公开(公告)号：WO2012012851A1

公开(公告)日：2012-02-02

申请号：PCT/AU2011/000971

申请日：2011-08-01

申请人： GRIFFITH UNIVERSITY ,  JENNINGS, Michael Paul ,  PEAK, Ian, Richard, Anselm

发明人： JENNINGS, Michael Paul ,  PEAK, Ian, Richard, Anselm

IPC分类号： C07K14/22 ,  A61P37/04 ,  G01N33/68 ,  A61K39/095 ,  G01N33/53

CPC分类号： C07K14/22 ,  A61K39/095 ,  C07K16/1217 ,  C07K2317/33

摘要： Neisseria meningitidis PorA constructs are provided which have one or more disrupted variable regions created by insertion of entire conserved regions or conserved region amino acids. The highly immunogenic variable regions of PorA are responsible for eliciting strain-specific immune responses that are not broadly protective, so disruption of the variable regions directs the immune response against conserved region epitopes to effectively immunize against a broader spectrum of N. meningitidis strains. Also provided are encoding nucleic acids, genetic constructs, host cells expressing the PorA constructs and compositions, kits and methods for detection and treatment of Neisseria meningitidis infections.

摘要翻译： 提供脑膜炎奈瑟氏球菌PorA构建体，其具有通过插入整个保守区域或保守区域氨基酸产生的一个或多个破坏的可变区。 PorA的高免疫原性可变区负责引发不广泛保护的菌株特异性免疫应答，因此可变区的破坏引导针对保守区表位的免疫应答以有效地免疫针对更广谱的脑膜炎奈瑟菌菌株。 还提供编码核酸，遗传构建体，表达PorA构建体的宿主细胞和用于检测和治疗脑膜炎奈瑟菌感染的组合物，试剂盒和方法。

公开(公告)号：WO2011006208A1

公开(公告)日：2011-01-20

申请号：PCT/AU2010/000905

申请日：2010-07-16

申请人： GRIFFITH UNIVERSITY ,  VON ITZSTEIN, Mark ,  DYASON, Jeffrey Clifford ,  THOMSON, Robin ,  RUDRAWAR, Santosh ,  PASCOLUTTI, Mauro

发明人： VON ITZSTEIN, Mark ,  DYASON, Jeffrey Clifford ,  THOMSON, Robin ,  RUDRAWAR, Santosh ,  PASCOLUTTI, Mauro

IPC分类号： C07D309/28 ,  A61K31/4192 ,  C07D309/30 ,  A61K31/351 ,  A61P31/16 ,  C07D405/06

CPC分类号： A61K31/351 ,  A61K31/4192 ,  C07D309/28 ,  C07H13/04

摘要： The present invention relates to compounds that selectively inhibit influenza A virus group (1) sialidases and are therefore potential anti-influenza agents.

摘要翻译： 本发明涉及选择性抑制甲型流感病毒组（1）唾液酸酶的化合物，因此是潜在的抗流感药物。

公开(公告)号：WO2009152546A1

公开(公告)日：2009-12-23

申请号：PCT/AU2008/000877

申请日：2008-06-18

申请人： GRIFFITH UNIVERSITY ,  GRIFFITHS, Lynette, Robyn ,  LEA, Rod, A. ,  FERNANDEZ, Francesca

发明人： GRIFFITHS, Lynette, Robyn ,  LEA, Rod, A. ,  FERNANDEZ, Francesca

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The invention provides a method of determining whether or not an individual has a predisposition to migraine including the step of determining whether an isolated nucleic acid obtained from the individual comprises a nucleotide sequence corresponding to at least a fragment of a dopamine β-hydroxylase (DBH) gene promoter, wherein the presence of a -1021C → T single nucleotide polymorphism (SNP) in said nucleotide sequence indicates whether or not said individual has an increased predisposition to migraine compared to an individual without the polymorphism. DBH -1021C/C homozygotes are particularly susceptible to migraine. The -1021T allele may exert a protective effect. The method is particularly suited to detection of a predisposition to migraine with aura in females. The invention also provides a diagnostic kit for detecting a -1021C→ T SNP associated with migraine. The method and kit may facilitate selection of individuals for migraine therapy which targets the dopaminergic system.

