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    METHODS AND APPARATUS FOR ULTRATHIN CATALYST LAYER FOR PHOTOELECTRODE
    1.
    发明申请
    METHODS AND APPARATUS FOR ULTRATHIN CATALYST LAYER FOR PHOTOELECTRODE 审中-公开
    用于光电子的超级催化层的方法和装置

    公开(公告)号：WO2013006867A1

    公开(公告)日：2013-01-10

    申请号：PCT/US2012/045988

    申请日：2012-07-09

    Applicant: MASSACHUSSETTS INSTITUTE OF TECHNOLOGY ,  JUN, Kimin ,  JACOBSON, Joseph

    Inventor： JUN, Kimin ,  JACOBSON, Joseph

    IPC: C25B1/04

    CPC classification number: C25B1/003 ,  C25B11/02 ,  C25B11/0452 ,  H01G9/2031 ,  H01G9/2036 ,  Y02E10/542 ,  Y02P20/135

    Abstract: In exemplary implementations of this invention, a photoelectrode includes a semiconductor for photocarrier generation, and a catalyst layer for altering the reaction rate in an adjacent electrolyte. The catalyst layer covers part of the semiconductor. The thickness of the catalyst layer is less than 60% of its minority carrier diffusion distance. If the photoelectrode is a photoanode, it has an OEP that is more than the potential of the valance band edge but less than the potential of the Fermi level of the semiconductor. If it is a photocathode, it has an RHE potential that is less than the potential of the conduction band edge but more than the potential of the Fermi level of the semiconductor. The absolute value of difference (OEP minus potential of valence band edge, or RHE potential minus potential of conduction band edge) is greater than zero and less than or equal to 0.2V.

    Abstract translation: 在本发明的示例性实施方案中，光电极包括用于光载体产生的半导体和用于改变相邻电解质中的反应速率的催化剂层。 催化剂层覆盖半导体的一部分。 催化剂层的厚度小于其少数载流子扩散距离的60％。 如果光电极是光电阳极，则其具有超过有效带边缘的电位但小于半导体的费米能级的电位的OEP。 如果它是一个光电阴极，它的RHE电位小于导带边缘的电位，但大于半导体费米能级的电位。 差值的绝对值（OEP减去价带边缘的电位，或RHE电位减去导带边缘的电位）大于零且小于或等于0.2V。

    PROTEIN ARRAYS AND METHODS OF USING AND MAKING THE SAME
    2.
    发明申请
    PROTEIN ARRAYS AND METHODS OF USING AND MAKING THE SAME 审中-公开
    蛋白质阵列及其使用和制备方法

    公开(公告)号：WO2012064975A1

    公开(公告)日：2012-05-18

    申请号：PCT/US2011/060217

    申请日：2011-11-10

    Applicant: Gen9, Inc. ,  JACOBSON, Joseph ,  HUDSON, Mike ,  CHU, Larry Li-Yang

    Inventor： JACOBSON, Joseph ,  HUDSON, Mike ,  CHU, Larry Li-Yang

    IPC: B01J19/00 ,  C40B50/14 ,  B82Y30/00

    CPC classification number: C12N15/1086 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00509 ,  B01J2219/00531 ,  B01J2219/00596 ,  B01J2219/00621 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B50/14

    Abstract: Methods and devices are provided for preparing a protein array having a plurality of proteins. In one embodiment, the method includes providing a plurality of nucleic acids each having a predefined sequence and expressing in vitro a plurality of proteins from the plurality of nucleic acids. In another embodiment, protein arrays having a solid surface and a microvolume are also provided. The solid surface can have a plurality of anchor oligonucleotides capable of hybridizing with a plurality of nucleic acids. The microvolume can cover each of the plurality of anchor oligonucleotides and can be configured to produce a polypeptide from each of the plurality of nucleic acids.

    Abstract translation: 提供了用于制备具有多种蛋白质的蛋白质阵列的方法和装置。 在一个实施方案中，所述方法包括提供多个核酸，其各自具有预定义的序列并且在体外表达来自所述多个核酸的多种蛋白质。 在另一个实施方案中，还提供了具有固体表面和微量体积的蛋白质阵列。 固体表面可以具有能够与多个核酸杂交的多个锚寡核苷酸。 微体积可以覆盖多个锚定寡核苷酸中的每一个，并且可以被配置为从多个核酸中的每一个生成多肽。

    METHODS AND APPARATUSES FOR CHIP-BASED DNA ERROR REDUCTION
    4.
    发明申请
    METHODS AND APPARATUSES FOR CHIP-BASED DNA ERROR REDUCTION 审中-公开
    用于基于芯片的DNA错误减少的方法和装置

