公开(公告)号：WO2006102520A3

公开(公告)日：2007-02-15

申请号：PCT/US2006010612

申请日：2006-03-22

Applicant: UNIV CARNEGIE MELLON ,  BIER MARK E

Inventor： BIER MARK E

IPC: H01J49/04

CPC classification number: B01D59/44 ,  G01N1/00 ,  G01N1/22 ,  G01N1/28 ,  G01N35/1095

Abstract: The disclosed method and apparatus couple a membrane interface directly to a mass spectrometer at atmospheric pressure. The membrane may be in capillary or sheet form and allows the introduction of a liquid or gaseous sample to one side of the membrane while the other side of the membrane is bathed with a solution that can easily be used in an atmospheric pressure ionization source. Volatile molecules permeate through a suitable membrane such as poly-dimethyl silicone (PDMS), mix into the appropriate solvent, and are ionized. Because of the rules governing abstracts, this abstract should not be used in construing the claims.

Abstract translation: 所公开的方法和装置在大气压力下将膜界面直接耦合到质谱仪。 膜可以是毛细管或片状，并且允许将液体或气体样品引入膜的一侧，同时膜的另一侧用可容易地用于大气压电离源的溶液洗涤。 挥发性分子渗透通过合适的膜，例如聚二甲基硅氧烷（PDMS），混合到合适的溶剂中并被电离。 由于管理摘要的规则，本摘要不应用于解释索赔。

公开(公告)号：WO2006045200A1

公开(公告)日：2006-05-04

申请号：PCT/CA2005/001654

申请日：2005-10-28

Applicant: LITHERLAND, Albert, Edward ,  DOUPE, Jonathan, P. ,  KIESER, William, Edward ,  ZHAO, Xiao-Lei ,  JAVAHERY, Gholamreza ,  COUSINS, Lisa ,  TOMSKI, Ilia ,  JOLLIFFE, Charles

Inventor： LITHERLAND, Albert, Edward ,  DOUPE, Jonathan, P. ,  KIESER, William, Edward ,  ZHAO, Xiao-Lei ,  JAVAHERY, Gholamreza ,  COUSINS, Lisa ,  TOMSKI, Ilia ,  JOLLIFFE, Charles

IPC: H01J49/04 ,  G01N37/00 ,  G01N27/62

CPC classification number: H01J49/0086 ,  B01D59/44 ,  H01J49/0077 ,  H01J49/06

Abstract: This invention relates to a method and apparatus for separation of rare stable or radioactive isotopes from their atomic or molecular isobars in mass spectrometry (MS). In the present invention, the approach taken to removing atomic isobars utilizes a high transmission device for decelerating ions in combination with low energy reactions, such as ion-molecule reactions or near resonant electron transfer, in RF ion guides. The isobar is selectively depleted by electron transfer or other reactions between negative ions and gaseous targets in pressurized RF ion guides at low energies. The energy is controlled in such a way as to prevent reaction of the ion of interest while inducing reactions with the undesired isobar interference. The technique is of particular relevance to accelerator mass spectrometry (AMS) for which it allows substantial reductions in the necessary terminal voltage. The effect is to allow reductions in the size and cost of AMS installations.

Abstract translation: 本发明涉及在质谱（MS）中从其原子或分子等值线分离稀有稳定或放射性同位素的方法和装置。 在本发明中，用于除去原子等压线的方法利用高传输装置，用于在RF离子导向器中结合低能量反应（例如离子分子反应或接近谐振电子转移）来减速离子。 在低能量下，加压RF离子导向器中的等离子体被电子转移或负离子与气态靶之间的其它反应选择性地耗尽。 控制能量以防止感兴趣的离子的反应，同时诱导与不期望的等压线干涉的反应。 该技术与加速器质谱（AMS）特别相关，其能够显着降低必需的终端电压。 其效果是可以减少AMS安装的尺寸和成本。

