公开(公告)号：WO2019086684A1

公开(公告)日：2019-05-09

申请号：PCT/EP2018/080213

申请日：2018-11-05

申请人： CEROFLO LIMITED

发明人： ANDERSSON, Sven Tommy ,  BRADY, Eamon Oliver

IPC分类号： A61F2/90 ,  A61F2/91

CPC分类号： A61F2/90 ,  A61F2/91 ,  A61F2210/0014 ,  A61F2230/001 ,  A61F2250/0039

摘要： An expandable stent (1) to enhance the supply of blood to downstream tissue which is being supplied with blood through a diseased intracranial artery (100) with a stenosis (102) formed therein by plaque with a bore (103) therethrough. The expandable stent (1) comprises first and second end portions (3,4) joined by a central portion (5). The central portion (5) is configured in the expanded state of the stent (1) to be 10 located in the bore (103) of the stenosis (102) with the first and second end portions (3,4) abutting non- diseased parts (104,106) of the artery (100) adjacent the proximal and distal ends (105,107) of the stenosis (102) for anchoring the stent (1) in the artery (100). The central portion (5) with the stent (1) in the expanded state is configured to apply a radial outward pressure to the stenosis (102) such that the diameter of the bore (103) of the stenosis (102) is maintained at its current diameter or increased to 15 approximately 50% of the non-diseased parts (104,106) of the artery (100).

公开(公告)号：WO2019040372A1

公开(公告)日：2019-02-28

申请号：PCT/US2018/047097

申请日：2018-08-20

申请人： YALE UNIVERSITY

发明人： KURAL, Mehmet Hamdi ,  GUI, Liqiong ,  NIKLASON, Laura Elizabeth ,  SALTZMAN, William Mark

IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/90 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61F2/91 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/416 ,  A61M2025/105

摘要： The present invention provides compositions and devices that release (a) a nitric oxide (NO) donor and/or NO, and (b) an agent that aggregates and/or trimerizes the Fas receptor, such as but not limited to a Fas-ligand (FasL). In certain embodiments, the invention includes a stent that elutes (a) a NO donor and/or NO, and (b) FasL. In other embodiments, the invention includes methods of treating a condition, such as intimal hyperplasia, in a subject by administering a stent that releases (a) a NO donor and/or NO, and (b) FasL.

公开(公告)号：WO2017035372A1

公开(公告)日：2017-03-02

申请号：PCT/US2016/048729

申请日：2016-08-25

申请人： INNOVEIN, INC.

发明人： CHIN, Albert K. ,  WALKER, Austin ,  KRAMER, Thomas A.

IPC分类号： A61F2/00 ,  A61F2/01 ,  A61F2/02 ,  A61F2/04 ,  A61F2/06 ,  A61F2/07 ,  A61F2/24

CPC分类号： A61F2/2475 ,  A61F2/91 ,  A61F2/966 ,  A61F2230/001 ,  A61F2250/0039 ,  A61F2250/0067

摘要： A venous valve prosthetic implant for treatment of venous disease may include an expandable anchoring frame, a valve seat attached to the anchoring frame, a ball retention member attached to the anchoring frame, and a ball disposed within the lumen of the anchoring frame, between the valve seat and the ball retention member. The anchoring frame may include a first end, a second end, and a middle valve portion, where the middle valve portion expands to a smaller diameter than a diameter of either the first end or the second end. The ball may move back and forth within the middle valve portion, between a fully open position and a fully closed position.

摘要翻译： 用于治疗静脉疾病的静脉瓣膜假体植入物可以包括可膨胀锚固框架，附接到锚固框架的阀座，附接到锚固框架的球保持构件和设置在锚定框架的内腔内的球之间 阀座和球保持构件。 锚固框架可以包括第一端，第二端和中间阀部分，其中中间阀部分扩展到比第一端或第二端的直径小的直径。 球可以在中间阀部分内，在完全打开位置和完全关闭位置之间来回移动。

公开(公告)号：WO2016186262A1

公开(公告)日：2016-11-24

申请号：PCT/KR2015/009900

申请日：2015-09-21

申请人： (주)시지바이오 ,  재단법인 아산사회복지재단

发明人： 김한기 ,  유현승 ,  서준혁 ,  박준규 ,  송석범 ,  금창헌 ,  조재화 ,  진규현 ,  이덕희 ,  황선문 ,  김태일 ,  임옥균 ,  이가영

IPC分类号： A61F2/88 ,  A61F2/90 ,  A61F2/82

CPC分类号： A61F2/88 ,  A61F2/07 ,  A61F2/82 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/828

摘要： 하이브리드 스텐트는, 사선으로 배열되되, 일정거리 이격되어 배열된 복수의 제1링크부와, 상기 복수의 제1링크부 중 인접한 제1링크부를 연결하되 일정거리 이격되어 배열되는 복수의 제2링크부를 포함하고, 나선형상으로 배열되는 복수의 메인셀과, 상기 복수의 메인셀에 대하여 길이방향으로 이웃하여 나선형상으로 배열되는 하나 이상의 오픈셀을 포함할 수 있다.

