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公开(公告)号：WO2019034671A1
公开(公告)日：2019-02-21
申请号：PCT/EP2018/072072
申请日：2018-08-14
Applicant: BIOSAFE S.A.
Inventor： SUBLET, Yannick, Andre
Abstract: The present invention relates to a system for separating biological fluids into components that makes use of a hollow centrifugal processing chamber of variable volume. The system is a functionally closed centrifugation chamber that extracts sub-components of a biological fluid according to their density and size, such as platelets, plasma or red cells from whole blood.
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公开(公告)号：WO2015186057A1
公开(公告)日：2015-12-10
申请号：PCT/IB2015/054165
申请日：2015-06-02
Applicant: BIOSAFE S.A.
Inventor： FELL, Claude , CAMISANI, Julien Pierre
CPC classification number: B04B5/0442 , A61M1/3696 , A61M2202/0437 , A61M2202/0462 , B04B5/0428 , B04B5/10 , B04B11/02 , B04B2005/0485
Abstract: A system for the processing and separation of biological fluids into components comprises an apparatus that cooperates with a disposable set, comprising a cabinet (100) for housing a hollow centrifugal processing chamber (20) of the disposable set. The cabinet comprises a plurality of side-by-side locations (110) for receiving a corresponding plurality of centrifugal processing chambers (20) in side-by-side spaced-apart relation. Each location comprises an individual drive means (52) for driving its centrifugal processing chamber. Remotely-actuable valves (124) associated with the disposable sets are located on the apparatus' cabinet in the proximity of said locations. Valve actuation provides a display of the state of actuation of the valves (124). Selection of this state of actuation is arranged to control connection of the centrifugal processing chamber (20) of each fitted disposable set with a flexible container (200) of the same disposable set or another container, and to control connection of the centrifugal processing chambers (20) with flexible containers of the same or other fitted disposable sets in different combinations, in particular with series and/or parallel connections.
Abstract translation: 用于将生物流体加工和分离成部件的系统包括与一次性组合配合的装置，其包括用于容纳一次性组件的中空离心处理室（20）的机壳（100）。 机柜包括多个并排位置（110），用于以并排间隔的关系接收相应的多个离心处理室（20）。 每个位置包括用于驱动其离心处理室的单独的驱动装置（52）。 与一次性组合相关联的远程可致动的阀（124）位于所述位置附近的设备柜上。 阀致动提供阀（124）的致动状态的显示。 这种致动状态的选择被布置成控制每个装配的一次性组件的离心处理室（20）与同一个一次性组件或另一个容器的柔性容器（200）的连接，并且控制离心处理室 20）具有不同组合的相同或其它装配的一次性组的柔性容器，特别是具有串联和/或并联连接。
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公开(公告)号：WO2009138966A3
公开(公告)日：2009-11-19
申请号：PCT/IB2009/052032
申请日：2009-05-15
Applicant: BIOSAFE S.A. , FOUCAUT, Bertrand Marcel Alexandre , FELL, Claude
Inventor： FOUCAUT, Bertrand Marcel Alexandre , FELL, Claude
Abstract: A method of manufacturing a bag (20) for the cryopreservation of thermolabile liquids. The manufacturing method is characterized by being versatile, simple and inexpensive and allows to manufacture single and multi-compartment bags without modifying the main sealing molds (31, 32). The relative size and the number of the compartments (28) can be modified without change in the molds. Only a closure sealing tool (50) must be adjusted as a function of the number of chosen compartments (28). The process is compatible with standard high frequency sealing processes. This method provides bags (20) with uniformly thick walls and with a predetermined bag volume.
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公开(公告)号：WO2014181158A1
公开(公告)日：2014-11-13
申请号：PCT/IB2013/058403
申请日：2013-09-09
Applicant: BIOSAFE S.A.
Inventor： CAMISANI, Julien Pierre , WARIDEL, Olivier
CPC classification number: A61J1/2003 , A01N1/0242 , A61J1/10 , A61J1/165 , A61M1/025 , A61M2205/36 , B01F5/0602 , B01F11/0065 , B01F15/0085 , B01F15/065 , B01F2015/062 , B01F2215/0037
Abstract: A device for mixing biological specimens contained in flexible storage bags (104) at controlled temperature, comprising a support (105) for supporting a storage bag containing a biological specimen to be mixed; means for imparting a displacement to a specimen in a storage bag on the support to mix the specimen; and temperature control means for maintaining the specimens at a controlled temperature during mixing. The means for imparting displacement to a specimen comprises at least one inflatable/deflatable bag (102, 103) (air bag) that when inflated contacts the surface of a part of a storage bag to progressively squeeze the storage bag and displace the contained specimen into another part of the storage bag.
