公开(公告)号：WO2020244788A1

公开(公告)日：2020-12-10

申请号：PCT/EP2019/072792

申请日：2019-08-27

Applicant: ELEKTA AB (PUBL)

Inventor： FAY, Dominik ,  SJÖLUND, Jens Olof

IPC: G06F21/62 ,  A61N5/10 ,  G06N3/08

Abstract: Techniques for producing segmentation with privacy are provided. The techniques include receiving a medical image; processing the medical image with a student machine learning model to estimate radiotherapy plan parameters, the student machine learning model being trained to establish a relationship between a plurality of public training medical images and corresponding radiotherapy plan parameters, the radiotherapy plan parameters of the plurality of public training medical images being generated by aggregating a plurality of radiotherapy plan parameter estimates produced by: processing the plurality of public training medical images with a plurality of teacher machine learning models to generate sets of radiotherapy plan parameter estimates; and reducing respective dimensions of the sets of radiotherapy plan parameter estimates or medical images, the radiotherapy plan parameters of the plurality of public training medical images being perturbed in accordance with privacy criteria; and generating a radiotherapy treatment plan based on the estimated radiotherapy plan parameters.

公开(公告)号：WO2016091337A1

公开(公告)日：2016-06-16

申请号：PCT/EP2014/077817

申请日：2014-12-15

Applicant: ELEKTA AB (PUBL)

Inventor： NYMAN, Markus ,  RURLING, Erik

IPC: A61B19/00

CPC classification number: A61B90/11 ,  A61B2017/00477

Abstract: The present invention relates to the field of stereotactical surgery. In particular, the invention concerns a stereotactic surgical instrument for use in stereotactical therapy and surgery and a coupling mechanism for such an instrument. The stereotactic surgical instrument includes a semi-circular arc part (28) and a head frame (24), wherein the head frame is arranged for fixation to a head of a patient by means of pins or screws, wherein the arc part comprises coupling members (30) shaped as rings arranged at a fixed distance from each other for attaching and locking the arc part to the head frame, wherein the head frame comprises support members formed as rings for receiving corresponding coupling members, wherein each coupling member includes a pivotable clamp element arranged to partly surround a respective support member circumferentially when the arc part is coupled to the head frame, and wherein the coupling members includes locking elements arranged to receive a tip portion of the respective clamp element and adjustable locking knobs for tightening and locking respective coupling member to respective support member.

Abstract translation: 本发明涉及立体定向手术领域。 特别地，本发明涉及用于立体定向治疗和手术的立体定向手术器械和用于这种器械的联接机构。 立体定向手术器械包括半圆弧部分（28）和头部框架（24），其中头部框架布置成通过销或螺钉固定到患者的头部，其中弧形部分包括联接构件 （30），形成为彼此固定距离设置的环，用于将弧形部分附接和锁定到头部框架，其中头部框架包括形成为用于接收相应联接构件的环的支撑构件，其中每个联接构件包括可枢转夹具 元件，其布置成当弧形部件联接到头部框架时周向地部分地围绕相应的支撑构件，并且其中联接构件包括锁定元件，该锁定元件布置成容纳相应的夹紧元件的尖端部分和可调节的锁定旋钮，用于紧固和锁定相应的联接器 成员到相应的支持成员。

公开(公告)号：WO2015158372A1

公开(公告)日：2015-10-22

申请号：PCT/EP2014/057659

申请日：2014-04-15

Applicant: ELEKTA AB (PUBL)

Inventor： SJÖLUND, Jens

IPC: A61N5/10

CPC classification number: A61B6/583 ,  A61B6/032 ,  A61B6/50 ,  A61N5/1039 ,  A61N5/1075 ,  A61N2005/1061 ,  A61N2005/1076

Abstract: The present invention relates to the field of radiation therapy. In particular, the invention concerns a method of calibrating a positioning system in a radiation therapy system comprising a radiation therapy unit having a fixed radiation focus. The method comprises the steps of irradiating a calibration tool comprising at least one reference object, capturing at least one two-dimensional image including cross- sectional representations of reference objects of the calibration tool and determining image coordinates of the representation of each reference object. Based on the reference objects image coordinates, positions of the reference objects in the stereotactic coordinate system relative to an origin of the calibration tool and the position of the origin of the calibration tool relative to the imaging unit, a position difference between the position of the calibration tool in the stereotactic coordinate system and a position of the calibration tool in an imaging system coordinate system including a translational and rotational position difference is calculated.