    公开(公告)号：WO2011066186A1

    公开(公告)日：2011-06-03

    申请号：PCT/US2010/057405

    申请日：2010-11-19

    Applicant: GEN9, INC. ,  RAMU, Senthil ,  JACOBSON, Joseph ,  CHU, Larry Li-Yang

    Inventor： RAMU, Senthil ,  JACOBSON, Joseph ,  CHU, Larry Li-Yang

    IPC: C12Q1/68

    CPC classification number: C12N15/1058 ,  C12Q1/6848 ,  C12Q2521/514 ,  C12Q2565/537

    Abstract: Methods and apparatus relate to reduction of sequence errors generated during synthesis of nucleic acids on a microarray chip. The error reduction can include synthesis of complementary stands (to template strands), using a short universal primer complementary to the template strands and polymerase. Heteroduplex can be formed be melting and re-annealing complementary stands and template strands. The heteroduplexes containing a mismatch can be recognized and cleaved by a mismatch endonuclease. The mismatch-containing cleaved heteroduplexes can be removed from the microarray chip using a global buffer exchange. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.

    Abstract translation: 方法和装置涉及在微阵列芯片上核酸合成期间产生的序列错误的减少。 误差减少可以包括使用与模板链和聚合酶互补的短通用引物来合成互补基团（模板链）。 Heteroduplex可以形成为熔化和再退火互补架和模板链。 含有错配的异源双链可以被不匹配的内切核酸酶识别和切割。 可以使用全局缓冲液交换从微阵列芯片中去除含错配的切割异源双链体。 由此产生的无错误的合成核酸可用于各种应用，包括生物燃料的合成和增值药物产品。

    ENGINEERED METABOLIC PATHWAYS
    5.
    发明申请
    ENGINEERED METABOLIC PATHWAYS 审中-公开
    工程代表途径

    公开(公告)号：WO2008127283A2

    公开(公告)日：2008-10-23

    申请号：PCT/US2007021473

    申请日：2007-10-06

    Applicant: CODON DEVICES INC ,  JACOBSON JOSEPH M ,  CHURCH GEORGE ,  BAYNES BRIAN M

    Inventor： JACOBSON JOSEPH M ,  CHURCH GEORGE ,  BAYNES BRIAN M

    CPC classification number: C12N15/10 ,  C12N15/1093 ,  C12N15/52

    Abstract: Certain aspects of the present invention provide methods for designing and engineering metabolic pathways. Aspects of the invention also provide metabolic pathway components and cells containing engineered metabolic pathways. Certain aspects of the invention provide medical, pharmaceutical, industrial, agricultural, environmental, and other Nuses for engineered metabolic pathways of the invention.

    Abstract translation: 本发明的某些方面提供了用于设计和工程化代谢途径的方法。 本发明的方面还提供含有工程化代谢途径的代谢途径成分和细胞。 本发明的某些方面为本发明的工程代谢途径提供医学，制药，工业，农业，环境和其它用途。

    METHODS AND COMPOSITIONS FOR APTAMER PRODUCTION AND USES THEREOF
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR APTAMER PRODUCTION AND USES THEREOF 审中-公开
    APTAMER生产的方法和组合及其用途

    公开(公告)号：WO2007136833A2

    公开(公告)日：2007-11-29

    申请号：PCT/US2007012075

    申请日：2007-05-19

    Applicant: CODON DEVICES INC ,  CHURCH GEORGE ,  JACOBSON JOSEPH M ,  BAYNES BRIAN M

    Inventor： CHURCH GEORGE ,  JACOBSON JOSEPH M ,  BAYNES BRIAN M

    IPC: C12Q1/68 ,  C12N15/11 ,  C12N15/115

    CPC classification number: C12N15/115 ,  C12N15/1048 ,  C12N15/111 ,  C12N2310/16 ,  C12N2320/10 ,  C12N2330/31

    Abstract: Certain aspects of the present invention provide methods for assembling nucleic acid libraries that represent large numbers of sequence variants. Some embodiments involve generating libraries of RNA molecules that can be subjected to in vivo screens or selections to identify one or more aptamers. Certain aspects of the invention provide cells that transcribe one or more different aptamers (e.g., 10) that each bind to a different ligand and are each fused to a different reporter RNA.

    Abstract translation: 本发明的某些方面提供组装代表大量序列变体的核酸文库的方法。 一些实施方案涉及产生可以经受体内筛选或选择以鉴定一种或多种适体的RNA分子的文库。 本发明的某些方面提供转录一种或多种不同适配体（例如，10）的细胞，其各自结合不同的配体并且各自与不同的报道RNA融合。

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