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公开(公告)号：WO2013013211A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/047731
申请日：2012-07-20
Applicant: DSM IP ASSETS B.V. , APT, Kirk, E. , BEHRENS, Paul Warren , HANSEN, Jon Milton , PFEIFER III, Joseph, W. , STAHL, Tracey Lynn , ZIRKLE, Ross
Inventor： APT, Kirk, E. , BEHRENS, Paul Warren , HANSEN, Jon Milton , PFEIFER III, Joseph, W. , STAHL, Tracey Lynn , ZIRKLE, Ross
IPC: A61K31/202
CPC classification number: A61K31/202 , A23K20/158 , A23K50/80 , A23L2/52 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K2800/10 , A61Q19/00 , C12P7/6427 , A61K2300/00
Abstract: The disclosure is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils.
Abstract translation: 本发明涉及含有ω-3多不饱和脂肪酸的微生物油，其包含二十二碳六烯酸，二十碳五烯酸和任选的二十二碳五烯酸以及含有这种油的剂型。
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2.发明申请EICOSAPENTAENOIC ACID-PRODUCING MICROORGANISMS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 审中-公开生产苹果酸的微生物，脂肪酸组合物及其制备方法及用途
公开(公告)号：WO2013013208A2
公开(公告)日：2013-01-24
申请号：PCT/US2012/047728
申请日：2012-07-20
Applicant: DSM IP ASSETS B.V. , PFEIFER, III, Joseph W. , HANSEN, Jon Milton , GARCIA, Jose R. , DONG, Xiao Daniel , BEHRENS, Paul Warren , APT, Kirk E.
Inventor： PFEIFER, III, Joseph W. , HANSEN, Jon Milton , GARCIA, Jose R. , DONG, Xiao Daniel , BEHRENS, Paul Warren , APT, Kirk E.
IPC: C12P7/64
CPC classification number: A23K50/00 , A23K10/16 , A23K20/158 , A23K50/80 , C11B1/10 , C12N1/12 , C12P7/6427 , C12R1/89
Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
Abstract translation: 本发明涉及分离的微生物以及其菌株和突变体，生物质，微生物油，组合物和培养物; 生产微生物油，生物质和突变体的方法; 以及使用分离的微生物，生物质和微生物油的方法。
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3.发明申请POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 审中-公开聚氨酯脂肪酸合成酶核酸分子和多肽，组合物及其制备方法及用途
公开(公告)号：WO2010108114A2
公开(公告)日：2010-09-23
申请号：PCT/US2010028009
申请日：2010-03-19
Applicant: MARTEK BIOSCIENCES CORP , APT KIRK E , RICHTER LESLIE , SIMPSON DAVID , ZIRKLE ROSS
Inventor： APT KIRK E , RICHTER LESLIE , SIMPSON DAVID , ZIRKLE ROSS
IPC: C12N15/52 , A61K38/43 , A61K48/00 , A61P3/00 , C12N1/00 , C12N5/10 , C12N9/00 , C12N15/63 , C12P7/64
CPC classification number: C12N15/52 , A61K38/00 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y101/01 , C12Y103/01 , C12Y203/01039 , C12Y203/01041 , C12Y402/01 , C12Y402/01059 , Y02P20/52
Abstract: The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
Abstract translation: 本发明涉及涉及PUFA生产的分离的核酸分子和多烯突变多不饱和脂肪酸（PUFA）合成酶，包括富含二十二碳六烯酸（DHA），二十碳五烯酸（EPA）或其组合的PUFA。 本发明涉及包含核酸分子，核酸分子编码的多肽，包含核酸分子或多肽的组合物及其制备和用途的载体和宿主细胞。
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4.发明申请EICOSAPENTAENOIC ACID-PRODUCING MICROORGANISMS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 审中-公开生产苹果酸的微生物，脂肪酸组合物及其制备方法及用途
公开(公告)号：WO2011090493A1
公开(公告)日：2011-07-28
申请号：PCT/US2010/028175
申请日：2010-03-22
Applicant: MARTEK BIOSCIENCES CORPORATION , APT, Kirk, E. , BEHRENS, Paul, Warren , HANSEN, Jon, Milton , PFEIFER III, Joseph, W. , STAHL, Tracey, Lynn , ZIRKLE, Ross