Abstract translation: 本发明涉及放射治疗领域。 特别地，本发明涉及一种校准放射治疗系统中的定位系统的方法，该放射治疗系统包括具有固定辐射聚焦的放射线治疗单元。 该方法包括以下步骤：照射包括至少一个参考对象的校准工具，捕获包括校准工具的参考对象的横截面表示的至少一个二维图像并确定每个参考对象的表示的图像坐标。 基于参考对象图像坐标，立体定向坐标系中的参考对象相对于校准工具的原点的位置和校准工具的原点相对于成像单元的位置，位置差异 计算立体定向坐标系中的校准工具和校准工具在包括平移和旋转位置差的成像系统坐标系中的位置。

公开(公告)号：WO2015150575A1

公开(公告)日：2015-10-08

申请号：PCT/EP2015/057513

申请日：2015-04-07

Applicant: ELEKTA AB (PUBL) ,  KONTAXIS, Charis ,  BOL, Gijsbert Herman ,  RAAYMAKERS, Bas Willem

Inventor： KONTAXIS, Charis ,  BOL, Gijsbert Herman ,  RAAYMAKERS, Bas Willem

IPC: A61N5/10

CPC classification number: A61N5/1067 ,  A61N5/1031 ,  A61N5/1037 ,  A61N5/1038 ,  A61N5/1039 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/1071 ,  A61N2005/1034 ,  A61N2005/1054 ,  A61N2005/1055 ,  A61N2005/1058

Abstract: Systems and methods for Image-Guided Radiation Therapy (IGRT), particularly but not exclusively when practised with a magnetic resonance imaging (MRI) system, which utilises an iterative approach which adjusts a treatment plan based on inter- or intra-fraction images to significantly improve the accuracy of the radiation delivered during the overall treatment. The prescribed dose of radiotherapeutic radiation is mapped onto the patient's anatomy using an image acquired of the region which is to be the target for radiotherapeutic radiation. Following beam-angle-optimisation, fluence optimisation and segmentation, the efficiency of delivery of each segment is determined using an objective function, and the segments ranked according to their efficiency. The plan proceeds with the choice of the most efficient segment (or segments) to be delivered first. When this radiation has been delivered, having been tracked to establish its distribution, this delivered distribution can be subtracted from the original prescribed dose and the process repeated so that the delivered radiation gradually converges on the original prescribed dose.

Abstract translation: 用于影像引导放射治疗（IGRT）的系统和方法，特别地但不排他地用磁共振成像（MRI）系统实施时，该系统利用迭代方法，该迭代方法基于图像间或图像内图像来调整治疗计划， 提高整体治疗过程中辐射的准确性。 放射治疗辐射的规定剂量使用获得的作为放射治疗辐射靶标的区域的图像映射到患者的解剖结构上。 在光束角优化，能量密度优化和分割之后，使用目标函数确定每个片段的传递效率，并且根据片段的效率进行分级。 该计划继续选择首先要交付的最有效的部分（或细分）。 当已经传送这种辐射时，已经被跟踪以建立其分布，可以从原始规定的剂量中减去该传送的分布并重复该过程，使得递送的辐射逐渐收敛于原始的规定剂量。

公开(公告)号：WO2014207641A1

公开(公告)日：2014-12-31

申请号：PCT/IB2014/062498

申请日：2014-06-20

Applicant: ELEKTA AB (PUBL)

Inventor： WINFIELD, Colin ,  SAYEED, Abdul

IPC: A61N5/10

CPC classification number: G06T7/0012 ,  A61N5/1071 ,  A61N2005/1054 ,  G06F17/30259 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3481 ,  G06K9/6202 ,  G06T2207/10004 ,  G06T2207/10116 ,  G16H20/40 ,  G16H30/20 ,  G16H50/20

Abstract: Embodiments of the invention provide systems and methods for evaluating treatment parameters for a patient undergoing radiotherapy. The method includes the step of generating a portal dosimetry image showing differences between a planning image obtained prior to a treatment session and a portal image obtained during the treatment session. A database of prior portal dosimetry results is accessed, and a processor is used to perform a similarity measurement between the portal dosimetry image and the prior portal dosimetry results. Based on the similarity measurement, the system determines whether radiation was delivered as planned during the treatment session.

