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公开(公告)号：WO2017062176A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/052853
申请日：2016-09-21
申请人： INVETECH, INC.
发明人： FITZPATRICK, Ian , ROB, Mark , CUSICK, Adam , CRAIG, Tim
CPC分类号： B04B9/08 , B01D21/262 , B01L3/5021 , B04B5/0442 , B04B2005/0471 , B04B2005/0492
摘要： An apparatus of a counter flow centrifuge can include at least one vessel, a handle assembly, and a plurality of tubes extending through the handle assembly and to the vessel. The vessel can be rotated at twice a speed of the handle assembly when the apparatus is inserted into a bowl of the counter flow centrifuge.
摘要翻译： 逆流离心机的装置可以包括至少一个容器，手柄组件和延伸穿过手柄组件和容器的多个管。 当装置插入对流离心机的碗中时，容器可以以手柄组件的两倍的速度旋转。
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公开(公告)号：WO2016063111A1
公开(公告)日：2016-04-28
申请号：PCT/IB2014/065558
申请日：2014-10-23
CPC分类号： A61M1/0281 , A61M1/3692 , A61M1/3696 , A61M2205/12 , B04B5/0442 , B04B7/00 , B04B7/08
摘要： An autotransfusion system for separating fluid constituents includes a centrifuge housing and a rotatable driving member mounted within the centrifuge housing. The rotatable driving member is configured to receive therein and rotationally engage any one of a plurality of centrifuge bowls with different heights. In some embodiments, the centrifuge bowl is integrated with a fluid line organizer to provide for easy and efficient organization of a plurality of different fluid lines incorporated into the autotransfusion system. In some embodiments, the centrifuge bowl and fluid line organizer are easily and efficiently coupled to the centrifuge housing for autotransfusion processing. After autotransfusion processing, the centrifuge bowl and fluid line organizer are easily and efficiently decoupled from the centrifuge housing and discarded.
摘要翻译： 用于分离流体成分的自动输送系统包括安装在离心机壳体内的离心机壳体和可旋转驱动构件。 可旋转的驱动构件构造成容纳在其中并旋转地接合具有不同高度的多个离心碗中的任何一个。 在一些实施例中，离心机碗与流体管线组合器集成，以提供组合到自体输送系统中的多个不同流体管线的容易和有效组织。 在一些实施例中，离心机碗和流体管线组合器容易且有效地耦合到离心机壳体用于自动输送处理。 自动输液处理后，离心机碗和流体管线机构可以方便，有效地从离心机壳体上分离出来并丢弃。
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公开(公告)号：WO2016025914A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/045409
申请日：2015-08-14
申请人： TERUMO BCT, INC.
CPC分类号： B01D21/262 , B04B5/0442 , B04B2005/0471 , C12M47/04
摘要： Embodiments relate to systems, chambers, and methods for processing particles by washing, concentrating, and/or treating the particles. Some embodiments provide for the processing of cells that may be in a liquid medium (e.g., a liquid in which the cells were grown) and are processed by being washed and concentrated for later use in research or other therapies.
摘要翻译： 实施例涉及通过洗涤，浓缩和/或处理颗粒来处理颗粒的系统，室和方法。 一些实施方案提供了可以处于液体培养基（例如其中细胞生长的液体）中的细胞的处理，并且通过洗涤和浓缩以后用于研究或其它治疗中进行处理。
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公开(公告)号：WO2015160320A1
公开(公告)日：2015-10-22
申请号：PCT/TR2015/000152
申请日：2015-04-14
申请人： PROMEDART BIYOTEKNOLOJI VE OZEL SAGLIK HIZMETLERI SANAYI TICARET LIMITED SIRKETI , LITERAL MAKINE VE KIMYA SANAYI TICARET LIMITED SIRKETI
CPC分类号： C12M47/02 , A61M1/0209 , A61M1/3693 , A61M1/3696 , B04B5/0442 , B04B2005/0485 , C12M33/10 , C12M41/46 , C12N5/0647 , C12N5/0669
摘要： This invention is about a separation system (1) that effectively separates the biological material into its different components by means of centrifugal force and performs processes such as separation of stem cells from bone marrow or fatty tissue with ease.
