公开(公告)号：WO2017059003A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/054323

申请日：2016-09-29

Applicant: SASSO, Eric ,  EASTMAN, Paul Scott ,  BOLCE, Rebecca ,  KAVANAUGH, Arthur ,  CRESCENDO BIOSCIENCE ,  UNIVERSITY OF CALIFORNIA SAN DIEGO

Inventor： SASSO, Eric ,  EASTMAN, Paul Scott ,  BOLCE, Rebecca ,  KAVANAUGH, Arthur

IPC: G01N33/68 ,  G01N33/536 ,  G06F19/18

CPC classification number: G01N33/6893 ,  G01N2800/102 ,  G06F19/18 ,  G06F19/20

Abstract: Provided herein are biomarkers and methods for generating scores useful for assessing psoriatic arthritis (PsA) disease activity in subjects previously diagnosed with PsA. The invention also provides predictive model methods based on the biomarkers, as well as computer systems, software embodiments of the models for scoring and optionally classifying samples, and methods of recommending optimal therapeutic regimens.

Abstract translation: 本文提供的生物标志物和产生评估的方法可用于评估先前诊断为PsA的受试者的牛皮癣关节炎（PsA）疾病活动。 本发明还提供了基于生物标志物的预测模型方法以及计算机系统，用于评分和可选地分类样品的模型的软件实施方案以及推荐最佳治疗方案的方法。

公开(公告)号：WO2015191423A1

公开(公告)日：2015-12-17

申请号：PCT/US2015/034631

申请日：2015-06-08

Applicant: CRESCENDO BIOSCIENCE ,  KAROLINSKA INSTITUTE ,  VAN VOLLENHOVEN, Ronald Frits ,  HAMBARDZUMYAN, Karen ,  BOLCE, Rebecca ,  CRUICKSHANK, Scott

Inventor： VAN VOLLENHOVEN, Ronald Frits ,  HAMBARDZUMYAN, Karen ,  BOLCE, Rebecca ,  CRUICKSHANK, Scott

IPC: G01N33/53 ,  A61K31/519 ,  A61K31/635 ,  A61K31/47 ,  A61P37/00

CPC classification number: A61K31/4706 ,  A61K31/519 ,  A61K31/635 ,  G01N33/564 ,  G01N2800/52 ,  G01N2800/60

Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays at different time periods to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers. The methods further include recommending optimal therapeutic regimens, in particular disease modifying anti-rheumatic drugs or biologics, based on changes to the scores.

Abstract translation: 本文提供了评估炎性疾病治疗反应的方法。 所述方法包括在不同时间段进行免疫测定以基于与炎性生物标志物相关的生物标志物的表达的定量数据产生得分。 该方法还包括基于评分的变化来推荐最佳治疗方案，特别是疾病改善抗风湿药物或生物制剂。