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    FLUORESCENCE COLORING FOR EYE SURGERY
    3.
    发明申请
    FLUORESCENCE COLORING FOR EYE SURGERY 审中-公开
    眼科手术的荧光染色

    公开(公告)号：WO2014072831A2

    公开(公告)日：2014-05-15

    申请号：PCT/IB2013003099

    申请日：2013-11-01

    Applicant: CESACAR HOLDING S L

    Inventor： TELANDRO ALAIN

    CPC classification number: A61K49/0043 ,  A61B90/30 ,  A61B2090/306 ,  A61F9/007 ,  A61F9/00745 ,  A61K49/0021 ,  A61K49/006 ,  A61K49/0073

    Abstract: Disclosed herein is a method of use of colored dye in ophthalmic surgery. In one embodiment the colored dye is fluorescent. In another embodiment the fluorescent dye is combined with viscoelastic gel for anterior segment eye surgery.

    Abstract translation: 本文公开了一种在眼科手术中使用有色染料的方法。 在一个实施方案中，着色染料是荧光的。 在另一个实施方案中，荧光染料与用于前段眼部手术的粘弹性凝胶组合。

    OPTICAL IMAGING PROBES
    4.
    发明申请
    OPTICAL IMAGING PROBES 审中-公开
    光学成像探测器

    公开(公告)号：WO2012136958A8

    公开(公告)日：2013-05-16

    申请号：PCT/GB2012000314

    申请日：2012-04-05

    Applicant: UNIV EDINBURGH ,  WALTON TASHFEEN ,  BRADLEY MARK ,  DHALIWAL KEV ,  AVLONITIS NIKOLAOS ,  HASLETT CHRIS ,  MCDONALD NEIL ,  DEBUNNE MANUELLE

    Inventor： WALTON TASHFEEN ,  BRADLEY MARK ,  DHALIWAL KEV ,  AVLONITIS NIKOLAOS ,  HASLETT CHRIS ,  MCDONALD NEIL ,  DEBUNNE MANUELLE

    IPC: A61K49/00

    CPC classification number: A61K49/0043 ,  A61K49/0041 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/006 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441

    Abstract: The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched- dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.

    Abstract translation: 本发明涉及可视化细胞的方法，特别是尽管不是在体内使用染料，例如由细胞内化的树枝状聚合物 - 染料分子或多分支染料分子，从而允许通过共聚焦荧光内显微镜或其它光学检测器 。 还提供用于可视化细胞的内部淬灭的探针，特别是虽然不是通过共聚焦荧光内显微镜而不是专门在体内使用内部淬灭的探针结合共聚焦荧光内显微术，通过内在化和通过探针的去猝灭使细胞可视化 细胞。 在特定实施方案中，细胞是活化的嗜中性粒细胞，例如在受试者的肺内。

    MEDICAL TISSUE-MARKER AND MANUFACTURING METHOD FOR SAME
    5.
    发明申请
    MEDICAL TISSUE-MARKER AND MANUFACTURING METHOD FOR SAME 审中-公开
    医用组织标记及其制造方法

    公开(公告)号：WO2012173003A3

    公开(公告)日：2013-02-14

    申请号：PCT/JP2012064235

    申请日：2012-05-31

    Applicant: UNIV CHIBA NAT UNIV CORP ,  HAYASHI HIDEKI ,  HATAKEYAMA HIROYA ,  FUJINAMI MASANORI ,  TOYOTA TARO

    Inventor： HAYASHI HIDEKI ,  HATAKEYAMA HIROYA ,  FUJINAMI MASANORI ,  TOYOTA TARO

    IPC: A61K49/00 ,  A61K9/10 ,  A61K47/24 ,  A61K49/04

    CPC classification number: A61K49/0034 ,  A61K49/0002 ,  A61K49/0023 ,  A61K49/006 ,  A61K49/0084 ,  A61K49/0438 ,  A61K49/0461 ,  A61K49/0466

    Abstract: Provided is a medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also provided is a manufacturing method for the same. The medical tissue-marker as in the present invention includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent, and a plurality of capsules are formed by means of an emulsifier.

    Abstract translation: 提供一种能够从器官外部识别位置的医疗组织标记物，可以长时间保持局部，并且能够容易地识别整个器官内的标记位置; 也提供了其制造方法。 本发明的医疗组织标记物包括通过合成磷脂和近红外荧光染料形成的囊泡，以及通过磷脂和X射线造影剂的合成形成的乳液，并且具有团聚体，其中， 囊泡和乳液包含在亲水溶剂中，并且通过乳化剂形成多个胶囊。

    SENTINEL LYMPH NODE MARKER CAPABLE OF MULTI-MODE IMAGING
    7.
    发明申请
    SENTINEL LYMPH NODE MARKER CAPABLE OF MULTI-MODE IMAGING 审中-公开

