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    A LOW NOISE BACK PRESSURE REGULATOR FOR SUPERCRITICAL FLUID CHROMATOGRAPHY
    2.
    发明申请
    A LOW NOISE BACK PRESSURE REGULATOR FOR SUPERCRITICAL FLUID CHROMATOGRAPHY 审中-公开
    用于超临界流体色谱的低噪声背压调节器

    公开(公告)号：WO2012177259A1

    公开(公告)日：2012-12-27

    申请号：PCT/US2011/041711

    申请日：2011-06-23

    Applicant: AURORA SFC SYSTEMS, LLC ,  BERGER, Terry A. ,  COLGATE, Samuel O. ,  CASALE, Michael A.

    Inventor： BERGER, Terry A. ,  COLGATE, Samuel O. ,  CASALE, Michael A.

    IPC: B01D15/10 ,  B01D15/14 ,  B01D15/26 ,  B01D11/00

    CPC classification number: G01N30/32 ,  B01D11/0203 ,  B01D11/0207 ,  G01N30/02 ,  G05D16/0647 ,  B01D15/40

    Abstract: A drive mechanism for back pressure regulator (BPR) used in liquid chromatography, supercritical fluid chromatography, or supercritical fluid extraction allows very fine automated control over a very wide range of pressures by combining a linear actuator compressing a spring, pushing a pin. The nozzle assembly of the regulator comprises a flow through chamber containing a diaphragm and a seat, in which the pin pushes the diaphragm against the seat, together with an upstream pressure sensor and electronic feedback control to the motor of the actuator. The BPR of the embodiments exhibits high pressure stability and extremely low pressure noise, even at moderate to high pressures. The exemplary BPR can be use at either constant pressure or to generate pressure programs where the pressure is varied versus time. Further, the nozzle assembly has a field-replaceable head, requiring no mechanical adjustment on replacement.

    Abstract translation: 用于液相色谱，超临界流体色谱或超临界流体萃取的背压调节器（BPR）的驱动机构通过组合压缩弹簧的线性致动器，推动销，可以在非常宽的压力范围内进行非常精细的自动化控制。 调节器的喷嘴组件包括流通室，其包含隔膜和座，其中销将隔膜压靠在座上，以及上游压力传感器和电子反馈控制到致动器的电动机。 实施例的BPR表现出高压稳定性和极低压力噪声，即使在中等至高压下。 示例性BPR可以在恒定压力下使用或产生压力程序，其中压力随时间变化。 此外，喷嘴组件具有现场可更换头部，在更换时不需要机械调节。

    AUTOMATED CONVERSION BETWEEN SFC AND HPLC
    4.
    发明申请
    AUTOMATED CONVERSION BETWEEN SFC AND HPLC 审中-公开
    SFC和HPLC之间的自动转换

    公开(公告)号：WO2013062635A2

    公开(公告)日：2013-05-02

    申请号：PCT/US2012042844

    申请日：2012-06-16

    Applicant: AGILENT TECHNOLOGIES INC ,  WIKFORS EDWIN E ,  FOGELMAN KIMBER ,  BERGER TERRY A

    Inventor： WIKFORS EDWIN E ,  FOGELMAN KIMBER ,  BERGER TERRY A

    IPC: G01N30/02 ,  G01N30/22 ,  G01N30/32

    CPC classification number: G01N30/32 ,  B01D15/40 ,  G01N2030/324 ,  G01N2030/022

    Abstract: An apparatus, system, and process of converting a standard, high performance liquid chromatography (HPLC) flow path to a flow path suitable for supercritical fluid chromatography (SFC) are described. This reversible technique is applied to a variety of flow configurations including binary, high pressure solvent mixing systems and quaternary, low pressure solvent mixing systems than can be conventionally operated or automated. The technique is generally applied to the fields of supercritical fluid chromatography and high pressure liquid chromatography, but users skilled in the art will find utility for any flow system where pressurization components must be periodically applied to and removed from both ends of a flow stream in an automated manner.

