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公开(公告)号：WO2022271587A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034156
申请日：2022-06-20
摘要： Sustainable paper-based packaging materials, e.g., paper-based food packaging materials, are described. The packaging materials are based on paper formed from fiber derived from waste biomass, such as hemp hurds, mixes containing hemp hurds and hemp bast fibers, bagasse, and cocoa pod husks. Also described are methods of making the packaging materials. The methods can include environmentally friendly pulping and/or bleaching processes.
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公开(公告)号：WO2022192183A1
公开(公告)日：2022-09-15
申请号：PCT/US2022/019247
申请日：2022-03-08
发明人： GAO, Wei , HE, Nanfei , HONG, Ki , KOTEK, Richard , PATIL, Shradha V.
摘要： Exemplary catalysts may comprise a two-dimensional substrate and at least one organometallic compound bonded to the two-dimensional substrate. The at least one organometallic compound may comprise a carbonyl group. Exemplary methods of preparing a polymer product may comprise combining a catalyst with an alcohol and an ester in a solvent, thereby generating a mixture, and obtaining the polymer product from the mixture.
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公开(公告)号：WO2022020644A2
公开(公告)日：2022-01-27
申请号：PCT/US2021/042845
申请日：2021-07-22
发明人： GU, Zhen , HU, Quanyin , LI, Hongjun
IPC分类号： A61K35/17 , A61K39/395 , A61P35/00 , C12N5/0783 , A61K35/00 , A61K38/00 , A61K39/00 , A61K47/12 , A61K47/32 , A61K47/36 , A61K47/42 , A61K47/6901 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/19 , A61K9/5153 , C07K14/00
摘要： A therapeutic hydrogel material is disclosed for the delivery of CAR-T cells that allows their distribution in the tumor resection recess, cavity, or void in combination with platelets decorated with the anti-programmed death-ligand 1 (PDL1) blocking antibody (aPDL1). The delivered hydrogel material acts as a reservoir for both CAR-T cells and platelet-bound aPDL1. Furthermore, inflammation occurring during the surgical wound healing triggers the release of platelet-derived microparticles containing the aPDL1. Cells delivered by the engineered hydrogel show significant control of local and distant tumor recurrence without causing toxic effects. In some embodiments, nanoparticles containing cytokines are also loaded in the therapeutic hydrogel material to maintain the activity and proliferation ability of CAR-T cells.
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公开(公告)号：WO2022006203A2
公开(公告)日：2022-01-06
申请号：PCT/US2021/039766
申请日：2021-06-30
申请人： NORTH CAROLINA STATE UNIVERSITY , INSTITUTE OF CYTOLOGY AND GENETICS, SIBERIAN BRANCH OF RUSSIAN ACADEMY OF SCIENCES
发明人： STEPANOVA, Anna N. , ALONSO, Jose M. , FERNANDEZ-MORENO, Josefina Patricia , ZEMLYANSKAYA, Elena , LEVITSKY, Victor
IPC分类号： C12N15/82
摘要： Provided is a recombinant nucleic acid construct comprising a sequence of Formula I (SEQ ID NO:48): X-N1-N2-N3-N4-N5-N6-N7-N8-N9-N10-N11-Y as an ethylene binding sequence (EBS). Tandems of two or more directly adjoining EBS are also described, and may be included in an expression cassette useful for modulating the expression of a nucleic acid of interest in a plant in response to plant hormone ethylene.
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公开(公告)号：WO2021257680A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037595
申请日：2021-06-16
摘要： An isolated gate driver power supply device disclosed herein comprises an enclosure element configured to contain an electronic encapsulant material. The device further includes a first planar coil element situated in the electronic encapsulant material, a second planar coil element situated in the electronic encapsulant material, and a repeater coil element situated in the electronic encapsulant material. The repeater coil element is positioned in between the first planar coil element and the second planar coil element and is separated from the second planar coil element by a gap distance based on minimizing a coupling capacitance between the first planar coil element and the second planar coil element.
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公开(公告)号：WO2021236664A1
公开(公告)日：2021-11-25
申请号：PCT/US2021/032998
申请日：2021-05-18
摘要： The present disclosure provides compositions and methods related to the production of human milk oligosaccharides (HMOs). In particular, the present disclosure provides compositions and methods for converting lactose and N-acetylglucosamine (GlcNAc) into N-acetyllactosamine (LacNAc)-enriched galactooligosaccharide (GOS) compositions using novel β-hexosyl-transferase (BHT) enzymes.
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公开(公告)号：WO2021225826A1
公开(公告)日：2021-11-11
申请号：PCT/US2021/029381
申请日：2021-04-27
发明人： GU, Zhen , CHEN, Zhaowei
摘要： A bioorthogonal catalytic patch integrates TiO2 nanosheets populated with metallic nanoparticles into polyvinyl alcohol-based microneedles arranged in an array. This bioorthogonal patch-based device is robust, removable and can effectively mediate the conversion of caged substrates into their active states once placed at the site of application. The capacity of the patch in executing bioorthogonal catalysis in high-level living systems was demonstrated by localized dealkylation of a caged doxorubicin prodrug at the melanoma tumor site and restoration of its pharmacological properties for cancer therapy. This in situ applied patch facilitated to enhance the local treatment efficacy and eliminate off-targeted prodrug activation or dose-dependent side effect towards healthy organs or tissues located away from the application site.
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8.发明申请
公开(公告)号：WO2021222898A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/030484
申请日：2021-05-03
发明人： MARTIN, James , HOLT, Jonathan
摘要： Disclosed is a composition comprising an effective amount of a dietary metal and a coordinating ligand, wherein the dietary metal is provided as a cationic complex and/or as an anionic complex and wherein the coordinating ligand coordinates the dietary metal cationic complex and/or the dietary metal anionic complex. The composition is used to deliver a dietary metal to a subject in need thereof by administering the composition to the subject, optionally perorally. Examples of the dietary metal include zinc (Zn), copper (Cu), magnesium (Mg), manganese (Mn), iron (Fe), cobalt (Co) and combinations thereof. In a particular example, the coordinating ligand comprises cellulose.
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公开(公告)号：WO2021207297A1
公开(公告)日：2021-10-14
申请号：PCT/US2021/026093
申请日：2021-04-07
摘要： In one aspect, the disclosure relates to a compact membrane reactor for parahydrogeninduced hyperpolarization, the reactor including an inner tube constructed of a semipermeable membrane, an outer tube surrounding the inner tube, and a means for controlling the magnetic field surrounding the outer tube. In some aspects, multiple compact membrane reactors can be arranged in parallel. In other aspects, the compact membrane reactor is equipped with a mechanism for magnetic field control. Also disclosed are fluid handling systems and sample preparation systems comprising the compact membrane reactors disclosed herein. The compact membrane reactor can be operated in a batch mode, a stopped-flow mode, or a continuous flow mode and can be configured to work with existing NMR spectrometers and MRI instruments.
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公开(公告)号：WO2021183504A1
公开(公告)日：2021-09-16
申请号：PCT/US2021/021493
申请日：2021-03-09
IPC分类号： C12N9/22 , C12N15/10 , C12N15/113
摘要： The present disclosure provides compositions, methods, and systems related to genome editing technology. In particular, the present disclosure provides a novel CRISPR-based genome editing technology that involves the generation of abasic sites to facilitate genetic recombination, without the need for breaks in the DNA. The compositions, methods, and systems described herein address many of the drawbacks of currently available approaches, including off-target effects and cellular toxicity.
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