公开(公告)号：WO2018067788A1

公开(公告)日：2018-04-12

申请号：PCT/US2017/055282

申请日：2017-10-05

Applicant: VON OEPEN, Randolf ,  MCNIVEN, Sean A. ,  VALENCIA, Francisco

Inventor： VON OEPEN, Randolf ,  MCNIVEN, Sean A. ,  VALENCIA, Francisco

IPC: A61B17/00 ,  A61F2/24 ,  A61M25/00 ,  A61M25/01

Abstract: The present disclosure describes devices, systems, and methods for loading, delivering, positioning, and deploying an artificial heart valve device at the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly. The valve device is attached at the distal end of the delivery member, and is constrained within a valve cover of an outer sheath. A delivery catheter is configured to advance the valve relative to the outer sheath, and a suture catheter includes sutures/tethers which maintain proximal tension on the valve prior to deployment.

Abstract translation: 本公开描述了用于在二尖瓣环处加载，递送，定位和部署人造心脏瓣膜装置的装置，系统和方法。 递送系统包括递送构件，递送构件联接到手柄组件并且从手柄组件向远侧延伸。 阀装置附接在输送构件的远端处，并被约束在外部护套的阀盖内。 输送导管被构造成相对于外鞘推进瓣膜，并且缝合导管包括在展开前保持瓣膜上的近端张力的缝合线/系绳。

公开(公告)号：WO2013055490A1

公开(公告)日：2013-04-18

申请号：PCT/US2012/055234

申请日：2012-09-13

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS, INC ,  BREGULLA, Rainer ,  VON OEPEN, Randolf ,  KRAMER-BROWN, Pamela, A. ,  LEACH, Austin, M.

Inventor： BREGULLA, Rainer ,  VON OEPEN, Randolf ,  KRAMER-BROWN, Pamela, A. ,  LEACH, Austin, M.

IPC: A61L31/02 ,  A61L31/10

CPC classification number: A61L31/088 ,  A61L31/022 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

Abstract: The present disclosure is directed to a drug-eluting implantable medical devices that includes a tantalum-alloy body having a drug-eluting coating thereon for delivering a drug to treat, for example, restenosis. In an embodiment, an implantable medical device includes a body sized and configured to be implanted in a living subject. At least a portion of the body may comprise a tantalum alloy. The tantalum alloy includes a tantalum content of about 77 weight % ("wt %") to about 92 wt %, a niobium content of about 7 wt % to about 13 wt %, and a tungsten content of about 1 wt % to about 10 wt %. The tantalum alloy exhibits at least one mechanical property modified by heat treatment thereof. The body has a drug-eluting coating thereon.

Abstract translation: 本公开涉及药物洗脱可植入医疗装置，其包括其上具有药物洗脱涂层的钽合金体，用于递送药物以治疗例如再狭窄。 在一个实施例中，可植入医疗装置包括尺寸和构造成植入生物体内的体。 身体的至少一部分可以包括钽合金。 钽合金包括约77重量％（“重量％”）至约92重量％的钽含量，约7重量％至约13重量％的铌含量和约1重量％至约10重量％的钨含量 重量％。 钽合金具有通过其热处理而改性的至少一种机械性能。 身体上有药物洗脱涂层。

公开(公告)号：WO2011094048A1

公开(公告)日：2011-08-04

申请号：PCT/US2011/020466

申请日：2011-01-07

Applicant: ABBOTT LABORATORIES ,  VON OEPEN, Randolf ,  YRIBARREN, Travis R.

Inventor： VON OEPEN, Randolf ,  YRIBARREN, Travis R.

IPC: A61F2/84 ,  A61F2/00

CPC classification number: A61F2/95 ,  A61F2/958 ,  A61F2/97 ,  A61F2002/9583 ,  A61F2250/0018

Abstract: A sheath assembly ( 10 ) is provided for protecting a stent (42) mounted on a catheter (40). An inner tubular member (30) having two longirudinal slits (16) is positioned over the stent without longitudinal movement of the inner tubular member along the stent surface thereby eliminating the possibility of scraping or scratching a drug coating or polymer coating on the stent surface or balloon surface. An outer tubular member (14) slides over the inner tubular member to hold it onto the stent for further protection. In use, the outer tubular member is removed from over the inner tubular member so that the two half - cylindrical portions of the inner tubular member can fall away from the stent without longitudinal movement along the stent surface.

