的中间通气框架中定义的肿瘤区域与4D CBCT的每个阶段相匹配。 动画技术提供快速的视觉验证; 计算肿瘤的平均位置并用于校正，同时检查振幅以验证边缘。

公开(公告)号：WO2008040522A2

公开(公告)日：2008-04-10

申请号：PCT/EP2007/008534

申请日：2007-10-02

Applicant: ELEKTA AB (PUBL) ,  GARDING, Jonas ,  KJÄLL, Per ,  LIDBERG, Pär

Inventor： GARDING, Jonas ,  KJÄLL, Per ,  LIDBERG, Pär

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1084

Abstract: A treatment planning method comprises the steps of identifying a plurality of treatment locations and an overall dose to be applied to each, for each specific location identifying the global dose applied at that location by doses aimed at different locations, as a proportion of the dose applied at the respective different location, constructing a dose factor matrix containing for each location, the global doses arising from the dose applied at each other location, inverting the dose factor matrix and multiplying it with a prescription matrix containing the overall doses to be applied to each location, thereby to obtain a resultant matrix containing a local dose for each location. This provides a mathematically straightforward method of deriving the necessary doses to be applied to each target so that, including the global doses delivered while irradiating a different target, each target receives the correct total dose. Some locations can be omitted from the treatment planning method, for example if they are located so far from the other locations that they will not have a significant interaction with them. A corresponding treatment planning apparatus is also described.

Abstract translation: 治疗计划方法包括以下步骤：识别多个治疗位置和将要应用于每个治疗位置的总体剂量;针对每个特定位置，通过针对不同位置的剂量来识别在该位置应用的总体剂量 ，作为在相应不同位置施加的剂量的比例，构建包含每个位置的剂量因子矩阵，由在每个其他位置施加的剂量引起的全局剂量，反转剂量因子矩阵并将其与包含处方矩阵的处方矩阵相乘 要施加到每个位置的整体剂量，从而获得每个位置包含局部剂量的所得矩阵。 这提供了一种数学上直接的方法，用于推导应用于每个目标的必要剂量，以便包括在照射不同目标时递送的全局剂量，每个目标接收正确的总剂量。 某些地点可以从治疗计划方法中省略，例如，如果他们位于离其他地点很远的地方，他们就不会与他们进行重要的交流。 还描述了相应的治疗计划设备。

公开(公告)号：WO2006066791A1

公开(公告)日：2006-06-29

申请号：PCT/EP2005/013488

申请日：2005-12-15

Applicant: ELEKTA AB (publ) ,  ERIKSSON, Andréas, Lars, Gunnar

Inventor： ERIKSSON, Andréas, Lars, Gunnar

IPC: G06T7/00

CPC classification number: G06K9/3216 ,  G06K2209/05 ,  G06T7/30 ,  G06T2207/30004

Abstract: Methods for the registration of images typically assume that there are only two images, an assumption that is not always valid. By using the remaining images to obtain a choice of paths between two selected images, the transformation between the two can be determined with greater accuracy by averaging those paths. When averaging the paths, greater weight can be given to paths whose accuracy is known or reasonably believed to be greatest. Iteration of the process may be possible, where the available computation power is available.

Abstract translation: 用于注册图像的方法通常假设只有两个图像，一个并不总是有效的假设。 通过使用剩余的图像来获得两个所选图像之间的路径选择，可以通过对这些路径求平均，以更高的精度确定两者之间的变换。 当对路径进行平均时，可以将更大的权重给予准确度已知或合理认为最大的路径。 在可用的计算能力可用的情况下，迭代过程是可能的。

公开(公告)号：WO2006027416A1

公开(公告)日：2006-03-16

申请号：PCT/FI2005/000385

申请日：2005-09-08

Applicant: ELEKTA AB (publ). ,  ETS-LINDGREN EUROSHIELD OY ,  SIMOLA, Juha ,  LAINE, Petteri ,  RAKKOLAINEN, Heikki

Inventor： SIMOLA, Juha ,  LAINE, Petteri ,  RAKKOLAINEN, Heikki

IPC: H05K9/00 ,  E04B1/92

CPC classification number: H05K9/0003 ,  E04B2001/925 ,  Y10T403/17 ,  Y10T403/46

Abstract: The present invention discloses a joint structure between the wall elements of a light-weight magnetically shielded room. In the joint structure, the end of the aluminium plate of the element is stepped and its surface roughened. In addition to this, the aluminium plate is coated, for example, with tin to improve the electrical contact. The joint includes µ metal plates which are used to make a magnetic contact between the µ metal plates of the elements. The compression force achieved by means of bolts is transmitted to the joint by means of an aluminium moulding. The non-continuous compression force is balanced over the entire joint area by using presser rubbers. The joint structure is protected by means of supporting profiles which are used to electrically couple the thinner aluminium plate of the sandwich type wall element to the thinner aluminium plate of an adjacent element. The thinner aluminium plate and the supporting profile can also be coated, for example, with tin to improve the contact.

