公开(公告)号：WO2011028603A3

公开(公告)日：2011-03-10

申请号：PCT/US2010/046794

申请日：2010-08-26

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  ROBERTS, William, W. ,  HALL, Timothy, L. ,  CAIN, Charles, A. ,  FOWLKES, J., Brian ,  XU, Zhen ,  KUSNER, Michael, Thomas, Jr. ,  TEOFILOVIC, Dejan

发明人： ROBERTS, William, W. ,  HALL, Timothy, L. ,  CAIN, Charles, A. ,  FOWLKES, J., Brian ,  XU, Zhen ,  KUSNER, Michael, Thomas, Jr. ,  TEOFILOVIC, Dejan

IPC分类号： A61N7/00 ,  A61B8/00 ,  A61B8/13 ,  B25J7/00

摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

公开(公告)号：WO2009094554A3

公开(公告)日：2009-10-15

申请号：PCT/US2009031857

申请日：2009-01-23

申请人： UNIV MICHIGAN ,  MAXWELL ADAM ,  XU ZHEN ,  GURM HITINDER S ,  CAIN CHARLES A

发明人： MAXWELL ADAM ,  XU ZHEN ,  GURM HITINDER S ,  CAIN CHARLES A

IPC分类号： A61N7/00 ,  A61B18/18

CPC分类号： A61N7/02 ,  A61B2017/22001

摘要： Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as 'Thrombolysis.'

摘要翻译： 在一些实施方式中，使用一个或多个超声换能器来执行利用超声进行非侵入性溶栓的方法，以将高强度超声波束聚焦或放置到血块（血栓）或其他血管夹杂物或闭塞物（例如，透析移植物中的凝块 ，深静脉血栓形成，浅静脉血栓形成，动脉栓塞，旁路移植物血栓形成或栓塞，肺栓塞），它们将通过超声波能量被消融（侵蚀，机械分馏，液化或溶解）。 该过程可以采用一种或多种机制，例如根据所选声学参数的空化，声化学，机械分馏或热过程。 此一般过程（包括本文所述的应用的例子）此后称为“血栓溶解”。

公开(公告)号：WO2009094554A2

公开(公告)日：2009-07-30

申请号：PCT/US2009/031857

申请日：2009-01-23

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  MAXWELL, Adam ,  XU, Zhen ,  GURM, Hitinder S. ,  CAIN, Charles A.

发明人： MAXWELL, Adam ,  XU, Zhen ,  GURM, Hitinder S. ,  CAIN, Charles A.

IPC分类号： A61N7/00 ,  A61B18/18

CPC分类号： A61N7/02 ,  A61B2017/22001

摘要： Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as 'Thrombolysis.'

摘要翻译： 在一些实施例中，使用一个或多个超声换能器进行非侵入性溶栓治疗的方法，以将高强度超声波束聚焦或放置在血块（血栓）或其它血管夹层或闭塞（例如，透析移植物中的凝块） ，深静脉血栓形成，浅静脉血栓形成，动脉栓塞，旁路移植物血栓形成或栓塞，肺栓塞），其将被超声能量消融（侵蚀，机械分级，液化或溶解）。 根据所选择的声学参数，该方法可采用一种或多种机制，例如空化，声化学，机械分级或热过程。 这个通用方法，包括本文所述的应用实例，以下称为“溶栓”。

公开(公告)号：WO2007038160A3

公开(公告)日：2009-04-16

申请号：PCT/US2006036721

申请日：2006-09-20

申请人： UNIV MICHIGAN ,  CAIN CHARLES A ,  FOWLKES J BRIAN ,  XU ZHEN ,  HALL TIMOTHY L

发明人： CAIN CHARLES A ,  FOWLKES J BRIAN ,  XU ZHEN ,  HALL TIMOTHY L

IPC分类号： A61B8/00

CPC分类号： A61M37/0092 ,  A61B8/00 ,  A61B8/485 ,  A61B17/22004 ,  A61B2017/22088 ,  A61B2017/22089

摘要： Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial- temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.