Abstract translation: 提供护套组件（10），用于保护安装在导管（40）上的支架（42）。 具有两个长颈部狭缝（16）的内部管状构件（30）定位在支架上方，而不沿着支架表面纵向移动内部管状构件，从而消除刮擦或刮擦支架表面上的药物涂层或聚合物涂层的可能性， 气球表面。 外部管状构件（14）在内部管状构件上滑动以将其保持在支架上用于进一步保护。 在使用中，外部管状构件从内部管状构件上方移除，使得内部管状构件的两个半圆柱形部分可以从支架脱落而不沿着支架表面纵向移动。

公开(公告)号：WO2010141897A3

公开(公告)日：2011-03-03

申请号：PCT/US2010037511

申请日：2010-06-04

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  KRAMER-BROWN PAMELA A ,  BOYLAN JOHN F ,  VON OEPEN RANDOLF

Inventor： KRAMER-BROWN PAMELA A ,  BOYLAN JOHN F ,  VON OEPEN RANDOLF

IPC: A61L31/02 ,  C22C27/00 ,  C22C27/04

CPC classification number: A61L31/022 ,  C22C27/00

Abstract: A medical device such as, for example, an implantable expandable stent is constructed of a ternary alloy of molybdenum, rhenium, and a third metal. In a preferred embodiment, the third metal is a refractory metal selected to improve the ductility of the alloy. The alloy may further be advantageously constructed to have a crystal structure selected from HCP, BCC, FCC, and tetragonal to further optimize the physical characteristics of the medical device.

Abstract translation: 诸如例如可植入式可扩张支架的医疗装置由钼，铼和第三金属的三元合金构成。 在优选实施例中，第三金属是选择用于改善合金的延展性的难熔金属。 还可以有利地将合金构造成具有选自HCP，BCC，FCC和四方晶的晶体结构，以进一步优化医疗器件的物理特性。

公开(公告)号：WO2010111124A3

公开(公告)日：2010-11-18

申请号：PCT/US2010027878

申请日：2010-03-18

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  MAGANA JESUS ,  VON OEPEN RANDOLF ,  WEBLER JR WILLIAM E ,  BRADSHAW ALLAN ,  EHRENREICH KEVIN J

Inventor： MAGANA JESUS ,  VON OEPEN RANDOLF ,  WEBLER JR WILLIAM E ,  BRADSHAW ALLAN ,  EHRENREICH KEVIN J

IPC: A61F2/958 ,  B24C1/04 ,  B26F1/00 ,  B29C49/00

CPC classification number: A61M25/1027 ,  A61M25/007 ,  A61M25/1006 ,  A61M2025/0057 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1061 ,  A61M2025/1086 ,  B23K26/382 ,  B23K2201/04 ,  B23K2203/42 ,  B23K2203/50 ,  B24C1/045 ,  B26F1/31 ,  B29C49/00 ,  B29C49/08 ,  B29C67/0018 ,  B29C2049/0089 ,  B29C2793/0045 ,  B29K2027/06 ,  B29K2067/00 ,  B29K2105/258 ,  B29L2031/7542

Abstract: A porous balloon (14) or other catheter structure is formed by creating specific size pores (24) for delivering an agent to a body lumen (18). The pores can be created by passing matter or energy through the surface of the catheter structure, as by a laser (35) or a projectile (51). In the case of laser, the catheter structure can be reversed so that the inner surface becomes the outer surface to convert diverging pores into converging pores. In the case of projectiles, a pore size can be achieved by selecting an appropriate size and shaped projectile to obtain the desired characteristic. Alternatively, a material to make the catheter structure can include impurities (29,59) that can be removed once the catheter structure is set, leaving pores where the material formed around the impurities.

Abstract translation: 通过产生用于将药剂递送到体腔（18）的特定尺寸的孔（24）来形成多孔气囊（14）或其它导管结构。 可以通过将物质或能量通过导管结构的表面，如激光（35）或射弹（51）来产生孔。 在激光的情况下，导管结构可以反转，使得内表面变成外表面，以将发散的孔转化成会聚的孔。 在弹丸的情况下，可以通过选择合适的尺寸和成形的抛射体来获得孔径，以获得所需的特性。 或者，用于制造导管结构的材料可以包括杂质（29,59），其可以在导管结构设置后被去除，留下在杂质周围形成材料的孔。

公开(公告)号：WO2008024943A1

公开(公告)日：2008-02-28

申请号：PCT/US2007/076694

申请日：2007-08-23

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  VON OEPEN, Randolf ,  COFFEY, Lorcan, James ,  RIETH, Thomas ,  NEWHAUSER, Richard ,  YRIBARREN, Travis, Richard

Inventor： VON OEPEN, Randolf ,  COFFEY, Lorcan, James ,  RIETH, Thomas ,  NEWHAUSER, Richard ,  YRIBARREN, Travis, Richard