摘要翻译： 本发明涉及一种分离系统（1），其通过离心力将生物材料有效地分离成其不同的组分，并且执行诸如将干细胞从骨髓或脂肪组织分离容易的方法。
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公开(公告)号：WO2015147606A1
公开(公告)日：2015-10-01
申请号：PCT/KR2015/003096
申请日：2015-03-30
申请人： 이준석
发明人： 이준석
CPC分类号： B01L3/5021 , B01L2300/0851 , B01L2300/0858 , B01L2400/0409 , B01L2400/0478 , B04B5/0414 , B04B5/0442 , B04B13/00 , B04B2005/0485 , G01N1/286
摘要： 본 발명은 원심 분리 장치, 원심 분리 방법, 및 분리용기에 관한 것으로서, 보다 상세하게는, 원심력을 이용하여 체액 및 조직 내의 물질을 분리하는 원심 분리 장치로서, 소정의 체액 및 조직이 충진, 분리, 세척되며 소정의 회전 중심축을 중심으로 원 운동하도록 구비된 분리용기; 상기 분리용기와 연결되며 상기 분리용기 내에 세척액을 공급하는 공급부; 상기 분리용기와 연결되며 원심 분리를 통해 분리된 물질이 배출되는 배출부; 상기 공급부 및 배출부와 상기 분리용기 사이의 유통을 통제하는 밸브; 상기 분리용기, 공급부, 배출부를 소정의 회전 중심축을 중심으로 회전시키며 상기 분리용기, 공급부, 배출부에 직각 방향으로 설치된 구동 장치; 및 상기 구동 장치의 구동을 제어하는 제어 장치;를 포함하며, 상기 분리용기는, 상기 회전 중심축을 중심으로 외측부에 배치된 피스톤, 및 상기 피스톤의 외측에 배치되어 상기 피스톤을 원심력의 반대방향으로 가압하는 탄성부를 포함하는 원심 분리 장치에 관한 것이다.
摘要翻译： 本发明涉及一种离心装置，离心方法和分离容器，更具体地，涉及一种使用离心力分离体液和组织中的物质分离装置的离心装置，包括：分离容器，其构造成执行圆形 围绕旋转轴的运动，其中体液和组织在分离容器中容纳，分离和清洁; 连接到分离容器以将清洁溶液供应到分离容器中的供应单元; 排出单元，连接到分离容器以排出通过离心分离的物质; 用于调节供给单元，排出单元和分离容器之间的流体连通的阀; 安装成垂直于分离容器，供给单元和排出单元的致动装置，用于围绕旋转轴旋转分离容器，供给单元和排出单元; 以及用于控制所述致动装置的控制装置，其中所述分离容器包括相对于所述旋转轴设置在其外侧的活塞和设置在所述活塞外侧的弹性单元，以沿与离心力相反的方向推压所述活塞。
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公开(公告)号：WO2015110229A1
公开(公告)日：2015-07-30
申请号：PCT/EP2014/078121
申请日：2014-12-17
CPC分类号： B04B11/02 , A61M1/0272 , A61M1/3692 , A61M1/3696 , B04B5/0442 , B04B9/10
摘要： The invention relates to a device for processing an initial liquid medium (4) comprising cells in an initial concentration in order to obtain a product liquid medium (4') comprising cells in a product concentration, the device (2) comprising a separator (6) adapted to separate the initial liquid medium (4) into various constituents, a first supply system (8) for supplying the initial liquid medium (4) to the separator (6), a first outlet system (12) for extracting the product liquid medium (4') from the separator (6), a sensor (22, 22') adapted to measure a physical parameter related to the concentration of the cells in the initial or product liquid medium (4, 4'), and a control unit (24) coupled to the sensor (22, 22') and adapted to control at least one process parameter of the device (2) as a function of the physical parameter measured by the sensor (22, 22'). The device is characterized by a second supply system (10) for supplying a solution (18) to the separator (6) with a given flow rate. The flow rate of the solution (18) in the second supply system (10) during its supply to the separator (6) is determined based on the at least one process parameter.
