公开(公告)号：WO2003030995A3

公开(公告)日：2003-04-17

申请号：PCT/US2002/032595

申请日：2002-10-11

Applicant: LIFE MIST, LLC ,  BORISOV, Yulian Y. ,  KUTCHINSKI, David, P.

Inventor： BORISOV, Yulian Y. ,  KUTCHINSKI, David, P.

IPC: B05B17/04

Abstract: A fire-suppression apparatus that includes a pneumoacoustic atomizer (108) for delivering a mist of liquid (e.g., water) in the form of droplets having a size in the range of about 50 to 90 microns. The mist is suspended in a fire-suppressing gas such as nitrogen. Gas is supplied to the pneumoacoustic atomizer (108) from a system that, in some embodiments, includes both bottles (218A, 218B) and a gas generator (214). To minimize consumption of fire-suppressing materials, the fire-suppression apparatus can be operated in a pulsed mode wherein delivery of fire-suppressing materials is interrupted unless a sensor (234) detects a fire re-flash. In some variations, the pneumoacoustic atomizer (108) operates at very low pressures, as is desirable for use in aircraft.

公开(公告)号：WO0224324A3

公开(公告)日：2003-03-06

申请号：PCT/US0130094

申请日：2001-09-25

Applicant: PICOLITER INC

Inventor： ELLSON RICHARD N ,  FOOTE JAMES K ,  MUTZ MITCHELL W

IPC: G01N33/53 ,  B01J4/02 ,  B01J19/00 ,  B01J19/10 ,  B01J19/12 ,  B05B17/04 ,  B05B17/06 ,  B41J2/04 ,  B41J2/14 ,  C07B61/00 ,  C40B20/02 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N35/10 ,  G01N37/00

CPC classification number: B41J2/04 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/00378 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L2400/0433 ,  B05B17/0607 ,  B05B17/0615 ,  B41J2/14008 ,  C07B2200/11 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

Abstract: The present invention provides a method for the acoustic ejection of fluid droplets (49) from each of a plurality of fluid-containing reservoirs (13, 15) to prepare combinatorial libraries in the form of microarrays. An acoustic ejection device (11) is used comprised of a plurality of fluid reservoirs (13, 15), an ejector (33) for generating acoustic radiation and focusing the acoustic radiation generated at a focal point sufficiently near the fluid surface (17, 19) in each of the reservoirs (13, 15) such that a fluid droplet (49) is ejected therefrom toward a site on a substrate surface (51), and a means for positioning (43) the ejector (33) in acoustically coupled relationship to each of the reservoirs (13, 15). The combinatorial libraries may comprise biological or nonbiological moieties.

Abstract translation: 本发明提供了一种用于从多个含液体储存器（13,15）中的每一个的声弹出液体（49）的方法，以制备微阵列形式的组合文库。 使用由多个流体储存器（13,15）组成的声学喷射装置（11），用于产生声辐射的喷射器（33）并且聚焦在足够靠近流体表面（17,19）的焦点处产生的声辐射 ），使得流体液滴（49）从其中朝向基板表面（51）上的位置喷射，并且用于将喷射器（33）定位（43）为声耦合关系的装置 到每个储存器（13,15）。 组合文库可以包括生物或非生物部分。

公开(公告)号：WO02098390A3

公开(公告)日：2003-02-20

申请号：PCT/US0218608

申请日：2002-05-13

Applicant: ALEXZA MOLECULAR DELIVERY CORP

Inventor： HODGES CRAIG C ,  LLOYD PETER M ,  MUFSON DANIEL ,  ROGERS DANIEL D ,  WENSLEY MARTIN J

IPC: A61K9/72 ,  A61K9/00 ,  A61K9/16 ,  A61K31/4468 ,  A61M11/00 ,  A61M11/04 ,  A61M15/00 ,  A61M16/00 ,  A61P23/00 ,  B05B7/16 ,  B05B17/04

CPC classification number: A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to the delivery of drug containing aerosols having particles with a mass median aerodynamic diameter less than 1 µ for inhalation therapy. In a composition aspect of the present invention the drug containing aerosol comprises particles having a mass median aerodynamic diameter between 10 nm and 1 µ. Preferably, the particles have a mass median aerodynamic diameter between 10 nm and 900 nm. More preferably, the particles have a mass median aerodynamic diameter between 10 nm and 800 nm, 10 nm and 700 nm, 10 nm and 600 nm, 10 nm and 500 nm, 10 nm and 400 nm, 10 nm and 300 nm, 10 nm and 200nm, 10 nm and 100 nm.