公开(公告)号：WO2005050196A1

公开(公告)日：2005-06-02

申请号：PCT/CN2004/000939

申请日：2004-08-12

IPC: G01N33/48

CPC classification number: G01N31/12 ,  B01D59/44 ,  C01B4/00 ,  G01N33/48

Abstract: The invention provides a method of analyzing hydrogen isotope, especially a method of confirming hydrogen/deuterium exchange in constructions of biological samples and determining the percentage of deuterium in biological samples. The method comprises the following steps: selecting a matrix, mixing uniformly the prepared biological sample with a suitable amount of the matrix, then lyophilizing; the lyophilized mixture burns completely with an oxidant, so hydrogen in the mixed sample is oxidized into water; after separating, the water obtained reacts with zinc to produce hydrogen gas; then measuring H/ H ratio in hydrogen gas by a gas isotope mass spectrograph; calculating the percentage of deuterium in biological samples increases, the biological properties, mainly thermostabilization, of samples will change obviously. By determining the percentage of deuterium for biological samples with the optimal thermostabilization and the optical deuterium treatment conditions for biological samples, the stability of biological samples such as polypeptide will improve. The method is simple and easy to operate, with good reproducibility and low costs.

公开(公告)号：WO2017178453A1

公开(公告)日：2017-10-19

申请号：PCT/EP2017/058610

申请日：2017-04-11

Applicant: ROCHE DIAGNOSTICS GMBH ,  F. HOFFMANN-LA ROCHE AG ,  ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： KOBOLD, Uwe ,  THIELE, Roland ,  WEISS, Noah ,  TIEMANN, Benjamin

IPC: G01N33/68 ,  G01N35/10 ,  G01N33/96 ,  G01N33/58 ,  H01J49/00

CPC classification number: G01N33/6848 ,  B01D59/44 ,  G01N30/72 ,  G01N33/58 ,  G01N33/96 ,  G01N2001/2893 ,  G01N2458/15 ,  H01J49/0009

Abstract: A method and an apparatus for determining a concentration of a target analyte in a sample of bodily fluid are disclosed. The method comprises providing a sample of bodily fluid including the target analyte, providing an internal standard solution including a mixture of components comprising a plurality of isotopes of the target analyte, wherein a concentration of each isotope is unknown, adding the internal standard solution to the sample, analyzing the sample including the internal standard solution by means of a mass spectrometer, creating a sample function curve based on signal intensities, wherein the signal intensities define arbitrary units, transferring an analyte signal into a corresponding arbitrary analyte unit by means of the sample function curve, and transferring the arbitrary analyte unit into the concentration of a target analyte by means of a standardization function representing a curve of concentrations depending on the arbitrary units.

Abstract translation: 公开了一种用于确定体液样品中的目标分析物浓度的方法和设备。 该方法包括提供包括目标分析物的体液样品，提供包括含有目标分析物的多个同位素的组分的混合物的内部标准溶液，其中每种同位素的浓度是未知的，将内部标准溶液添加到 样品，通过质谱仪分析包括内标溶液的样品，基于信号强度产生样品函数曲线，其中信号强度定义任意单位，通过样品将分析物信号转移到相应的任意分析物单元中 功能曲线，并通过代表取决于任意单位的浓度曲线的标准化函数将任意分析物单元转换成目标分析物的浓度。

公开(公告)号：WO2011140040A1

公开(公告)日：2011-11-10

申请号：PCT/US2011/034933

申请日：2011-05-03

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION ,  BATTELLE MEMORIAL INSTITUTE ,  ENKE, Christie, G. ,  RAY, Steven, J. ,  GRAHAM, Alexander ,  HIEFTJE, Gary, M. ,  BARINAGA, Charles, J. ,  KOPPENAAL, David, W.

Inventor： ENKE, Christie, G. ,  RAY, Steven, J. ,  GRAHAM, Alexander ,  HIEFTJE, Gary, M. ,  BARINAGA, Charles, J. ,  KOPPENAAL, David, W.

IPC: B01D59/44

CPC classification number: H01J49/26 ,  B01D59/44 ,  H01J49/34 ,  H01J49/40

Abstract: A combined distance-of-flight mass spectrometry (DOFMS) and time-of-flight mass spectrometry (TOFMS) instrument (100) includes an ion source configured to produce ions having varying mass-to-charge ratios, a first detector (112) configured to determine when each of the ions travels a predetermined distance, a second detector (114) configured to determine how far each of the ions travels in a predetermined time, and a detector extraction region (110) operable to direct portions of the ions either to the first detector (112) or to the second detector (114).

