公开(公告)号：WO2011040898A1

公开(公告)日：2011-04-07

申请号：PCT/US2009/005410

申请日：2009-10-01

Applicant: ADVANCED APPLIED PHYSICS SOLUTIONS, INC. ,  LAPI, Suzanne ,  RUTH, Thomas J. ,  BECKER, Dirk W. ,  D'AURIA, John M.

Inventor： LAPI, Suzanne ,  RUTH, Thomas J. ,  BECKER, Dirk W. ,  D'AURIA, John M.

IPC: B01D59/44

CPC classification number: B01D59/44 ,  G21G1/001 ,  G21G1/06 ,  G21G2001/0036 ,  G21G2001/0042

Abstract: A method of isolating 99Mo produced using a (n, ) reaction according to example embodiments may include vaporizing a source compound containing 98Mo and 99Mo. The vaporized source compound may be ionized to form ions containing 98Mo and 99Mo. The ions may be separated to isolate the ions containing 99Mo. The isolated ions containing 99Mo may be collected with a collector. Accordingly, the isolated 99Mo may have a relatively high specific radioactivity and, in turn, may be used to produce the diagnostic radioisotope, 99mTc, through radioactive decay.

Abstract translation: 根据实施例的使用（n）反应分离的99Mo的分离方法可以包括蒸发含有98Mo和99Mo的源化合物。 蒸发的源化合物可以被离子化以形成含有98Mo和99Mo的离子。 可以分离离子以分离含有99Mo的离子。 含有99Mo的离子离子可以用收集器收集。 因此，分离的99Mo可以具有相对较高的比放射性，并且依次可以通过放射性衰变来产生99m Tc的诊断放射性同位素。

公开(公告)号：WO2008120084A3

公开(公告)日：2013-07-18

申请号：PCT/IB2008000761

申请日：2008-03-31

Applicant: ADVANCED APPLIED PHYSICS SOLUTIONS INC ,  LAPI SUZANNE ,  RUTH THOMAS J ,  BECKER DIRK WOLFRAM

Inventor： LAPI SUZANNE ,  RUTH THOMAS J ,  BECKER DIRK WOLFRAM

IPC: B01D59/42 ,  A61K51/04

CPC classification number: C01G47/00 ,  A61K51/1282 ,  B01D59/44 ,  C01G39/00 ,  C01P2006/88

Abstract: A method of isolating 186Re according to example embodiments may include vaporizing a source compound containing 185Re and 186Re. The vaporized source compound may be ionized to form negatively-charged molecules containing 185Re and 186Re. The negatively-charged molecules may be separated to isolate the negatively-charged molecules containing 186Re. The isolated negatively-charged molecules containing 186Re may be collected with a positively-charged collector. Accordingly, the isolated 186Re may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.

Abstract translation: 根据实施例的分离186Re的方法可以包括蒸发含有185Re和186Re的源化合物。 蒸发的源化合物可以被电离以形成含有185Re和186Re的带负电荷的分子。 可以分离带负电荷的分子以分离含有186Re的带负电荷分子。 含有186Re的分离的带负电荷分子可以用带正电收集器收集。 因此，分离的186Re可用于产生具有较高比活性的治疗和/或诊断放射性药物。

公开(公告)号：WO2010094130A1

公开(公告)日：2010-08-26

申请号：PCT/CA2010/000234

申请日：2010-02-22

Applicant: ADVANCED APPLIED PHYSICS SOLUTIONS, INC. ,  ADAMS, Michael J. ,  ORVIG, Christopher J. ,  SALAS, Paloma

Inventor： ADAMS, Michael J. ,  ORVIG, Christopher J. ,  SALAS, Paloma

IPC: C07H23/00 ,  A61K31/365 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/49 ,  A61K31/505 ,  A61K31/635 ,  A61K47/48 ,  A61P33/06 ,  C07F17/00 ,  C07F17/02 ,  C07H13/00

CPC classification number: A61K31/70 ,  A61K47/549 ,  C07H23/00 ,  Y02A50/411

Abstract: An antimalarial conjugate according to a non-limiting embodiment of the present invention may include a metallocene, a carbohydrate, and an antimalarial agent. The metallocene may include two cyclopentadienyl rings bound to a central metal atom. The carbohydrate and the antimalarial agent may be appended to at least one of the cyclopentadienyl rings of the metallocene, wherein the antimalarial agent has therapeutic properties directed to treating and/or preventing malaria. The metallocene may be ferrocene, the carbohydrate may be glucose, and the antimalarial agent may be chloroquine.

Abstract translation: 根据本发明的非限制性实施方案的抗疟疾缀合物可以包括茂金属，碳水化合物和抗疟药。 茂金属可以包括与中心金属原子结合的两个环戊二烯基环。 碳水化合物和抗疟剂可以附着在金属茂的至少一个环戊二烯基环上，其中抗疟剂具有治疗和/或预防疟疾的治疗性质。 茂金属可以是二茂铁，碳水化合物可以是葡萄糖，抗疟剂可以是氯喹。