    Abstract translation: 描述了将标准的高效液相色谱（HPLC）流路转换成适用于超临界流体色谱（SFC）的流路的装置，系统和方法。 这种可逆技术适用于多种流动配置，包括二元，高压溶剂混合系统和四元低压溶剂混合系统，这些系统可以采用常规操作或自动化操作。 该技术通常应用于超临界流体色谱和高压液相色谱的领域，但本领域的技术人员将会发现对于任何流动系统的实用性，其中加压组分必须周期性地施加到流动流的两端并从流动流的两端移除 自动的方式。

    SYSTEM AND PROCESS FOR AN ACTIVE DRAIN FOR GAS-LIQUID SEPARATORS
    5.
    发明申请
    SYSTEM AND PROCESS FOR AN ACTIVE DRAIN FOR GAS-LIQUID SEPARATORS 审中-公开

    公开(公告)号：WO2012040252A3

    公开(公告)日：2012-03-29

    申请号：PCT/US2011/052426

    申请日：2011-09-20

    Applicant: AURORA SFC SYSTEMS, INC. ,  FOGELMAN, Kimber, D. ,  WIKFORS, Edwin, E. ,  BERGER, Terry, A.

    Inventor： FOGELMAN, Kimber, D. ,  WIKFORS, Edwin, E. ,  BERGER, Terry, A.

    IPC: B01D15/40

    Abstract: An apparatus and process to effectively create an active drain for high and low pressure gas-liquid separator. The invention accomplishes a deterministic drainage rate of variable volume and viscosity liquid fractions from the separator. The mechanisms and methods thereof create a flow path from the separator that dramatically favors controlled liquid flow over a wide range of flow rates and viscosities while restricting gas flow. The invention is a superior method of drainage over conventional systems that employ pressure, vacuum, isolation valves and/or passive flow restrictors to achieve drainage of the separators. The embodiments are primarily directed to the fields of preparative supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE). An advantage of one embodiment allows the economical conversion of typical HPLC systems to state of-the-art supercritical fluid chromatography (SFC) systems with minimal modification to system components.

    EFFICIENT CHILLER FOR A SUPERCRITICAL FLUID CHROMATOGRAPHY PUMP
    6.
    发明申请
    EFFICIENT CHILLER FOR A SUPERCRITICAL FLUID CHROMATOGRAPHY PUMP 审中-公开
    超级液体色谱泵的高效冷却器

    公开(公告)号：WO2011149456A1

    公开(公告)日：2011-12-01

    申请号：PCT/US2010/036255

    申请日：2010-05-26

    Applicant: BERGER, Terry A. ,  FOGELMAN, Kimber

    Inventor： BERGER, Terry A. ,  FOGELMAN, Kimber

    IPC: F04B39/00

    CPC classification number: F25B21/04 ,  B01D15/12 ,  B01D15/40 ,  F04B39/064 ,  F04B53/08 ,  F25B21/02 ,  G01N2030/326

    Abstract: Methods and systems for pumping compressible fluids in high pressure applications such as high-pressure liquid chromatography (HPLC) or supercritical fluid chromatography (SFC) applications are disclosed. An improved cooling device for a pump head for use in a supercritical fluid chromatography (SFC) system is described. A system for chilling a pumping system, includes a Peltier cooling element in thermal contact with a pump head, wherein the cooling element chills the pump head and a mobile phase fluid flowstream prior to the mobile phase fluid entering the pump; a fluid-cooled heat exchanger, attached to the Peltier cooling element, which removes heat from the cooling element using a circulating fluid; and a second heat exchanger which cools the circulating fluid.

