公开(公告)号：WO2011091539A1

公开(公告)日：2011-08-04

申请号：PCT/CA2011/050055

申请日：2011-02-01

Applicant: R. I. D. E. INC. ,  HARTMAN, Gregory, A. ,  SMITH, Dan, S.

Inventor： HARTMAN, Gregory, A. ,  SMITH, Dan, S.

IPC: B61H9/02 ,  A62B1/04 ,  A62B1/08

CPC classification number: B61H9/02 ,  A62B1/04 ,  A62B1/08 ,  H02K2213/09

Abstract: A movable cable loop descent system comprises a cable for forming into a loop, a receiver for attachment to a structure having a receiver pulley for engaging the cable loop, a brake assembly, having a drive pulley for being rotated by the cable loop, the brake assembly for slowing a rate of travel of the cable loop and a carriage supporting a load for attachment to the cable loop at a point and for movement between the structure and the ground. A rotor and substantially parallel conductive frame is mounted on an axle passing through the drive pulley. Magnets on a surface of the rotor and/or the frame induce eddy currents, as they are relatively rotated, which create a rotational braking force controlling descent of the carriage and load. The brake assembly may be removably positioned by a drive-on anchor. The cable is removable and the system may form a kit.

Abstract translation: 可动电缆环路下降系统包括用于形成环路的电缆，用于附接到具有用于接合电缆环路的接收器滑轮的结构的接收器，具有用于由电缆环路旋转的驱动皮带轮的制动器组件，制动器 用于减慢电缆回路的行进速度的组件以及支撑用于在一个点处连接到电缆回路并用于在结构和地面之间运动的负载的滑架。 转子和基本上平行的导电框架安装在通过驱动滑轮的轴上。 在转子和/或框架的表面上的磁体引起涡流，因为它们相对旋转，这产生控制滑架和负载的下降的旋转制动力。 制动器组件可以通过驱动锚固件被可移除地定位。 电缆是可拆卸的，系统可以形成套件。

公开(公告)号：WO2007022477A3

公开(公告)日：2007-02-22

申请号：PCT/US2006/032512

申请日：2006-08-17

Applicant: MULTICELL IMMUNOTHERAPEUTICS, INC. ,  WANG, Lilin ,  SMITH, Dan ,  PHILLIPS, Bill ,  BOT, Adrian

Inventor： WANG, Lilin ,  SMITH, Dan ,  PHILLIPS, Bill ,  BOT, Adrian

IPC: A61K39/00

Abstract: The present invention is directed to novel compositions and methods and their use in treating an autoimmune disorder or achieving tolerance to an antigen. More specifically, the present invention is directed to human immunoglobulin constructs for loading a delivered T cell epitope on to the surface of an antigen presenting cell for achieving tolerance to that delivered T cell epitope. The present invention may be applied to any T cell epitope mediated autoimmune disorder.

公开(公告)号：WO2004027049A3

公开(公告)日：2004-05-21

申请号：PCT/US0330188

申请日：2003-09-18

Applicant: ASTRAL INC ,  BOT ADRIAN ,  WANG LILIN ,  SMITH DAN ,  PHILLIPS BILL

Inventor： BOT ADRIAN ,  WANG LILIN ,  SMITH DAN ,  PHILLIPS BILL

IPC: A61K39/00 ,  A61K31/70 ,  A61K31/7105 ,  A61K31/713 ,  A61K39/12 ,  A61K39/145 ,  A61K39/21 ,  A61K39/39 ,  A61K39/395 ,  A61K48/00 ,  A61P37/04 ,  C07K16/00 ,  C12N5/10 ,  C12P21/08

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/145 ,  A61K39/21 ,  A61K39/385 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5252 ,  A61K2039/53 ,  A61K2039/544 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/6056 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2760/16134 ,  A61K2300/00

Abstract: Abstract The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Te 1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-y, IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process.

