公开(公告)号：WO2010141897A2

公开(公告)日：2010-12-09

申请号：PCT/US2010/037511

申请日：2010-06-04

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  KRAMER-BROWN, Pamela A. ,  BOYLAN, John F. ,  VON OEPEN, Randolf

Inventor： KRAMER-BROWN, Pamela A. ,  BOYLAN, John F. ,  VON OEPEN, Randolf

IPC: A61L31/02

CPC classification number: A61L31/022 ,  C22C27/00

Abstract: A medical device such as, for example, an implantable expandable stent is constructed of a ternary alloy of molybdenum, rhenium, and a third metal. In a preferred embodiment, the third metal is a refractory metal selected to improve the ductility of the alloy. The alloy may further be advantageously constructed to have a crystal structure selected from HCP, BCC, FCC, and tetragonal to further optimize the physical characteristics of the medical device.

Abstract translation: 诸如例如可植入式可扩张支架的医疗装置由钼，铼和第三金属的三元合金构成。 在优选实施例中，第三金属是选择用于改善合金的延展性的难熔金属。 还可以有利地将合金构造成具有选自HCP，BCC，FCC和四方晶的晶体结构，以进一步优化医疗器件的物理特性。

公开(公告)号：WO2006081011A3

公开(公告)日：2006-08-31

申请号：PCT/US2005046022

申请日：2005-12-20

Applicant: ADVANCED CARDIOVASCULAR SYSTEM ,  BOYLAN JOHN F ,  LIN ZHICHENG ,  STALKER KENT C B

Inventor： BOYLAN JOHN F ,  LIN ZHICHENG ,  STALKER KENT C B

IPC: A61L29/00 ,  C22C14/00 ,  A61F2/00 ,  A61F2/06 ,  A61F2/84 ,  A61F2/90 ,  A61L31/02 ,  C22F1/00

CPC classification number: C22C30/00 ,  A61F2/915 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/18 ,  A61L2400/16 ,  C22C14/00 ,  C22C19/00 ,  C22F1/006

Abstract: A nickel-titanium alloy having a large, superelastic operating temperature window or range. The nickel-titanium alloy includes at least an additional element such as platinum, palladium, manganese, boron aluminum, tungsten, and/or zirconium. When processed through heat treat and area reduction steps, the resultant alloy exhibits a wide superelastic temperature operating window if the characteristics of the alloy when plotted on a temperature versus stress curve can be expresses as UP=(0.66ksi/°C)(T)+s 0 , with R 2 =0.98, wherein s 0 is the upper plateau stress of the alloy at about 0°C, R 2 is the coefficient of determination, and UP is the upper plateau stress of the alloy.

Abstract translation: 具有大的，超弹性的工作温度窗口或范围的镍钛合金。 镍 - 钛合金至少包括另外的元素，如铂，钯，锰，硼铝，钨和/或锆。 当通过热处理和面积缩小步骤加工时，如果在温度对应力曲线上绘制时合金的特性可表示为UP =（0.66ksi /℃）（T），则所得合金表现出宽的超弹性温度操作窗口 + 0 其中R 2 = 0.98，其中s 0 0是合金在约0℃的上平台应力， SUP> 2 是确定系数，UP是合金的上平台应力。

公开(公告)号：WO2008141336A1

公开(公告)日：2008-11-20

申请号：PCT/US2008/063690

申请日：2008-05-15

Applicant: ABBOTT LABORATORIES ,  SIMPSON, John, A. ,  BOYLAN, John, F. ,  CORNISH, Wayne

Inventor： SIMPSON, John, A. ,  BOYLAN, John, F. ,  CORNISH, Wayne

IPC: A61F2/90

CPC classification number: A61F2/91 ,  A61F2250/0098

Abstract: There is disclosed medical devices, such as stents, guidewires and embolic filters, comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold. There is also disclosed a radiopaque marker comprising the disclosed binary alloy, as well as medical devices having the radiopaque marker attached thereto. Methods of attaching the radiopaque marker to the medical devices, such as by welding, are also disclosre also disclosed.

Abstract translation: 公开了包括钛的二元合金和选自铂，钯，铑和金的一种二元元素的医疗装置，例如支架，导丝和栓塞过滤器。 还公开了一种包括所公开的二元合金的不透射线标记，以及具有附着于其上的不透射线标记的医疗装置。 另外还公开了将不透射线标记物附接到医疗装置的方法，例如通过焊接。

公开(公告)号：WO2010141897A3

公开(公告)日：2011-03-03

申请号：PCT/US2010037511

申请日：2010-06-04

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  KRAMER-BROWN PAMELA A ,  BOYLAN JOHN F ,  VON OEPEN RANDOLF

Inventor： KRAMER-BROWN PAMELA A ,  BOYLAN JOHN F ,  VON OEPEN RANDOLF

IPC: A61L31/02 ,  C22C27/00 ,  C22C27/04

CPC classification number: A61L31/022 ,  C22C27/00

Abstract: A medical device such as, for example, an implantable expandable stent is constructed of a ternary alloy of molybdenum, rhenium, and a third metal. In a preferred embodiment, the third metal is a refractory metal selected to improve the ductility of the alloy. The alloy may further be advantageously constructed to have a crystal structure selected from HCP, BCC, FCC, and tetragonal to further optimize the physical characteristics of the medical device.

Abstract translation: 诸如例如可植入式可扩张支架的医疗装置由钼，铼和第三金属的三元合金构成。 在优选实施例中，第三金属是选择用于改善合金的延展性的难熔金属。 还可以有利地将合金构造成具有选自HCP，BCC，FCC和四方晶的晶体结构，以进一步优化医疗器件的物理特性。

公开(公告)号：WO2006081011A2

公开(公告)日：2006-08-03

申请号：PCT/US2005/046022

申请日：2005-12-20

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  BOYLAN, John, F. ,  LIN, Zhicheng ,  STALKER, Kent, C., B.

Inventor： BOYLAN, John, F. ,  LIN, Zhicheng ,  STALKER, Kent, C., B.

IPC: C22C14/00 ,  C22F1/00 ,  A61L31/02

CPC classification number: C22C30/00 ,  A61F2/915 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/18 ,  A61L2400/16 ,  C22C14/00 ,  C22C19/00 ,  C22F1/006

Abstract: A nickel-titanium alloy having a large, superelastic operating temperature window or range. The nickel-titanium alloy includes at least an additional element such as platinum, palladium, manganese, boron aluminum, tungsten, and/or zirconium. When processed through heat treat and area reduction steps, the resultant alloy exhibits a wide superelastic temperature operating window if the characteristics of the alloy when plotted on a temperature versus stress curve can be expresses as UP=(0.66ksi/°C)(T)+σ 0 , with R 2 ≥0.98, wherein σ 0 is the upper plateau stress of the alloy at about 0°C, R 2 is the coefficient of determination, and UP is the upper plateau stress of the alloy.

Abstract translation: 具有大的，超弹性的工作温度窗口或范围的镍钛合金。 镍 - 钛合金至少包括另外的元素，如铂，钯，锰，硼铝，钨和/或锆。 当通过热处理和面积缩小步骤加工时，如果在温度对应力曲线上绘制时合金的特性可表示为UP =（0.66ksi /℃）（T），则所得合金表现出宽的超弹性温度操作窗口 + 0 其中R 2 = 0.98，其中s 0 0是合金在约0℃的上平台应力， SUP> 2 是确定系数，UP是合金的上平台应力。