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公开(公告)号：WO2004087877A3
公开(公告)日：2004-10-14
申请号：PCT/US2004/009261
申请日：2004-03-25
Applicant: ASTRAL INC. , SMITH, Dan , BOT, Adrian
Inventor： SMITH, Dan , BOT, Adrian
IPC: C12Q1/68
Abstract: The present application is directed to the use of dsRNA and/or ssRNA for the purpose of inducing apoptosis or cell death in proliferating cells. Specifically, low molecular weight and high molecular weight dsRNA and ssRNA are shown to induce apoptosis and/or cell death in proliferating cells, to arrest proliferation of transformed cells or tumor cells and to cause rapid induction of the cytokine TNF-alpha and/or also induce production of IL-12 which directs a Th-1 response.
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公开(公告)号：WO2004087877A2
公开(公告)日：2004-10-14
申请号：PCT/US2004009261
申请日：2004-03-25
Applicant: ASTRAL INC , SMITH DAN , BOT ADRIAN
Inventor： SMITH DAN , BOT ADRIAN
IPC: A01N43/04 , A61K31/07 , C07H21/04 , C12N20060101 , C12N15/117 , C12Q1/68 , C12N
CPC classification number: C12N15/117 , C12N2310/17
Abstract: The present application is directed to the use of dsRNA and/or ssRNA for the purpose of inducing apoptosis or cell death in proliferating cells. Specifically, low molecular weight and high molecular weight dsRNA and ssRNA are shown to induce apoptosis and/or cell death in proliferating cells, to arrest proliferation of transformed cells or tumor cells and to cause rapid induction of the cytokine TNF-alpha and/or also induce production of IL-12 which directs a Th-1 response.
Abstract translation: 本申请涉及dsRNA和/或ssRNA用于在增殖细胞中诱导凋亡或细胞死亡的目的。 具体地，低分子量和高分子量的dsRNA和ssRNA显示在增殖细胞中诱导凋亡和/或细胞死亡，以阻止转化的细胞或肿瘤细胞的增殖并引起细胞因子TNF-α的快速诱导和/或 诱导产生引导Th-1反应的IL-12。
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3.发明申请IMMUNOSTIMULATORY DOUBLE STRANDED RNA AND METHODS OF INDUCING, ENHANCING OR MODULATING THE IMMUNE RESPONSE 审中-公开免疫刺激双链RNA及诱导，增强或调节免疫应答的方法
公开(公告)号：WO03078595B1
公开(公告)日：2004-05-21
申请号：PCT/US0307995
申请日：2003-03-14
Applicant: ASTRAL INC , BOT ADRIAN I , WANG LILIN , DELLAMARY LUIS , SMITH DAN , PHILLIPS BILL
Inventor： BOT ADRIAN I , WANG LILIN , DELLAMARY LUIS , SMITH DAN , PHILLIPS BILL
IPC: A61K39/00 , A61K31/7105 , A61K31/713 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K39/395 , A61K48/00 , A61P37/04 , C07H21/04
CPC classification number: A61K39/12 , A61K31/7105 , A61K31/713 , A61K39/0011 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/543 , A61K2039/544 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C12N2710/24143 , C12N2740/16134 , C12N2760/16134 , A61K2300/00
Abstract: The present application is directed to non-coding RNA motifs that are used in conjunction with an antigen or without an antigen to induce, enhance or modulate an immune response that comprises a B cell and a T cell component.
Abstract translation: 本申请涉及与抗原或不含抗原结合使用以诱导，增强或调节包含B细胞和T细胞组分的免疫应答的非编码RNA基序。
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Patent Agency Ranking4.发明申请COMPOSITIONS AND METHODS TO INITIATE OR ENHANCE ANTIBODY AND MAJOR-HISTOCOMPATIBILITY CLASS I OR CLASS II-RESTRICTED T CELL RESPONSES BY USING IMMUNOMODULATORY, NON-CODING RNA MOTIFS 审中-公开组合物和方法通过使用免疫调节剂，非编码RNA MOTIFS来启动或增强抗体和主要组氨酸分类I或II类限制性T细胞应答
公开(公告)号：WO03078595A2
公开(公告)日：2003-09-25
申请号：PCT/US0307995
申请日：2003-03-14
Applicant: ASTRAL INC , BOT ADRIAN I , WANG LILIN , DELLAMARY LUIS , SMITH DAN , PHILLIPS BILL
Inventor： BOT ADRIAN I , WANG LILIN , DELLAMARY LUIS , SMITH DAN , PHILLIPS BILL
IPC: A61K39/00 , A61K31/7105 , A61K31/713 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K39/395 , A61K48/00 , A61P37/04 , C12N
CPC classification number: A61K39/12 , A61K31/7105 , A61K31/713 , A61K39/0011 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/543 , A61K2039/544 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C12N2710/24143 , C12N2740/16134 , C12N2760/16134 , A61K2300/00
Abstract: The present application is directed to non-coding RNA motifs that are used in conjunction with an antigen or without an antigen to induce, enhance or modulate an immune response that comprises a B cell and a T cell component.