Abstract translation: 本发明公开了一种轻型磁屏蔽室的壁元件之间的接合结构。 在接头结构中，元件的铝板的端部是阶梯状的并且其表面变粗糙。 此外，铝板例如用锡涂覆以改善电接触。 接头包括用于在元件的μ金属板之间形成磁接触的μ金属板。 通过螺栓实现的压缩力通过铝成型体传递到接头。 通过使用压紧橡胶，非连续压缩力在整个接合区域平衡。 接头结构通过支撑轮廓来保护，所述支撑轮廓用于将夹层型壁元件的较薄铝板电连接到相邻元件的较薄铝板。 更薄的铝板和支撑轮廓也可以涂覆，例如用锡来改善接触。

公开(公告)号：WO2005104975A1

公开(公告)日：2005-11-10

申请号：PCT/SE2005/000600

申请日：2005-04-27

Applicant: ELEKTA AB (PUBL) ,  ARN, Thomas

Inventor： ARN, Thomas

IPC: A61B19/00

CPC classification number: A61B90/14

Abstract: The present invention relates to a device for fixation to a head of a patient during neurological diagnosis, therapy or surgery, in particular during MRI diagnosis. The device comprises at lest one fixation pin for fixation to the head, a sleeve member (5) having n internal threaded through bore to t lest partly receive and hold said fixation pin, and pin support member for supporting said fixation pin and sleeve member. The sleeve member is exchangeable and provided in t lest two different lengths in order to allow adaptation of the sleeve member to the size of the head to improve the fixation of the head and avoid the fixation pin to protrude beyond the outer boundary of the pin support member. The invention also relates to a method for fixation of a head.

Abstract translation: 本发明涉及一种用于在神经系统诊断，治疗或手术期间固定到患者头部的装置，特别是在MRI诊断期间。 该装置至少包括一个用于固定到头部的固定销，套筒构件（5）具有n个内螺纹通孔，以便部分地容纳和保持所述固定销，以及销支撑构件，用于支撑所述固定销和套筒构件。 套筒构件是可交换的，并且设置有两个不同的长度，以便允许套筒构件适应头部的尺寸以改善头部的固定，并且避免固定销突出超过销支撑件的外边界 会员。 本发明还涉及用于固定头部的方法。

公开(公告)号：WO2005041774A1

公开(公告)日：2005-05-12

申请号：PCT/GB2004/004475

申请日：2004-10-22

Applicant: ELEKTA AB (PUBL) ,  BROWN, Kevin, John

Inventor： BROWN, Kevin, John

IPC: A61B6/00

CPC classification number: A61N5/1081 ,  A61N5/10 ,  A61N5/1042 ,  A61N5/1082

Abstract: A radiation therapy/surgery device optimised to meet the needs of the Neurosurgeon is provided, i.e. one for the treatment of tumours in the brain. It combines the qualities of a good penumbra and accuracy, simple prescription and operation, together with high reliability and minimal technical support. The device comprises a rotateable support, on which is provided a mount extending from the support out of the plane of the circle, and a radiation source attached to the mount via a pivot, the pivot having an axis which passes through the axis of rotation of the support, the radiation source being aligned so as to produce a beam which passes through the co-incidence of the rotation axis and the pivot. It will generally be easier to engineer the apparatus if the rotateable support is planar, and more convenient if the rotateable support is disposed in an upright position. The rotation of the rotateable support will be eased if this part of the apparatus is circular. A particularly preferred orientation is one in which the radiation source is spaced from the rotateable support, to allow it to pivot without fouling the latter. It is thus preferred that the mount extends transverse to the support. In this way, the pivot axis is spaced from the rotateable support providing free space in which the radiation source can pivot. Another way of expressing this preference is to state that the pivot axis is located out of the plane of the rotateable support. To simplify the geometry of the device and the associated arithmetic, it is preferred both that the pivot axis is substantially perpendicular to the rotation axis, and that the beam direction is perpendicular to the pivot axis. It is preferred that the radiation source is a linear accelerator. The output of the radiation source is preferably collimated to conform to the shape of the area to be treated.

Abstract translation: 提供了优化以满足神经外科医生需求的放射治疗/手术装置，即用于治疗脑中肿瘤的放射治疗/手术装置。 它结合了良好的半暗带的质量和准确性，简单的处方和操作，以及高可靠性和最小的技术支持。 该装置包括可旋转的支撑件，其上设置有从支撑件延伸出圆的平面的安装座，以及经由枢轴连接到安装座的辐射源，该枢轴具有穿过轴的旋转轴线 支撑件，辐射源被对准以便产生通过旋转轴线和枢轴的共同入射的梁。 如果可旋转支撑件是平面的，通常更容易设计设备，并且如果可旋转支撑件设置在直立位置，则更方便。 如果设备的这部分是圆形的，则可旋转支撑件的旋转将被缓解。 特别优选的方向是其中辐射源与可旋转支撑件间隔开的方向，以允许其枢转而不使其污染。 因此，优选地，安装件横向于支撑件延伸。 以这种方式，枢转轴线与可旋转支撑件间隔开，从而提供辐射源能在其中枢转的自由空间。 表示这种偏好的另一种方式是说明枢转轴线位于可旋转支撑平面之外。 为了简化装置的几何形状和相关联的运算，优选地，枢转轴线基本上垂直于旋转轴线，并且梁方向垂直于枢转轴线。 优选的是，辐射源是线性加速器。 辐射源的输出优选地被准直以符合待处理区域的形状。