摘要翻译： 本发明涉及一种用于处理初始液体介质（4）的装置，其中初始液体介质（4）包含初始浓度的单元，以便获得产品浓度的细胞的产品液体介质（4'），该装置（2）包括分离器 ）适于将初始液体介质（4）分离成各种组分，用于将初始液体介质（4）供应到分离器（6）的第一供应系统（8），用于提取产物液体的第一出口系统（12） 来自分离器（6）的介质（4'），适于测量与初始或产品液体介质（4,4'）中的细胞浓度相关的物理参数的传感器（22,22'），以及控制 单元（24），其耦合到所述传感器（22,22'），并且适于根据由所述传感器（22,22'）测量的物理参数来控制所述设备（2）的至少一个过程参数。 该装置的特征在于用于以给定的流量将溶液（18）供应到分离器（6）的第二供应系统（10）。 基于至少一个工艺参数来确定第二供应系统（10）在供应到分离器（6）期间的溶液（18）的流量。
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公开(公告)号：WO2013116800A2
公开(公告)日：2013-08-08
申请号：PCT/US2013/024530
申请日：2013-02-02
发明人： CASTILLO GONZALEZ, Jose, Antonio , DRUGMAND, Jean-Christophe , PETHE, Vishwas , TERENTIEV, Alexandre
CPC分类号： B04B1/04 , B04B1/02 , B04B5/0442 , B04B7/08 , B04B9/00 , B04B9/04 , B04B9/08 , B04B11/04 , B04B11/082
摘要： In one aspect, a disposable centrifuge includes a container including an interior compartment for receiving the liquid and solids. The container is capable of rotating to urge the solids toward the periphery of the interior compartment. A fixed extraction conduit may be provided for extracting at least a portion of the solids from adjacent the periphery of the interior compartment of the container. A motive device may also be provided for forming a non-contact coupling with the container, which may rotate and/or levitate the container. A relatively low, continuous flow rate (about 250 ml/min to about 500 ml/min) may also be utilized. Related methods are also disclosed.
摘要翻译： 在一个方面，一次性离心机包括容器，该容器包括用于接收液体和固体的内部隔室。 容器能够旋转以将固体推向内部隔室的周边。 可以提供固定的抽取导管，用于从容器的内部隔室的周边附近抽取至少一部分固体。 动力装置也可以被提供用于形成与容器的非接触联接，其可以旋转和/或悬浮容器。 也可以使用较低的连续流速（约250ml / min至约500ml / min）。 还披露了相关的方法。
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公开(公告)号：WO2013048984A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/056992
申请日：2012-09-25
申请人： FENWAL, INC.
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/3693 , A61M1/3696 , A61M2205/12 , A61M2205/14 , A61M2205/276 , A61M2205/3306 , A61M2205/331 , A61M2205/3313 , A61M2205/3317 , A61M2205/6063 , A61M2205/6072 , B04B5/0442 , B04B2005/045 , B04B2013/006
摘要： An optical monitoring system is provided for use with a blood processing system. The system includes a light source configured to illuminate a disposable flow circuit received in a centrifuge and a light detector configured to receive an image of the disposable flow circuit. A controller combines two or more of the images received by the light detector to generate a two-dimensional output. The output is used to control the separation of blood within the disposable flow circuit. The monitoring system may also be used to verify that the disposable flow circuit is suitable for use with the centrifuge or that the disposable flow circuit is properly aligned within the centrifuge. The monitoring system may be positioned outside of the centrifuge bucket which receives the centrifuge.