摘要翻译： 使用脉冲空化超声治疗的治疗方法可以包括组织过程的起始，维持，治疗和反馈的子过程，其涉及创建和维护微泡组合以及反馈的使用，以便基于观察到的空间来优化过程 - 时间泡沫云动态。 该方法提供了组织的细分或侵蚀，组织的液化以及增强的治疗剂的递送。 各种反馈机制允许超声参数的变化并且提供对脉冲空化过程的控制，允许该过程针对多个应用进行调整。 这样的应用可以包括特定的组织侵蚀，本体组织均质化和跨越障碍物的治疗剂的递送。

公开(公告)号：WO2008143998A1

公开(公告)日：2008-11-27

申请号：PCT/US2008/006327

申请日：2008-05-16

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  CAIN, Charles, A. ,  XU, Zhen ,  FOWLKES, J., Brian ,  HALL, Timothy, L. ,  ROBERTS, William, W.

发明人： CAIN, Charles, A. ,  XU, Zhen ,  FOWLKES, J., Brian ,  HALL, Timothy, L. ,  ROBERTS, William, W.

IPC分类号： A61B8/00 ,  A61B17/22

CPC分类号： A61B17/22004 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B8/4272 ,  A61B8/485 ,  A61B17/225 ,  A61B2017/00154 ,  A61B2017/00172 ,  A61B2017/22008 ,  A61B2017/22088 ,  A61B2017/22089 ,  A61B2090/378 ,  A61M37/0092

摘要： Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and/or the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.

摘要翻译： 使用脉冲空化超声治疗的治疗方法可以包括组织过程的起始，维持，治疗和反馈的子过程，其涉及创建和维护微泡组合以及反馈的使用，以便基于观察到的空间来优化过程 - 时空泡云动力学。 这些方法提供组织的细分或侵蚀，组织液化和/或治疗剂的增强递送。 各种反馈机制允许超声参数的变化并且提供对脉冲空化过程的控制，允许该过程针对多个应用进行调整。 这样的应用可以包括特定的组织侵蚀，本体组织均质化和跨越障碍物的治疗剂的递送。

公开(公告)号：WO2011028603A2

公开(公告)日：2011-03-10

申请号：PCT/US2010046794

申请日：2010-08-26

申请人： UNIV MICHIGAN ,  ROBERTS WILLIAM W ,  HALL TIMOTHY L ,  CAIN CHARLES A ,  FOWLKES J BRIAN ,  XU ZHEN ,  KUSNER MICHAEL THOMAS JR ,  TEOFILOVIC DEJAN

发明人： ROBERTS WILLIAM W ,  HALL TIMOTHY L ,  CAIN CHARLES A ,  FOWLKES J BRIAN ,  XU ZHEN ,  KUSNER MICHAEL THOMAS JR ,  TEOFILOVIC DEJAN

IPC分类号： A61N7/00 ,  A61B8/00 ,  A61B8/13 ,  B25J7/00

CPC分类号： A61N7/02 ,  A61B8/12 ,  A61B8/4218 ,  A61B34/72 ,  A61B90/50 ,  A61B2017/22008 ,  A61B2090/378

摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

摘要翻译： 提供了可以包括许多特征中的任何一个的医学成像和治疗装置。 该装置的一个特点是可以对目标组织体积进行成像，并将超声能量应用于目标组织体积。 在一些实施例中，医疗成像和治疗装置被配置为可控制地将超声能量施加到前列腺中，通过维持由成像系统产生的前列腺图像内的超声治疗系统产生的空泡气泡云。 医学成像和治疗装置可用于治疗应用，例如组织切除术，碎石术和HIFU。 还涉及与使用医学成像和治疗装置相关的方法。

公开(公告)号：WO2007038160A2

公开(公告)日：2007-04-05

申请号：PCT/US2006/036721

申请日：2006-09-20

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  CAIN, Charles A. ,  FOWLKES, J. Brian ,  XU, Zhen ,  HALL, Timothy L.

