公开(公告)号：WO2013139496A1

公开(公告)日：2013-09-26

申请号：PCT/EP2013/050935

申请日：2013-01-18

Applicant: BIOTAGE AB

Inventor： HALLIN, Erik

IPC: G01N30/86

CPC classification number: G01N30/8693 ,  G06F17/13 ,  G06F17/5009

Abstract: The present invention relates to a method for simulating a chromatographic run on a chromatograph (5) with a computation device (3) comprising at least one processor (7) and an associated digital memory (9), wherein the chromatographic run uses a mobile phase (31) comprising a mixture of at least two eluent constituents having different chromatographic properties and forming an eluent profile (33). The invention also relates to a computer program for performing the method, and an apparatus comprising a computation device and a chromatograph for performing the method.

Abstract translation: 本发明涉及一种利用包括至少一个处理器（7）和相关联的数字存储器（9）的计算装置（3）在色谱仪（5）上模拟色谱运行的方法，其中色谱运行使用流动相 （31），其包含具有不同色谱性质的至少两种洗脱剂组分的混合物并形成洗脱液图谱（33）。 本发明还涉及一种用于执行该方法的计算机程序，以及包括用于执行该方法的计算装置和色谱仪的装置。

公开(公告)号：WO2008074799A1

公开(公告)日：2008-06-26

申请号：PCT/EP2007/064133

申请日：2007-12-18

Applicant: BIOTAGE AB ,  FAGRELL, Magnus

Inventor： FAGRELL, Magnus

IPC: B01J19/12 ,  B01L3/00 ,  G01N1/44 ,  H05B6/64

CPC classification number: H05B6/806 ,  B01J19/0053 ,  B01J19/126 ,  B01J2219/1209 ,  B01J2219/1233 ,  G01N1/44 ,  H05B6/705 ,  H05B6/74

Abstract: There is described a rection vessel (25) for microwave heating of the load (5 in said vessel. The reaction vessel has a main axis and is provided with at least one reaction chamber in fluid connection with an inlet and an outlet. The reaction vessel is adapted to be irradiated with microwaves. The reaction vessel comprises adjusting means (4,16) to adjust the position, shape and/or volume of the reaction chamber in order to optimise the heating conditions of the load in said reaction chamber, during microwave irradiation.

Abstract translation: 描述了用于微波加热负载的反应容器（25）（在所述容器中为5），反应容器具有主轴，并且设置有至少一个与入口和出口流体连接的反应室，反应容器 反应容器包括用于调节反应室的位置，形状和/或体积的调节装置（4,16），以便在微波期间优化所述反应室中负载的加热条件 照射。

公开(公告)号：WO2005064518A3

公开(公告)日：2006-04-27

申请号：PCT/EP2004053625

申请日：2004-12-21

Applicant: BIOTAGE AB ,  ULFENDAHL PER JOHAN ,  BERG MAGNUS

Inventor： ULFENDAHL PER JOHAN ,  BERG MAGNUS

IPC: C12Q1/68

CPC classification number: G06F19/22

Abstract: The present invention relates to an apparatus, method and computer program for de­termining the identity of at least one nucleotide in a nucleic acid molecule, by way of sequentially detecting a measurable quantity of a reaction when the nucleotide is incorporated to form a base pair with a complementary base in the nucleic acid molecule. Means (15) is arranged for provision of nucleotides to the nucleic acid molecule, a detector (10) is adapted to determine whether or not a dispensated nu­cleotide is incorporated in the nucleic acid sequence of the molecule, registration means (20) is provided for storage of the detected nucleic acid sequence, a cata­logue (30) includes a retrievable plurality of possible sequences of the detected and registered nucleic acid sequence, the catalogue being accessible for a comparing means (40). The comparing means is adapted to retrieve and compare the detected registered nucleic acid sequence, which is stored in the registration means, with the possible sequences of the catalogue. Moreover the invention is characterised in that dispensation control means (50) is provided to adapt the order of following dispen­sations in response to the correspondence, which is established by the comparing means, between the nucleotides of the detected and registered sequence and the catalogue of possible sequences.