摘要翻译： 混合支架可以包括：多个主单元，其被螺旋地布置，并且包括多个第一链接单元，其以对角线并且以预定距离分开排列;以及多个第二链接单元，其将相邻的第一链接单元 多个第一链接单元，并且以预定距离分开布置; 以及一个或多个相对于多个主电池在纵向相邻地螺旋地布置的开放电池。

公开(公告)号：WO2016141215A1

公开(公告)日：2016-09-09

申请号：PCT/US2016/020743

申请日：2016-03-03

申请人： EFEMORAL MEDICAL LLC ,  SCHWARTZ, Lewis B. ,  ORR, Gregory ,  SANTOS, Jayson Delos ,  HAIG, Christopher

发明人： SCHWARTZ, Lewis B. ,  ORR, Gregory ,  SANTOS, Jayson Delos ,  HAIG, Christopher

IPC分类号： A61F2/90 ,  A61F2/958

CPC分类号： A61F2/91 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/826 ,  A61F2210/0004 ,  A61F2230/0017 ,  A61F2230/0026 ,  A61F2240/001 ,  A61F2250/0012 ,  A61F2250/0018 ,  A61F2250/0023 ,  A61F2250/0036 ,  A61F2250/0067 ,  B29C64/135 ,  B29C64/30 ,  B29K2067/046 ,  B29K2995/006 ,  B29L2031/7534 ,  B33Y10/00 ,  B33Y80/00

摘要： A multi-element, bioresorbable, vascular stent may be used to maintain or enhance patency of a blood vessel. The stent may be used in peripheral blood vessels, which may be long and/or tortuous. By using multiple, separate stent elements that are balloon expandable, the multi- element stent may be stronger than a traditional self-expanding stent but may also be more flexible, due to its multiple-element configuration, than a traditional balloon-expandable stent. Thus, the multi-element, bioresorbable, vascular stent described herein may be particularly advantageous for treating long lesions in tortuous peripheral blood vessels.

摘要翻译： 可以使用多元素，生物可再吸收的血管支架来维持或增强血管的通畅。 支架可以用于外周血管，其可以是长的和/或曲折的。 通过使用球囊可扩张的多个独立的支架元件，多元支架​​可能比传统的自扩张支架更坚固，但由于其多元件构型，传统的自扩张支架可能比传统的球囊可扩张支架更灵活。 因此，本文描述的多元素，生物可再吸收的血管支架对于治疗曲折的外周血管中的长的损伤可能是特别有利的。

公开(公告)号：WO2016098113A1

公开(公告)日：2016-06-23

申请号：PCT/IL2015/051221

申请日：2015-12-16

申请人： ENDOSPAN LTD.

发明人： MARMUR, Yaniv ,  NAE, Nir Shalom ,  SHALEV, Alon

IPC分类号： A61F2/07

CPC分类号： A61F2/91 ,  A61F2/07 ,  A61F2/848 ,  A61F2/89 ,  A61F2002/061

摘要： A stent-graft (20) comprises strut members (30) and a graft member (32), which is fixed to the strut members (30). The strut members (30) and the graft member (32) are arranged so as to define, when the stent-graft (20) is in a radially-expanded state: a main tube (40), which is shaped so as to define a main lumen (42); and a lateral tube (50), which (a) has (i) a distal end (52) and (ii) a proximal end (54) that is joined to a lateral wall (56) of the main tube (40) at a junction (60), (b) is shaped so as to define a lateral lumen (62) that is in fluid communication with the main lumen (42), and (c) defines a central longitudinal axis (64). The strut members (30) that define the lateral tube (50) are shaped so as to define two to four non-contiguous arcuate members (70), which (a) are centered around the central longitudinal axis (64), and (b) collectively subtend at least 150 degrees around the central longitudinal axis (64).

摘要翻译： 支架移植物（20）包括固定到支柱构件（30）上的支柱构件（30）和移植构件（32）。 支架构件（30）和移植构件（32）布置成当支架移植物（20）处于径向展开状态时限定：主管（40），其被成形为限定 主管腔（42）; 和侧管（50），其中（a）具有（i）远端（52）和（ii）接近主管（40）的侧壁（56）的近端（54） （60），（b）成形为限定与主腔（42）流体连通的侧腔（62），（c）限定中心纵向轴线（64）。 限定侧管（50）的支柱构件（30）成形为限定两个至四个不连续的弓形构件（70），其中（a）围绕中心纵向轴线（64）居中，并且（b ）围绕中心纵向轴线（64）共同对向至少150度。

公开(公告)号：WO2015195794A4

公开(公告)日：2016-04-07

申请号：PCT/US2015036216

申请日：2015-06-17

申请人： ABBOTT CARDIOVASCULAR SYSTEMS

发明人： MA XIAO ,  KOSSUTH MARY BETH ,  OBERHAUSER JAMES ,  PACETTI STEPHEN D ,  GADA MANISH

IPC分类号： A61L31/04 ,  A61L31/06

CPC分类号： A61F2/90 ,  A61F2/91 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148

摘要： Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having thin struts in a selected range and sufficient radial strength to support a vessel upon deployment are disclosed. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.

