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公开(公告)号：WO2006025887A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/017648
申请日：2005-05-20
申请人： BECTON, DICKINSON AND COMPANY , PITNER, Bruce, J. , SHERMAN, Douglas, B. , AMBROISE, Arounaguiry , THOMAS, Joseph, K.
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodiaxazole nucleus, coumarin nucleus or aza coumarin nucleus.
摘要翻译： 公开了反应性荧光染料组合物及其使用方法。 公开了具有巯基反应性基团的染料，所述染料具有巯基反应性基团。 公开了表现出至少约575nm的荧光发射的Squaraine核，尼罗红核，苯并二恶唑核，香豆素核或氮杂香豆素核染料。 公开了具有结合蛋白和方酸菁核，尼罗红核，苯并二唑核，香豆素核或氮杂香豆素核的生物传感器。
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公开(公告)号：WO2006025887A3
公开(公告)日：2006-08-10
申请号：PCT/US2005017648
申请日：2005-05-20
申请人： BECTON DICKINSON CO , PITNER BRUCE J , SHERMAN DOUGLAS B , AMBROISE AROUNAGUIRY , THOMAS JOSEPH K
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodiaxazole nucleus, coumarin nucleus or aza coumarin nucleus.
摘要翻译： 公开了活性荧光染料组合物及其使用方法。 披露了方酸核，尼罗红核，苯并恶唑核，香豆素核或氮杂香豆素核染料，公开了具有硫醇反应性基团的染料。 披露了方解子核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核染料，其表现出至少约575nm的荧光发射。 公开了具有结合蛋白和方酸核，尼罗红核，苯并咔唑核，香豆素核或氮杂香豆素核的生物传感器。
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公开(公告)号：WO2010022320A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/054595
申请日：2009-08-21
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , YANG, Guohan , HAI, Ton, That , MELNICK, Bennett , SAUNDERS, Paul , JIANG, Cong , QUINN, Catherine , LI, Jie , AMBROISE, Arounaguiry , BROWN, Larry, R.
发明人： YANG, Guohan , HAI, Ton, That , MELNICK, Bennett , SAUNDERS, Paul , JIANG, Cong , QUINN, Catherine , LI, Jie , AMBROISE, Arounaguiry , BROWN, Larry, R.
CPC分类号： A61K47/48215 , A61K31/405 , A61K47/60
摘要： The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
摘要翻译： 本发明涉及聚合物衍生物，其可以与含氨基的药物缀合以改善其体内性质。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合衍生物和药物缀合物的方法。
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公开(公告)号：WO2010022320A3
公开(公告)日：2010-08-19
申请号：PCT/US2009054595
申请日：2009-08-21
申请人： BAXTER INT , BAXTER HEALTHCARE SA , YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SAUNDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
发明人： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SAUNDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
CPC分类号： A61K47/48215 , A61K31/405 , A61K47/60
摘要： The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
摘要翻译： 本发明涉及聚合衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。
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