公开(公告)号：WO2013011461A1

公开(公告)日：2013-01-24

申请号：PCT/IB2012/053652

申请日：2012-07-17

Applicant: RANBAXY LABORATORIES LIMITED ,  ARYAN, Ram Chander ,  MISHRA, Anamika ,  NAIDU, Pudi, Giri, J. ,  SHARMA, Ramnik

Inventor： ARYAN, Ram Chander ,  MISHRA, Anamika ,  NAIDU, Pudi, Giri, J. ,  SHARMA, Ramnik

IPC: C07D491/044 ,  A61K31/407 ,  A61P25/00

CPC classification number: C07D491/044

Abstract: The present invention provides a process for the preparation of asenapine maleate of Formula (I), comprising: intra-molecular cyclization of the intermediate of Formula (II) to obtain the intermediate of Formula (III) using aluminium halide.

Abstract translation: 本发明提供制备式（I）的马来酸asenapine的方法，其包括：式（II）的中间体的分子内环化，以使用卤化铝获得式（III）的中间体。

公开(公告)号：WO2012150561A1

公开(公告)日：2012-11-08

申请号：PCT/IB2012/052200

申请日：2012-05-02

Applicant: RANBAXY LABORATORIES LIMITED ,  JARYAL, Jagdev, Singh ,  KAPOOR, Munish ,  SATHYANARAYANA, Swargam ,  THAPER, Rajesh Kumar ,  PRASAD, Mohan ,  ARORA, Sudershan, Kumar

Inventor： JARYAL, Jagdev, Singh ,  KAPOOR, Munish ,  SATHYANARAYANA, Swargam ,  THAPER, Rajesh Kumar ,  PRASAD, Mohan ,  ARORA, Sudershan, Kumar

IPC: C07D498/22 ,  A61K31/437 ,  A61P1/00

CPC classification number: C07D498/22

Abstract: The present invention provides a new polymorphic form of rifaximin designated as DMF solvate and the process for its preparation. It also provides a pharmaceutical composition comprising the same and its use for the treatment of bowel related disorders.

Abstract translation: 本发明提供了称为DMF溶剂化物的新的多福昔莫明的多晶型物及其制备方法。 它还提供了包含其的药物组合物及其用于治疗肠道相关疾病的用途。

公开(公告)号：WO2012038943A1

公开(公告)日：2012-03-29

申请号：PCT/IB2011/054228

申请日：2011-09-26

Applicant: RANBAXY LABORATORIES LIMITED ,  KHERA, Manoj Kumar ,  SATTIGERI, Jitendra ,  YADAV, Neeraj Kumar ,  RAUF, Abdul Rehman Abdul ,  CLIFFE, Ian A. ,  BHATNAGAR, Pradip Kumar ,  RAY, Abhijit ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

Inventor： KHERA, Manoj Kumar ,  SATTIGERI, Jitendra ,  YADAV, Neeraj Kumar ,  RAUF, Abdul Rehman Abdul ,  CLIFFE, Ian A. ,  BHATNAGAR, Pradip Kumar ,  RAY, Abhijit ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

IPC: C07C309/60 ,  C07C321/28 ,  C07C333/08 ,  A61K31/192 ,  A61K31/325 ,  A61P11/00 ,  A61P19/02 ,  A61P35/00

CPC classification number: C07C317/46 ,  C07C323/52 ,  C07C323/60

Abstract: The present invention relates to certain sulfone acetic acid derivatives of formula I as MMP inhibitor and processes for its syntheses. The invention also relates to pharmacological compositions containing the compounds of the present invention and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple scleorisis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of a matrix metalloproteinase using the compounds.

