公开(公告)号：WO2012038489A1

公开(公告)日：2012-03-29

申请号：PCT/EP2011/066464

申请日：2011-09-21

Applicant: GE HEALTHCARE AS ,  HEALEY, Andrew ,  BENDIKSEN, Ragnar ,  SOOD, Anup ,  BALINOV, Balin

Inventor： HEALEY, Andrew ,  BENDIKSEN, Ragnar ,  SOOD, Anup ,  BALINOV, Balin

IPC: A61K49/00

CPC classification number: A61K49/006 ,  A61B5/0073 ,  A61K49/0032 ,  A61K49/0054

Abstract: The present invention relates to a method of in vivo optical imaging, of the blood vessels and/or blood pool of a mammalian subject, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of far-red or near-infrared dyes with synthetic polyethyleneglycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are methods of treatment monitoring, methods of diagnosis and medical uses involving the contrast agents.

Abstract translation: 本发明涉及哺乳动物受试者的体内光学成像，血管和/或血液池的方法，其包括光学成像造影剂。 光学成像剂包括远红或近红外染料与分子量在15-45kDa范围内的合成聚乙二醇（PEG）聚合物的共轭物。 还公开了治疗监测方法，诊断方法和涉及造影剂的医疗用途。

公开(公告)号：WO2004049950A1

公开(公告)日：2004-06-17

申请号：PCT/NO2003/000397

申请日：2003-11-27

Applicant: AMERSHAM HEALTH AS ,  BENDIKSEN, Ragnar ,  RASMUSSEN, Henrik ,  ØSTENSEN, Jonny

Inventor： BENDIKSEN, Ragnar ,  RASMUSSEN, Henrik ,  ØSTENSEN, Jonny

IPC: A61B8/06

CPC classification number: A61B8/481 ,  A61B8/065 ,  A61B8/0883 ,  A61B8/543

Abstract: The invention relates to a triggered ultrasound imaging method for imaging of the myocardium, minimizing the risk of eliciting cardiac arrhythmia. Particularly, the invention is directed to a method of assessing cardiac perfusion. Destruction pulses are triggered such that they fall within the refractory period of the heart, while imaging pulses are triggered at any given time of the ECG cycle, preferably during end-systole.

Abstract translation: 本发明涉及一种用于心肌成像的触发超声成像方法，使得引起心律失常的风险最小化。 特别地，本发明涉及评估心脏灌注的方法。 触发破坏脉冲使得它们落入心脏的不应期内，而在ECG周期的任何给定时间，优选在末期收缩期间触发成像脉冲。