Inventor： APT, Kirk, E. , BEHRENS, Paul, Warren , HANSEN, Jon, Milton , PFEIFER III, Joseph, W. , STAHL, Tracey, Lynn , ZIRKLE, Ross
CPC classification number: A23K20/158 , A23C9/1528 , A23D9/00 , A23D9/007 , A23K10/12 , A23K50/00 , A23K50/40 , A23K50/80 , A23L2/52 , A23L33/115 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K31/201 , A61K31/202 , A61K35/68 , A61K2800/10 , A61Q19/00 , C11B1/10 , C11B3/04 , C12P7/6427 , C12P7/6472 , C12R1/89 , C12R1/90
Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
Abstract translation: 本发明涉及分离的微生物以及其菌株和突变体，生物质，微生物油，组合物和培养物; 生产微生物油，生物质和突变体的方法; 以及使用分离的微生物，生物质和微生物油的方法。
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5.发明申请PRODUCTION OF HEMAGGLUTININ-NEURAMINIDASE PROTEIN IN MICROALGAE 审中-公开在微藻中生产HEMAGGLUTININ-NEURAMINIDASE蛋白
公开(公告)号：WO2011082189A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062274
申请日：2010-12-28
Applicant: MARTEK BIOSCIENCES CORPORATION , APT, Kirk E.
Inventor： APT, Kirk E.
CPC classification number: C12Y302/01018 , C12N7/00 , C12N9/2402 , C12N15/8257 , C12N2760/18151 , C12N2760/18651
Abstract: The present invention is directed to recombinant microalgal cells and their use production of heterologous hemagglutinin-neuraminidase (HN) polypeptides, as well compositions and uses thereof.
Abstract translation: 本发明涉及重组微藻细胞及其产生异源血凝素 - 神经氨酸酶（HN）多肽，以及其组合物和用途。
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Patent Agency Ranking6.发明申请THRAUSTOCHYTRIDS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 审中-公开肉豆蔻酸，脂肪酸组合物及其制备方法及用途
公开(公告)号：WO2010107415A1
公开(公告)日：2010-09-23
申请号：PCT/US2009/001720
申请日：2009-03-19
Applicant: MARTEK BIOSCIENCES CORPORATION , APT, Kirk, E. , PFEIFER, Joseph, W., III , HANSEN, Jon, Milton , BEHRENS, Paul, Warren , ZIRKLE, Ross , STAHL, Tracey, Lynn
Inventor： APT, Kirk, E. , PFEIFER, Joseph, W., III , HANSEN, Jon, Milton , BEHRENS, Paul, Warren , ZIRKLE, Ross , STAHL, Tracey, Lynn
IPC: C12N15/82
CPC classification number: C12R1/89 , C12N1/12 , C12P7/6427 , C12P7/6472
Abstract: The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
Abstract translation: 本发明涉及分离的破釜状菌属微生物以及其菌株和突变体。 本发明进一步涉及生物质，微生物油，组合物，培养物，生产微生物油的方法，以及使用分离的破釜蛇疮，生物质和微生物油的方法。
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公开(公告)号：WO2011153246A3
公开(公告)日：2012-04-19
申请号：PCT/US2011038768
申请日：2011-06-01
Applicant: MARTEK BIOSCIENCES CORP , CHERINKO STEPHEN ROBERT , KERTIS ROBERT CODY , APT KIRK E , BEHRENS PAUL WARREN , HANSEN JON MILTON , PFEIFER JOSEPH W III , STAHL TRACEY LYNN , ZIRKLE ROSS , BURKE NASRIN TABAYEH , RAMAN KRISHNA , LEININGER NEIL FRANCIS
Inventor： CHERINKO STEPHEN ROBERT , KERTIS ROBERT CODY , APT KIRK E , BEHRENS PAUL WARREN , HANSEN JON MILTON , PFEIFER JOSEPH W III , STAHL TRACEY LYNN , ZIRKLE ROSS , BURKE NASRIN TABAYEH , RAMAN KRISHNA , LEININGER NEIL FRANCIS
Abstract: Processes for obtaining a lipid from a cell by lysing the cell, contacting the cell with a base and/or salt, and separating the lipid, as well as lipids prepared by said process are disclosed. Also disclosed are microbial lipids having a particular anisidine value, peroxide value, and/or phosphorus content.