Abstract translation: 一种用于混合在受控温度下容纳在柔性储存袋（104）中的生物样品的装置，包括用于支撑包含要混合的生物样本的储存袋的支撑件（105） 用于对所述支撑体上的储存袋中的样本施加位移以混合所述样本的装置; 以及用于在混合期间将样品保持在受控温度的温度控制装置。 用于赋予样品置换的装置包括至少一个充气/可放气的袋（102,103）（气袋），当充气接触存储袋的一部分的表面时，逐渐挤压储存袋并将所容纳的样品置于 储物袋的另一部分。
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公开(公告)号：WO2003009889A1
公开(公告)日：2003-02-06
申请号：PCT/EP2002/007172
申请日：2002-06-28
Applicant: CELLGENIX TECHNOLOGIE TRANSFER GMBH , BIOSAFE S.A. , THOMA, Stefan , SCHULZ, Gregor , BOSSE, Roland , WARIDEL, Olivier , FELL, Claude
Inventor： THOMA, Stefan , SCHULZ, Gregor , BOSSE, Roland , WARIDEL, Olivier , FELL, Claude
IPC: A61M1/36
CPC classification number: C12N5/0087 , A61M1/0209 , A61M1/3618 , A61M1/362 , A61M1/3693 , A61M1/3698
Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Anreicherung von Zellen, bei dem man eine Zusammensetzung, die ein Gemisch unterschiedlicher Zelltypen enthält, mit Partikeln in Kontakt bringt, die an eine Subpopulation unerwünschter Zellen in der Zusammensetzung binden ; das Gemisch aus Zellen und Partikeln zentrifugiert und die gewünschte Zellfraktion gewonnen, bevor die Zentrifugation beedet ist. Das Verfahren ist besonders geeignet zur Gewinnung von therapeutischen Zellen.
Abstract translation: 本发明涉及一种用于细胞，其包含使含有不同细胞类型的混合物的组合物，其中在接触结合到该组合物中不需要的细胞的一个亚群颗粒的富集的方法; 细胞并离心颗粒的混合物中，并获得期望的细胞级分，前离心是beedet。 该方法特别适用于治疗细胞的恢复。
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Patent Agency Ranking
公开(公告)号：WO2019110767A3
公开(公告)日：2019-06-13
申请号：PCT/EP2018/083882
申请日：2018-12-06
Applicant: BIOSAFE S.A.
Inventor： CAMISANI, Julien , MATO SABAT, Pau
Abstract: Disclosed is a bioprocessing system comprising apparatus (200) including a centrifugal separation housing (210) having a temperature controllable compartment (215) for removably accepting a separation chamber (50), the apparatus further comprising at least one mixing station (250) for supporting one or more fluid storage vessels (10, 20, 30, 40), the station including a temperature controllable area (252) for increasing or decreasing the temperature of the contents of the or each supported vessel. The system further includes a disposable fluidic arrangement (100) including a centrifugal separation chamber (50) removably mountable within the compartment (215) and having one or more ports (52) allowing fluid ingress into, or egress out of the chamber, via the one or more ports in use, said ports being in fluid communication with one or more of said fluid storage vessels via fluid conduits (12,22,32,42) and via one or more valve arrangements
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公开(公告)号：WO2019110767A2
公开(公告)日：2019-06-13
申请号：PCT/EP2018/083882
申请日：2018-12-06
Applicant: BIOSAFE S.A.