Abstract translation: 本申请涉及与抗原或没有抗原结合使用以诱导，增强或调节包含B细胞和T细胞组分的免疫应答的非编码RNA基序。
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5.发明申请METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS BY SIMULTANEOUS LOADING AND ACTIVATION OF SELECTED SUBSETS OF ANTIGEN PRESENTING CELLS 审中-公开用于通过同时加载和激活选择的抗原呈递细胞的子集来产生和控制T细胞的效应子谱的方法和组合物
公开(公告)号：WO2004027049A3
公开(公告)日：2004-05-21
申请号：PCT/US0330188
申请日：2003-09-18
Applicant: ASTRAL INC , BOT ADRIAN , WANG LILIN , SMITH DAN , PHILLIPS BILL
Inventor： BOT ADRIAN , WANG LILIN , SMITH DAN , PHILLIPS BILL
IPC: A61K39/00 , A61K31/70 , A61K31/7105 , A61K31/713 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K39/395 , A61K48/00 , A61P37/04 , C07K16/00 , C12N5/10 , C12P21/08
CPC classification number: A61K31/7105 , A61K31/713 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/385 , A61K39/39 , A61K45/06 , A61K2039/5252 , A61K2039/53 , A61K2039/544 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , A61K2039/6056 , C12N2710/20034 , C12N2740/16034 , C12N2760/16134 , A61K2300/00
Abstract: Abstract The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Te 1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-y, IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process.
Abstract translation: 摘要本发明涉及引起I型免疫力对Te 1效应物有效重定向的新型组合物，该组合物利用IgG主链内的肽与抗原呈递细胞的合适指示结合而意外加载MHC I。 这样的组合物能够将似乎无效的治疗剂转化为高度有效的治疗剂，其与产生I类限制性细胞溶解细胞和产生IFN-γ，产生IL-2的T细胞相关，进一步与防止高毒力微生物或从 恶性肿瘤过程。
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6.发明申请METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS BY SIMULTANEOUS LOADING AND ACTIVATION OF SELECTED SUBSETS OF ANTIGEN PRESENTING CELLS 审中-公开通过同时加载和激活选择的抗原呈递细胞的子集来产生和控制T细胞的效应子轮廓的方法和组合物
公开(公告)号：WO2004027049B1
公开(公告)日：2004-07-22
申请号：PCT/US0330188
申请日：2003-09-18
Applicant: ASTRAL INC , BOT ADRIAN , WANG LILIN , SMITH DAN , PHILLIPS BILL
Inventor： BOT ADRIAN , WANG LILIN , SMITH DAN , PHILLIPS BILL
IPC: A61K39/00 , A61K31/70 , A61K31/7105 , A61K31/713 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K39/395 , A61K48/00 , A61P37/04 , C07K16/00 , C12N5/10 , C12P21/08
CPC classification number: A61K31/7105 , A61K31/713 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/385 , A61K39/39 , A61K45/06 , A61K2039/5252 , A61K2039/53 , A61K2039/544 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , A61K2039/6056 , C12N2710/20034 , C12N2740/16034 , C12N2760/16134 , A61K2300/00
Abstract: Abstract The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Te 1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-y, IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process.
Abstract translation: 摘要本发明涉及引起I类免疫力有效地重定向至Te 1效应物的新型组合物，其利用IgG主链中的肽意外加载MHC I并结合抗原呈递细胞的适当说明。 这样的组合物能够将看似无效的治疗剂转化为与产生I类限制性细胞溶解细胞和产生IFN-Y，IL-2的T细胞相关的高效的治疗剂，其进一步与防止高毒力微生物或从 恶性肿瘤过程。
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7.发明申请METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS BY SIMULTANEOUS LOADING AND ACTIVATION OF SELECTED SUBSETS OF ANTIGEN PRESENTING CELLS 审中-公开通过同时加载和激活选择的抗原呈递细胞的子集来产生和控制T细胞的效应子轮廓的方法和组合物
公开(公告)号：WO2004027049A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/030188
申请日：2003-09-18
Applicant: ASTRAL, INC. , BOT, Adrian , WANG, Lilin , SMITH, Dan , PHILLIPS, Bill
Inventor： BOT, Adrian , WANG, Lilin , SMITH, Dan , PHILLIPS, Bill
IPC: C12N
CPC classification number: A61K31/7105 , A61K31/713 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/385 , A61K39/39 , A61K45/06 , A61K2039/5252 , A61K2039/53 , A61K2039/544 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , A61K2039/6056 , C12N2710/20034 , C12N2740/16034 , C12N2760/16134 , A61K2300/00
Abstract: Abstract The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Te 1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-y, IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process.
Abstract translation: 发明内容本发明涉及导致I类免疫力有效地重定向至Te 1效应物的新组合物，其利用IgG主链中的肽意外加载MHC I并结合适当的指令 的抗原呈递细胞。 这样的组合物能够将看似无效的治疗剂转化为与产生I类限制性细胞溶解细胞和产生IFN-Y，IL-2的T细胞相关的高效的治疗剂，其进一步与防止高毒力微生物或从 恶性肿瘤过程。
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8.发明申请
公开(公告)号：WO2003078595A3
公开(公告)日：2003-09-25
申请号：PCT/US2003/007995
申请日：2003-03-14
Applicant: ASTRAL, INC. , BOT, Adrian, I. , WANG, Lilin , DELLAMARY, Luis , SMITH, Dan , PHILLIPS, Bill
Inventor： BOT, Adrian, I. , WANG, Lilin , DELLAMARY, Luis , SMITH, Dan , PHILLIPS, Bill
IPC: C07H21/04
Abstract: The present application is directed to non-coding RNA motifs that are used in conjunction with an antigen or without an antigen to induce, enhance or modulate an immune response that comprises a B cell and a T cell component.
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