公开(公告)号：WO2010039997A3

公开(公告)日：2011-02-24

申请号：PCT/US2009059281

申请日：2009-10-01

Applicant: UNIV NORTH CAROLINA ,  SHARPLESS NORMAN E ,  STRUM JAY C ,  BISI JOHN E ,  ROBERTS PATRICK J ,  RAMSEY MATTHEW R

Inventor： SHARPLESS NORMAN E ,  STRUM JAY C ,  BISI JOHN E ,  ROBERTS PATRICK J ,  RAMSEY MATTHEW R

IPC: A61K31/519 ,  A61K31/407 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K31/353 ,  A61K31/407 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5375 ,  A61K45/06 ,  G01N33/5008 ,  G01N2333/4739 ,  A61K2300/00

Abstract: Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin- dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.

Abstract translation: 提供了减少或防止细胞毒性化合物在健康细胞中的作用的方法。 所述方法涉及使用选择性细胞周期蛋白依赖性激酶（CDK）4/6抑制剂诱导CDK4 / 6依赖性细胞（例如造血干细胞和/或造血祖细胞）中的暂时性静止。 还描述了选择用于减少或防止健康细胞中的细胞毒剂化合物的作用的化合物的方法。

公开(公告)号：WO2010039997A2

公开(公告)日：2010-04-08

申请号：PCT/US2009/059281

申请日：2009-10-01

Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  SHARPLESS, Norman, E. ,  STRUM, Jay, C. ,  BISI, John, E. ,  ROBERTS, Patrick, J. ,  RAMSEY, Matthew, R.

Inventor： SHARPLESS, Norman, E. ,  STRUM, Jay, C. ,  BISI, John, E. ,  ROBERTS, Patrick, J. ,  RAMSEY, Matthew, R.

IPC: A61K31/519 ,  A61K31/407 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K31/353 ,  A61K31/407 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5375 ,  A61K45/06 ,  G01N33/5008 ,  G01N2333/4739 ,  A61K2300/00

Abstract: Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin- dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.

Abstract translation: 提供减少或预防细胞毒性化合物在健康细胞中的作用的方法。 该方法涉及使用选择性细胞周期蛋白依赖性激酶（CDK）4/6抑制剂诱导CDK4 / 6依赖性细胞如造血干细胞和/或造血祖细胞中的暂时静止。 还描述了选择用于减少或预防细胞毒性剂化合物在健康细胞中的作用的化合物的方法。

公开(公告)号：WO2010039997A9

公开(公告)日：2011-05-05

申请号：PCT/US2009059281

申请日：2009-10-01

Applicant: UNIV NORTH CAROLINA ,  SHARPLESS NORMAN E ,  STRUM JAY C ,  BISI JOHN E ,  ROBERTS PATRICK J ,  RAMSEY MATTHEW R

Inventor： SHARPLESS NORMAN E ,  STRUM JAY C ,  BISI JOHN E ,  ROBERTS PATRICK J ,  RAMSEY MATTHEW R

IPC: A61K31/519 ,  A61K31/407 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K31/353 ,  A61K31/407 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5375 ,  A61K45/06 ,  G01N33/5008 ,  G01N2333/4739 ,  A61K2300/00

Abstract: Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin- dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.

Abstract translation: 提供减少或预防细胞毒性化合物在健康细胞中的作用的方法。 该方法涉及使用选择性细胞周期蛋白依赖性激酶（CDK）4/6抑制剂诱导CDK4 / 6依赖性细胞如造血干细胞和/或造血祖细胞中的暂时静止。 还描述了选择用于减少或预防细胞毒性剂化合物在健康细胞中的作用的化合物的方法。