公开(公告)号：WO2002100477A2

公开(公告)日：2002-12-19

申请号：PCT/SE2002/001070

申请日：2002-06-05

Applicant: ELEKTA AB (publ) ,  NILSSON, Börje ,  ARNDT, Jürgen

Inventor： NILSSON, Börje ,  ARNDT, Jürgen

IPC: A61N

CPC classification number: A61B6/583 ,  A61N5/1048

Abstract: A device for recording in at least two planes radiation from a radiotherapy apparatus in a limited area at which the radiation is directed. The device comprises a dimensionally stable frame (1) which is adapted to be arranged in a defined position relative to said radiotherapy apparatus, an attachment (4) on the frame (1) for a recording means, and a recording means (5) which extends from the attachment (4) at an acute angle to the frame (1) along an axis of rotation (6) and to the center of the frame (1). The recording means (5) is adapted to assume at least two defined rotational positions on said axis (6). In addition, the recording means (5) exhibits a surface (14) for supporting a radiation recording unit (13), which surface (14) is located in a plane (9) that forms an acute angle with the axis of rotation (6), the plane (9) of the surface (14) when rotating the recording means (5) being adapted to turn on a single pivot point (7) which is fixed relative to the frame (1).

Abstract translation: 一种用于在辐射被引导的有限区域中的放射治疗装置的至少两个平面的辐射中记录的装置。 该装置包括尺寸稳定的框架（1），其适于布置在相对于所述放射治疗装置的限定位置，在用于记录装置的框架（1）上的附件（4）和记录装置（5） 从附件（4）沿着旋转轴线（6）以及与框架（1）的中心以锐角延伸到框架（1）。 记录装置（5）适于在所述轴线（6）上呈现至少两个限定的旋转位置。 另外，记录装置（5）具有用于支撑辐射记录单元（13）的表面（14），该表面（14）位于与旋转轴线形成锐角的平面（9）中（6） ），当旋转记录装置（5）时，表面（14）的平面（9）适于打开相对于框架（1）固定的单个枢转点（7）。

公开(公告)号：WO2023041167A1

公开(公告)日：2023-03-23

申请号：PCT/EP2021/075541

申请日：2021-09-16

Applicant: ELEKTA AB (PUBL)

Inventor： SJOLUND, Jens Olof ,  NORDSTRÖM, Carl Axel Håkan

IPC: A61N5/10 ,  G16H20/40

Abstract: Systems and methods are disclosed for simulating dose deposition. The systems and methods perform operations comprising: receiving a set of training data representing phase space of a radiotherapy treatment device comprising propagation and scattering of particles inside the radiotherapy treatment device; training a generative machine learning model based on the set of training data to generate one or more samples of the phase space of the radiotherapy treatment device; and simulating dose deposition at a particular region of interest based on the one or more samples of the phase space generated by the generative machine learning model.

公开(公告)号：WO2021009055A1

公开(公告)日：2021-01-21

申请号：PCT/EP2020/069582

申请日：2020-07-10

Applicant: ELEKTA AB (PUBL)

Inventor： SJÖLUND, Jens

IPC: A61N5/10 ,  G16H50/20 ,  G06N3/02 ,  G06N3/08 ,  G06N20/10

Abstract: Techniques for generating a radiotherapy treatment plan parameter are provided. The techniques include receiving radiotherapy treatment plan information; processing the radiotherapy treatment plan information to estimate one or more radiotherapy treatment plan parameters based on a process that depends on the output of a subprocess that estimates a derivative of a dose calculation; and generating a radiotherapy treatment plan using the estimated one or more radiotherapy treatment plan parameters.

公开(公告)号：WO2021001052A1

公开(公告)日：2021-01-07

申请号：PCT/EP2019/076488

申请日：2019-09-30

Applicant: ELEKTA AB (PUBL)

Inventor： RIAD, Stella Lucie ,  TILLY, David Andreas ,  KIMSTRAND, Peter ,  WÜRTEMBERG, Klas Marcks von ,  TILLY, Nina Terese

IPC: A61N5/10

Abstract: Techniques for adjusting radiotherapy treatment for a patient in real time are provided. The techniques include retrieving a reference plan that includes three- dimensional (3D) volume representation of information for the patient and a plurality of radiotherapy beam delivery segments; identifying a first portion of the 3D volume representation of information for a first beam delivery segment of the plurality of radiotherapy beam delivery segments that includes a volumetric portion of a target irradiated by the first beam delivery segment; accessing a deformation model representing patient deformation during a radiotherapy treatment fraction; deforming the first portion of the 3D volume representation of information based on the deformation model; and updating one or more parameters of a radiotherapy treatment device based on the deformed first portion of the 3D volume representation of information.