发明人： CAIN, Charles A. ,  FOWLKES, J. Brian ,  XU, Zhen ,  HALL, Timothy L.

IPC分类号： A61B8/00

CPC分类号： A61M37/0092 ,  A61B8/00 ,  A61B8/485 ,  A61B17/22004 ,  A61B2017/22088 ,  A61B2017/22089

摘要： Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial- temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.

摘要翻译： 使用脉冲空化超声治疗的治疗方法可以包括组织过程的起始，维持，治疗和反馈的子过程，其涉及创建和维护微泡组合以及反馈的使用，以便基于观察到的空间来优化过程 - 时间泡沫云动态。 该方法提供了组织的细分或侵蚀，组织的液化以及增强的治疗剂的递送。 各种反馈机制允许超声参数的变化并且提供对脉冲空化过程的控制，允许该过程针对多个应用进行调整。 这样的应用可以包括特定的组织侵蚀，本体组织均质化和跨越障碍物的治疗剂的递送。

公开(公告)号：WO2011028609A3

公开(公告)日：2011-06-16

申请号：PCT/US2010046810

申请日：2010-08-26

申请人： UNIV MICHIGAN ,  CAIN CHARLES A ,  HALL TIMOTHY L ,  ROBERTS WILLIAM R ,  XU ZHEN ,  FOWLKES J BRIAN ,  DAVISON THOMAS W

发明人： CAIN CHARLES A ,  HALL TIMOTHY L ,  ROBERTS WILLIAM R ,  XU ZHEN ,  FOWLKES J BRIAN ,  DAVISON THOMAS W

IPC分类号： A61B17/225 ,  A61B6/12 ,  A61B8/00 ,  A61B18/26

CPC分类号： A61N7/00 ,  A61B8/00 ,  A61B17/225 ,  A61B17/2256 ,  A61B2017/00172 ,  A61B2017/22008 ,  A61B2090/378

摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.

摘要翻译： 提供了可以包括许多特征中的任何一个的医学成像和治疗装置。 该装置的一个特征是它可以向病人提供Lithotripsy治疗，以便分泌尿石。 该装置的另一个特征是可以将Histotripsy治疗方法提供给患者，以便侵蚀尿石。 在一些实施例中，医学成像和治疗装置被配置为在治疗期间靶向和跟踪患者的尿石。 还涉及与使用医学成像和治疗装置相关的方法。

公开(公告)号：WO2011028609A2

公开(公告)日：2011-03-10

申请号：PCT/US2010/046810

申请日：2010-08-26

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  CAIN, Charles A. ,  HALL, Timothy L. ,  ROBERTS, William R. ,  XU, Zhen ,  FOWLKES, J. Brian ,  DAVISON, Thomas W.

发明人： CAIN, Charles A. ,  HALL, Timothy L. ,  ROBERTS, William R. ,  XU, Zhen ,  FOWLKES, J. Brian ,  DAVISON, Thomas W.

IPC分类号： A61B17/225 ,  A61B18/26 ,  A61B6/12 ,  A61B8/00

CPC分类号： A61N7/00 ,  A61B8/00 ,  A61B17/225 ,  A61B17/2256 ,  A61B2017/00172 ,  A61B2017/22008 ,  A61B2090/378

摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.

摘要翻译： 提供了一种医学成像和治疗设备，其可以包括许多特征中的任何特征。 该装置的一个特点是它可以为患者提供碎石治疗，以便分泌尿道结石。 该装置的另一个特点是它可以为病人提供组织治疗疗法，从而消除泌尿系结石。 在一些实施例中，医疗成像和治疗装置被配置为在治疗期间靶向和追踪患者的泌尿结石。 还包括与使用医疗成像和治疗设备相关的方法。