IPC: A61M25/10 ,  A61F2/06

CPC classification number: A61M25/1011 ,  A61F2/86 ,  A61F2/954 ,  A61F2/958 ,  A61F2002/065 ,  A61M25/0071 ,  A61M2025/018 ,  A61M2025/1045 ,  A61M2025/1081 ,  A61M2025/1093

Abstract: A system for delivering a medical device, such as an angioplasty balloon, includes two catheter shafts. The distal portion of a first shaft includes a first balloon and is narrower than the proximal portion. A second catheter shaft includes a second balloon and is connected to a medial portion of the first shaft. The second shaft includes a guidewire passageway which is in communication with the passwageway of a third shaft that is removablly connected to the first shaft. The distal tips of the first and second balloons are connected together to allow the system to be advanced to an anatommical site using a single guidewire. A second guidewire may be used to separate the distal ends of the balloons and to position the balloons at vascular bifurcation. A stent can be crimped onto the balloons such that inflation of the balloons implants the stent within the bifurcation.

Abstract translation: 用于递送诸如血管成形术气囊的医疗装置的系统包括两个导管轴。 第一轴的远侧部分包括第一球囊并且比近侧部分窄。 第二导管轴包括第二球囊并连接到第一轴的中间部分。 第二轴包括导丝通道，其与第三轴的通风道连通，第三轴可移除地连接到第一轴。 第一和第二气囊的远侧末端连接在一起，以允许系统使用单根导丝前进到一个使用场所。 可以使用第二导丝来分离气囊的远端并将气囊定位在血管分叉处。 支架可以卷曲到气囊上，使得气囊的充气将支架植入分叉内。

公开(公告)号：WO2007124496A3

公开(公告)日：2008-01-31

申请号：PCT/US2007067238

申请日：2007-04-23

Applicant: ABBOTT LAB ,  VON OEPEN RANDOLF ,  JACOBS JAMES M ,  NEWHAUSER RICHARD

Inventor： VON OEPEN RANDOLF ,  JACOBS JAMES M ,  NEWHAUSER RICHARD

IPC: A61M25/00 ,  A61M25/06

CPC classification number: A61M25/0029 ,  A61M25/0071 ,  A61M2025/0037 ,  A61M2025/0183 ,  A61M2025/107

Abstract: A dual lumen guidewire support catheter for accurately crossing a chronic total occlusion in a vessel is disclosed. The dual lumen guidewire support catheter includes a first lumen portion and a second lumen portion sharing a common side and a common distal end. The first lumen portion can be a rapid exchange or over-the-wire portion, while the second lumen portion is an over the wire portion. One or both of the portions can include a discontinuity to enable removal of a guidewire following placement through or at an occlusion or lesion.

Abstract translation: 公开了用于准确地穿过血管中的慢性完全闭塞的双腔导丝支撑导管。 所述双腔导丝支撑导管包括共享共同侧和共同远端的第一管腔部分和第二管腔部分。 第一管腔部分可以是快速交换或线上部分，而第二管腔部分在线部分之上。 这些部分中的一个或两个可以包括不连续性，以便能够在放置穿过或闭塞或损伤之后移除导丝。

公开(公告)号：WO2007124145A3

公开(公告)日：2008-01-31

申请号：PCT/US2007009817

申请日：2007-04-19

Applicant: ABBOTT LAB ,  VON OEPEN RANDOLF

Inventor： VON OEPEN RANDOLF

IPC: A61F2/06 ,  A61F2/82

CPC classification number: A61F2/856 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/825 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2230/0091 ,  A61F2250/006

Abstract: The present invention concerns a novel bifurcated (20) stent apparatus for use in treating lesions at or near a bifurcation point in bifurcated vessel. More particularly, a dedicated bifurcation stent apparatus is fabricated from a single tube structure for use in a bifurcated body vessel having a main lumen and a side lumen. The stent apparatus includes a first stent portion (26) comprised of a first stent pattern that is configured for radial expansion into a generally cylindrical main body. A second stent portion is integrally formed with the first stent portion, and includes a second stent pattern configured to form a first branch leg (31) and a second branch leg (32). Collectively, the first stent portion, and the branch legs form a crocodile cut shape. Each branch leg is of a cylindrical shell-shaped arc segment in a first condition, and each of the first branch leg and the second branch leg is patterned for manipulation and radial expansion, in a second condition, into a generally cylindrical first body and a generally cylindrical second body, respectively.