Abstract translation: 本发明涉及一种用于在核酸分子中确定至少一个核苷酸的身份的装置，方法和计算机程序，其方式是当核苷酸被掺入以形成碱基对时，依次检测可测量的反应量 核酸分子中的互补碱基。 布置装置（15）用于向核酸分子提供核苷酸，检测器（10）适于确定分配的核苷酸是否并入分子的核酸序列中，登记装置（20）用于 存储检测到的核酸序列，目录（30）包括检测和登记的核酸序列的可检索的多个可能序列，所述目录可用于比较装置（40）。 比较装置适于检索并比较存储在登记装置中的检测到的登录核酸序列与目录的可能序列。 此外，本发明的特征在于，提供分配控制装置（50）以响应于由比较装置建立的对应关系，以便根据检测到的和登记的序列的核苷酸与可能的目录之间的顺序 序列。

公开(公告)号：WO2019078773A1

公开(公告)日：2019-04-25

申请号：PCT/SE2018/051053

申请日：2018-10-17

Applicant: BIOTAGE AB

Inventor： DAVIES, Geoff ,  SENIOR, Adam ,  WILLIAMS, Lee ,  JONES, Rhys

IPC: B01J20/00 ,  G01N30/00

Abstract: The present invention relates to a flow-through device comprising at least one separation column wherein a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts are provided. The two packing components may be blended or layered in the device, which may comprise a single tube or a plurality of tubes arranged in a plate format, such as the wells of a multiwall plate or tubes in a rack. In addition, the invention relates to a method for removing one or more matrix components, such as pigments, from a biological sample, by passing said sample across a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts.

公开(公告)号：WO2018197294A1

公开(公告)日：2018-11-01

申请号：PCT/EP2018/059881

申请日：2018-04-18

Applicant: BIOTAGE AB

Inventor： JÖNSSON, Stig

IPC: B01D15/26

Abstract: The present invention relates to a method for separating metal ions from a liquid, which method comprises contacting liquid comprising metal ions with non-functionalized cellulose, adsorbing the metal ions to the cellulose, and separating the liquid from the cellulose, wherein the liquid is an essential oil.

公开(公告)号：WO2015028599A1

公开(公告)日：2015-03-05

申请号：PCT/EP2014/068364

申请日：2014-08-29

Applicant: BIOTAGE AB

Inventor： REES, Anthony

IPC: C07K1/04

CPC classification number: C07K1/045 ,  C07K1/04

Abstract: The invention relates to a method of cleaving a linker molecule attaching a peptide, polypeptide or a small protein to a solid phase comprising contacting the attached peptide, polypeptide or small protein with water under subcritical conditions. An acid may be added to the water, and the method is advantageously microwave supported.

Abstract translation: 本发明涉及一种切割将肽，多肽或小蛋白连接到固相的连接分子的方法，包括在亚临界条件下使连接的肽，多肽或小蛋白与水接触。 可以向水中加入酸，该方法有利于微波负载。

公开(公告)号：WO2014154766A1

公开(公告)日：2014-10-02

申请号：PCT/EP2014/056088

申请日：2014-03-26

Applicant: BIOTAGE AB

Inventor： YILMAZ, Ecevit ,  NIVHEDE, David ,  BILLING, Johan ,  RUDOLFSSON, Markus ,  LEEMAN, Mats ,  SENIOR, Adam

IPC: B01J20/26 ,  B01J20/32 ,  G01N1/40 ,  B01J20/30 ,  B01J20/28 ,  G01N30/00

CPC classification number: B01J20/267 ,  B01D15/20 ,  B01J20/261 ,  B01J20/28019 ,  B01J20/28042 ,  B01J20/28052 ,  B01J20/3092 ,  B01J20/3293 ,  B01J2220/62 ,  G01N1/405 ,  G01N2030/009

Abstract: The present invention relates to a sorbent for extracting polar components from a sample where the sorbent comprises a cross-linked polymer comprising nitrogen containing cyclic compounds, for example1-vinylimidazole and/or 4-vinylpyridine. The invention further relates to a method of producing said sorbent and the use of the sorbent.

