公开(公告)号：WO2020120716A1

公开(公告)日：2020-06-18

申请号：PCT/EP2019/084993

申请日：2019-12-12

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： STEVENSON, Alexander ,  YUILLE, Samantha

IPC: A61K35/741 ,  A61K45/06 ,  A61P31/04

Abstract: The invention provides a composition comprising a strain of a bacteria for use in the treatment or prevention of a Gram-positive bacterial infection in a subject, wherein the strain produces valeric acid.

公开(公告)号：WO2020089488A1

公开(公告)日：2020-05-07

申请号：PCT/EP2019/080131

申请日：2019-11-04

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： HENNESSY, Emma Elizabeth Clare ,  AHMED, Suaad ,  HOLT, Amy Beth ,  COWIE, Philip ,  ETTORRE, Anna ,  YUILLE, Samantha ,  MULDER, Imke Elisabeth

IPC: A61K39/39 ,  A61K39/00

Abstract: The invention provides compositions comprising bacterial strains for use as a vaccine adjuvant; for use in treating, preventing or delaying immunosenescence; or for use in enhancing a cell therapy, such as CAR-T. The invention also provides vaccine compositions comprising bacterial strains and one or more antigens.

公开(公告)号：WO2020074569A8

公开(公告)日：2020-04-16

申请号：PCT/EP2019/077332

申请日：2019-10-09

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  STEVENSON, Alexander ,  JEFFERY, Ian

IPC: A61K35/74 ,  A61P1/00 ,  A61P37/00

Abstract: Provided are compositions comprising a bacterial strain of the genus Bacteroides, for use in a method of increasing the microbiota diversity and/or inducing stability of the microbiota of a subject.

公开(公告)号：WO2019215346A1

公开(公告)日：2019-11-14

申请号：PCT/EP2019/062238

申请日：2019-05-13

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  FOTIADOU, Parthena ,  HOLT, Amy Beth ,  AHMED, Suaad ,  ETTORRE, Anna ,  YUILLE, Samantha ,  DINAN, Ted ,  CRYAN, John

IPC: A61K35/74 ,  A61K39/02 ,  A23L33/135 ,  A61P1/00 ,  A61P11/06 ,  A61P3/10 ,  A61P17/06 ,  A61P19/02 ,  A61P37/00 ,  A61P35/00 ,  A61P43/00

Abstract: The invention provides a composition comprising a bacterial strain of the genus Megasphaera , for use in stimulating the immune system in subject.

公开(公告)号：WO2019211469A1

公开(公告)日：2019-11-07

申请号：PCT/EP2019/061446

申请日：2019-05-03

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： YUILLE, Samantha ,  REICHARDT, Nicole

IPC: C12N1/20 ,  C12Q1/02 ,  G09B23/28 ,  G01N33/50

Abstract: The invention provides compositions, processes and kits for determining the metabolic properties of cells of interest in vitro .

公开(公告)号：WO2019180051A1

公开(公告)日：2019-09-26

申请号：PCT/EP2019/056894

申请日：2019-03-19

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： PANZICA, Domenico ,  HOLT, Amy Beth ,  AHMED, Suaad ,  ETTORE, Anna ,  MULDER, Imke Elisabeth ,  COWIE, Philip ,  RAFTIS, Emma ,  HENNESSY, Emma Elizabeth Clare ,  LAUTE-CALY, Delphine Louise Claudette ,  COUTURIER-MAILLARD, Aurélie Pascale Patricia ,  DELDAY, Margaret Inkster ,  ADRIANI, Marsilio ,  CHRISTOFI, Maria

IPC: A61K35/744 ,  A23L33/135 ,  A61P37/04 ,  A61K38/16

Abstract: The invention provides compositions comprising bacterial strains for stimulating the immune system and treating and preventing diseases.

公开(公告)号：WO2019141999A1

公开(公告)日：2019-07-25

申请号：PCT/GB2019/050144

申请日：2019-01-18

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： STEVENSON, Alexander

IPC: A61K35/74 ,  A61K39/395 ,  A61P35/00

Abstract: The invention provides a combination therapy comprising a bacterial strain for treating or preventing cancer.

公开(公告)号：WO2018115879A1

公开(公告)日：2018-06-28

申请号：PCT/GB2017/053849

申请日：2017-12-21

Applicant: MEREO BIOPHARMA 3 LIMITED

Inventor： JUNKER, Uwe ,  KNEISSEL, Michaela ,  HALL, Anthony Kent ,  EUDY, Rena Joy ,  RIGGS, Matthew Manning

IPC: C07K16/22

Abstract: Disclosed are methods for treating a patient suffering from osteogenesis imperfecta comprising administering to the patient a therapeutically effective amount of an anti-sclerostin antibody. Methods for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient by administering to the patient a therapeutically effective amount of an anti-sclerostin antibody are also disclosed. Further disclosed are compositions for increasing bone formation and reducing bone resorption in an osteogenesis imperfecta patient. The compositions comprise a therapeutically effective amount of an anti-sclerostin antibody. The invention also provides an anti-sclerostin antibody for use in the treatment of osteogenesis im perfecta.

公开(公告)号：WO2017064308A1

公开(公告)日：2017-04-20

申请号：PCT/EP2016/074814

申请日：2016-10-14

Applicant: PROQR THERAPEUTICS II B.V.

Inventor： DE VLAAM, Thomas Petrus Gerardus ,  HAILU, Tsinatkeab Tadesse ,  KARNEVA, Zhana

IPC: C12N15/113 ,  A61K31/7088

CPC classification number: C12N15/113 ,  A61K31/713

Abstract: Theinvention relates to oligonucleotides suitable for use in treating human disease. More in particular the inventionrelates to antisense oligonucleotides suitable for the treatment of Alzheimer's disease.

Abstract translation: 本发明涉及适用于治疗人类疾病的寡核苷酸。 更具体而言，本发明涉及适用于治疗阿尔茨海默氏病的反义寡核苷酸。

公开(公告)号：WO2015140575A1

公开(公告)日：2015-09-24

申请号：PCT/GB2015/050836

申请日：2015-03-20

Applicant: ATLAS GENETICS LIMITED

Inventor： MARSH, Barrie J. ,  FROST, Christopher G. ,  GOGGINS, Sean

IPC: C12Q1/00 ,  G01N33/543 ,  C12Q1/42 ,  G01N27/327

CPC classification number: C12Q1/004 ,  C12Q1/42 ,  G01N33/54393

Abstract: A method for detecting the presence of an enzyme in a composition. The method involves incubating the composition with a pro-ligand, a proto-catalyst and a substrate. Any enzyme present can cause conversion of the pro-ligand to a ligand. The ligand can activate the proto-catalyst to provide an active catalyst. The active catalyst can cause conversion of the substrate to a detectable product and the detectable product may be detected distinguishably from the substrate. The presence of enzyme is detected by detecting the detectable product. The method may be used to detect the presence of an analyte in a composition.

Abstract translation: 检测组合物中酶的存在的方法。 该方法包括用前配体，原催化剂和底物孵育组合物。 存在的任何酶可导致前配位体转化为配体。 配体可以活化原催化剂以提供活性催化剂。 活性催化剂可导致底物转化为可检测的产物，并且可检测的产物可以与底物可区分地检测。 通过检测可检测的产物来检测酶的存在。 该方法可用于检测组合物中分析物的存在。