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1.发明申请HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS 审中-公开使用选择性的依赖于细胞周期蛋白酶4/6的抑制剂对造血干细胞化合物造血的保护作用
公开(公告)号：WO2010039997A3
公开(公告)日：2011-02-24
申请号：PCT/US2009059281
申请日：2009-10-01
Applicant: UNIV NORTH CAROLINA , SHARPLESS NORMAN E , STRUM JAY C , BISI JOHN E , ROBERTS PATRICK J , RAMSEY MATTHEW R
Inventor： SHARPLESS NORMAN E , STRUM JAY C , BISI JOHN E , ROBERTS PATRICK J , RAMSEY MATTHEW R
IPC: A61K31/519 , A61K31/407 , A61P35/00
CPC classification number: A61K31/519 , A61K31/353 , A61K31/407 , A61K31/4545 , A61K31/4725 , A61K31/4738 , A61K31/496 , A61K31/506 , A61K31/52 , A61K31/5375 , A61K45/06 , G01N33/5008 , G01N2333/4739 , A61K2300/00
Abstract: Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin- dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.
Abstract translation: 提供了减少或防止细胞毒性化合物在健康细胞中的作用的方法。 所述方法涉及使用选择性细胞周期蛋白依赖性激酶（CDK）4/6抑制剂诱导CDK4 / 6依赖性细胞（例如造血干细胞和/或造血祖细胞）中的暂时性静止。 还描述了选择用于减少或防止健康细胞中的细胞毒剂化合物的作用的化合物的方法。
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公开(公告)号：WO2012050975A3
公开(公告)日：2012-07-05
申请号：PCT/US2011054004
申请日：2011-09-29
Applicant: UNIV NORTH CAROLINA , SHARPLESS NORMAN E , WANG ZEFENG , BURD CHRISTIN E , JECK WILLIAM R , SIEBOLD ALEX P
Inventor： SHARPLESS NORMAN E , WANG ZEFENG , BURD CHRISTIN E , JECK WILLIAM R , SIEBOLD ALEX P
CPC classification number: C12Q1/6883 , C12Q1/686 , C12Q1/6886 , C12Q2600/136 , C12Q2600/172 , C12Q2521/319 , C12Q2525/307
Abstract: This invention is directed to isolated and purified nucleic acids encoding circular RNA comprising one or more ANRIL exons, methods for detecting such nucleic acids, and uses thereof. The invention provides methods for detecting ANRIL associated disorders such as atherosclerosis, related kits, and methods of screening for compounds to prevent or treat such disorders.
Abstract translation: 本发明涉及编码包含一个或多个ANRIL外显子的环状RNA的分离和纯化的核酸，检测这种核酸的方法及其用途。 本发明提供了检测ANRIL相关病症如动脉粥样硬化的方法，相关试剂盒以及筛选预防或治疗这些病症的化合物的方法。
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公开(公告)号：WO2010132725A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/034816
申请日：2010-05-13
Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SHARPLESS, Norman, E. , ROBERTS, Patrick, J. , WONG, Kwok , LIU, Yan , JOHNSON, Soren
Inventor： SHARPLESS, Norman, E. , ROBERTS, Patrick, J. , WONG, Kwok , LIU, Yan , JOHNSON, Soren
CPC classification number: A61K31/519 , A61K38/1816 , A61K45/06 , A61K2300/00
Abstract: The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.
Abstract translation: 目前公开的主题涉及用于保护健康细胞免受DNA损伤剂损伤的方法和组合物。 特别地，目前公开的主题涉及对暴露于或处于暴露于DNA损伤的风险的受试者施用的选择性细胞周期蛋白依赖性激酶4/6（CDK4 / 6）抑制剂的保护作用。
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4.发明申请HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS 审中-公开使用选择性游离依赖性激酶4/6抑制剂的化学疗法抗化学物质保护
公开(公告)号：WO2010039997A2
公开(公告)日：2010-04-08
申请号：PCT/US2009/059281
申请日：2009-10-01
Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SHARPLESS, Norman, E. , STRUM, Jay, C. , BISI, John, E. , ROBERTS, Patrick, J. , RAMSEY, Matthew, R.
