公开(公告)号：WO2002071977A2

公开(公告)日：2002-09-19

申请号：PCT/US2002/007009

申请日：2002-03-08

Applicant: ATRITECH, INC.

Inventor： SUTTON, Gregg, S. ,  PETERSON, Dean ,  WELCH, Jeffrey

IPC: A61F2/00

CPC classification number: A61B17/12045 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00615 ,  A61B2017/00632 ,  A61B2017/1205 ,  A61B2017/12059 ,  A61B2017/12072 ,  A61F2/01 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0076 ,  A61F2230/008 ,  A61F2230/0093

Abstract: Implant devices for filtering blood flowing through atrial appendage ostiums have elastic cover and anchoring substructures. The substructures may include reversibly folding tines or compressible wire braid structures. The devices are folded to fit in catheter tubes for delivery to the atrial appendages. The devices elastically expand to their natural sizes when they are expelled from the catheter tubes. Filter elements in the covers block emboli from escaping through the ostiums. The devices with tine substructures may have H-shaped cross sections. These devices seal the appendages by pinching an annular region of ostium tissue between the cover and the anchoring substructures. The shallow deployment depth of these H-shaped devices allows use of an universal device size for atrial appendages of varying lengths. The devices may include remotely activated fixtures for refolding the tines for device recovery or position adjustment.

Abstract translation: 用于过滤通过心耳附件的血液的植入装置具有弹性覆盖物和锚固子结构。 子结构可以包括可逆地折叠齿或可压缩的线编织结构。 这些装置被折叠以适合导管，用于递送到心房附件。 当装置从导管管排出时，这些装置弹性膨胀至其自然尺寸。 过滤元件在盖子阻塞栓塞从逃离通过口。 具有叉形结构的装置可具有H形横截面。 这些装置通过在盖和锚定子结构之间夹住口腔组织的环形区域来密封附件。 这些H型装置的浅部署深度允许使用通用装置尺寸用于不同长度的心房附件。 这些装置可以包括用于重新折叠齿的用于装置恢复或位置调整的远程激活的固定装置。

公开(公告)号：WO2003008030A3

公开(公告)日：2003-01-30

申请号：PCT/US2002/023201

申请日：2002-07-18

Applicant: ATRITECH, INC.

Inventor： WELCH, Jeffrey

IPC: A61M25/00

Abstract: Catheterization apparatus for implanting devices is provided with a device tether. The apparatus includes a device delivery tube that provides a pathway for moving implant devices through a patient's vasculature to internal body cavities. The implant devices are carried or pushed through the device delivery tube by a tubular push rod. The implant devices are tethered to a line passing through the push rod lumen. After deployment, the implant devices may be retracted into the device delivery tube for repositioning or retrieval by pulling on the tether.

公开(公告)号：WO2003007825A1

公开(公告)日：2003-01-30

申请号：PCT/US2002/023176

申请日：2002-07-19

Applicant: ATRITECH, INC.

Inventor： BORILLO, Thomas, E. ,  SUTTON, Gregg, S. ,  WELCH, Jeffrey

IPC: A61B17/12

CPC classification number: A61B17/12172 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/1219 ,  A61B34/10

Abstract: Implant devices for modifying blood flow between an atrial appendage and its associated atrium, are customized for use in subject atrial appendages. The implant devices are tailored to uniquely match individual anatomical characteristics. Cardiac imaging techniques are used to obtain data on the size, shape and orientation of the subject atrial appendage. The raw imaging data is electronically processed using computer modeling to obtain multi-dimensional anatomical images of the subject atrial appendages. Three-dimensional computer aided design tools are used to generate customized device designs from the anatomical images of the subject atrial appendages.

