公开(公告)号：WO1995023615A1

公开(公告)日：1995-09-08

申请号：PCT/GB1995000437

申请日：1995-03-01

Applicant: HOLMES, Michael, John ,  NYCOMED IMAGING AS ,  KLAVENESS, Jo ,  BALINOV, Balin

Inventor： HOLMES, Michael, John ,  NYCOMED IMAGING AS

IPC: A61K49/00

CPC classification number: A61K49/223

Abstract: Gas-containing microcapsules useful as imaging agents, e.g. as ultrasound contrast agents, may be prepared by forming a dispersion of gas microbubbles in an aqueous medium comprising a solution or dispersion of a wall-forming material and subsequently inducing direct microencapsulation of these microbubbles by the wall-forming material.

Abstract translation: 含气微胶囊可用作显像剂，例如 作为超声造影剂，可以通过在包含壁形成材料的溶液或分散体的水性介质中形成气体微泡的分散体并随后通过壁形成材料直接微囊化这些微泡来制备。

公开(公告)号：WO2012038489A1

公开(公告)日：2012-03-29

申请号：PCT/EP2011/066464

申请日：2011-09-21

Applicant: GE HEALTHCARE AS ,  HEALEY, Andrew ,  BENDIKSEN, Ragnar ,  SOOD, Anup ,  BALINOV, Balin

Inventor： HEALEY, Andrew ,  BENDIKSEN, Ragnar ,  SOOD, Anup ,  BALINOV, Balin

IPC: A61K49/00

CPC classification number: A61K49/006 ,  A61B5/0073 ,  A61K49/0032 ,  A61K49/0054

Abstract: The present invention relates to a method of in vivo optical imaging, of the blood vessels and/or blood pool of a mammalian subject, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of far-red or near-infrared dyes with synthetic polyethyleneglycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are methods of treatment monitoring, methods of diagnosis and medical uses involving the contrast agents.

Abstract translation: 本发明涉及哺乳动物受试者的体内光学成像，血管和/或血液池的方法，其包括光学成像造影剂。 光学成像剂包括远红或近红外染料与分子量在15-45kDa范围内的合成聚乙二醇（PEG）聚合物的共轭物。 还公开了治疗监测方法，诊断方法和涉及造影剂的医疗用途。