Abstract translation: 本发明的实施例提供了用于评估进行放射治疗的患者的治疗参数的系统和方法。 该方法包括生成门诊剂量测定图像的步骤，该图像显示在治疗会话之前获得的规划图像与在治疗期间获得的门静图像之间的差异。 访问先前的门户剂量测定结果的数据库，并且使用处理器来执行门户剂量测定图像和先前的门户剂量测定结果之间的相似性测量。 根据相似度测量，系统确定在治疗期间辐射是否按计划传送。

公开(公告)号：WO2013139353A1

公开(公告)日：2013-09-26

申请号：PCT/EP2012/001299

申请日：2012-03-23

Applicant: ELEKTA AB (PUBL) ,  ERIKSSON JÄRLIDEN, Andreas

Inventor： ERIKSSON JÄRLIDEN, Andreas

IPC: G06T7/00

CPC classification number: G06T7/0024 ,  G06T7/30 ,  G06T2207/10072 ,  G06T2207/30004

Abstract: The co-registration error can be estimated by performing a number of additional iterative co-registrations, each iteration having a starting point dictated by the found co-registration transformation, and using a set of initial parameters different to that of the co-registration being tested. The spread in the resulting co-registrations can then be used as the estimate of the co-registration error. The variations in the set of initial parameters can include (i) the candidate transformation which the iteration uses as its starting point, adopting starting points that are offset from the co-registration being tested, (ii) the sample points used for the mutual information metric (or whichever metric is used to optimise the transformation), and (iii) the region-of-interest that is selected. Ideally, all three are varied to some extent within the plurality of additional co-registrations that are performed, and an average value is taken.

Abstract translation: 可以通过执行多个附加的迭代共同注册来估计共同注册错误，每个迭代具有由所发现的共同注册转换指定的起始点，并且使用与共同注册的初始参数不同的一组初始参数 测试。 然后，可以将所得到的共同注册中的扩展用作共同注册错误的估计。 初始参数集合中的变化可以包括（i）迭代使用的候选变换作为起始点，采用与正被测试的共同注册偏移的起始点，（ii）用于互信息的采样点 度量（或用于优化转化的任何度量），以及（iii）所选择的兴趣区域。 理想情况下，在执行的多个附加共同注册中，所有三个在一定程度上是变化的，并且采用平均值。

公开(公告)号：WO2013111072A1

公开(公告)日：2013-08-01

申请号：PCT/IB2013/050595

申请日：2013-01-24

Applicant: ELEKTA AB (PUBL).

Inventor： SIMOLA, Juha ,  TAULU, Samu ,  KAJOLA, Matti

IPC: A61B5/04 ,  A61B5/00 ,  G01R33/035

CPC classification number: A61B5/7203 ,  A61B5/04 ,  A61B5/04008 ,  A61B5/0476 ,  A61B5/055 ,  G01R29/12 ,  G01R33/02 ,  G01R33/035 ,  G01R33/56

Abstract: The present invention introduces a method, device and a computer program for removing artifacts present in individual channels of a multichannel measurement device. At first, a basis is generated defining an n-dimensional subspace of the N-dimensional signal space, where n is smaller than N, where using in the definition of the n-dimensional basis a physical model of a Signal Space Separation method, or a statistical model based on the statistics of recorded N-dimensional signals. Thereafter, a combined (n+m) - dimensional basis is formed by adding m signal vectors to the n-dimensional basis, each of these m signal vectors representing a signal present only in a single channel of the N-channel device. After this the recorded N-dimensional signal vector is decomposed into n+m components in the combined basis, and finally, components corresponding to the m added vectors in the combined basis are subtracted from the recorded N-dimensional signal vector.

Abstract translation: 本发明引入了一种用于去除存在于多通道测量装置的各个通道中的假象的方法，装置和计算机程序。 首先，生成定义N维信号空间的n维子空间的基础，其中n小于N，其中在n维基础的定义中使用信号空间分离方法的物理模型，或 基于记录的N维信号的统计的统计模型。 此后，通过将m个信号向量加到n维基础上来形成组合（n + m）维度，这些m个信号矢量中的每一个表示仅存在于N信道设备的单个信道中的信号。 之后，记录的N维信号向量在组合的基础上被分解为n + m个分量，最后，从记录的N维信号向量中减去与组合的m个相加向量相对应的分量。

公开(公告)号：WO2013107472A1

公开(公告)日：2013-07-25

申请号：PCT/EP2012/000248

申请日：2012-01-20

Applicant: ELEKTA AB (PUBL) ,  CHEN, Rui ,  BROWN, Kevin John

Inventor： CHEN, Rui ,  BROWN, Kevin John

IPC: A61N5/10 ,  A61B19/00

CPC classification number: A61N5/1049 ,  A61B2090/065 ,  A61N5/1064 ,  A61N2005/1058 ,  A61N2005/1059 ,  A61N2005/1061