摘要翻译： 本发明提供了一种确定个体是否具有偏头痛倾向的方法，包括确定从个体获得的分离的核酸是否包含对应于多巴胺β-羟化酶（DBH）的至少一个片段的核苷酸序列的步骤， 基因启动子，其中存在-1021℃〜 所述核苷酸序列中的T单核苷酸多态性（SNP）表示与没有多态性的个体相比，所述个体是否具有对偏头痛的倾向性增加。 DBH -1021C / C纯合子对偏头痛特别敏感。 -1021T等位基因可能发挥保护作用。 该方法特别适用于检测女性偏头痛偏头痛。 本发明还提供了一种用于检测-1021℃ T SNP与偏头痛相关。 该方法和试剂盒可以促进靶向多巴胺能系统的偏头痛治疗个体的选择。

公开(公告)号：WO2005051969A1

公开(公告)日：2005-06-09

申请号：PCT/AU2004/001660

申请日：2004-11-26

申请人： GRIFFITH UNIVERSITY ,  JARLMADANGAH BURU ABORIGINAL CORPORATION ,  QUINN, Ronald ,  MILLS, Clive

发明人： QUINN, Ronald ,  MILLS, Clive

IPC分类号： C07H15/256

CPC分类号： C07H15/256

摘要： Various compounds obtained from plants of the Barringtonia species which are derived from Barringtoside A and Barringtoside C as precursor compounds which especially have an arabinopyranosyl substituent at the 21 position which may optionally be further substituted with benzoyl, dibenzoyl, methyl butanoyl, methyl butyryl or tigloyl at the 3 or 4 positions. Alternatively at the 21 position there is provided tigloyl, benzoyl or dibenzoyl substituents.

摘要翻译： 从Barringtoside A和Barringtoside C衍生的Barringtonia物种的植物获得的各种化合物作为前体化合物，其特别是在21位具有阿拉伯吡喃糖基取代基，其可任选进一步被苯甲酰基，二苯甲酰基，甲基丁酰基，甲基丁酰基或二酪酰基取代 3或4个职位。 或者在21位置提供了二酰基，苯甲酰基或二苯甲酰基取代基。

公开(公告)号：WO2005026385A1

公开(公告)日：2005-03-24

申请号：PCT/AU2004/001248

申请日：2004-09-15

申请人： GRIFFITH UNIVERSITY ,  GRIFFITHS, Lynette, Robyn ,  COLSON, Natalie, Jane ,  LEA, Rod, A.

发明人： GRIFFITHS, Lynette, Robyn ,  COLSON, Natalie, Jane ,  LEA, Rod, A.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

摘要： A method of determining whether an individual has a predisposition to migraine is provided, which method includes the step of isolating a nucleic acid that has a guanine to adenine polymorphism at nucleotide (2014) of a human estrogen receptor and/or a nucleic acid that has a (306) base pair insertion in intron (7) of a human progesterone receptor gene. The presence of either polymorphism is indicative of an increased predisposition to migraine. Furthermore, the presence of both the human estrogen receptor polymorphism and the human progesterone receptor gene polymorphism indicates a three-fold greater predisposition to migraine. Also provided are kits for use with these methods, the kits comprising primers and, optionally, a restriction endonuclease such as Btg 1, for molecular detection of a genetic a predisposition to migraine.

摘要翻译： 提供了确定个体是否具有偏头痛倾向的方法，该方法包括在人雌激素受体的核苷酸（2014）和/或具有鸟嘌呤核苷酸核苷酸的核酸上分离具有鸟嘌呤至腺嘌呤多态性的核酸的步骤 （306）碱基对插入人孕酮受体基因的内含子（7）中。 多态性的存在表明偏头痛的倾向增加。 此外，人雌激素受体多态性和人孕酮受体基因多态性的存在表明偏头痛倾向三倍。 还提供了用于这些方法的试剂盒，所述试剂盒包含引物和任选的限制性内切核酸酶如Btg1，用于分子检测偏头痛的遗传倾向。

公开(公告)号：WO2005019237A1

公开(公告)日：2005-03-03

申请号：PCT/AU2004/001115

申请日：2004-08-20

申请人： GRIFFITH UNIVERSITY ,  VON ITZSTEIN, Laurence Mark ,  DAVIS, Christopher Bonner ,  THOMSON, Robin Joy ,  HARTNELL, Regan David ,  MADGE, Paul David Orr

发明人： VON ITZSTEIN, Laurence Mark ,  DAVIS, Christopher Bonner ,  THOMSON, Robin Joy ,  HARTNELL, Regan David ,  MADGE, Paul David Orr