摘要翻译： 提供了一种与血液处理系统一起使用的光学监测系统。 该系统包括被配置为照亮接收在离心机中的一次性流动回路的光源和被配置为接收一次性流动回路的图像的光检测器。 控制器组合由光检测器接收的两个或更多个图像以产生二维输出。 该输出用于控制一次性流动回路内的血液分离。 监测系统还可用于验证一次性流路是否适合与离心机一起使用，或者一次性流路在离心机内适当对准。 监测系统可以位于接收离心机的离心机桶的外部。
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公开(公告)号：WO2011044237A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/051631
申请日：2010-10-06
申请人： KBI BIOPHARMA, INC. , MEHTA, Sunil , HERMAN, Tod , MCMAHON, Joe , WILSON, Stephen , FITZPATRICK, Ian , CRAIG, Timothy
发明人： MEHTA, Sunil , HERMAN, Tod , MCMAHON, Joe , WILSON, Stephen , FITZPATRICK, Ian , CRAIG, Timothy
IPC分类号： B04B5/04
CPC分类号： B04B5/0442 , B04B2005/0471 , B04B2005/0492
摘要： An apparatus for manipulating particles includes : a rotor rotatable at a speed about an axis, the rotor having an outer periphery and front and rear opposite sides; at least one chamber (50) mounted on the rotor, each chamber having an inlet and an outlet; an umbilical assembly rotatable about the axis; and a drive mechanism configured to rotate the umbilical assembly at about one-half the speed of the rotor. The umbilical assembly includes: a curvilinear guide tube (125) connecting to a drum at the rear side of the rotor; a flexible conduit (130) residing in the guide tube; and first and second elongate passageways (135) for each chamber extending through the conduit, wherein the first passageway is in fluid communication with the inlet of a respective chamber and the second passageway is in fluid communication with the outlet of the respective chamber. The passageways are held in a spaced-apart relationship relative to one another.
摘要翻译： 一种用于操纵颗粒的装置包括：以围绕轴线的速度旋转的转子，所述转子具有外周边和前后相对侧; 安装在转子上的至少一个室（50），每个室具有入口和出口; 围绕所述轴线旋转的脐带组件; 以及驱动机构，其构造成使所述脐带组件以所述转子的大约一半的速度旋转。 脐带组件包括：连接到转子后侧的鼓的曲线导管（125）; 位于引导管中的柔性导管（130）; 以及用于每个腔室延伸穿过导管的第一和第二细长通道（135），其中第一通道与相应室的入口流体连通，并且第二通道与相应室的出口流体连通。 通道相对于彼此保持间隔开的关系。
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10.发明申请METHOD AND APPARATUS FOR CONTINUOUS REMOVAL OF SUBMICRON SIZED PARTICLES IN A CLOSED LOOP LIQUID FLOW SYSTEM 审中-公开在封闭式循环液体流动系统中连续去除亚型尺寸颗粒的方法和装置
公开(公告)号：WO2011025756A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046421
申请日：2010-08-24
申请人： OSTAFIN, Agnes , MIZUKAMI, Hiroshi
发明人： OSTAFIN, Agnes , MIZUKAMI, Hiroshi
IPC分类号： B01D33/15
CPC分类号： A61K9/5192 , A61K9/0026 , A61K9/5073 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5169 , A61K31/01 , A61K38/42 , A61M1/3679 , A61M1/3687 , A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/34 , B04B5/0442 , B04B7/08 , B04B13/00 , B04B2005/045 , B04B2013/006
摘要： A method and apparatus for continuous removal of submicron sized artificial oxygen carriers (rAOC) and other materials such as cancer cells and bacteria from blood and other liquids. A centrifuge rotor having a curved shape is offset on a spinning rotor base and creates contiguous areas of low to high centrifugal force depending on the distances from the axis of the rotor base. This creates a density gradient field that separates materials of different densities input to the centrifuge that exit via different outputs. A monitor detects any red blood cells (RBC) with the rAOC before they exit the centrifuge. If there are any RBC detected logic circuitry changes the speed of rotation of the rotor, and the flow rate of pumps inputting and removing separated blood and rAOC to and from the centrifuge until there are no RBC in the rAOC exiting the centrifuge.
摘要翻译： 一种用于从血液和其他液体中连续去除亚微米尺寸的人造氧载体（rAOC）和其它材料如癌细胞和细菌的方法和装置。 具有弯曲形状的离心机转子在旋转转子基座上偏移，并且根据与转子基座的轴线的距离产生低至高离心力的连续区域。 这创建了一个密度梯度场，将不同密度的材料分离成离心机，通过不同的输出排出。 监视器在离开离心机之前，用rAOC检测任何红细胞（RBC）。 如果有任何RBC检测到的逻辑电路改变转子的旋转速度，以及泵输入和分离血液和rAOC进出离心机的流速，直到离开离心机的rAOC中没有RBC。
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