Inventor： CAMISANI, Julien , MATO SABAT, Pau
Abstract: Disclosed is a bioprocessing system comprising apparatus (200) including a centrifugal separation housing (210) having a temperature controllable compartment (215) for removably accepting a separation chamber (50), the apparatus further comprising at least one mixing station (250) for supporting one or more fluid storage vessels (10, 20, 30, 40), the station including a temperature controllable area (252) for increasing or decreasing the temperature of the contents of the or each supported vessel. The system further includes a disposable fluidic arrangement (100) including a centrifugal separation chamber (50) removably mountable within the compartment (215) and having one or more ports (52) allowing fluid ingress into, or egress out of the chamber, via the one or more ports in use, said ports being in fluid communication with one or more of said fluid storage vessels via fluid conduits (12,22,32,42) and via one or more valve arrangements
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公开(公告)号：WO2019081678A1
公开(公告)日：2019-05-02
申请号：PCT/EP2018/079348
申请日：2018-10-25
Applicant: BIOSAFE S.A.
Inventor： MATO SABAT, Pau
CPC classification number: A61M5/281 , A61M5/3135 , A61M5/3145 , A61M5/31511 , A61M2005/3117 , A61M2005/3121
Abstract: The invention discloses a sterile syringe (100) comprising a barrel (1) having internal surfaces (2), a plunger (3) movable within the barrel, a non-sliding seal (7) between the barrel and the plunger defining a sealed volume (8) and at least one filter (9) allowing only filtered gases to enter the sealed volume such that the syringe maintains its sterility even after several uses. The filters could be positioned on different locations on the syringe like on the non-sliding seal, the barrel, the barrel flange or the plunger handle.
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公开(公告)号：WO2016097889A1
公开(公告)日：2016-06-23
申请号：PCT/IB2015/057527
申请日：2015-10-01
Applicant: BIOSAFE S.A.
Inventor： CAMISANI, Julien , LINK, Oliver
CPC classification number: A61M1/029 , A01N1/0221 , A61K35/14 , A61M1/0209 , A61M1/0272 , A61M1/0281 , A61M1/3618 , A61M1/3692 , A61M1/3693 , A61M1/3698 , A61M2205/3313
Abstract: A process for the sequential processing of opaque and transparent biological fluids such as whole blood, apheresis blood, bone marrow blood, umbilical cord blood, buffy coat or cultured cells by processing steps in a hollow cylindrical centrifugal processing chamber (300) which is part of a disposable set. At least three different procedures selected from washing, incubation, transduction, separation, density gradient separation, dilution and volume adjustment are each carried out once or repeated a number of times according to a given processing profile in the processing chamber. Each procedure involves an input into the processing chamber, an operation in the processing chamber and an output from the processing chamber by displacement of a piston (310). The at least three different procedures are sequentially chained one after the other to constitute an overall sequential operation in the processing chamber and its disposable set. A first application is incubation for binding magnetic beads with human blood cells or stem cells. A second application is transduction by which foreign genetic material is inserted into human blood cells or stem cells by a virus. A third application is reconditioning biological fluids to achieve reproducible concentration and volumes of blood cells or stem cells.
Abstract translation: 一种通过在中空圆柱形离心处理室（300）中的加工步骤来顺序处理不透明和透明生物流体如全血，单采血液，骨髓血液，脐带血，血沉棕黄层或培养细胞的方法， 一次性套装 根据处理室中的给定处理轮廓，选择洗涤，孵育，转导，分离，密度梯度分离，稀释和体积调节中的至少三种不同方法分别进行一次或重复多次。 每个过程涉及通过活塞（310）的位移进入处理室的输入，处理室中的操作和来自处理室的输出。 至少三个不同的程序依次连续地链接，以构成处理室及其一次性集合中的整体顺序操作。 第一个应用是将人血细胞或干细胞结合磁珠的温育。 第二个应用是通过病毒将外来遗传物质插入人血细胞或干细胞的转导。 第三个应用是修复生物流体以实现血细胞或干细胞的可重复浓度和体积。
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公开(公告)号：WO2019043093A1
公开(公告)日：2019-03-07
申请号：PCT/EP2018/073337
申请日：2018-08-30
Applicant: BIOSAFE S.A.
Inventor： DE MELO, Daniel
Abstract: Disclosed is a centrifugal separation chamber (100) rotatable about an axis (AR) and having a variable volume separation space (116) therewithin and a port (102) in fluid communication with the volume for filling and emptying the volume, the chamber including a relatively rigid portion (104) proximal to the port which has walls defining a part of the volume and arranged to provide reducing dimensions of the volume toward the port, the chamber further including a flexible portion (106) distal to the port for providing said variable volume, the flexible portion including a mechanical interface (110) for transmitting movement to the flexible portion to cause said variable volume.
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