IPC分类号： C07H15/14

CPC分类号： C07H15/14 ,  A61K31/70

摘要： Sulfenamide compounds of general formula (I) are disclosed wherein A, R 1, R 2 , X 1 , X 1 ’, X 2 , X 2 ’, X 3 , X 3 ’, X 4 , X 4 ’, X 5 and X 5 ’ define a variety of variables and q is 0 or 1. The compounds of the examples are galactofuranosyl and arabinofuranosyl compounds wherein the variable A is oxygen. Methods for the synthesis of compounds of general formula (I), pharmaceutical compositions them and methods of using them to treat patients suffering a microbial infection are also disclosed.

摘要翻译： 公开了通式（I）的亚磺酰胺化合物，其中A，R1，R2，X1，X1'，X2，X2'，X3，X3'，X4，X4'，X5和X5'定义各种变量，q为0 实例的化合物是半乳糖呋喃糖基和阿拉伯呋喃糖基化合物，其中变量A是氧。 还公开了合成通式（I）的化合物的方法，药物组合物及其用于治疗患有微生物感染的患者的方法。

公开(公告)号：WO2003102227A1

公开(公告)日：2003-12-11

申请号：PCT/AU2003/000684

申请日：2003-06-02

申请人： GRIFFITH UNIVERSITY ,  GRIFFITHS, Lynette, Robyn ,  TAJOURI, Lotti

发明人： GRIFFITHS, Lynette, Robyn ,  TAJOURI, Lotti

IPC分类号： C12Q1/68

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/564 ,  G01N2800/285

摘要： Genes and encoded proteins that are differentially expressed in cells and tissues of individuals suffering from multiple sclerosis compared to cells and tissues of non-sufferers are provided. Examples of these genes include Serum Transferrin; Ribonuclease pancreatic precursor; Eucaryotic translation elongation factor 1, alpha 1; Guanine nucleotide binding protein; Glutathione peroxidase 1; SLC10A1; Calpain subunit 1; Inositol 1,4,5 triphosphate 3 kinaseB; Peripheral myelin Protein 22; Mal (T cell differentiation Protein); CRYAB Crystallin, alpha B; Betaine-Homocysteine methyl transferase; ADP-ribosylation factor 5; Glutathione S-transferase; Phosphomannomutase1; Tubulin beta 5; Ubiquitin A-52 residue ribosomal protein factor product 1; SOD1 Superoxide dismutase 1; CST3 Cystatin C protease inhibitor; Small nuclear ribonucleoprotein polypeptide N; and Solute carrier 25. Genes of the invention may, at least in some cases, carry mutations or other sequence variations that affect gene expression and contribute to multiple sclerosis pathophysiology. These genes may be of diagnostic value in predicting a predisposition to multiple sclerosis, confirming clinical diagnosis of multiple sclerosis and in the discovery of compounds for use in treating multiple sclerosis.

摘要翻译： 提供了与非患者的细胞和组织相比，在患有多发性硬化症的个体的细胞和组织中差异表达的基因和编码的蛋白质。 这些基因的实例包括血清转铁蛋白; 核糖核酸酶胰腺前体; 真核翻译延伸因子1，α1; 鸟嘌呤核苷酸结合蛋白; 谷胱甘肽过氧化物酶1 SLC10A1; 钙蛋白酶亚基1; 肌醇1,4,5三磷酸3激酶B; 外周髓鞘蛋白22; Mal（T细胞分化蛋白）; CRYAB晶状蛋白，αB; 甜菜碱 - 同型半胱氨酸甲基转移酶; ADP-核糖基化因子5; 谷胱甘肽S-转移酶; Phosphomannomutase1; 微管蛋白β5 泛素A-52残基核糖体蛋白因子产物1; SOD1超氧化物歧化酶1; CST3半胱氨酸蛋白酶抑制剂C蛋白酶抑制剂 小核糖核蛋白多肽N; 和溶质载体25.本发明的基因至少在一些情况下可能携带影响基因表达并有助于多发性硬化病理生理学的突变或其它序列变异。 这些基因在预测多发性硬化易感性，确认多发性硬化症的临床诊断和发现用于治疗多发性硬化症的化合物方面可能具有诊断价值。

公开(公告)号：WO2003097657A1

公开(公告)日：2003-11-27

申请号：PCT/AU2003/000620

申请日：2003-05-22

申请人： GRIFFITH UNIVERSITY ,  VON ITZSTEIN, Laurence, Mark ,  DAVIS, Christopher, Bonner ,  THOMSON, Robin, Joy

发明人： VON ITZSTEIN, Laurence, Mark ,  DAVIS, Christopher, Bonner ,  THOMSON, Robin, Joy

IPC分类号： C07H15/14

CPC分类号： C07H5/10 ,  A61K31/7004 ,  C07H15/14 ,  C07H15/18

摘要： The present invention relates to novel thioglycosides of D-galactofuranose that have an antimicrobial action, methods for their synthesis, pharmaceutical compositions containing them and methods for the treatment of patients suffering microbial infection.

