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1.发明申请PROCESSES USING AMINO ACID DEHYDROGENASES AND KETOREDUCTASE-BASED COFACTOR REGENERATING SYSTEM 审中-公开使用氨基酸脱氢酶和基于结构酶的辅酶再生系统的过程
公开(公告)号：WO2011100265A2
公开(公告)日：2011-08-18
申请号：PCT/US2011/024102
申请日：2011-02-08
CPC分类号： C12P41/007 , C12N9/0004 , C12N9/0006 , C12N9/0016 , C12P7/40 , C12P13/04 , C12P13/06 , C12Y101/00 , C12Y101/01 , C12Y104/01009 , C12Y104/99001
摘要： The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase.
摘要翻译： 本公开涉及氨基酸脱氢酶与包含酮还原酶的辅因子再生系统的组合的用途。 在具体的实施方案中，该方法可以用于使用亮氨酸脱氢酶制备L-叔亮氨酸。
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公开(公告)号：WO2013036861A8
公开(公告)日：2013-03-14
申请号：PCT/US2012/054300
申请日：2012-09-07
申请人： CODEXIS, INC , CABIROL, Fabien, L. , CHEN, Haibin , GOHEL, Anupam , SALIM, Paulina , SMITH, Derek , JANEY, Jacob , KOSJEK, Birgit , TANG, Weng, Lin , HSIEH, Helen , PHAM, Son
发明人： CABIROL, Fabien, L. , CHEN, Haibin , GOHEL, Anupam , SALIM, Paulina , SMITH, Derek , JANEY, Jacob , KOSJEK, Birgit , TANG, Weng, Lin , HSIEH, Helen , PHAM, Son
IPC分类号： C07K14/435
摘要： The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.
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3.发明申请BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE 审中-公开（1R，2R）-2-（3,4-二甲氧基苯基）环己烷胺的合成的生物化学和方法
公开(公告)号：WO2012024104A3
公开(公告)日：2012-05-18
申请号：PCT/US2011046932
申请日：2011-08-08
申请人： CODEXIS INC , CABIROL FABIEN L , GOHEL ANUPAM , COLLIER STEVEN J , LIANG JACK , MOCK MARISSA , MUNDORFF EMILY , NOVICK SCOTT , LIMANTO JOHN , SMITH DEREK , BEUTNER GREGORY , KLAPARS ARTIS , ASHLEY ERIC , STROTMAN HALLENA , TRUPPO MATTHEW , HUGHES GREGORY , GRAU BRENDAN , JANEY JACOB
发明人： CABIROL FABIEN L , GOHEL ANUPAM , COLLIER STEVEN J , LIANG JACK , MOCK MARISSA , MUNDORFF EMILY , NOVICK SCOTT , LIMANTO JOHN , SMITH DEREK , BEUTNER GREGORY , KLAPARS ARTIS , ASHLEY ERIC , STROTMAN HALLENA , TRUPPO MATTHEW , HUGHES GREGORY , GRAU BRENDAN , JANEY JACOB
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译： 本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成至少2:1非对映异构体的反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽 比例相对于顺式非对映异构体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺。 本公开还提供了多核苷酸，载体，宿主细胞以及在制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的方法，产物化合物可以是 进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。
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4.发明申请PROCESSES USING AMINO ACID DEHYDROGENASES AND KETOREDUCTASE-BASED COFACTOR REGENERATING SYSTEM 审中-公开使用氨基酸脱氢酶和基于糖的蔗糖酶的再生系统的方法
公开(公告)号：WO2011100265A3
公开(公告)日：2011-12-29
申请号：PCT/US2011024102
申请日：2011-02-08
CPC分类号： C12P41/007 , C12N9/0004 , C12N9/0006 , C12N9/0016 , C12P7/40 , C12P13/04 , C12P13/06 , C12Y101/00 , C12Y101/01 , C12Y104/01009 , C12Y104/99001
摘要： The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase.
摘要翻译： 本公开涉及氨基酸脱氢酶与包含酮还原酶的辅因子再生系统的组合的用途。 在具体实施方案中，该方法可用于使用亮氨酸脱氢酶制备L-叔亮氨酸。
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5.发明申请
公开(公告)号：WO2013036861A1
公开(公告)日：2013-03-14
申请号：PCT/US2012054300
申请日：2012-09-07
申请人： CODEXIS INC , CABIROL FABIEN L , CHEN HAIBIN , GOHEL ANUPAM , SALIM PAULINA , SMITH DEREK , JANEY JACOB , KOSJEK BIRGIT , TANG WENG LIN , HSIEN HELEN , PHAM SON
发明人： CABIROL FABIEN L , CHEN HAIBIN , GOHEL ANUPAM , SALIM PAULINA , SMITH DEREK , JANEY JACOB , KOSJEK BIRGIT , TANG WENG LIN , HSIEN HELEN , PHAM SON
IPC分类号： C07K14/435
CPC分类号： C12N9/1096 , C07D211/76 , C12P13/001 , C12P13/005 , C12P17/12 , C12Y206/01
摘要： The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.
摘要翻译： 本公开涉及能够胺化二羰基底物的转氨酶多肽，以及多核苷酸，载体，宿主细胞，以及制备和使用转氨酶多肽的方法。
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6.发明申请BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE 审中-公开生物催化剂和（1R，2R）-2-（3,4-二甲氧基苯氧基）环己胺合成方法
公开(公告)号：WO2012024104A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/046932
申请日：2011-08-08
申请人： CODEXIS, INC. , CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
发明人： CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译： 本公开提供能够将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽 以相对于顺式非对映异构体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺至少2:1的非对映异构体比例。 本公开还提供了用于制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的多核苷酸，载体，宿主细胞和方法， 进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。
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