Inventor： SHARPLESS, Norman, E. , STRUM, Jay, C. , BISI, John, E. , ROBERTS, Patrick, J. , RAMSEY, Matthew, R.
IPC: A61K31/519 , A61K31/407 , A61P35/00
CPC classification number: A61K31/519 , A61K31/353 , A61K31/407 , A61K31/4545 , A61K31/4725 , A61K31/4738 , A61K31/496 , A61K31/506 , A61K31/52 , A61K31/5375 , A61K45/06 , G01N33/5008 , G01N2333/4739 , A61K2300/00
Abstract: Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin- dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.
Abstract translation: 提供减少或预防细胞毒性化合物在健康细胞中的作用的方法。 该方法涉及使用选择性细胞周期蛋白依赖性激酶（CDK）4/6抑制剂诱导CDK4 / 6依赖性细胞如造血干细胞和/或造血祖细胞中的暂时静止。 还描述了选择用于减少或预防细胞毒性剂化合物在健康细胞中的作用的化合物的方法。
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公开(公告)号：WO2012050975A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/054004
申请日：2011-09-29
Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SHARPLESS, Norman, E. , WANG, Zefeng , BURD, Christin, E. , JECK, William, R. , SIEBOLD, Alex, P.
Inventor： SHARPLESS, Norman, E. , WANG, Zefeng , BURD, Christin, E. , JECK, William, R. , SIEBOLD, Alex, P.
CPC classification number: C12Q1/6883 , C12Q1/686 , C12Q1/6886 , C12Q2600/136 , C12Q2600/172 , C12Q2521/319 , C12Q2525/307
Abstract: This invention is directed to isolated and purified nucleic acids encoding circular RNA comprising one or more ANRIL exons, methods for detecting such nucleic acids, and uses thereof. The invention provides methods for detecting ANRIL associated disorders such as atherosclerosis, related kits, and methods of screening for compounds to prevent or treat such disorders.
Abstract translation: 本发明涉及编码包含一个或多个ANRIL外显子的环状RNA的分离和纯化的核酸，用于检测该核酸的方法及其用途。 本发明提供了检测ANRIL相关疾病如动脉粥样硬化，相关试剂盒以及筛选化合物以预防或治疗这些疾病的方法。
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Patent Agency Ranking6.发明申请HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS 审中-公开使用选择性循环激素激酶4/6抑制剂进行离子辐照的化学防护
公开(公告)号：WO2010051127A9
公开(公告)日：2010-06-24
申请号：PCT/US2009059254
申请日：2009-10-01
Applicant: UNIV NORTH CAROLINA , SHARPLESS NORMAN E , TORRICE CHAD D , RAMSEY MATTHEW R , JOHNSON SOREN , BELL JESSICA F
Inventor： SHARPLESS NORMAN E , TORRICE CHAD D , RAMSEY MATTHEW R , JOHNSON SOREN , BELL JESSICA F
IPC: A61K31/47 , A61K31/403 , A61K31/443 , A61K31/506 , A61K31/519 , A61K35/12 , A61P35/00
CPC classification number: A61K31/403 , A61K31/443 , A61K31/47 , A61K31/506 , A61K31/519
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7.发明申请
公开(公告)号：WO2006036943A3
公开(公告)日：2009-04-16
申请号：PCT/US2005034542
申请日：2005-09-27
Applicant: UNIV NORTH CAROLINA , SHARPLESS NORMAN E , JANAKIRAMAN KRISHNAMURTHY
Inventor： SHARPLESS NORMAN E , JANAKIRAMAN KRISHNAMURTHY
CPC classification number: C12Q1/6883 , C12Q1/6809 , C12Q2600/118 , C12Q2600/142 , C12Q2600/158
Abstract: The presently disclosed subject matter provides methods for determining the molecular age of a tissue. Also provided are methods for employing a molecular age that has been determined for a tissue for assessing the appropriateness of various therapeutic applications for the tissue or a subject comprising the tissue.