Abstract translation: 摘要本发明涉及引起I型免疫力对Te 1效应物有效重定向的新型组合物，该组合物利用IgG主链内的肽与抗原呈递细胞的合适指示结合而意外加载MHC I。 这样的组合物能够将似乎无效的治疗剂转化为高度有效的治疗剂，其与产生I类限制性细胞溶解细胞和产生IFN-γ，产生IL-2的T细胞相关，进一步与防止高毒力微生物或从 恶性肿瘤过程。

公开(公告)号：WO2011127603A1

公开(公告)日：2011-10-20

申请号：PCT/CA2011/050196

申请日：2011-04-13

Applicant: 6N SILICON INC. ,  NICHOL, Scott ,  TUMMILLO, Anthony ,  SMITH, Dan

Inventor： NICHOL, Scott ,  TUMMILLO, Anthony ,  SMITH, Dan

IPC: C01B33/037 ,  C01B33/02

CPC classification number: C01B33/037

Abstract: The present invention relates to a method of purifying silicon using a cascading dissolution and washing process. The dissolution and washing processes can contain single or multiple stages. Water and dissolving chemicals are recycled through the process towards the beginning of the process.

Abstract translation: 本发明涉及使用级联溶解和洗涤方法提纯硅的方法。 溶解和洗涤过程可以包含单级或多级。 水和溶解化学品在开始过程中通过该过程进行回收。

公开(公告)号：WO2004066058A8

公开(公告)日：2004-10-28

申请号：PCT/GB2004000176

申请日：2004-01-20

Applicant: IBM ,  IBM UK ,  FAY SEAN ,  SALMON GLEN ,  SMITH DAN ,  WU LYNN

Inventor： FAY SEAN ,  SALMON GLEN ,  SMITH DAN ,  WU LYNN

IPC: G06Q10/10 ,  G06F3/033 ,  G06F9/44

CPC classification number: G06Q10/10

公开(公告)号：WO2004066058A2

公开(公告)日：2004-08-05

申请号：PCT/GB2004/000176

申请日：2004-01-20

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  IBM UNITED KINGDOM LIMITED ,  FAY, Sean ,  SALMON, Glen ,  SMITH, Dan ,  WU, Lynn

Inventor： FAY, Sean ,  SALMON, Glen ,  SMITH, Dan ,  WU, Lynn

IPC: G06F

CPC classification number: G06Q10/10

Abstract: The present invention provides, a user interface for conducting chats over a network is provided. The user interface includes a list tab for revealing a list of receiving chat partners and a status of each of the receiving chat partners, a status tab for selecting a status of a sending chat partner, and a chat tab for revealing information pertaining to a set of active chats between the sending chat partner and the receiving chat partners. In addition, indicators could be provided on the tabs to provide various functionality/information.

Abstract translation: 本发明提供了一种用于通过网络进行聊天的用户界面。 用户界面包括用于显示接收聊天伙伴的列表和每个接收聊天伙伴的状态的列表选项卡，用于选择发送聊天对象的状态的状态选项卡和用于显示与集合有关的信息的聊天选项卡 在发送聊天合作伙伴和接收聊天合作伙伴之间进行主动聊天。 此外，可以在标签上提供指标以提供各种功能/信息。

公开(公告)号：WO1993016720A1

公开(公告)日：1993-09-02

申请号：PCT/US1992001296

申请日：1992-02-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  ALLIANCE PHARMACEUTICAL CORPORATION ,  LANE, Thomas, A. ,  WANCEWICZ, Edward, V. ,  FUNK, Rhonda ,  SMITH, Dan, J.

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  ALLIANCE PHARMACEUTICAL CORPORATION

IPC: A61K37/10

CPC classification number: A61K31/02

Abstract: A method for inhibiting the biological effect of bacterial endotoxin on mammalian cells in a system containing such endotoxin, comprising the step of administering to the cells an effective endotoxin-inhibiting amount of a fluorocarbon emulsion. Although the method may be used to treat cells in vitro, the invention is preferably used to treat whole organisms. In a preferred aspect of the invention, the emulsion is administered to a mammal having a bacterial infection in a dosage effective to prevent or reduce endotoxic or septic shock in the mammal.