Abstract translation: 本发明涉及作为MMP抑制剂的某些式I的砜乙酸衍生物及其合成方法。 本发明还涉及含有本发明化合物的药物组合物和治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，银屑病关节炎，银屑病，肺纤维化，肺部炎症，急性呼吸窘迫综合征，牙周炎，多发性硬化症， 牙龈炎，动脉粥样硬化，干眼症，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移以及其他以使用该化合物过度表达和过度激活基质金属蛋白酶为特征的炎症性疾病。

公开(公告)号：WO2012014127A1

公开(公告)日：2012-02-02

申请号：PCT/IB2011/053238

申请日：2011-07-20

Applicant: RANBAXY LABORATORIES LIMITED ,  VERMA, Ashwani Kumar ,  MALHOTRA, Sanjay ,  GHORPADE, Satish Madhav ,  DAWANGE, Mahesh Balasaheb ,  RAY, Abhijit ,  GUPTA, Suman ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

Inventor： VERMA, Ashwani Kumar ,  MALHOTRA, Sanjay ,  GHORPADE, Satish Madhav ,  DAWANGE, Mahesh Balasaheb ,  RAY, Abhijit ,  GUPTA, Suman ,  SRIVASTAVA, Punit ,  DASTIDAR, Sunanda Ghosh

IPC: C07D233/42 ,  C07C311/08 ,  A61K31/18 ,  A61P29/00

CPC classification number: C07D233/42 ,  A61K45/06 ,  C07C311/08 ,  C07C311/14 ,  C07C311/21 ,  C07C2601/02 ,  C07C2602/08

Abstract: The present invention relates to sulfonamides derivatives as 5-lipoxygenase (5-LO) inhibitors and a process for their synthesis. The present invention also relates to pharmacological compositions containing these sulfonamides derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, Type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders.

Abstract translation: 本发明涉及作为5-脂氧合酶（5-LO）抑制剂的磺酰胺衍生物及其合成方法。 本发明还涉及含有这些磺酰胺衍生物的药物组合物，以及治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮的方法 ，动脉粥样硬化，癌症，瘙痒症，过敏性鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：WO2012014117A1

公开(公告)日：2012-02-02

申请号：PCT/IB2011/053171

申请日：2011-07-15

Applicant: RANBAXY LABORATORIES LIMITED ,  CHATTERJEE, Pranab ,  NATH, Asok ,  SOKHI, Sarbjot Singh ,  PRASAD, Mohan

Inventor： CHATTERJEE, Pranab ,  NATH, Asok ,  SOKHI, Sarbjot Singh ,  PRASAD, Mohan

IPC: C07D277/56

CPC classification number: C07D277/56

Abstract: An improved and efficient process for the preparation of 2-[3-cyano-4-(2- methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided.

Abstract translation: 提供了一种改进和有效的制备基本上不含酰胺副产物的2- [3-氰基-4-（2-甲基丙氧基）苯基] -4-甲基噻唑-5-羧酸（febustostat）的方法。

公开(公告)号：WO2011107922A2

公开(公告)日：2011-09-09

申请号：PCT/IB2011/050830

申请日：2011-02-25

Applicant: RANBAXY LABORATORIES LIMITED ,  MADAN, Sumit ,  ARORA, Vinod Kumar

Inventor： MADAN, Sumit ,  ARORA, Vinod Kumar

IPC: A61K9/20

CPC classification number: A61K31/165 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2866 ,  A61K9/5026 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to an extended release composition comprising milnacipran or its pharmaceutically acceptable salts for oral administration, and process for their preparation.

Abstract translation: 本发明涉及一种包含米那普仑或其用于口服给药的药学上可接受的盐的延长释放组合物及其制备方法。

公开(公告)号：WO2011107912A1

公开(公告)日：2011-09-09

申请号：PCT/IB2011/050795

申请日：2011-02-24

Applicant: RANBAXY LABORATORIES LIMITED ,  DURVASULA, Venugopal Venkatarama ,  RATHOD, Parendu Dhirajlal ,  ARYAN, Ram Chander

Inventor： DURVASULA, Venugopal Venkatarama ,  RATHOD, Parendu Dhirajlal ,  ARYAN, Ram Chander

IPC: C07F5/02 ,  A61K31/69

CPC classification number: C07F5/025

Abstract: The present invention relates to polymorphic forms of bortezomib. The polymorphic forms of the present invention are designated as Form A1 and Form A2 of bortezomib. The present invention also relates to processes for the preparation of the polymorphic Form A1 and Form A2 of bortezomib.

