公开(公告)号：WO2003014105A1

公开(公告)日：2003-02-20

申请号：PCT/JP2002/008043

申请日：2002-08-07

Applicant: TAKEDA CHEMICAL INDUSTRIES, LTD. ,  SHIRAISHI, Mitsuru ,  BABA, Masanori ,  AIKAWA, Katsuji ,  KANZAKI, Naoyuki ,  SETO, Masaki ,  IIZAWA, Yuji

Inventor： SHIRAISHI, Mitsuru ,  BABA, Masanori ,  AIKAWA, Katsuji ,  KANZAKI, Naoyuki ,  SETO, Masaki ,  IIZAWA, Yuji

IPC: C07D313/20

CPC classification number: A61K31/4196 ,  A61K31/395 ,  A61K31/4178 ,  C07D225/06 ,  C07D313/20 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12

Abstract: The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula (I) wherein: R?1¿ is a 5- to 6-membered ring group which may be substituted; X?1¿ is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X?2¿ is a bivalent group of 1 to 4 atoms; Z?1¿ is a bivalent cyclic ring group or the like; Z?2¿ is a bond or the like; and R?2¿ is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

Abstract translation: 本发明提供具有CCR拮抗剂活性，特别是CCR5拮抗剂活性的新的环状化合物及其用途。 本发明的化合物由式（I）表示，其中：R 1为可被取代的5至6元环基; X 1是键或类似物; 环A是可以被取代的5至6元环基团; 环B是可以被取代的8至10元环基团; X 2是1至4个原子的二价基团; Z 1是二价环状环基等; Z 2是键或类似物; R 2为氨基，可以被取代的含氮杂环基等，或其盐。

公开(公告)号：WO03014105A9

公开(公告)日：2003-11-20

申请号：PCT/JP0208043

申请日：2002-08-07

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD ,  SHIRAISHI MITSURU ,  BABA MASANORI ,  AIKAWA KATSUJI ,  KANZAKI NAOYUKI ,  SETO MASAKI ,  IIZAWA YUJI

Inventor： SHIRAISHI MITSURU ,  BABA MASANORI ,  AIKAWA KATSUJI ,  KANZAKI NAOYUKI ,  SETO MASAKI ,  IIZAWA YUJI

IPC: C07D403/12 ,  A61K31/395 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/472 ,  A61K31/496 ,  A61K31/513 ,  A61K31/536 ,  A61K31/5513 ,  A61K31/7072 ,  A61K31/708 ,  A61K45/00 ,  A61P9/10 ,  A61P13/12 ,  A61P29/00 ,  A61P31/18 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D225/06 ,  C07D313/20 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  A61K31/335 ,  C07D405/14

CPC classification number: A61K31/4196 ,  A61K31/395 ,  A61K31/4178 ,  C07D225/06 ,  C07D313/20 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12

Abstract: The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula (I) wherein: R?1¿ is a 5- to 6-membered ring group which may be substituted; X?1¿ is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X?2¿ is a bivalent group of 1 to 4 atoms; Z?1¿ is a bivalent cyclic ring group or the like; Z?2¿ is a bond or the like; and R?2¿ is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

Abstract translation: 本发明提供具有CCR拮抗剂活性，特别是CCR5拮抗剂活性的新的环状化合物及其用途。 本发明的化合物由式（I）表示，其中：R 1是可被取代的5至6元环基; X 1是键或类似物; 环A是可以被取代的5至6元环基团; 环B是可以被取代的8至10元环基团; X 2是1至4个原子的二价基团; Z 1是二价环状环基等; Z 2是键或类似物; R 2是氨基，可以被取代的含氮杂环基等，或其盐。