公开(公告)号：WO9928347A8

公开(公告)日：1999-09-02

申请号：PCT/AU9800998

申请日：1998-11-27

Applicant: COMMW SCIENT IND RES ORG ,  TULLOCH PAUL ALEXANDER LM ,  BENTLEY JOHN DAVID ,  COSGROVE LEAH JANE ,  FRENKEL MAURICE JOHN ,  GARRETT THOMAS PETER JOHN ,  LAWRENCE LYNNE JEAN ,  LOU MEIZHEN ,  LOVRECZ GEORGE OSCAR ,  MCKERN NEIL MORETON ,  WARD COLIN WESLEY

Inventor： TULLOCH PETER ARCHIBALD DI ,  BENTLEY JOHN DAVID ,  COSGROVE LEAH JANE ,  FRENKEL MAURICE JOHN ,  GARRETT THOMAS PETER JOHN ,  LAWRENCE LYNNE JEAN ,  LOU MEIZHEN ,  LOVRECZ GEORGE OSCAR ,  MCKERN NEIL MORETON ,  WARD COLIN WESLEY

IPC: G01N33/50 ,  C07B61/00 ,  C07K14/65 ,  C07K14/705 ,  C07K14/71 ,  G01N33/15 ,  G01N33/566 ,  G06F17/50 ,  G06F19/00 ,  G06F159/00

CPC classification number: C07K14/65 ,  G01N2333/65 ,  G01N2333/71

Abstract: The present invention relates to a method of designing compounds able to bind to a molecule of the insulin receptor family and to modulate the activity mediated by the receptor based on the 3-D structure coordinates of a IGF-1 receptor crystal of Figure 1.

Abstract translation: 本发明涉及基于图1的IGF-1受体晶体的3-D结构坐标设计能够结合胰岛素受体家族分子的化合物并调节受体介导的活性的化合物的方法。