Abstract translation: 目前公开的主题提供了确定组织的分子年龄的方法。 还提供了采用已经为组织确定的分子年龄以评估组织或包含组织的受试者的各种治疗应用的适当性的方法。
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8.发明申请PROTECTION OF RENAL TISSUES FROM ISCHEMIA THROUGH INHIBITION OF THE PROLIFERATIVE KINASES CDK4 AND CDK6 审中-公开通过抑制增殖型CDK4和CDK6来保护ISCHEMIA的肾组织
公开(公告)号：WO2012068381A8
公开(公告)日：2012-11-08
申请号：PCT/US2011061202
申请日：2011-11-17
Applicant: UNIV NORTH CAROLINA , DIROCCO DEREK PAUL , BRIGHAM & WOMENS HOSPITAL , ZERO THERAPEUTICS G , SHARPLESS NORMAN E , STRUM JAY COPELAND , BISI JOHN EMERSON , ROBERTS PATRICK JOSEPH , HUMPHREYS BENJAMIN DUANE , WONG KWOK-KIN
Inventor： DIROCCO DEREK PAUL , SHARPLESS NORMAN E , STRUM JAY COPELAND , BISI JOHN EMERSON , ROBERTS PATRICK JOSEPH , HUMPHREYS BENJAMIN DUANE , WONG KWOK-KIN
IPC: A61K31/519 , A61K31/505 , A61K31/506 , A61P7/00 , A61P7/06
CPC classification number: A61K31/519 , A61K31/192 , A61K31/436 , A61K31/505 , A61K31/616 , A61K38/13 , A61K2300/00
Abstract: The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter relates to the protective action of cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to, or that are at risk of, ischemia.
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公开(公告)号：WO2010132725A3
公开(公告)日：2011-03-31
申请号：PCT/US2010034816
申请日：2010-05-13
Applicant: UNIV NORTH CAROLINA , SHARPLESS NORMAN E , ROBERTS PATRICK J , WONG KWOK , LIU YAN , JOHNSON SOREN
Inventor： SHARPLESS NORMAN E , ROBERTS PATRICK J , WONG KWOK , LIU YAN , JOHNSON SOREN
CPC classification number: A61K31/519 , A61K38/1816 , A61K45/06 , A61K2300/00
Abstract: The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.
Abstract translation: 目前公开的主题涉及用于保护健康细胞免受DNA损伤剂损伤的方法和组合物。 特别地，目前公开的主题涉及对暴露于或处于暴露于DNA损伤的风险的受试者施用的选择性细胞周期蛋白依赖性激酶4/6（CDK4 / 6）抑制剂的保护作用。
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10.发明申请HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS 审中-公开使用选择性循环激素激酶4/6抑制剂进行离子辐射的化学防护
公开(公告)号：WO2010051127A2
公开(公告)日：2010-05-06
申请号：PCT/US2009/059254
申请日：2009-10-01
Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SHARPLESS, Norman, E. , TORRICE, Chad, D. , RAMSEY, Matthew, R. , JOHNSON, Soren , BELL, Jessica, F.
Inventor： SHARPLESS, Norman, E. , TORRICE, Chad, D. , RAMSEY, Matthew, R. , JOHNSON, Soren , BELL, Jessica, F.
IPC: A61K31/47 , A61K31/443 , A61K31/403 , A61K31/506 , A61K31/519 , A61K35/12 , A61P35/00
CPC classification number: A61K31/403 , A61K31/443 , A61K31/47 , A61K31/506 , A61K31/519
Abstract: Methods for reducing or preventing the effects of ionizing radiation in healthy cells are provided. The methods relate to the use of selective cyclin- dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Radioprotection can be effected in mammals by treatment with selective CDK4/6 inhibitor compounds either before, at the same time as, or after exposure to the ionizing radiation.
Abstract translation: 提供减少或防止电离辐射对健康细胞的影响的方法。 该方法涉及使用选择性细胞周期蛋白依赖性激酶（CDK）4/6抑制剂诱导CDK4 / 6依赖性细胞如造血干细胞和/或造血祖细胞中的暂时静止。 通过在暴露于电离辐射之前，同时或之后用选择性CDK4 / 6抑制剂化合物进行处理，可以在哺乳动物中进行放射防护。
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