Abstract translation: 一种抑制细菌内毒素对含有这种内毒素的系统中细菌内毒素对哺乳动物细胞的生物学作用的方法，包括向细胞施用有效的内毒素抑制量的氟碳乳液的步骤。 虽然该方法可以用于体外处理细胞，但是本发明优选用于治疗整个生物体。 在本发明的优选方面，将乳剂以有效预防或减少哺乳动物内毒性或败血性休克的剂量给予具有细菌感染的哺乳动物。

公开(公告)号：WO2011139625A1

公开(公告)日：2011-11-10

申请号：PCT/US2011/033738

申请日：2011-04-25

Applicant: FLUOR TECHNOLOGIES CORPORATION ,  LEITCH, James S. ,  SMITH, Dan ,  RITCH, Peter

Inventor： LEITCH, James S. ,  SMITH, Dan ,  RITCH, Peter

IPC: G06Q40/00

CPC classification number: G06Q10/0635

Abstract: Risk management systems and methods for plant EPCCOM are described. The system comprises a risk management database for storing risk objects, each object representing a real-world risk mitigation factor. A risk recommendation engine is communicatively coupled to the risk management database and is configured to provide recommendations for mitigating and managing risks as a function of efficacy attributes of the risk objects. The efficacy attributes represent the effectiveness of previously implemented and/or simulated risk mitigation strategies. The efficacy attributes are preferably multi-variable dependent and are defined by prioritizing and weighing different objectives.

Abstract translation: 描述了植物EPCCOM的风险管理系统和方法。 该系统包括用于存储风险对象的风险管理数据库，每个对象代表真实世界的风险缓解因子。 风险推荐引擎通信地耦合到风险管理数据库，并且被配置为提供风险对象的效能属性的函数的减轻和管理风险的建议。 功效属性代表以前实施和/或模拟的风险缓解策略的有效性。 功效属性优选是多变量依赖的，并且通过对不同目标进行优先排序和加权来定义。

公开(公告)号：WO2004087877A3

公开(公告)日：2004-10-14

申请号：PCT/US2004/009261

申请日：2004-03-25

Applicant: ASTRAL INC. ,  SMITH, Dan ,  BOT, Adrian

Inventor： SMITH, Dan ,  BOT, Adrian

IPC: C12Q1/68

Abstract: The present application is directed to the use of dsRNA and/or ssRNA for the purpose of inducing apoptosis or cell death in proliferating cells. Specifically, low molecular weight and high molecular weight dsRNA and ssRNA are shown to induce apoptosis and/or cell death in proliferating cells, to arrest proliferation of transformed cells or tumor cells and to cause rapid induction of the cytokine TNF-alpha and/or also induce production of IL-12 which directs a Th-1 response.

公开(公告)号：WO2004087877A2

公开(公告)日：2004-10-14

申请号：PCT/US2004009261

申请日：2004-03-25

Applicant: ASTRAL INC ,  SMITH DAN ,  BOT ADRIAN

Inventor： SMITH DAN ,  BOT ADRIAN

IPC: A01N43/04 ,  A61K31/07 ,  C07H21/04 ,  C12N20060101 ,  C12N15/117 ,  C12Q1/68 ,  C12N

CPC classification number: C12N15/117 ,  C12N2310/17

Abstract: The present application is directed to the use of dsRNA and/or ssRNA for the purpose of inducing apoptosis or cell death in proliferating cells. Specifically, low molecular weight and high molecular weight dsRNA and ssRNA are shown to induce apoptosis and/or cell death in proliferating cells, to arrest proliferation of transformed cells or tumor cells and to cause rapid induction of the cytokine TNF-alpha and/or also induce production of IL-12 which directs a Th-1 response.

Abstract translation: 本申请涉及dsRNA和/或ssRNA用于在增殖细胞中诱导凋亡或细胞死亡的目的。 具体地，低分子量和高分子量的dsRNA和ssRNA显示在增殖细胞中诱导凋亡和/或细胞死亡，以阻止转化的细胞或肿瘤细胞的增殖并引起细胞因子TNF-α的快速诱导和/或 诱导产生引导Th-1反应的IL-12。