Abstract translation: 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，它涉及具有质量中值空气动力学直径小于1μ的吸入剂量的含有气溶胶的药物的递送。 在本发明的组合物方面，含药物气溶胶包含质量中值空气动力学直径在10nm和1μ之间的颗粒。 优选地，颗粒具有在10nm和900nm之间的质量中值空气动力学直径。 更优选地，颗粒具有10nm和800nm，10nm和700nm，10nm和600nm，10nm和500nm，10nm和400nm，10nm和300nm，10nm之间的质量中值空气动力学直径 和200nm，10nm和100nm。

公开(公告)号：WO02056988A2

公开(公告)日：2002-07-25

申请号：PCT/IL2001/001217

申请日：2001-12-31

IPC: B05B7/00 ,  B05B7/24 ,  B05B17/04 ,  F02M29/00 ,  F28C3/06 ,  B01B

CPC classification number: F28C3/06 ,  B05B7/0012 ,  B05B7/2483 ,  B05B17/04 ,  F02M29/00 ,  Y10S261/25 ,  Y10S261/65

Abstract: The invention includes a method and apparatus (100) for producing mist of a liquid phase having very fine and mono-dispersed droplets. The method is realized by an apparatus (100) including a partition (101), defined by a first side surface (107) and a second side surface (113). The first side surface (107) is wetted by a liquid phase to form a film thereon, while the second side surface (113) is substantially dry. A gas stream is directed through the partition (101) from the dry side (113) to the wetted side (107) thereby forming a mist having droplets of less than i micron in size and a concentration of at least 1,000,000,000,000 per cubic cm.

Abstract translation: 本发明包括一种用于产生具有非常精细和单分散液滴的液相的雾的方法和装置（100）。 该方法由包括由第一侧表面（107）和第二侧表面（113）限定的分隔件（101）的装置（100）实现。 第一侧表面（107）被液相润湿以在其上形成膜，而第二侧表面（113）基本上是干的。 气流从干燥侧（113）引导到分隔部（101）到润湿侧（107），从而形成尺寸小于1微米，浓度至少为1,000,000,000,000立方厘米的雾。

公开(公告)号：WO02043793A1

公开(公告)日：2002-06-06

申请号：PCT/EP2001/013421

申请日：2001-11-20

IPC: A61M11/00 ,  A61M15/00 ,  B05B1/14 ,  B05B17/04 ,  B23H3/00 ,  B23H9/00 ,  B23H9/14 ,  C25F3/16 ,  C25F3/24

CPC classification number: B23H3/00 ,  A61M15/0085 ,  B05B1/14 ,  B23H9/00 ,  B23H9/14 ,  Y10T29/494

Abstract: A process for manufacturing inhalation sprayheads comprising: (a) providing a metallic substrate having a thickness; (b) removing material from the metallic substrate to create one or more holes through the thickness, to create a holed metallic substrate possessing residual material upon said substrate; and (c) exposing the holed metallic substrate to an electrolyte and anodically eroding said residual material from the holed metallic substrate. Devices incorporating such sprayheads for the generation of small droplets are also described.

