公开(公告)号：WO2014127134A1

公开(公告)日：2014-08-21

申请号：PCT/US2014/016272

申请日：2014-02-13

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： LAWSON, Matthew ,  RASKAR, Ramesh

IPC: A61B3/12 ,  A61B3/14 ,  A61B3/15

CPC classification number: A61B3/12 ,  A61B3/14

Abstract: In exemplary implementations, this invention comprises apparatus for retinal self- imaging. Visual stimuli help the user self-align his eye with a camera. Bi-ocular coupling induces the test eye to rotate into different positions. As the test eye rotates, a video is captured of different areas of the retina. Computational photography methods process this video into a mosaiced image of a large area of the retina. An LED is pressed against the skin near the eye, to provide indirect, diffuse illumination of the retina. The camera has a wide field of view, and can image part of the retina even when the eye is off-axis (when the eye's pupillary axis and camera's optical axis are not aligned). Alternately, the retina is illuminated directly through the pupil, and different parts of a large lens are used to image different parts of the retina. Alternately, a plenoptic camera is used for retinal imaging.

Abstract translation: 在示例性实施方案中，本发明包括用于视网膜自体成像的装置。 视觉刺激帮助用户用相机自行调整眼睛。 双眼耦合引起测试眼旋转到不同的位置。 当测试眼旋转时，捕获视网膜的不同区域的视频。 计算摄影方法将该视频处理成视网膜大面积的马赛克图像。 LED被压在眼睛附近的皮肤上，以提供视网膜的间接的漫射照明。 相机具有宽视野，即使眼睛离轴（眼睛的瞳孔轴和相机的光轴未对齐），也可以对视网膜的一部分进行成像。 或者，视网膜直接通过瞳孔照射，并且使用大透镜的不同部分来对视网膜的不同部分进行成像。 或者，全视相机用于视网膜成像。

公开(公告)号：WO2019216995A1

公开(公告)日：2019-11-14

申请号：PCT/US2019/023217

申请日：2019-03-20

Applicant: SHAPE MATRIX GEOMETRIC INSTRUMENTS, LLC

Inventor： CRAMER, Jonathan

IPC: G06F21/36 ,  G06F21/62 ,  G06F21/31

Abstract: In illustrative implementations, shape is used to encode computer passwords or other information. The passwords may be easy for a human to remember - and yet have an extremely high number of permutations (e.g., in some cases, greater than 1030 permutations, or greater than 10261permutations, or greater than 106264 permutations). This combination of a password being easy for a human to remember - yet having a large number of permutations - offers many practical benefits. Among other things, the huge number of permutations makes the password extremely resistant to guessing attacks. In addition, in some cases, the passwords that are created with the shapes are highly resistant to attacks by keystroke logging, mouse logging, touch-gesture logging, screen logging, shoulder surfing, phishing, and social engineering. Alternatively, the shapes may be used to encode other information, such as information that uniquely identifies a product or a machine part.

公开(公告)号：WO2012158984A1

公开(公告)日：2012-11-22

申请号：PCT/US2012/038463

申请日：2012-05-17

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  POH, Ming-zher ,  PICARD, Rosalind

Inventor： POH, Ming-zher ,  PICARD, Rosalind

IPC: A61B5/04

CPC classification number: A61B5/4094 ,  A61B5/02405 ,  A61B5/0533 ,  A61B5/1118 ,  A61B5/7275 ,  G06F19/00

Abstract: In exemplary implementations of this invention, sensor measurements are taken before, during and after an epileptiform seizure of a human. The sensors measure electrodermal activity (EDA) and heart rate variability (HRV) of the human. The EDA and HRV measurements are used to assess sympathetic activity and parasympathetic activity, respectively. More particularly, in the case of HRV measurements, HF power is used to assess parasympathetic innervation of the heart. HF power is the power of the high frequency (e.g. 0.15 to 0.4 Hz) spectral component of the RRI signal. One or more processors analyze the sensor data to calculate the magnitude of a post-ictal autonomic disturbance. Based on that calculated magnitude, the processors assess the severity of the seizure. A wrist- worn sensor may take long-term, continuous EDA and motion measurements. The processors may analyze these measurements to detect the onset of a tonic-clonic seizure.

