公开(公告)号：WO9633214A3

公开(公告)日：1996-12-27

申请号：PCT/US9605441

申请日：1996-04-18

Applicant: UNIV CALIFORNIA ,  FISHER SUSAN J ,  GENBACEV OLGA ,  FOULK RUSSELL ,  CLAUSER KARL R ,  BURLINGAME ALAMA L

Inventor： FISHER SUSAN J ,  GENBACEV OLGA ,  FOULK RUSSELL ,  CLAUSER KARL R ,  BURLINGAME ALAMA L

IPC: G01N33/15 ,  C07K14/47 ,  C07K14/775 ,  C12N5/073 ,  G01N33/569 ,  G01N33/68 ,  C12N5/08 ,  G01N33/574 ,  G01N33/92

CPC classification number: C07K14/47 ,  C07K14/4715 ,  C07K14/775 ,  C12N5/0605 ,  C12N2500/02 ,  G01N33/56966 ,  G01N33/689 ,  G01N2800/36

Abstract: This invention is the discovery that hypoxic mammalian fetal trophoblast cells are a valid model of abnormal maternal plancental function and of other invasive cell types. The trophoblast cells differentially express a number of proteins when grown under hypoxic conditions. These proteins are useful for determining the health of the trophoblasts, the condition of a maternal placental interface and the invasive properties of metastatic and other invasive cell types. The hypoxic cytotrophoblast cells provide a convenient means to isolate these proteins and develope assay kits based upon the presence or absence of the proteins in a human test sample.

公开(公告)号：WO1996033214A2

公开(公告)日：1996-10-24

申请号：PCT/US1996005441

申请日：1996-04-18

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  FISHER, Susan, J. ,  GENBACEV, Olga ,  FOULK, Russell ,  CLAUSER, Karl, R. ,  BURLINGAME, Alama, L.

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

IPC: C07K14/47

CPC classification number: C07K14/47 ,  C07K14/4715 ,  C07K14/775 ,  C12N5/0605 ,  C12N2500/02 ,  G01N33/56966 ,  G01N33/689 ,  G01N2800/36

Abstract: This invention is the discovery that hypoxic mammalian fetal trophoblast cells are a valid model of abnormal maternal plancental function and of other invasive cell types. The trophoblast cells differentially express a number of proteins when grown under hypoxic conditions. These proteins are useful for determining the health of the trophoblasts, the condition of a maternal placental interface and the invasive properties of metastatic and other invasive cell types. The hypoxic cytotrophoblast cells provide a convenient means to isolate these proteins and develope assay kits based upon the presence or absence of the proteins in a human test sample.

Abstract translation: 本发明是缺氧哺乳动物胎儿滋养层细胞是母体平面功能异常和其他浸润细胞类型的有效模型的发现。 当在缺氧条件下生长时，滋养层细胞差异表达许多蛋白质。 这些蛋白质可用于确定滋养层的健康状况，母体胎盘界面的状况以及转移性和其他侵入性细胞类型的侵入性质。 缺氧细胞滋养层细胞提供了一种方便的手段来分离这些蛋白质，并且基于人类测试样品中存在或不存在蛋白质开发测定试剂盒。