Abstract translation: 一种制造吸入喷头的方法，包括：（a）提供具有厚度的金属基材; （b）从所述金属基板上移除材料以产生穿过所述厚度的一个或多个孔，以产生在所述基板上具有残余材料的孔金属基底; 和（c）将所述带孔的金属基底暴露于电解质，并从所述带孔的金属基底阳极腐蚀所述残留的材料。 还描述了并入用于产生小液滴的喷头的装置。

公开(公告)号：WO0172429A3

公开(公告)日：2002-04-11

申请号：PCT/US0140320

申请日：2001-03-16

Applicant: KIM CHANG JIN ,  HO CHIH MING ,  TSENG FAN GANG

Inventor： KIM CHANG-JIN ,  HO CHIH-MING ,  TSENG FAN-GANG

IPC: B41J2/05 ,  B05B1/14 ,  B05B17/04 ,  B41J2/14 ,  F02M53/04 ,  B41J2/17

CPC classification number: B41J2/1404 ,  B05B1/14 ,  B05B17/04 ,  B41J2/14056 ,  B41J2/14072 ,  B41J2/14137 ,  B41J2002/1437 ,  B41J2002/14387 ,  B41J2202/05

Abstract: An apparatus and method for forming a bubble within a microchannel of a microinjector (12) to function as a valve mechanism between the chamber (14) and manifold (16), that provides for a high resistance to liquid exiting the chamber through the manifold during fluid ejection through an orifice (18) and that also provides a low resistance to refilling of liquid (26) into the chamber after ejection of fluid and collapse of the bubble. This effectively minimizes cross talk between adjacent chambers ad increases injection frequency of the microinjector. The formation of a second bubble within the chamber coalesces with a first formed bubble between the chamber and manifold to abruptly terminate the ejection of fluid, thereby eliminating satellite droplets.

Abstract translation: 一种用于在微型注射器（12）的微通道内形成气泡以用作腔室（14）和歧管（16）之间的阀机构的装置和方法，其提供对通过歧管离开腔室的液体的高抵抗力 通过孔口（18）的流体喷射，并且还在喷射流体和气泡破裂之后提供低的液体（26）重新注入到腔室中的低阻力。 这有效地最小化相邻室之间的串扰增加了微型注射器的注射频率。 室内的第二个气泡的形成与腔室和歧管之间的第一个形成的气泡结合在一起，从而突然终止流体的喷射，从而消除卫星液滴。

公开(公告)号：WO01054823A1

公开(公告)日：2001-08-02

申请号：PCT/US2001/002103

申请日：2001-01-18

IPC: B05B3/02 ,  B05B12/08 ,  B05B12/12 ,  B67D7/56 ,  G05D7/06 ,  B05B3/00 ,  B05B17/00 ,  B05B17/04 ,  B67D5/08 ,  G05D7/00

CPC classification number: G05D7/0635 ,  B05B3/02 ,  B05B3/14 ,  B05B12/085 ,  B05B12/12 ,  B05B12/124 ,  Y10S239/15

Abstract: Irrigation sprinkler system includes a controller (100), sprinkler heads (102), a water main (106), a power/data line (104), a optional weather station (108) and a remote programming unit (110).

Abstract translation: 灌溉喷淋系统包括控制器（100），喷头（102），水主机（106），电源/数据线（104），可选的气象站（108）和远程编程单元（110）。

公开(公告)号：WO01051110A1

公开(公告)日：2001-07-19

申请号：PCT/US2001/000728

申请日：2001-01-09

IPC: A61M11/00 ,  A61M15/00 ,  A61M16/00 ,  B05B17/00 ,  B05B17/04 ,  B05B17/06

CPC classification number: B05B17/0646 ,  A61M11/005 ,  A61M11/007 ,  A61M15/0065 ,  A61M15/0085 ,  A61M15/025 ,  A61M2016/0021 ,  A61M2205/0233 ,  A61M2205/3306 ,  A61M2205/707 ,  A61M2205/8206 ,  B05B17/0676

Abstract: A device for aerosolizing a liquid includes a chamber (502) having a deformable wall (510) which expands and contracts as fluid is delivered and expelled from a fluid chamber (500). The chamber is partially bounded by a vibrating structure (506) having holes (504) therein for expelling the fluid. In another aspect, the invention provides exemplary aerosolization apparatus (300) and methods for aerosolizing a substance. A liquid is transferred from a first chamber (328) into a second chamber (330) having a substance that is in a dry state to form a solution. The solution is then transferred from the second chamber and onto an atomization member (308). The atomization member is operated to aerosolize the solution.