Abstract translation: 在本发明的示例性实施方案中，在人的癫痫发作之前，期间和之后进行传感器测量。 传感器测量人体的皮肤活性（EDA）和心率变异性（HRV）。 EDA和HRV测量分别用于评估交感神经活动和副交感神经活动。 更具体地，在HRV测量的情况下，使用HF功率来评估心脏的副交感神经支配。 HF功率是RRI信号的高频（例如0.15至0.4Hz）频谱分量的功率。 一个或多个处理器分析传感器数据以计算发明后自主神经障碍的大小。 根据该计算的数量，处理者评估缉获的严重程度。 手腕式传感器可以进行长期，连续的EDA和运动测量。 处理器可以分析这些测量以检测强直阵挛发作的发作。

公开(公告)号：WO2012106639A1

公开(公告)日：2012-08-09

申请号：PCT/US2012/023836

申请日：2012-02-03

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  GERSHENFELD, Neil ,  KENNETH, Cheung ,  PEEK, Nadya ,  WATSON, David

Inventor： GERSHENFELD, Neil ,  KENNETH, Cheung ,  PEEK, Nadya ,  WATSON, David

IPC: B29C35/02

CPC classification number: B29C35/0288 ,  B29C35/0227 ,  B29C2035/0811

Abstract: In exemplary implementations of this invention, a network of nodes controls and senses the cure of a thermosetting plastic in a component that is made of fiber composite material. The network comprises multiple nodes, which are separated spatially from each other. Each of the nodes, respectively, comprises a heat transfer device for actively transferring thermal energy, a temperature sensor for taking local temperature measurements, and a processor. In each of the nodes, respectively: (a) the processor locally performs closed loop control over the temperature of the heat transfer device, and (b) the closed loop control is based at least in part on the local temperature measurements and on estimated or measured input current to the heat transfer device.

Abstract translation: 在本发明的示例性实施方案中，节点网络控制和感测由纤维复合材料制成的部件中的热固性塑料的固化。 该网络包括在空间上彼此分开的多个节点。 每个节点分别包括用于主动传递热能的传热装置，用于进行局部温度测量的温度传感器和处理器。 在每个节点中，分别：（a）处理器在本地对传热装置的温度执行闭环控制，以及（b）闭环控制至少部分地基于局部温度测量以及估计或 测量到传热装置的输入电流。

公开(公告)号：WO2020055445A1

公开(公告)日：2020-03-19

申请号：PCT/US2018/067425

申请日：2018-12-22

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NUVU, LLC

Inventor： GROSSMAN, Nir ,  WANG, David ,  BOYDEN, Edward

IPC: A61B5/0476

Abstract: A neuromodulator may output stimuli that causes a user to fall asleep faster than the user would in the absence of the stimuli. Alternatively, the stimuli may modify a sleep state or behavior associated with a sleep state, or may cause or hinder a transition from a waking state to a sleep state or from a sleep state to another sleep state. The neuromodulator may take electroencephalography measurements. Based on these measurements, the neuromodulator may detect, in real time, instantaneous amplitude and instantaneous phase of an endogenous brain signal. The neuromodulator may output stimulation that is, or that causes sensations which are, phase-locked with the endogenous brain signal. In the course of calculating instantaneous phase and amplitude, the neuromodulator may perform an endpoint- corrected Hilbert transform. The stimuli may comprise auditory, visual, electrical, magnetic, vibrotactile or haptic stimuli.

公开(公告)号：WO2017015428A1

公开(公告)日：2017-01-26

申请号：PCT/US2016/043259

申请日：2016-07-21

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NUVU LLC

Inventor： GROSSMAN, Nir ,  WANG, David ,  BOYDEN, Edward, S.

IPC: G06F17/14 ,  A61B5/0476 ,  A61B5/00

CPC classification number: A61B5/4836 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/0482 ,  A61B5/1101 ,  A61B5/4082 ,  A61B5/486 ,  A61B5/6868 ,  A61B5/725 ,  A61B5/7253 ,  A61B5/7257 ,  A61N5/0622 ,  A61N7/00 ,  A61N2005/063 ,  A61N2007/0021 ,  G06F17/14

Abstract: A neuromodulator accurately measures - in real time and over a range of frequencies - the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.