Abstract translation: 组合的飞行距离质谱（DOFMS）和飞行时间质谱（TOFMS）仪器（100）包括被配置为产生具有不同质荷比的离子的离子源，第一检测器（112） 被配置为确定每个离子何时行进预定距离，第二检测器（114）被配置为确定每个离子在预定时间内行进的距离;以及检测器提取区域（110），其可操作地将部分离子引导到 到第一检测器（112）或第二检测器（114）。

公开(公告)号：WO2011040898A1

公开(公告)日：2011-04-07

申请号：PCT/US2009/005410

申请日：2009-10-01

Applicant: ADVANCED APPLIED PHYSICS SOLUTIONS, INC. ,  LAPI, Suzanne ,  RUTH, Thomas J. ,  BECKER, Dirk W. ,  D'AURIA, John M.

Inventor： LAPI, Suzanne ,  RUTH, Thomas J. ,  BECKER, Dirk W. ,  D'AURIA, John M.

IPC: B01D59/44

CPC classification number: B01D59/44 ,  G21G1/001 ,  G21G1/06 ,  G21G2001/0036 ,  G21G2001/0042

Abstract: A method of isolating 99Mo produced using a (n, ) reaction according to example embodiments may include vaporizing a source compound containing 98Mo and 99Mo. The vaporized source compound may be ionized to form ions containing 98Mo and 99Mo. The ions may be separated to isolate the ions containing 99Mo. The isolated ions containing 99Mo may be collected with a collector. Accordingly, the isolated 99Mo may have a relatively high specific radioactivity and, in turn, may be used to produce the diagnostic radioisotope, 99mTc, through radioactive decay.

Abstract translation: 根据实施例的使用（n）反应分离的99Mo的分离方法可以包括蒸发含有98Mo和99Mo的源化合物。 蒸发的源化合物可以被离子化以形成含有98Mo和99Mo的离子。 可以分离离子以分离含有99Mo的离子。 含有99Mo的离子离子可以用收集器收集。 因此，分离的99Mo可以具有相对较高的比放射性，并且依次可以通过放射性衰变来产生99m Tc的诊断放射性同位素。

公开(公告)号：WO2006050226A3

公开(公告)日：2006-08-03

申请号：PCT/US2005039186

申请日：2005-10-28

Applicant: CERNO BIOSCIENCE LLC ,  WANG YONGDONG ,  GU MING

Inventor： WANG YONGDONG ,  GU MING

IPC: H01J49/00

CPC classification number: H01J49/0009 ,  B01D59/44 ,  G01N33/6848 ,  G06K9/00543 ,  H01J49/0036

Abstract: A method for analyzing data from a mass spectrometer includes the steps of acquiring raw mass spectral data in a profile mode (510); generating a peak list containing one of peak mass locations and peak mass ranges (510C) and being representative of candidate ions (510G); calculating a theoretical mass spectral isotope profile for each of the candidate ions (510H); forming a different peak component matrix for each of the candidate ions identified (510); performing regression analysis involving the peak component matrix for each of the candidate ions and the acquired profile mode data (510J); and ranking the candidate ions with a fitting statistic with that ion corresponding to the most significant statistic being the most likely candidate ion present (510K).

Abstract translation: 用于分析来自质谱仪的数据的方法包括以简档模式获取原始质谱数据的步骤（510）; 产生包含峰质量位置和峰质量范围（510℃）中的一个并且代表候选离子（510G）的峰列表; 计算每个候选离子（510H）的理论质谱同位素谱; 为所识别的每个候选离子形成不同的峰分量矩阵（510）; 执行涉及每个候选离子的峰分量矩阵和所获取的分布模式数据（510J）的回归分析; 并用适合的统计量排列候选离子，其中对应于最显着统计量的离子是存在的最可能的候选离子（510K）。

公开(公告)号：WO2002060565A1

公开(公告)日：2002-08-08

申请号：PCT/US2001/046539

申请日：2001-12-05

Applicant: KINGSTON, Howard, M.

Inventor： KINGSTON, Howard, M.

IPC: B01D59/44

CPC classification number: H01J49/0031 ,  B01D59/44 ,  C08J9/0004 ,  C08J2300/14 ,  H01J49/0009 ,  H01J49/04

Abstract: A method and associated apparatus for in-process automated analysis employing a modified form of isotope dilution mass spectrometry is disclosed. It involves elemental and speciation threshold measurement that is optimized for quality assurance at and is capable of functioning at and near quantitative instrumental detection limits. The system is automated and may be employed in an unattended operation for identification and quantification of elemental or specie contaminants. In a preferred aspect of the method, a sample is subjected to equilibration with at least one spiked enriched stable isotope element or specie (38) after which it is subjected to ionization in an atmospheric ion generator (32) and processed by a microprocessor which through a controller (20), coordinates operation of sample and spike delivery and equilibration as well as, the operation of the atmospheric ion generator and mass spectrometer (36). The method may in the alternative be employed qualitatively.