    公开(公告)号：WO2012021045A3

    公开(公告)日：2012-05-10

    申请号：PCT/KR2011005994

    申请日：2011-08-16

    Applicant: NAT CANCER CT ,  KIM SEOK KI ,  KANG SE HUN ,  KIM SEO IL ,  KIM YOUNG SANG ,  BAEK NAM SUK ,  NOH JIN HEE

    Inventor： KIM SEOK KI ,  KANG SE HUN ,  KIM SEO IL ,  KIM YOUNG SANG ,  BAEK NAM SUK ,  NOH JIN HEE

    IPC: G01N33/60 ,  A61K51/00 ,  G01N33/52 ,  G21H5/00

    CPC classification number: A61K51/081 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0034 ,  A61K49/0056 ,  A61K49/006 ,  G01N33/534 ,  G01N2333/765

    Abstract: The present invention relates to a sentinel lymph node marker comprising albumin to which a radioactive isotope, one or more dyes selected from near-infrared ray absorbing dyes, and a visible ray absorbing dye are coupled, a preparation method thereof, a kit for preparing the same for multi-mode imaging the sentinel lymph node, and a multi-mode imaging method of the sentinel lymph node using the same. The sentinel lymph node marker of the present invention has a long retention time at a lymph node and enables multi-mode imaging, and thus it is possible to precisely check the sentinel lymph node without a skin incision by ex vivo imaging through a near-infrared image and/or gamma ray image, and it is possible to precisely check the location of the sentinel lymph node with the naked eye when used in conjunction with surgery for removing the checked sentinel lymph node.

    Abstract translation: 本发明涉及包含白蛋白的前哨淋巴结标记物，其中放射性同位素，一种或多种选自近红外线吸收染料和可见光吸收染料的染料偶联，其制备方法，用于制备 前哨淋巴结的多模式成像相同，前哨淋巴结的多模式成像方法也是如此。 本发明的前哨淋巴结标记物在淋巴结处具有较长的保留时间，能够实现多模式成像，因此可以通过近红外线的离体成像来精确检查前哨淋巴结，无需皮肤切口 图像和/或γ射线图像，并且当与用于移除检查的前哨淋巴结的手术结合使用时，可以用肉眼精确地检查前哨淋巴结的位置。

    VASCULAR IMAGING AGENTS
    8.
    发明申请
    VASCULAR IMAGING AGENTS 审中-公开
    血管成像剂

    公开(公告)号：WO2012038489A1

    公开(公告)日：2012-03-29

    申请号：PCT/EP2011/066464

    申请日：2011-09-21

    Applicant: GE HEALTHCARE AS ,  HEALEY, Andrew ,  BENDIKSEN, Ragnar ,  SOOD, Anup ,  BALINOV, Balin

    Inventor： HEALEY, Andrew ,  BENDIKSEN, Ragnar ,  SOOD, Anup ,  BALINOV, Balin

    IPC: A61K49/00

    CPC classification number: A61K49/006 ,  A61B5/0073 ,  A61K49/0032 ,  A61K49/0054

    Abstract: The present invention relates to a method of in vivo optical imaging, of the blood vessels and/or blood pool of a mammalian subject, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of far-red or near-infrared dyes with synthetic polyethyleneglycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are methods of treatment monitoring, methods of diagnosis and medical uses involving the contrast agents.

    Abstract translation: 本发明涉及哺乳动物受试者的体内光学成像，血管和/或血液池的方法，其包括光学成像造影剂。 光学成像剂包括远红或近红外染料与分子量在15-45kDa范围内的合成聚乙二醇（PEG）聚合物的共轭物。 还公开了治疗监测方法，诊断方法和涉及造影剂的医疗用途。

    KIT AND METHOD FOR DETECTING POROUS DENTAL HYDROXY APATITE
    9.
    发明申请
    KIT AND METHOD FOR DETECTING POROUS DENTAL HYDROXY APATITE 审中-公开
    用于检测多孔牙齿羟基磷灰石的试剂盒和方法

    公开(公告)号：WO2011113107A1

    公开(公告)日：2011-09-22

    申请号：PCT/AU2011/000303

    申请日：2011-03-18

    Applicant: THE UNIVERSITY OF MELBOURNE ,  HUBBARD, Michael James ,  MANGUM, Jonathan Edward

    Inventor： HUBBARD, Michael James ,  MANGUM, Jonathan Edward

    IPC: A61K6/00 ,  A61K49/00 ,  A61Q11/00

    CPC classification number: A61K6/002 ,  A61B5/4547 ,  A61K49/001 ,  A61K49/006 ,  A61K49/0438 ,  C07K14/00 ,  G01N33/6893

    Abstract: The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite, comprising a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite comprising detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralisation developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite.

    Abstract translation: 本发明涉及一种用于检测多孔牙羟基磷灰石的试剂盒和探针，其包含能够结合多孔牙羟基磷灰石的蛋白质或其检测器。 本发明还涉及一种用于检测涉及多孔牙羟基磷灰石的病症的方法，其包括检测受试者的牙齿或牙齿样品中与多孔牙羟基磷灰石结合的蛋白质。 本发明还涉及用于检测低矿化发育牙缺损或检测完整和/或破碎的MIH釉质的方法，以及用于去除结合多孔牙羟磷灰石的蛋白质的试剂盒和方法。

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