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公开(公告)号：WO2006007378A3
公开(公告)日：2006-05-04
申请号：PCT/US2005021187
申请日：2005-06-15
申请人： SQUIBB BRISTOL MYERS CO , CAI ZHEN-WEI , LOMBARDO LOUIS J , BHIDE RAJEEV S , QIAN LIGANG , WEI DONNA D , BARBOSA STEPHANIE
发明人： CAI ZHEN-WEI , LOMBARDO LOUIS J , BHIDE RAJEEV S , QIAN LIGANG , WEI DONNA D , BARBOSA STEPHANIE
IPC分类号： C07D487/04 , A61K31/53 , A61P19/02 , A61P35/00 , C07D487/12
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如VEGFR-2和FGFR-1的酪氨酸激酶活性，从而使其成为抗癌剂。 式（I）化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：WO2008060907A3
公开(公告)日：2008-05-22
申请号：PCT/US2007/083850
申请日：2007-11-07
发明人： BHIDE, Rajeev, S. , MARINIER, Anne
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof. The Formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1 and IGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：WO2004013145A1
公开(公告)日：2004-02-12
申请号：PCT/US2003/024273
申请日：2003-08-04
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention provides compounds of formula I, (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式I，（I）的化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如VEGFR-2和FGFR-1的酪氨酸激酶活性，从而使其成为抗癌剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：WO2004001059A3
公开(公告)日：2003-12-31
申请号：PCT/US2003/019243
申请日：2003-06-18
IPC分类号： C07D233/70
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：WO2008060907A2
公开(公告)日：2008-05-22
申请号：PCT/US2007083850
申请日：2007-11-07
发明人： BHIDE RAJEEV S , MARINIER ANNE
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof. The Formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1 and IGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制生长因子受体如VEGFR-2，FGFR-1和IGFR-1的酪氨酸激酶活性，从而使其成为抗癌剂。 式（I）化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：WO2006007378A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/021187
申请日：2005-06-15
申请人： BRISTOL-MYERS SQUIBB COMPANY , CAI, Zhen-wei , LOMBARDO, Louis J. , BHIDE, Rajeev S. , QIAN, Ligang , WEI, Donna D. , BARBOSA, Stephanie
发明人： CAI, Zhen-wei , LOMBARDO, Louis J. , BHIDE, Rajeev S. , QIAN, Ligang , WEI, Donna D. , BARBOSA, Stephanie
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如VEGFR-2和FGFR-1的酪氨酸激酶活性，从而使其成为抗癌剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：WO2004001059A2
公开(公告)日：2003-12-31
申请号：PCT/US0319243
申请日：2003-06-18
IPC分类号： C07D277/20 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P35/00 , A61P43/00 , C07D233/70 , C07D233/84 , C07D233/88 , C07D263/28 , C07D263/46 , C07D263/48 , C07D277/34 , C07D277/36 , C07D277/38 , C07D277/42 , C07D417/12 , C07D417/14 , C12Q
CPC分类号： C07D277/42 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）化合物抑制生长因子受体如VEGFR-2，FGFR-1的酪氨酸激酶活性，从而使其成为抗癌剂。 式（I）化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：WO2003099286A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/016179
申请日：2003-05-20
申请人： BRISTOL-MYERS SQUIBB COMPANY , LOMBARDO, Louis, J. , BHIDE, Rajeev, S. , KIM, Kyoung, S. , LU, Songfeng
IPC分类号： A61K31/53
CPC分类号： C07D487/04 , A61K31/53
摘要： The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof useful for inducing mitotic arrest thereby making them useful as anti-cancer agents and other diseases which can be treated by inducing mitotic arrest.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，其可用于诱导有丝分裂停滞，从而使其可用作抗癌剂和可通过诱导有丝分裂停止治疗的其它疾病。
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