Abstract translation: 公开了一种使用同位素稀释质谱法的修改形式的在线自动化分析的方法和相关装置。 它涉及元素和形态阈值测量，该质量优化用于质量保证，并且能够在定量仪器检测限度附近起作用。 该系统是自动化的，可用于无人值守操作，用于识别和定量元素或物质污染物。 在该方法的优选方面，将样品与至少一种掺入的富集的稳定同位素元素或物质（38）进行平衡，然后在大气离子发生器（32）中进行离子化，并由微处理器进行处理，微处理器通过 控制器（20），协调样品和尖峰输送和平衡的操作以及大气离子发生器和质谱仪（36）的操作。 替代方法可以定性地使用。

公开(公告)号：WO0159476A3

公开(公告)日：2002-03-14

申请号：PCT/GB0100528

申请日：2001-02-09

Applicant: CBAMS LTD ,  GARNER RONALD COLIN ,  GARNER JUNE VALERIE ,  LEONG DANIEL NICHOL ,  WHATTAM MATTHEW MICHAEL ,  CALAM ANDREW DAVID ,  GREGORY SALLY JOANNE

Inventor： GARNER RONALD COLIN ,  GARNER JUNE VALERIE ,  LEONG DANIEL NICHOL ,  WHATTAM MATTHEW MICHAEL ,  CALAM ANDREW DAVID ,  GREGORY SALLY JOANNE

IPC: G01N23/225 ,  B01D59/44 ,  G01N1/28 ,  G01N1/36 ,  G01N27/62 ,  G01N33/483 ,  H01J49/00

CPC classification number: B01D59/44 ,  H01J49/0086 ,  H01J49/04

Abstract: The present invention provides a method of sample preparation for use in obtaining elemental isotope ratios of a material by accelerator mass spectrometry. The method comprises forming the material into a sample without any substantial chemical alteration of the material. The invention also provides a sample for use in obtaining elemental isotope ratios of a material.

Abstract translation: 本发明提供一种用于通过加速器质谱法获得材料的元素同位素比的样品制备方法。 该方法包括将材料形成样品，而不会对材料进行任何实质的化学改变。 本发明还提供了用于获得材料的元素同位素比的样品。

公开(公告)号：WO1995023018A1

公开(公告)日：1995-08-31

申请号：PCT/US1995002378

申请日：1995-02-27

Applicant: ANALYTICA OF BRANFORD, INC.

Inventor： ANALYTICA OF BRANFORD, INC. ,  WHITEHOUSE, Craig, M. ,  GULCICEK, Erol

IPC: B01D59/44

CPC classification number: B01D59/44 ,  H01J49/0481 ,  H01J49/063

Abstract: A multipole ion guide (40) which begins in one pumping stage (53) and extends continuously into one or more subsequent pumping stages (41, 42) has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an electrospray, atmospheric pressure chemical ionization or inductively coupled plasma ion source are guided and focused into a mass analyzer (57) with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide a and q values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of atmospheric pressure ion source mass spectrometer instruments.

Abstract translation: 在一个泵送阶段（53）中开始并连续延伸到一个或多个随后的泵送阶段（41,42）中的多极离子导向器（40）已经被并入到大气压离子源质谱仪系统中。 使用多极离子导向器，从电喷雾，大气压化学电离或电感耦合等离子体离子源进入真空的离子被引导并高效地聚焦到质量分析器（57）中。 多极离子导向器长度的一部分上的背景压力足够高，由于与中性背景气体分子的离子碰撞而导致横过离子导向器长度的离子的动能冷却。 这种离子动能冷却降低了穿过多极离子导向器长度的离子的能量扩散。 多极离子导向DC偏移电位可用于调节平均离子能量，离子导向器a和q值可设定为减小或扩大将通过离子导向器传输的离子质量至电荷的范围。 多极离子导向器和多泵级多极离子导向器的这些特点用于提高大气压力离子源质谱仪器的性能和降低成本。