Abstract translation: 本发明涉及硼替佐米的多晶型物。 本发明的多晶型物称为硼替佐米的A1型和A2型。 本发明还涉及制备硼替佐米的多晶型A1和A2的方法。

公开(公告)号：WO2011107903A1

公开(公告)日：2011-09-09

申请号：PCT/IB2011/050763

申请日：2011-02-23

Applicant: RANBAXY LABORATORIES LIMITED ,  HASHMI, Mohd Salman ,  MADHRA, Mukesh Kumar ,  INAMDAR, Murad Ismail

Inventor： HASHMI, Mohd Salman ,  MADHRA, Mukesh Kumar ,  INAMDAR, Murad Ismail

IPC: C07D265/30 ,  A61K31/5375 ,  A61P1/00

CPC classification number: C07D265/30

Abstract: The present invention provides for highly pure mosapride citrate dihydrate and processes for its preparation. The present invention further provides a process for the preparation of mosapride citrate dihydrate substantially free of impurity D-II.

Abstract translation: 本发明提供了高纯度的莫沙必利柠檬酸二水合物及其制备方法。 本发明还提供了一种制备基本上不含杂质D-II的柠檬酸二氢马来酸酐二水合物的方法。

公开(公告)号：WO2011092663A2

公开(公告)日：2011-08-04

申请号：PCT/IB2011/050396

申请日：2011-01-28

Applicant: RANBAXY LABORATORIES LIMITED ,  JARYAL, Jagdev Singh ,  SATHYANARAYANA, Swargam ,  THAPER, Rajesh Kumar ,  PRASAD, Mohan ,  ZADE, Sachin, Deorao ,  SINGH, Ajay, Shankar

Inventor： JARYAL, Jagdev Singh ,  SATHYANARAYANA, Swargam ,  THAPER, Rajesh Kumar ,  PRASAD, Mohan ,  ZADE, Sachin, Deorao ,  SINGH, Ajay, Shankar

IPC: C07D213/81

CPC classification number: C07D213/81 ,  G01N30/02

Abstract: The present invention provides dimethyl sulphoxide solvate of 4-(4-{3-[4-chloro- 3-(trifluoromethyl)phenyl]ureido }phenoxy)-N 2 -methylpyridine-2-carboxamide, process for its preparation, pharmaceutical composition comprising it and its use for the treatment of cancer. The present invention also provides a novel HPLC method for the identification, quantification and isolation of related substances of sorafenib.

Abstract translation: 本发明提供4-（4- {3- [4-氯-3-（三氟甲基）苯基]脲基}苯氧基）-N2-甲基吡啶-2-甲酰胺的二甲基亚砜溶剂合物，其制备方法，包含它的药物组合物 并用于治疗癌症。 本发明还提供了用于鉴定，定量和分离索拉非尼相关物质的新型HPLC方法。

公开(公告)号：WO2011058525A2

公开(公告)日：2011-05-19

申请号：PCT/IB2010/055155

申请日：2010-11-12

Applicant: RANBAXY LABORATORIES LIMITED ,  MURUGESAN, Balaguru ,  VEMPALI, Anandam ,  SATHYANARAYANA, Swargam ,  THAPER, Rajesh Kumar ,  PRASAD, Mohan

Inventor： MURUGESAN, Balaguru ,  VEMPALI, Anandam ,  SATHYANARAYANA, Swargam ,  THAPER, Rajesh Kumar ,  PRASAD, Mohan

IPC: C07D239/94

CPC classification number: C07D239/94

Abstract: The present invention relates to processes for the preparation of erlotinib hydrochloride Form A and erlotinib hydrochloride Form B.(I).

Abstract translation: 本发明涉及用于制备厄洛替尼盐酸盐形式A和厄洛替尼盐酸盐形式B（I）的方法。