摘要翻译： 公开了由具有选定范围的薄支柱的聚丙交酯和聚己内酯的组合制成的生物再吸收聚合物血管支架，并具有足够的径向强度以在展开时支撑血管。 支架具有有助于血管愈合的分子量，径向强度和质量的降解行为，包括向容器提供通畅性，降低径向强度，分解和再吸收以允许血管返回到自然状态。

公开(公告)号：WO2015195794A3

公开(公告)日：2016-02-11

申请号：PCT/US2015036216

申请日：2015-06-17

申请人： ABBOTT CARDIOVASCULAR SYSTEMS

发明人： MA XIAO ,  KOSSUTH MARY BETH ,  OBERHAUSER JAMES ,  PACETTI STEPHEN D ,  GADA MANISH

IPC分类号： A61L31/04 ,  A61L31/06

CPC分类号： A61F2/90 ,  A61F2/91 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148

摘要： Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having thin struts in a selected range and sufficient radial strength to support a vessel upon deployment are disclosed. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.

摘要翻译： 公开了由聚丙交酯和聚己内酯的组合制成的生物可吸收性聚合物血管支架，其具有选定范围内的细支柱和足够的径向强度以在部署时支撑血管。 支架具有有助于血管愈合的分子量，径向强度和质量的降解行为，包括为血管提供通畅性，减小径向强度，分解和再吸收以允许血管返回自然状态。

公开(公告)号：WO2013184183A3

公开(公告)日：2015-11-19

申请号：PCT/US2013027504

申请日：2013-02-22

申请人： ABBOTT CARDIOVASCULAR SYSTEMS

发明人： GREEN MICHAEL LEE

IPC分类号： B29C55/24 ,  A61F2/915

CPC分类号： A61F2/915 ,  A61B2017/00526 ,  A61B2017/00867 ,  A61F2/86 ,  A61F2/91 ,  A61F2210/0019 ,  A61F2240/001 ,  B21D39/20 ,  B29C55/24 ,  B29C71/02 ,  B29L2023/007

摘要： A system and method for manufacturing a medical device. The system can include a thermal chamber and an expander at least partially positioned within the thermal chamber. The expander can be configured to uniformly expand a medical device as the medical device is advanced over the heated expander and heat set the expanded medical device while the medical device is positioned on the heated expander. The method can include forming a medical device from a tube having a first diameter; uniformly expanding the medical device from the first diameter to a second diameter at which the medical device can be left within a body vessel, the medical device being expanded from the first diameter to the second diameter while being continuously positioned on an expander; and heat setting the expanded medical device at the second diameter while the medical device is positioned on the expander.

摘要翻译： 一种用于制造医疗装置的系统和方法。 该系统可以包括至少部分地定位在热室内的热室和膨胀器。 当医疗装置在加热的膨胀机上行进时，膨胀机可以构造成均匀地膨胀医疗装置，并且在将医疗装置定位在加热的膨胀器上的同时对膨胀的医疗装置进行加热。 该方法可以包括从具有第一直径的管形成医疗装置; 将医疗装置从第一直径均匀地扩展到第二直径，医疗装置可以在该第二直径处留置在体内容器内，医疗装置从第一直径膨胀到第二直径，同时连续地定位在膨胀机上; 以及当所述医疗装置位于所述扩张器上时将所述扩张的医疗装置热定形在所述第二直径处。

公开(公告)号：WO2015160974A1

公开(公告)日：2015-10-22

申请号：PCT/US2015/026007

申请日：2015-04-15

申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.

发明人： CONSIGNY, Paul ,  ELI, Erik ,  PACETTI, Stephen D. ,  TROLLSAS, Mikael ,  STANKUS, John ,  FOX, Julia

IPC分类号： A61F2/82 ,  A61F2/954 ,  A61B17/11

CPC分类号： A61B17/11 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61F2/064 ,  A61F2/848 ,  A61F2/856 ,  A61F2/89 ,  A61F2/91 ,  A61F2/954 ,  A61F2/958 ,  A61F2/966 ,  A61F2002/821 ,  A61F2002/828 ,  A61F2002/91575 ,  A61F2002/9583 ,  A61M1/3655

摘要： Medical devices and methods for forming an arteriovenous (AV) fistula include a stent (10) having an arterial tubular portion (12) and vein supporting tongue (16) connected by a pre-shaped connector (15) and a venous frustoconical stent (70) having a distal end for maintaining a take-off angle for the venous portion of the AV fistula. Also disclosed is an angled balloon (200) for assisting with the formation of the AV fistula. The medical devices disclosed herein support an AV fistula formation having a desired take off angle of about 30 degrees, or between about 15 and 45 degrees.

摘要翻译： 用于形成动静脉（AV）瘘的医疗装置和方法包括具有动脉管状部分（12）和通过预形连接器（15）和静脉截头圆锥形支架（70）连接的静脉支撑舌片（16）的支架（10） ）具有用于维持AV瘘静脉部分的起飞角度的远端。 还公开了一种用于协助形成AV瘘的成角度球囊（200）。 本文公开的医疗装置支持AV瘘形成，其具有约30度或约15度至45度的期望的脱离角度。