Abstract: There is a need within the art of radiation therapy for improved systems and methods that enable intra-fraction motion detection with a high degree of accuracy and reliability so as to avoid or at least significantly reduce the risk of undesired damage to surrounding tissue. We therefore disclose a radiotherapy apparatus for treating a patient, incorporating an ionising treatment modality, an ionising investigative source for determining the current patient position so as to guide the ionising treatment modality, a control system for the ionising investigative source, arranged to initiate the commencement of an investigative scan on a periodic basis, and a non-ionising monitoring system that runs continuously with the ionising treatment modality and alerts the control system as to when there appears to have been movement of the patient. In this way, unnecessary ionising investigative scans can be avoided. This reduces the ionising dose that is delivered to the patient whilst still watching for movement and retaining the accuracy of an ionising investigative source such as an x-ray system, computed tomography (CT) system, cone- beam CT apparatus, and the like. The control system initiates an investigative scan after a preset period unless the monitoring system indicates no movement, or if the monitoring system indicates movement. The monitoring system can comprises an ultrasound scanning system, and/or an optical tracking system, and/or a proximity sensor such as an infra-red proximity sensor.

Abstract translation: 在辐射治疗领域中需要改进的系统和方法，其能够以高精度和可靠性实现部分内运动检测，以避免或至少显着降低对周围组织的不期望的损伤的风险。 因此，我们公开了一种用于治疗患者的放射治疗装置，包括电离治疗模式，用于确定当前患者位置的电离调查来源以引导电离治疗模式，用于电离调查源的控制系统，其被设置为启动开始 定期进行调查扫描，以及非电离监测系统，其以电离处理模式连续运行，并且向控制系统警告患者何时发生移动。 以这种方式，可以避免不必要的电离调查扫描。 这降低了传递给患者的电离剂量，同时仍在观察运动并保持诸如x射线系统，计算机断层扫描（CT）系统，锥束CT装置等的电离调查源的准确性。 控制系统在预设的时间段之后启动调查扫描，除非监视系统指示没有移动，或监视系统是否指示移动。 监测系统可以包括超声波扫描系统和/或光学跟踪系统，和/或诸如红外接近传感器的接近传感器。

公开(公告)号：WO2013000488A1

公开(公告)日：2013-01-03

申请号：PCT/EP2011/003170

申请日：2011-06-28

Applicant: ELEKTA AB (publ) ,  BROWN, Kevin

Inventor： BROWN, Kevin

IPC: G06F19/00 ,  A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1036 ,  A61N5/1048 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63

Abstract: The present invention provides methods and apparatus for the management and provision of radiotherapy, in which values for dosimetric parameters are re-evaluated just prior to treatment (on the basis of the treatment plan as loaded into the radiotherapy apparatus) and during treatment (on the basis of monitored machine parameters). By displaying dosimetric parameters rather than complicated machine parameters, the technician operating the radiotherapy apparatus is able to monitor the dose provided to a patient undergoing therapy. Misadministrations of radiation as a result of corrupted data or corrupted control signals are prevented.

Abstract translation: 本发明提供了用于管理和提供放射治疗的方法和装置，其中剂量测量参数的值在治疗之前（基于装载到放射治疗装置中的治疗计划）和治疗期间（在 监控机器参数的基础）。 通过显示剂量测量参数而不是复杂的机器参数，操作放射治疗装置的技术人员能够监测提供给接受治疗的患者的剂量。 由于数据损坏或控制信号损坏导致的辐射管理不当。

公开(公告)号：WO2012119786A1

公开(公告)日：2012-09-13

申请号：PCT/EP2012/001071

申请日：2012-03-09

Applicant: ELEKTA AB (PUBL) ,  LARGE, Terry, Arthur

Inventor： LARGE, Terry, Arthur

IPC: H05H9/00 ,  H01J25/34 ,  H01J1/46 ,  H01J23/075

CPC classification number: H01J25/34 ,  H01J3/02 ,  H01J23/075 ,  H05H9/048 ,  H05H2007/084

Abstract: The present invention provides an electron gun (12) comprising a cathode (20), for generating electrons; an anode (22); an intermediate electrode (24), located between the cathode and the anode; and a controller (14). The controller applies an electrical potential to said intermediate electrode, analysing a resultant electrical parameter to determine the integrity of said intermediate electrode; and controls the electron gun to emit a pulse of electrons.

Abstract translation: 本发明提供一种电子枪（12），包括用于产生电子的阴极（20） 阳极（22）; 位于阴极和阳极之间的中间电极（24）; 和控制器（14）。 控制器向所述中间电极施加电势，分析所得的电参数以确定所述中间电极的完整性; 并控制电子枪发射电子脉冲。