Abstract translation: 用于修改心房附属物及其相关心房之间血流的植入装置，可定制用于主观心房附件。 植入装置被定制以独特地匹配单独的解剖特征。 心脏成像技术用于获取主体心房的尺寸，形状和方向的数据。 使用计算机建模对原始成像数据进行电子处理，以获得主题心耳的多维解剖图像。 三维计算机辅助设计工具用于从主题心耳的解剖图像生成定制的设备设计。

公开(公告)号：WO03008030A8

公开(公告)日：2004-02-12

申请号：PCT/US0223201

申请日：2002-07-18

Applicant: ATRITECH INC

Inventor： WELCH JEFFREY

IPC: A61B17/00 ,  A61F2/01 ,  A61M25/00

CPC classification number: A61F2/01 ,  A61F2230/0006

Abstract: Catheterization apparatus for implanting devices is provided with a device tether. The apparatus includes a device delivery tube that provides a pathway for moving implant devices through a patient's vasculature to internal body cavities. The implant devices are carried or pushed through the device delivery tube by a tubular push rod. The implant devices are tethered to a line passing through the push rod lumen. After deployment, the implant devices may be retracted into the device delivery tube for repositioning or retrieval by pulling on the tether.

Abstract translation: 用于植入装置的导管装置设置有装置系绳。 该装置包括装置输送管，其提供用于通过患者脉管系统将植入装置移动到内部体腔的通路。 植入装置通过管状推杆被携带或推送通过装置输送管。 植入装置系在通过推杆内腔的线上。 在部署之后，植入装置可以缩回到装置输送管中，以通过拉动系绳来重新定位或取回。

公开(公告)号：WO2003063732A3

公开(公告)日：2003-08-07

申请号：PCT/US2003/002395

申请日：2003-01-24

Applicant: ATRITECH, INC.

Inventor： SUTTON, Gregg, S. ,  WELCH, Jeffrey ,  PETERSON, Dean ,  BRIDGEMAN, John ,  YOUNGBERG, Bruce, R.

IPC: A61F2/01

Abstract: Instrumentation for percutaneous delivery of blood filtration devices to atrial appendages includes a curved access sheath (510) and a delivery tube (220). The curved access sheath is coursed through the patient's vasculature to gain transseptal access to a left atrial appendage (11). A compressed filter device (700) attached to a tether wire (410) is loaded in the delivery tube (220). The loaded delivery tube is advanced through the pre-positioned access sheath to place the device in a deployment position. The access sheath (510) and the delivery tube (220) can be mechanically locked and moved together to place the device in a suitable deployment position. The device (700) is deployed by expelling it from the delivery tube (220) either by retracting the delivery tube over the tether wire, or by moving the tether wire forward through the delivery tube. The expelled device, which is not constrained by the delivery tube walls, self expands to its useful size in the subject atrial appendage. A filter membrane (710) in the deployed extends across the appendage ostium (13) to filter blood flow through the ostium. The filter membrane is configured to present a flat surface to atrial blood flow past the ostium.

公开(公告)号：WO2003063732A2

公开(公告)日：2003-08-07

申请号：PCT/US2003/002395

申请日：2003-01-24

Applicant: ATRITECH, INC.

Inventor： SUTTON, Gregg, S. ,  WELCH, Jeffrey ,  PETERSON, Dean ,  BRIDGEMAN, John ,  YOUNGBERG, Bruce, R.

IPC: A61F2/01

CPC classification number: A61F2/01 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/12095 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/008 ,  A61F2230/0093

Abstract: Instrumentation for percutaneous delivery of blood filtration devices to atrial appendages includes a curved access sheath and a delivery tube. The curved access sheath is coursed through the patient's vasculature to gain transseptal access to a left atrial appendage. A compressed filter device attached to a tether wire is loaded in the delivery tube. The loaded delivery tube is advanced through the pre-positioned access sheath to place the device in a deployment position. The access sheath and the delivery tube can be mechanically locked and moved together to place the device in a suitable deployment position. The device is deployed by expelling it from the delivery tube either by retracting the delivery tube over the tether wire, or by moving the tether wire forward through the delivery tube. The expelled device, which is not constrained by the delivery tube walls, self expands to its useful size in the subject atrial appendage. A filter membrane in the deployed extends across the appendage ostium to filter blood flow through the ostium. The filter membrane is configured to present a flat surface to atrial blood flow past the ostium.