摘要翻译： 本发明涉及具有抗微生物作用的D-半乳糖呋喃糖的新型硫代糖苷，其合成方法，含有它们的药物组合物和用于治疗患有微生物感染的患者的方法。

公开(公告)号：WO2003089631A1

公开(公告)日：2003-10-30

申请号：PCT/AU2003/000476

申请日：2003-04-22

申请人： GRIFFITH UNIVERSITY ,  THE STATE OF QUEENSLAND (ACTING THROUGH ITS DEPARTMENT OF HEALTH) ,  MACKAY-SIM, Alan ,  FERON, François ,  MURRELL, Wayne ,  WETZIG, Andrew

发明人： MACKAY-SIM, Alan ,  FERON, François ,  MURRELL, Wayne ,  WETZIG, Andrew

IPC分类号： C12N5/08

CPC分类号： C12N5/0623 ,  A61K35/12 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/148 ,  C12N2503/02 ,  C12N2533/32

摘要： The present invention relates to a method for culturing and propagating a stem cell and/or progenitor cell and populations thereof. The method includes the step of selecting and transferring adherent cells from one surface to another for propagation. The method may be used with isolated adult human tissue. The propagated cells may be transplanted into a recipient as stem cells, progenitor cells and/or differentiated cells that may be genetically modified.

摘要翻译： 本发明涉及培养和繁殖干细胞和/或祖细胞及其群体的方法。 该方法包括从一个表面到另一个表面选择和转移粘附细胞以进行传播的步骤。 该方法可以与孤立的成人人体组织一起使用。 传播的细胞可以作为干细胞，祖细胞和/或可被遗传修饰的分化细胞移植到受体中。

公开(公告)号：WO2003018630A1

公开(公告)日：2003-03-06

申请号：PCT/AU2002/001136

申请日：2002-08-23

申请人： THE UNIVERSITY OF QUEENSLAND ,  GRIFFITH UNIVERSITY ,  THE CORPORATION OF THE TRUSTEES OF THE ORDER OF THE SISTERS OF MERCY IN QUEENSLAND ,  KENNEDY, Derek ,  HART, Derek ,  FRENCH, Juliet ,  RAMIREZ, Jose, Alejandro, Lopez

发明人： KENNEDY, Derek ,  HART, Derek ,  FRENCH, Juliet ,  RAMIREZ, Jose, Alejandro, Lopez

IPC分类号： C07K14/47

CPC分类号： G01N33/57415 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/665 ,  C07K2319/00

摘要： The present invention relates to an isolated domain of G3BP-2 that mediates binding between G3BP-2 and other proteins, and nucleic acids encoding same. The invention also relates to a method for diagnosing, treating and preventing breast cancer including the step of using a nucleic acid and/or encoded polypeptide for G3BP-2, or fragment thereof, to detect, treat or prevent breast cancer in a mammal, preferably human. In one particular form, the invention relates to an antigen presenting cell, preferably a dendritic cell, that is capable of presenting G3BP-2 or fragments thereof. The invention also relates to lymphocytes, in particular cytotoxic T-lymphocytes, that are G3BP-2 antigen specific.

摘要翻译： 本发明涉及介导G3BP-2与其他蛋白质之间的结合的G3BP-2的分离结构域，以及编码它们的核酸。 本发明还涉及用于诊断，治疗和预防乳腺癌的方法，包括使用核酸和/或编码多肽的G3BP-2或其片段在哺乳动物中检测，治疗或预防乳腺癌的步骤，优选地 人类。 在一个具体形式中，本发明涉及能够呈现G3BP-2或其片段的抗原呈递细胞，优选树突状细胞。 本发明还涉及G3BP-2抗原特异性的淋巴细胞，特别是细胞毒性T淋巴细胞。