Abstract translation: 公开了通过裂解细胞，使细胞与碱和/或盐接触并分离脂质以及通过所述方法制备的脂质从细胞获得脂质的方法。 还公开了具有特定茴香胺值，过氧化值和/或磷含量的微生物脂质。
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公开(公告)号：WO2011153246A2
公开(公告)日：2011-12-08
申请号：PCT/US2011/038768
申请日：2011-06-01
Applicant: MARTEK BIOSCIENCES CORPORATION , CHERINKO, Stephen, Robert , KERTIS, Robert, Cody , APT, Kirk, E. , BEHRENS, Paul, Warren , HANSEN, Jon, Milton , PFEIFER, Joseph, W., III , STAHL, Tracey, Lynn , ZIRKLE, Ross , BURKE, Nasrin Tabayeh , RAMAN, Krishna , LEININGER, Neil Francis
Inventor： CHERINKO, Stephen, Robert , KERTIS, Robert, Cody , APT, Kirk, E. , BEHRENS, Paul, Warren , HANSEN, Jon, Milton , PFEIFER, Joseph, W., III , STAHL, Tracey, Lynn , ZIRKLE, Ross , BURKE, Nasrin Tabayeh , RAMAN, Krishna , LEININGER, Neil Francis
Abstract: The present: invention relates to processes for obtaining a lipid from a cell by lysing the cell, contacting the cell with a base and/or salt, and separating the lipid. The present invention is also directed to a lipid prepared by the processes of the present invention. The present invention is also directed to microbial lipids having a particular anisidine value, peroxide value, and/or phosphorus content.
Abstract translation: 本发明涉及通过裂解细胞，使细胞与碱和/或盐接触并分离脂质从细胞获得脂质的方法。 本发明还涉及通过本发明的方法制备的脂质。 本发明还涉及具有特定茴香胺值，过氧化值和/或磷含量的微生物脂质。
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公开(公告)号：WO2011112948A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/028122
申请日：2011-03-11
Applicant: MARTEK BIOSCIENCES CORPORATION , APT, Kirk, E. , BARCLAY, William, R. , BEHRENS, Paul, Warren
Inventor： APT, Kirk, E. , BARCLAY, William, R. , BEHRENS, Paul, Warren
CPC classification number: C12N1/16 , C12P7/6409 , C12P7/6427 , C12R1/645
Abstract: The invention is directed to isolated microorganisms, as well as biomasses, cultures, microbial oils, and compositions thereof. The invention also provides methods of producing the microbial oils and methods of using the isolated microorganisms, biomasses, and microbial oils.
Abstract translation: 本发明涉及分离的微生物以及生物量，培养物，微生物油及其组合物。 本发明还提供了生产微生物油的方法和使用分离的微生物，生物质和微生物油的方法。
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10.发明申请RECOMBINANT THRAUSTOCHYTRIDS THAT GROW ON XYLOSE, AND COMPOSITIONS, METHODS OF MAKING, AND USES THEREOF 审中-公开在XYLOSE上生长的重组蛋白质及其组合物，制备方法及其用途
公开(公告)号：WO2011090730A1
公开(公告)日：2011-07-28
申请号：PCT/US2010/062275
申请日：2010-12-28
Applicant: MARTEK BIOSCIENCES CORPORATION , LIPPMEIER, James Casey , APT, Kirk E.
Inventor： LIPPMEIER, James Casey , APT, Kirk E.
CPC classification number: C12N1/10 , A23K50/00 , A23K50/80 , A23L2/52 , A23L33/10 , A23V2002/00 , C12N1/22 , C12N15/52 , C12N15/79 , C12P7/649 , Y02E50/13
Abstract: The present invention is directed to recombinant thraustochytrids that grow on xylose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.
Abstract translation: 本发明涉及在包含重组破囊索的木糖和细胞培养物上生长的重组thraustochytrid以及使用重组thraustochytrids生产细胞培养物，生物质，微生物油，组合物和生物燃料的方法。
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