公开(公告)号：WO1993006451A1

公开(公告)日：1993-04-01

申请号：PCT/US1992007796

申请日：1992-09-15

Applicant: CETAC TECHNOLOGIES INCORPORATED ,  ZHU, Jianzhong ,  SUTTON, John, E.

Inventor： CETAC TECHNOLOGIES INCORPORATED

IPC: G01N01/28

CPC classification number: H01J49/04

Abstract: An efficient sample introduction system (10, 40) and method of use, for accepting liquid sample solutions (4LC), nebulizing them to form nebulized sample solution droplets, and introducing the nebulized sample solution droplets (4SD) to sample analysis systems (11, 41) is disclosed. In the preferred embodiment desolvation of produced nebulized sample solution droplets, and solvent removal, to provide nebulized sample particles (4SP) is performed prior to entering sample to a sample analysis system (11). Nebulization of sample solutions is accomplished by use of high efficiency ultrasonic nebulizers (2) and solvent removal is accomplished by use of high efficiency enclosed filter and solvent vapor removal gas flow or low temperature condenser systems (8, 48). The sample introduction system provides improved sample solution nebulization, desolvation and solvent removal, as well as reduced sample loss and carry-over of sample from one analysis procedure to a subsequent analysis procedure, as compared to other systems which perform a similar overall function.

公开(公告)号：WO1993014515A1

公开(公告)日：1993-07-22

申请号：PCT/US1992011097

申请日：1992-12-18

Applicant: CETAC TECHNOLOGIES INCORPORATED ,  ZHU, Jianzhong

Inventor： CETAC TECHNOLOGIES INCORPORATED

IPC: H01J49/04

CPC classification number: H01J49/105 ,  H01J49/04

Abstract: A system and method of use for analyzing samples in mass spectrometers (14MS) using afterglow metastable species (AG) at atmospheric pressure to controllably dissociate, fragment and ionize sample (S) is disclosed. Metastable species (AG) are created at atmospheric pressure by application of adjustable intensity and/or frequency electric energy in one portion of a modular electric discharge chamber (3A), then are caused to interact with sample in a distally located portion of the electric discharge chamber (3A), termed the 'afterglow' portion (3B), to produce ionized sample molecules and ionized sample fragments (SE) etc. The system and method can be used with any source of sample (S) but a preferred embodiment utilizes an ultrasonic nebulizer (4) to nebulize sample solutions, such as conventional liquid chromatography system effluents (4LC), into sample solution droplets, followed by desolvation thereof to provide nebulized sample particles, prior to sample entry to the 'afterglow' portion (3B) of an electric discharge chamber (34). Ionization of sample (S) occurs as a result of interaction with energy released by relaxing metastable species (AG). Operation at atmospheric pressure reduces operational, contamination and maintenance problems and allows easy introduction of sample in a liquid form.

公开(公告)号：WO1993012904A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011089

申请日：1992-12-18

Applicant: CETAC TECHNOLOGIES INCORPORATED

Inventor： CETAC TECHNOLOGIES INCORPORATED ,  WIEDERIN, Daniel, R.

IPC: B23K09/00

CPC classification number: H05H1/42 ,  B23K9/328 ,  G01N21/714 ,  G01N35/1095 ,  G01N2001/1463

Abstract: A direct injection micro nebulizer based sample introduction system (10, 20, 40, 50) for use in nebulizing sample solutions in close proximity to sample analysis systems, with desolvation (F6, C6) and solvent removal (80, 90) capability is disclosed. The present invention offers design features and utility not available in previously known micro nebulizer systems. Predominantly unibody (1) design and use of nonmetallic, hydrofloric acid resistant construction materials are taught. The present invention allows easy cleaning and adjustment of element relationships which are necessary to proper operation of direct injection micro nebulizer systems via sample delivery tube system adjustment means (6, 7 and 8) and (46, 47 and 48) and removable top elements (2, 42 and 42m). Use of separate or integrated protective sleeving (3A) on otherwise crushable sample solution delivery tubing (3B) is disclosed. Special direct injection micro nebulizer top elements (2, 42, 42m) and torch designs (20, 40) are also disclosed.