Abstract translation: 本发明涉及一种用于治疗分叉血管中分叉点处或附近的病变的新型分支（20）支架装置。 更具体地，专用分叉支架装置由用于具有主腔和侧腔的分叉体体容器中的单管结构制成。 支架装置包括第一支架部分（26），第一支架部分（26）由第一支架图案构成，其被配置为径向膨胀成大致圆柱形的主体。 第二支架部分与第一支架部分整体形成，并且包括构造成形成第一分支支腿（31）和第二分支支脚（32）的第二支架图案。 总的来说，第一支架部分和分支腿形成鳄鱼切割形状。 每个分支腿在第一状态下是圆柱形的壳形弧段，并且第一分支腿和第二分支腿中的每一个被图案化以在第二状态下进行操纵和径向膨胀，形成大致圆柱形的第一主体和 分别为大致圆柱形的第二体。

公开(公告)号：WO2007143288A2

公开(公告)日：2007-12-13

申请号：PCT/US2007067240

申请日：2007-04-23

Applicant: ABBOTT LAB ,  YRIBARREN TRAVIS ,  NEWHAUSER RICHARD ,  VON OEPEN RANDOLF ,  JACOBS JAMES M

Inventor： YRIBARREN TRAVIS ,  NEWHAUSER RICHARD ,  VON OEPEN RANDOLF ,  JACOBS JAMES M

CPC classification number: A61M25/10 ,  A61B2017/22038 ,  A61M5/007 ,  A61M5/14526 ,  A61M5/172 ,  A61M2025/0004 ,  A61M2025/0681 ,  A61M2025/1052

Abstract: A system for delivering a contrast medium to a treatment site including a delivery device, and a portable power injector. The delivery device includes a guidewire lumen and a contrast injection lumen, the guidewire lumen and contrast injection lumen being at least partially coaxial. The portable power injector includes an injector body and is configured to contain a contrast medium. The injector body has a plunger disposed therein. The portable power injector also includes a pressure generator, the pressure generator being configured to apply a pressure to the plunger to drive the contrast medium from the injector body and through a distal end of the contrast injection lumen.

Abstract translation: 一种用于将造影剂输送到包括输送装置和便携式动力注射器的治疗部位的系统。 输送装置包括导丝管腔和造影剂注射内腔，导丝管腔和造影剂注射腔至少部分同轴。 便携式动力注射器包括注射器主体并且构造成容纳造影剂。 喷射器主体具有设置在其中的柱塞。 便携式动力注射器还包括压力发生器，压力发生器被配置为向柱塞施加压力以从注射器主体和造影剂注射腔的远端驱动造影剂。

公开(公告)号：WO2007136647A2

公开(公告)日：2007-11-29

申请号：PCT/US2007011721

申请日：2007-05-15

Applicant: ABBOTT LAB ,  VON OEPEN RANDOLF ,  ZUCKER ARIK ,  YRIBARREN TRAVIS R ,  RIETH THOMAS ,  COFFEY LORCAN

Inventor： VON OEPEN RANDOLF ,  ZUCKER ARIK ,  YRIBARREN TRAVIS R ,  RIETH THOMAS ,  COFFEY LORCAN

IPC: A61F2/82

CPC classification number: A61F2/958 ,  A61F2002/821 ,  A61F2002/9586

Abstract: Disclosed are stent delivery apparatus (200) and methods for moving a balloon (204) catheter carrying a stent (206) through a body vessel without the stent slipping from the balloon are provided. In general, the stent delivery system includes a stent stopper (208, 408, 600) that impedes the stent from slipping from the balloon. The stent stopper is sized to serve as a barrier to the stent as it is carried on the balloon. In a specific embodiment, the stent stopper is formed from a material that encircles the proximal end of the balloon and abuts the proximal end of the stent. The stent stopper material expands with expansion of the balloon and collapses with deflation of the balloon. In some embodiments, the stent stopper material has a thickness (302, 502) that is about equal to or greater than the thickness of the stent so as to form a barrier against the stent and impede the stent from slipping off the proximal end of the balloon.

Abstract translation: 公开了支架输送装置（200）和用于移动携带支架（206）的球囊（204）穿过身体容器而没有支架从气囊滑落的方法。 通常，支架输送系统包括妨碍支架从气囊滑落的支架止动器（208,408,600）。 支架止动器的尺寸被设计成当支架承载在气囊上时用作支架的屏障。 在具体实施例中，支架止动器由围绕球囊的近端并邻接支架的近端的材料形成。 支架塞材料随气囊膨胀而膨胀，并伴随气囊的放气而塌陷。 在一些实施例中，支架止动器材料具有大约等于或大于支架厚度的厚度（302,502），以便形成抵靠支架的阻挡层并阻止支架从所述支架的近端滑落 气球。