Abstract translation: 神经调节器可以准确地测量实时和超过一定范围的频率 - 自然信号的瞬时相位和幅度。 例如，天然信号可以是由神经组织产生的电信号，或诸如肌肉震颤的运动。 神经调节器产生相对于自然信号的相位精确定时的信号。 例如，神经调节器可以产生与自然信号锁相的外生信号。 或者，例如，神经调节器可以产生包括仅在振荡自然信号的每个周期的窄相位范围内发生的短脉冲串的外部信号。 神经调节器纠正吉布斯现象造成的扭曲。 在某些情况下，在进行离散傅里叶逆变换之前，神经调节器通过在频域中对离散傅立叶变换应用因果滤波器来实现。

公开(公告)号：WO2015017733A1

公开(公告)日：2015-02-05

申请号：PCT/US2014/049305

申请日：2014-07-31

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  J. CRAIG VENTER INSTITUTE, INC. ,  GOVERNMENT OF U.S.A AS REP. BY THE SEC. OF COMMERCE, THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY

Inventor： MERSHIN, Andreas ,  PELLETIER, James ,  GERSHENFELD, Neil ,  GLASS, John ,  STRYCHALSKI, Elizabeth

IPC: C12N5/02

CPC classification number: C12M35/08 ,  C12N15/87

Abstract: In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some cases, the microfluidic chambers have only one orifice that opens to a flow channel. In some cases, flow through a microfluidic chamber temporarily ceases due to closing one or more valves. Transplantation occurs during a period in which the contents of the chambers are shielded from shear forces. Diffusion, centrifugation, suction from a vacuum channel, or dead-end loading may be used to move cells or buffers into the chambers.

Abstract translation: 在示例性实施方案中，将核酸移植到细胞中发生在微流体室中。 核酸可以是大于100kbp的大核酸分子。 在一些情况下，微流体室仅具有一个通向流动通道的孔口。 在一些情况下，由于关闭一个或多个阀门，流过微流体室的流动暂时停止。 移植发生在室内容物被剪切力屏蔽的期间。 可以使用扩散，离心，真空通道抽吸或死端装载将细胞或缓冲液移动到腔室中。

公开(公告)号：WO2015012784A1

公开(公告)日：2015-01-29

申请号：PCT/US2013/051412

申请日：2013-07-20

Applicant: EYENETRA, INC.

Inventor： PAMPLONA, Vitor ,  RASKAR, Ramesh

IPC: A61B3/02

CPC classification number: A61B3/18 ,  A61B3/103

Abstract: In exemplary implementations of this invention, a bi-ocular apparatus presents visual stimuli to one eye of a human subject in order to relax that eye, while measuring refractive aberration of the subject's other eye. Alternately, a monocular device presents stimuli to relax an eye while testing the same eye. The apparatus induces eye relaxation by displaying virtual objects at varying apparent distances from the subject. For example, the apparatus may do so by (i) changing distance between a backlit film and a lens; (ii) using extra lenses; (iii) using an adaptive lens that changes power; (v) selecting distinct positions in a progressive or multi-focal length lens; (vi)selecting distinct optical depths by fiber optical illumination; (vii) displaying a 3D virtual image at any given apparent depth; or (viii) display both a warped version of the real world and a test image at the same time.

Abstract translation: 在本发明的示例性实施方案中，双眼装置向人类对象的一只眼睛呈现视觉刺激，以便在测量受试者另一只眼睛的屈光差异的同时放松该眼睛。 或者，单眼装置在测试相同的眼睛时呈现刺激物以放松眼睛。 该装置通过以与受试者不同的视距离显示虚拟物体来诱导眼睛的放松。 例如，设备可以通过（i）改变背光膜和透镜之间的距离来实现; （ii）使用额外的镜头; （iii）使用改变功率的自适应透镜; （v）在渐进式或多焦距镜头中选择不同的位置; （vi）通过光纤照明选择不同的光学深度; （vii）在任何给定的表观深度显示3D虚拟图像; 或（viii）同时显示现实世界的扭曲版本和测试图像。

