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    A SERUM-FREE VIRUS PROPAGATION PLATFORM FOR A VIRUS VACCINE CANDIDATE
    5.
    发明申请
    A SERUM-FREE VIRUS PROPAGATION PLATFORM FOR A VIRUS VACCINE CANDIDATE 审中-公开
    一种用于病毒疫苗候选者的无血清病毒繁殖平台

    公开(公告)号：WO2008051698A3

    公开(公告)日：2008-07-10

    申请号：PCT/US2007080610

    申请日：2007-10-05

    Applicant: MEDIMMUNE VACCINES INC ,  YUK INN ,  ZENG WENLIN ,  SUGUI MISA

    Inventor： YUK INN ,  ZENG WENLIN ,  SUGUI MISA

    IPC: C12N15/85

    CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K2039/5256 ,  C12N7/00 ,  C12N2760/18534 ,  C12N2760/18552 ,  C12N2760/18634 ,  C12N2760/18651 ,  C12N2760/18652

    Abstract: The invention relates to methods for propagating viruses. In particular, the invention provides optimized conditions for propagating viruses. Optimization of the following parameters are provided: lipid concentrates as supplements to the medium, temperature shift from pre-infection to post-infection, multiplicity of infection, direct bead-to-bead transfer and serum supplementation of pre-infection medium. In particular, the invention provides for the first time a method for propagating a virus by culturing cells that are infected with the virus in a medium comprising chemically defined lipid concentrate (CDLC). In another claim, the CDLC is added to medium that is substantially free of serum for culture of virus-infected cells.

    Abstract translation: 本发明涉及用于繁殖病毒的方法。 特别地，本发明提供了用于繁殖病毒的优化条件。 提供以下参数的优化：作为培养基补充物的脂质浓缩物，从感染前到感染后的温度变化，感染复数，直接珠到珠转移和感染前培养基的血清补充。 具体而言，本发明首次提供了通过在包含化学定义的脂质浓缩物（CDLC）的培养基中培养被病毒感染的细胞来繁殖病毒的方法。 在另一个权利要求中，将CDLC添加到基本上不含血清的培养基中以培养病毒感染细胞。

    A SERUM-FREE VIRUS PROPAGATION PLATFORM FOR A VIRUS VACCINE CANDIDATE
    6.
    发明申请
    A SERUM-FREE VIRUS PROPAGATION PLATFORM FOR A VIRUS VACCINE CANDIDATE 审中-公开
    一种用于病毒疫苗候选药物的无血清病毒传播平台

    公开(公告)号：WO2008051698A2

    公开(公告)日：2008-05-02

    申请号：PCT/US2007/080610

    申请日：2007-10-05

    Applicant: MEDIMMUNE VACCINES, INC. ,  YUK, Inn ,  ZENG, Wenlin ,  SUGUI, Misa

    Inventor： YUK, Inn ,  ZENG, Wenlin ,  SUGUI, Misa

    IPC: C12N7/08

    CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K2039/5256 ,  C12N7/00 ,  C12N2760/18534 ,  C12N2760/18552 ,  C12N2760/18634 ,  C12N2760/18651 ,  C12N2760/18652

    Abstract: The invention relates to methods for propagating viruses. In particular, the invention provides optimized conditions for propagating viruses. Optimization of the following parameters are provided: lipid concentrates as supplements to the medium, temperature shift from pre-infection to post-infection, multiplicity of infection, direct bead-to-bead transfer and serum supplementation of pre-infection medium. In particular, the invention provides for the first time a method for propagating a virus by culturing cells that are infected with the virus in a medium comprising chemically defined lipid concentrate (CDLC). In another claim, the CDLC is added to medium that is substantially free of serum for culture of virus-infected cells.

    Abstract translation: 本发明涉及传播病毒的方法。 特别地，本发明提供了用于传播病毒的优化条件。 提供以下参数的优化：脂质浓缩物作为培养基的补充，从感染前到感染后的温度变化，感染的多样性，直接的珠珠转移和预感染培养基的血清补充。 特别地，本发明首次提供了通过在包含化学确定的脂质浓缩物（CDLC）的培养基中培养感染病毒的细胞来繁殖病毒的方法。 在另一个权利要求中，将CDLC加入到基本上不含病毒感染细胞培养的血清的培养基中。

    RESCUE OF INFLUENZA VIRUS
    8.
    发明申请
    RESCUE OF INFLUENZA VIRUS 审中-公开
    感染流感病毒

    公开(公告)号：WO2006067211A1

    公开(公告)日：2006-06-29

    申请号：PCT/EP2005/057092

    申请日：2005-12-22

    Applicant: SOLVAY PHARMACEUTICALS B.V. ,  ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM ,  DE WIT, Emmie ,  SPRONKEN, Monique I.j. ,  FOUCHIER, Ron A.m. ,  OSTERHAUS, Albert D.m.e.

    Inventor： DE WIT, Emmie ,  SPRONKEN, Monique I.j. ,  FOUCHIER, Ron A.m. ,  OSTERHAUS, Albert D.m.e.

    IPC: C12N7/00 ,  A61K39/00

    CPC classification number: C12N15/85 ,  A61K39/00 ,  C12N7/00 ,  C12N2760/18651

    Abstract: The invention relates to the field of influenza vaccine production. Influenza vaccines have been produced in embryonated hens'eggs for over 50 years, but recently there have been considerable efforts to develop cell culture systems for vaccine production. The invention provides a nucleic acid comprising an influenza gene segment and a bacteriophage polymerase promotor or a complementary strand of said nucleic acid, and a cell comprising such a nucleic acid capable of producing desired influenza virus. Furthermore, the invention provides a composition comprising a cell or material derived from a cell according to the invention and a virus or material derived from a viral particle according to the invention.

    Abstract translation: 本发明涉及流感疫苗生产领域。 流感疫苗已经在胚胎母鸡生产了50多年，但最近已经做了相当大的努力来开发疫苗生产的细胞培养系统。 本发明提供了包含流感基因片段和噬菌体聚合酶启动子或所述核酸的互补链的核酸，以及包含能够产生所需流感病毒的核酸的细胞。 此外，本发明提供了包含衍生自根据本发明的细胞的细胞或物质的组合物和源自本发明的病毒颗粒的病毒或物质。

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