Abstract translation: 用于将血液过滤装置经皮递送至心房附件的仪器包括弯曲通道护套和输送管。 弯曲的通路护套通过患者的脉管系统通过，以获得左心耳通过的通路。 附接到系绳的压缩过滤器装置装载在输送管中。 装载的输送管通过预定位的进入护套前进，以将装置置于展开位置。 进入护套和输送管可以机械地锁定并一起移动，以将装置放置在合适的展开位置。 通过将输送管缩回到系绳上，或者通过将系绳向前移动通过输送管，将装置从输送管排出。 不受输送管壁约束的排出的装置在主题心耳中自我膨胀到其有用的尺寸。 所部署的过滤膜延伸穿过附属口，以过滤通过口的血液流。 滤膜被配置成呈现出通过口的心房血流的平坦表面。

公开(公告)号：WO02071977A3

公开(公告)日：2003-06-26

申请号：PCT/US0207009

申请日：2002-03-08

Applicant: ATRITECH INC

Inventor： SUTTON GREGG S ,  PETERSON DEAN ,  WELCH JEFFREY

IPC: A61B17/00 ,  A61B17/12 ,  A61F2/01 ,  A61F2/02

CPC classification number: A61B17/12045 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00615 ,  A61B2017/00632 ,  A61B2017/1205 ,  A61B2017/12059 ,  A61B2017/12072 ,  A61F2/01 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0076 ,  A61F2230/008 ,  A61F2230/0093

Abstract: Implant devices for filtering blood flowing through atrial appendage ostiums have elastic cover and anchoring substructures. The substructures may include reversibly folding tines or compressible wire braid structures. The devices are folded to fit in catheter tubes for delivery to the atrial appendages. The devices elastically expand to their natural sizes when they are expelled from the catheter tubes. Filter elements in the covers block emboli from escaping through the ostiums. The devices with tine substructures may have H-shaped cross sections. These devices seal the appendages by pinching an annular region of ostium tissue between the cover and the anchoring substructures. The shallow deployment depth of these H-shaped devices allows use of an universal device size for atrial appendages of varying lengths. The devices may include remotely activated fixtures for refolding the tines for device recovery or position adjustment.

Abstract translation: 用于过滤通过心耳附件的血液的植入装置具有弹性覆盖物和锚固子结构。 子结构可以包括可逆地折叠齿或可压缩的线编织结构。 这些装置被折叠以适合导管，用于递送到心房附件。 当装置从导管管排出时，这些装置弹性膨胀至其自然尺寸。 过滤元件在盖子阻塞栓塞从逃离通过口。 具有叉形结构的装置可具有H形横截面。 这些装置通过在盖和锚定子结构之间夹住口腔组织的环形区域来密封附件。 这些H型装置的浅部署深度允许使用通用装置尺寸用于不同长度的心房附件。 这些装置可以包括用于重新折叠齿的用于装置恢复或位置调整的远程激活的固定装置。

公开(公告)号：WO0215793A3

公开(公告)日：2002-08-29

申请号：PCT/US0125920

申请日：2001-08-17

Applicant: ATRITECH INC

Inventor： BORILLO THOMAS E ,  PETERSON DEAN ,  SUTTON GREGG S ,  WELCH JEFFREY

IPC: A61B17/00 ,  A61B17/12 ,  A61F2/01

CPC classification number: A61F2/013 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/00575 ,  A61F2/01 ,  A61F2002/015 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0069 ,  A61F2230/008

Abstract: Implant devices for filtering blood flowing through the ostium of an atrial appendage have component structures one or more of which are expandable. Devices with component structures in their unexpanded state have a compact size suitable for intra-cutaneous delivery to an atrial appendage situs. The expandable component structures are expanded in situ to deploy the devices. A device may have sufficiently short axial length so that most or almost all of the device length may fit within the ostium region. An expandable component structure in the device may include a blood-permeable filter element. The device may be deployed so that this component structure covers the ostium so as to direct the blood flow to pass through the filter element. The filter elements used in the devices may have hole size distributions selected to filter out harmful-size emboli. The filter elements may be embedded in elastic material so that hole-size distributions remain substantially unaffected by expansion of the device structures. Anchors attached to a component structure engage tissue surrounding the device and maintain the devices in position. The anchors may include inflatable anchors which engage interior walls of the atrial appendage.