公开(公告)号：WO2013006867A1

公开(公告)日：2013-01-10

申请号：PCT/US2012/045988

申请日：2012-07-09

Applicant: MASSACHUSSETTS INSTITUTE OF TECHNOLOGY ,  JUN, Kimin ,  JACOBSON, Joseph

Inventor： JUN, Kimin ,  JACOBSON, Joseph

IPC: C25B1/04

CPC classification number: C25B1/003 ,  C25B11/02 ,  C25B11/0452 ,  H01G9/2031 ,  H01G9/2036 ,  Y02E10/542 ,  Y02P20/135

Abstract: In exemplary implementations of this invention, a photoelectrode includes a semiconductor for photocarrier generation, and a catalyst layer for altering the reaction rate in an adjacent electrolyte. The catalyst layer covers part of the semiconductor. The thickness of the catalyst layer is less than 60% of its minority carrier diffusion distance. If the photoelectrode is a photoanode, it has an OEP that is more than the potential of the valance band edge but less than the potential of the Fermi level of the semiconductor. If it is a photocathode, it has an RHE potential that is less than the potential of the conduction band edge but more than the potential of the Fermi level of the semiconductor. The absolute value of difference (OEP minus potential of valence band edge, or RHE potential minus potential of conduction band edge) is greater than zero and less than or equal to 0.2V.

Abstract translation: 在本发明的示例性实施方案中，光电极包括用于光载体产生的半导体和用于改变相邻电解质中的反应速率的催化剂层。 催化剂层覆盖半导体的一部分。 催化剂层的厚度小于其少数载流子扩散距离的60％。 如果光电极是光电阳极，则其具有超过有效带边缘的电位但小于半导体的费米能级的电位的OEP。 如果它是一个光电阴极，它的RHE电位小于导带边缘的电位，但大于半导体费米能级的电位。 差值的绝对值（OEP减去价带边缘的电位，或RHE电位减去导带边缘的电位）大于零且小于或等于0.2V。

公开(公告)号：WO2012078246A1

公开(公告)日：2012-06-14

申请号：PCT/US2011/056961

申请日：2011-10-19

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  GERSHENFELD, Neil ,  CHEUNG, Kenneth

Inventor： GERSHENFELD, Neil ,  CHEUNG, Kenneth

IPC: G06F19/00

CPC classification number: B23P11/00 ,  B32B5/12 ,  B32B5/26 ,  B64C1/06 ,  B64C1/08 ,  B64C3/48 ,  Y10T29/49826 ,  Y10T29/49828 ,  Y10T428/24 ,  Y10T428/24008

Abstract: In exemplary implementations of this invention, a digital material comprising many discrete units is used to fabricate a sparse structure. The units are reversibly joined by elastic connections. Each unit comprises fiber-reinforced composite material. Each unit is small compared to the sparse structure as a whole. Likewise, in a sparse structure made from this digital material, the number of types of units is small compared to the total number of units. The digital material is anisotropic. This anisotropy may be due to different fiber orientations within each unit. Furthermore, different units in a single sparse structure may be oriented in different directions and in different, non-parallel planes. In some cases, the digital material is reinforced with carbon fibers, and connections between units are stronger than the units themselves. The small discrete units may be assembled into a strong, lightweight sparse structure, such as an airframe.

Abstract translation: 在本发明的示例性实施方案中，使用包含许多分立单元的数字材料来制造稀疏结构。 这些单元通过弹性连接可逆连接。 每个单元包括纤维增强复合材料。 与整体稀疏结构相比，每个单位都很小。 同样，在由这种数字材料制成的稀疏结构中，与总单元数相比，单元类型的数量很小。 数字材料是各向异性的。 这种各向异性可能是由于每个单元内不同的纤维取向。 此外，单个稀疏结构中的不同单元可以在不同的方向和不同的非平行平面中取向。 在某些情况下，数字材料用碳纤维增强，单元之间的连接比单元本身更强。 小型分立单元可以组装成强大的，轻质的稀疏结构，例如机身。