Abstract translation: 本发明涉及一种用于从样品中提取极性组分的吸附剂，其中吸附剂包含含氮环状化合物的交联聚合物，例如1-乙烯基咪唑和/或4-乙烯基吡啶。 本发明还涉及生产所述吸附剂的方法和吸附剂的用途。

公开(公告)号：WO2014147186A1

公开(公告)日：2014-09-25

申请号：PCT/EP2014/055622

申请日：2014-03-20

Applicant: BIOTAGE AB

Inventor： WARNGREN, Anders ,  WESSMAN, Anders ,  HALLIN, Erik ,  JOHNSSON, Lars

IPC: G01N30/72 ,  B01D15/24 ,  G01N30/80 ,  G01N30/20

CPC classification number: G01N30/82 ,  B01D15/247 ,  G01N30/20 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/80 ,  Y10T137/794 ,  Y10T137/85986 ,  Y10T137/87281

Abstract: The present invention provides an apparatus that can be used to connect a flash chromatography instrument to a fraction collector and a mass detector to perform mass directed flash chromatography, said apparatus comprising a by-passable delay loop and an active splitter, and to a system comprising such an apparatus and to methods. The invention further relates to a method for separation of a sample into components and mass- directed collection of at least one of said component in at least one separate fraction, and to a computer program comprising instructions inducing a computer to perform a method for controlling a fraction collector in a chromatography system.

Abstract translation: 本发明提供一种装置，其可用于将快速色谱​​仪连接到级分收集器和质量检测器以进行质量指示的快速色谱，所述装置包括旁通延迟环和主动分离器，以及包括 这样的装置和方法。 本发明还涉及一种用于将样品分离成组分的方法和在至少一个分离部分中的所述组分中的至少一种的大量定向收集，以及包括引导计算机执行控制方法的指令的计算机程序 馏分收集器在色谱系统中。

公开(公告)号：WO2009077502A3

公开(公告)日：2010-01-21

申请号：PCT/EP2008067548

申请日：2008-12-15

Applicant: BIOTAGE AB ,  NORDLUND ERIK ,  STRANDELL AXEL ,  WESSMAN ANDERS

Inventor： NORDLUND ERIK ,  STRANDELL AXEL ,  WESSMAN ANDERS

IPC: B01J19/12 ,  B01J4/02 ,  B01J8/08 ,  B01J8/10

CPC classification number: B01J19/126 ,  B01J2219/089 ,  B01J2219/0892 ,  H05B6/806

Abstract: Devices and methods for performing microwave-assisted chemical synthesis including heterogeneous starting materials, comprising a reaction vessel (9), a microwave source (3) for generating microwave electromagnetic radiation, means for transporting microwave electromagnetic radiation (5) to said reaction vessel (9), at least one liquid reservoir (45) containing a liquid component, means for transporting a liquid component (43) from a liquid reservoir to said reaction vessel, wherein it further comprises an automated system for dispensing solid starting material (59) into said reaction vessel.

Abstract translation: 包括反应容器（9），用于产生微波电磁辐射的微波源（3），用于将微波电磁辐射（5）输送到所述反应容器（9）的装置的装置和方法，包括用于进行微波辅助化学合成的装置和方法 ），包含液体组分的至少一个液体储存器（45），用于将液体组分（43）从液体储存器输送到所述反应容器的装置，其中还包括用于将固体起始材料（59）分配到所述反应容器中的自动化系统 反应容器

公开(公告)号：WO2004046385A1

公开(公告)日：2004-06-03

申请号：PCT/SE2003/001771

申请日：2003-11-14

Applicant: BIOTAGE AB ,  KRABBE, Margareta ,  MOE, James

Inventor： KRABBE, Margareta ,  MOE, James

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q1/689

Abstract: The invention refers to a method and a kit for inter-species differentiation and identification of a gram-positive bacteria in a sample, comprising analysing the variable region(s) P10 and/or P10.1 of the rnpB-gene of the sample bacteria in a sequencing-by-synthesis analysis, the analysis thereby resulting in a nucleotide pattern. Hereby, bacterial identification of clinically relevant gram-positive bacteria is performed in a quick and accurate way, since typing of the rnpB-gene in combination with sequencing-by-synthesis provides an improved method in this technical field

Abstract translation: 本发明涉及样品中革兰氏阳性细菌的物种间分化和鉴定的方法和试剂盒，包括分析样品细菌的rnpB基因的可变区P10和/或P10.1 在合成序列分析中，分析从而导致核苷酸模式。 因此，以快速准确的方式进行临床相关的革兰氏阳性细菌的细菌鉴定，因为将rnpB基因与序列化合成相结合提供了本技术领域的改进方法