公开(公告)号：WO9921555A3

公开(公告)日：1999-07-22

申请号：PCT/JP9804837

申请日：1998-10-26

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD ,  OHKAWA SHIGENORI ,  KIMURA HIROYUKI ,  KANZAKI NAOYUKI

Inventor： OHKAWA SHIGENORI ,  KIMURA HIROYUKI ,  KANZAKI NAOYUKI

IPC: C07D417/04 ,  A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/535 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/10 ,  A61P11/00 ,  A61P11/06 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07D417/14

CPC classification number: A61K31/4439 ,  A61K31/4436

Abstract: A pharmaceutical composition for antagonizing adenosine at adenosine A3 receptors which comprises a 1,3-azole compound substituted on the 4- or 5- position, or both, by a pyridyl which may be substituted is provided and can be used as a prophylactic and therapeutic agent for asthma, allergosis, inflammation, and so on.

Abstract translation: 提供用于拮抗腺苷A3受体的腺苷的药物组合物，其包含通过可被取代的吡啶基取代的4-或5-位或二者取代的1,3-吡唑化合物，并且可用作预防和治疗 哮喘，过敏原，炎症等的代理。

公开(公告)号：WO2003014105A1

公开(公告)日：2003-02-20

申请号：PCT/JP2002/008043

申请日：2002-08-07

Applicant: TAKEDA CHEMICAL INDUSTRIES, LTD. ,  SHIRAISHI, Mitsuru ,  BABA, Masanori ,  AIKAWA, Katsuji ,  KANZAKI, Naoyuki ,  SETO, Masaki ,  IIZAWA, Yuji

Inventor： SHIRAISHI, Mitsuru ,  BABA, Masanori ,  AIKAWA, Katsuji ,  KANZAKI, Naoyuki ,  SETO, Masaki ,  IIZAWA, Yuji

IPC: C07D313/20

CPC classification number: A61K31/4196 ,  A61K31/395 ,  A61K31/4178 ,  C07D225/06 ,  C07D313/20 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12

Abstract: The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula (I) wherein: R?1¿ is a 5- to 6-membered ring group which may be substituted; X?1¿ is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X?2¿ is a bivalent group of 1 to 4 atoms; Z?1¿ is a bivalent cyclic ring group or the like; Z?2¿ is a bond or the like; and R?2¿ is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

Abstract translation: 本发明提供具有CCR拮抗剂活性，特别是CCR5拮抗剂活性的新的环状化合物及其用途。 本发明的化合物由式（I）表示，其中：R 1为可被取代的5至6元环基; X 1是键或类似物; 环A是可以被取代的5至6元环基团; 环B是可以被取代的8至10元环基团; X 2是1至4个原子的二价基团; Z 1是二价环状环基等; Z 2是键或类似物; R 2为氨基，可以被取代的含氮杂环基等，或其盐。

公开(公告)号：WO03014105A9

公开(公告)日：2003-11-20

申请号：PCT/JP0208043

申请日：2002-08-07

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD ,  SHIRAISHI MITSURU ,  BABA MASANORI ,  AIKAWA KATSUJI ,  KANZAKI NAOYUKI ,  SETO MASAKI ,  IIZAWA YUJI

Inventor： SHIRAISHI MITSURU ,  BABA MASANORI ,  AIKAWA KATSUJI ,  KANZAKI NAOYUKI ,  SETO MASAKI ,  IIZAWA YUJI

IPC: C07D403/12 ,  A61K31/395 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/472 ,  A61K31/496 ,  A61K31/513 ,  A61K31/536 ,  A61K31/5513 ,  A61K31/7072 ,  A61K31/708 ,  A61K45/00 ,  A61P9/10 ,  A61P13/12 ,  A61P29/00 ,  A61P31/18 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D225/06 ,  C07D313/20 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  A61K31/335 ,  C07D405/14

CPC classification number: A61K31/4196 ,  A61K31/395 ,  A61K31/4178 ,  C07D225/06 ,  C07D313/20 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12

Abstract: The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula (I) wherein: R?1¿ is a 5- to 6-membered ring group which may be substituted; X?1¿ is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X?2¿ is a bivalent group of 1 to 4 atoms; Z?1¿ is a bivalent cyclic ring group or the like; Z?2¿ is a bond or the like; and R?2¿ is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

Abstract translation: 本发明提供具有CCR拮抗剂活性，特别是CCR5拮抗剂活性的新的环状化合物及其用途。 本发明的化合物由式（I）表示，其中：R 1是可被取代的5至6元环基; X 1是键或类似物; 环A是可以被取代的5至6元环基团; 环B是可以被取代的8至10元环基团; X 2是1至4个原子的二价基团; Z 1是二价环状环基等; Z 2是键或类似物; R 2是氨基，可以被取代的含氮杂环基等，或其盐。

公开(公告)号：WO1997016560A1

公开(公告)日：1997-05-09

申请号：PCT/JP1996003162

申请日：1996-10-29

Applicant: TAKEDA CHEMICAL INDUSTRIES, LTD. ,  SHISEIDO COMPANY, LIMITED ,  KANZAKI, Naoyuki ,  KAWAMOTO, Tomohiro ,  MATSUI, Junji ,  NAKAHAMA, Kazuo ,  IFUKU, Ohji

Inventor： TAKEDA CHEMICAL INDUSTRIES, LTD. ,  SHISEIDO COMPANY, LIMITED

IPC: C12P17/18

CPC classification number: C12P17/186

Abstract: A microorganism resistant to a threonine analogue, which has a plasmid containing part or whole of a biotin operon; and a process for producing biotin, which comprises culturing a microorganism described above in a medium to produce and accumulate biotin in the medium, and collecting biotin.

Abstract translation: 对苏氨酸类似物具有抗性的微生物，其具有含有生物素操纵子的一部分或全部的质粒; 以及生物素的制造方法，其包括在培养基中培养上述微生物，在培养基中生成并积累生物素，收集生物素。