Abstract translation: 一种用于使液体雾化的装置包括具有可变形壁（510）的室（502），该可变形壁（510）随着流体被输送并从流体室（500）排出而膨胀和收缩。 腔室部分地由其中具有用于排出流体的孔（504）的振动结构（506）限定。 在另一方面，本发明提供了示例性雾化装置（300）和用于使物质雾化的方法。 液体从第一室（328）转移到具有处于干燥状态的物质形成溶液的第二室（330）中。 然后将溶液从第二室转移到雾化构件（308）上。 操作雾化构件以使溶液雾化。

公开(公告)号：WO01008808A1

公开(公告)日：2001-02-08

申请号：PCT/JP2000/005221

申请日：2000-08-03

IPC: B05B5/025 ,  B05B17/04 ,  B41J2/06 ,  B05B1/00

CPC classification number: B05B5/025 ,  B05B17/04 ,  B41J2/06 ,  B41J2002/061

Abstract: A device for forming trace-amount liquid droplet, comprising a nozzle (1) for storing therein liquid (2) forming a liquid droplet (3), a substrate (5) disposed opposite to the tip of this nozzle (1) and carrying thereon a liquid droplet (3) dropped from the nozzle (1) tip, and a pulse power supply (10) for applying a pulse voltage between an electrode (12) disposed in the liquid (2) in the nozzle (1) and the substrate (5), wherein a pulse voltage applied between the substrate (5) and the electrode (12) allows liquid to protrude from the nozzle tip to form a liquid column (2a), and then a nickel piece (7) disposed in the nozzle (1) is moved toward the nozzle (1) tip end via a magnet (8) by an XYZ stage (9) to thereby increase a fluid resistance at the nozzle tip end and separate the liquid droplet (3) from the liquid column (2a) using a pulling-back force that acts to pull back the liquid (2) into the nozzle (1).

Abstract translation: 一种用于形成微量液滴的装置，包括用于储存形成液滴（3）的液体（2）的喷嘴（1），与该喷嘴（1）的顶端相对设置并承载在其上的基板 从喷嘴（1）尖端落下的液滴（3）和用于在布置在喷嘴（1）中的液体（2）中的电极（12）和基板之间施加脉冲电压的脉冲电源（10） （5），其中施加在所述基板（5）和所述电极（12）之间的脉冲电压允许液体从所述喷嘴尖端突出以形成液体柱（2a），然后设置在所述喷嘴中的镍片（7） （1）通过XYZ级（9）经由磁体（8）朝向喷嘴（1）的尖端移动，从而增加喷嘴前端的流体阻力，并将液滴（3）与液柱分离 2a）使用用于将液体（2）拉回到喷嘴（1）中的拉回力。

公开(公告)号：WO99058251A1

公开(公告)日：1999-11-18

申请号：PCT/US1999/009918

申请日：1999-05-07

IPC: B05B3/10 ,  B05B3/02 ,  B05B5/00 ,  B05B17/04

CPC classification number: B05B3/1014

Abstract: A double angle rotospray dispenser (10) including a rotatable shaft (12) and a dispensing tip (14) connected to a free end of the rotatable shaft (12). The dispensing tip (14) includes a first angled surface (16) extending outwardly from the shaft axis (15), a second opposing angled surface (20) connected to the first angled surface (16) and extending inwardly towards the shaft axis (15) and a terminal surface (26) located at a bottom end of the dispensing tip (14), adjacent to the second opposing angled surface (20).

Abstract translation: 一种双角旋转喷雾分配器（10），包括可旋转轴（12）和连接到可旋转轴（12）的自由端的分配尖端（14）。 分配尖端（14）包括从轴线（15）向外延伸的第一倾斜表面（16），连接到第一倾斜表面（16）并朝向轴线（15）向内延伸的第二相对的倾斜表面（20） ）和位于分配尖端（14）的底端处的与第二相对的倾斜表面（20）相邻的端子表面（26）。