    Abstract translation: 公开了用于在高压液相色谱（HPLC）或超临界流体色谱（SFC）应用中的高压应用中泵送可压缩流体的方法和系统。 描述了用于超临界流体色谱（SFC）系统的用于泵头的改进的冷却装置。 用于冷却泵送系统的系统包括与泵头热接触的珀尔帖冷却元件，其中在移动相流体进入泵之前，冷却元件使泵头和流动相流体流动冷却; 附接到珀尔帖冷却元件的流体冷却的热交换器，其使用循环流体从冷却元件移除热量; 以及冷却循环流体的第二热交换器。

    AUTOMATED CONVERSION BETWEEN SFC AND HPLC
    8.
    发明申请
    AUTOMATED CONVERSION BETWEEN SFC AND HPLC 审中-公开

    公开(公告)号：WO2013062635A3

    公开(公告)日：2013-05-02

    申请号：PCT/US2012/042844

    申请日：2012-06-16

    Applicant: AGILENT TECHNOLOGIES, INC. ,  WIKFORS, Edwin, E. ,  FOGELMAN, Kimber ,  BERGER, Terry, A.

    Inventor： WIKFORS, Edwin, E. ,  FOGELMAN, Kimber ,  BERGER, Terry, A.

    IPC: G01N30/02 ,  G01N30/22 ,  G01N30/32

    Abstract: An apparatus, system, and process of converting a standard, high performance liquid chromatography (HPLC) flow path to a flow path suitable for supercritical fluid chromatography (SFC) are described. This reversible technique is applied to a variety of flow configurations including binary, high pressure solvent mixing systems and quaternary, low pressure solvent mixing systems than can be conventionally operated or automated. The technique is generally applied to the fields of supercritical fluid chromatography and high pressure liquid chromatography, but users skilled in the art will find utility for any flow system where pressurization components must be periodically applied to and removed from both ends of a flow stream in an automated manner.

    SYSTEM AND PROCESS FOR AN ACTIVE DRAIN FOR GAS-LIQUID SEPARATORS
    10.
    发明申请
    SYSTEM AND PROCESS FOR AN ACTIVE DRAIN FOR GAS-LIQUID SEPARATORS 审中-公开
    用于气液分离器主动排放的系统和方法

    公开(公告)号：WO2012040252A2

    公开(公告)日：2012-03-29

    申请号：PCT/US2011052426

    申请日：2011-09-20

    Applicant: AURORA SFC SYSTEMS INC ,  FOGELMAN KIMBER D ,  WIKFORS EDWIN E ,  BERGER TERRY A

    Inventor： FOGELMAN KIMBER D ,  WIKFORS EDWIN E ,  BERGER TERRY A

    IPC: B01D15/08 ,  B01D19/00

    CPC classification number: B01D19/0036 ,  B01D15/10 ,  B01D15/40 ,  B01D19/0057 ,  B01D19/0063

    Abstract: An apparatus and process to effectively create an active drain for high and low pressure gas-liquid separator. The invention accomplishes a deterministic drainage rate of variable volume and viscosity liquid fractions from the separator. The mechanisms and methods thereof create a flow path from the separator that dramatically favors controlled liquid flow over a wide range of flow rates and viscosities while restricting gas flow. The invention is a superior method of drainage over conventional systems that employ pressure, vacuum, isolation valves and/or passive flow restrictors to achieve drainage of the separators. The embodiments are primarily directed to the fields of preparative supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE). An advantage of one embodiment allows the economical conversion of typical HPLC systems to state of-the-art supercritical fluid chromatography (SFC) systems with minimal modification to system components.

    Abstract translation: 一种有效地产生用于高低压气液分离器的主动排放装置和方法。 本发明实现了来自分离器的可变体积和粘度液体馏分的确定性排放速率。 其机制和方法从分离器产生流动路径，该流动路径显着有利于在宽范围的流速和粘度下控制液体流动，同时限制气体流动。 本发明是一种优于使用压力，真空，隔离阀和/或被动限流器来实现分离器排水的常规系统的排水方法。 这些实施方案主要涉及制备型超临界流体色谱法（SFC）和超临界流体萃取（SFE）领域。 一个实施方案的优点允许将典型的HPLC系统经济转换为最新技术的超临界流体色谱（SFC）系统，对系统组分进行最小修改。

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