公开(公告)号：WO2023057746A1

公开(公告)日：2023-04-13

申请号：PCT/GB2022/052509

申请日：2022-10-04

申请人： GENOME RESEARCH LIMITED

发明人： WU, Qianxin ,  TREHAN, Ashutosh

IPC分类号： C12N9/22 ,  C12N15/113 ,  C12Q1/6806 ,  C12N15/10 ,  C12N15/1093 ,  C12N15/11 ,  C12N2310/20 ,  C12N2310/345 ,  C12N2330/31 ,  C12Y301/21004

摘要： The invention relates to a method of generating a library of polynucleotide molecules encoding guide RNAs (gRNAs) from target polynucleotide(s). The invention also relates to a library of polynucleotide molecules encoding gRNAs obtainable by the aforementioned method, and a gRNA library generation kit thereof.

公开(公告)号：WO2022079439A2

公开(公告)日：2022-04-21

申请号：PCT/GB2021/052666

申请日：2021-10-14

申请人： GENOME RESEARCH LIMITED

发明人： WRIGHT, Gavin ,  AUTHEMAN, Delphine

IPC分类号： A61K39/005 ,  A61P33/02 ,  C07K14/44

摘要： The present invention relates to a trypanosomal vaccine comprising an FLA1 binding protein, as well as to pharmaceutical compositions comprising said vaccine and their uses in vaccination to prevent or treat trypanosomal infection in a mammal. Thus, also provided are a method of preventing or treating trypanosomal infection comprising administering said vaccine and a kit of parts comprising a medical instrument or other means for administering.

公开(公告)号：WO2022058604A1

公开(公告)日：2022-03-24

申请号：PCT/EP2021/075877

申请日：2021-09-21

申请人： BELGIAN VOLITION SRL

发明人： MICALLEF, Jacob Vincent

IPC分类号： A61M1/36 ,  G01N33/53

摘要： The present invention relates to an extracorporeal device or an ex vivo organ perfusion device comprising an inline monitoring method or device for measuring cell free nucleosomes, particularly an apheresis device comprising a monitoring method or device for measuring cell free nucleosomes in the blood of a subject.