Abstract translation: 用于过滤血流通过心房的口的植入装置具有其中一个或多个可膨胀的部件结构。 具有未膨胀状态的组件结构的装置具有适合于皮内递送至心房附属部位的紧凑尺寸。 可扩展组件结构在现场扩展以部署设备。 装置可以具有足够短的轴向长度，使得装置长度的大部分或几乎全部可以适合于口腔区域。 该装置中的可扩张组件结构可包括透血过滤元件。 该装置可以部署成使得该部件结构覆盖口，以引导血液流过过滤元件。 在装置中使用的过滤器元件可以具有选择用于过滤有害尺寸栓塞的孔尺寸分布。 过滤元件可以嵌入弹性材料中，使得孔尺寸分布基本上不受设备结构的膨胀的影响。 附接到部件结构的锚点接合设备周围的组织并将设备维持在适当位置。 锚定器可以包括接合心房内壁附近的充气锚。

公开(公告)号：WO0130266A9

公开(公告)日：2002-08-15

申请号：PCT/US0029489

申请日：2000-10-26

Applicant: ATRITECH INC ,  VAN TASSEL ROBERT A ,  HAUSER ROBERT G ,  SCHWARTZ ROBERT ,  HOLMES DAVID ,  SUTTON GREGG S ,  BORILLO THOMAS E ,  WELCH JEFFREY

Inventor： VAN TASSEL ROBERT A ,  HAUSER ROBERT G ,  SCHWARTZ ROBERT ,  HOLMES DAVID ,  SUTTON GREGG S ,  BORILLO THOMAS E ,  WELCH JEFFREY

IPC: A61M31/00 ,  A61B17/00 ,  A61B17/12 ,  A61F2/01 ,  A61L29/00 ,  A61L31/00

CPC classification number: A61F2/01 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/12172 ,  A61B2017/00243 ,  A61B2017/00597 ,  A61B2017/00619 ,  A61B2017/00632 ,  A61B2017/1205 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2230/0093

Abstract: Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.

Abstract translation: 用于永久性放置在患者左心耳的口上的装置，其包括配置成延伸穿过左心耳的口的过滤膜。 过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。 该装置还包括附接到过滤膜的支撑结构，其通过永久地接合左心耳内壁的一部分而将过滤膜保持在左心耳的口处的适当位置。 支撑结构可以从第一构型径向扩张到接合左心耳的口或内壁的第二构型。 过滤膜可以限定穿过其中的开口，其被构造成从阻止血栓通过的第一尺寸膨胀到允许介入装置（例如膨胀气囊）穿过其中的第二尺寸，并且其中开口是弹性的 偏向于第一大小。

公开(公告)号：WO0224106A9

公开(公告)日：2003-11-13

申请号：PCT/US0129690

申请日：2001-09-21

Applicant: ATRITECH INC

Inventor： BORILLO THOMAS E ,  SUTTON GREGG S

IPC: A61N1/39 ,  A61B17/00 ,  A61B17/12 ,  A61B17/34 ,  A61F2/01 ,  A61F2/06

CPC classification number: A61B17/12122 ,  A61B17/12022 ,  A61B17/12172 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00615 ,  A61B2017/00623 ,  A61B2017/00632 ,  A61B2017/1205 ,  A61B2017/3484 ,  A61B2017/3488

Abstract: The invention provides a delivery system for placing devices in atrial appendages. The system includes a catheterization apparatus having a tubular structure with one or more nested tubes, wires, and shafts. The tubes establish a passageway for moving a device through a body's vasculature and heart into an atrial appendage. An expandagle positioning guide is disposed on the distal end of a tube passing through the apparatus. The positioning guide is expanded in situ to engage atrial wall surfaces proximate to the atrial appendage for mechanical stabilizes the device delivery passageway. A shaft passing through the tubes transports the device through the passageway to the atrial appendage.

Abstract translation: 本发明提供了一种用于将装置放置在心耳附件中的递送系统。 该系统包括具有带有一个或多个嵌套管，电线和轴的管状结构的导管插入装置。 管子建立一个通道，用于通过身体的脉管系统和心脏将装置移动到心房附近。 扩张器定位引导件设置在穿过设备的管的远端上。 定位引导件在现场扩张以接近靠近心耳附近的心房壁表面，用于机械稳定装置输送通道。 通过管的轴将装置通过通道传送到心耳。