公开(公告)号：WO2008038146A3

公开(公告)日：2008-04-03

申请号：PCT/IB2007/003757

申请日：2007-07-13

Applicant: MEDICHEM, S.A. ,  ARNALOT AGUILAR, Carmen ,  CHAMORRO GUTIÉRREZ, Iolanda

Inventor： ARNALOT AGUILAR, Carmen ,  CHAMORRO GUTIÉRREZ, Iolanda

IPC: C07C213/08 ,  C07C217/74 ,  C07C213/10

Abstract: The invention relates generally to an improved process for manufacturing venlafaxine base and/or salts thereof.

公开(公告)号：WO2010136522A3

公开(公告)日：2010-12-02

申请号：PCT/EP2010/057315

申请日：2010-05-27

Applicant: MEDICHEM S.A. ,  CHAMORRO GUTIÉRREZ, Iolanda ,  BOU BOSCH, Raquel

Inventor： CHAMORRO GUTIÉRREZ, Iolanda ,  BOU BOSCH, Raquel

IPC: C07D295/15 ,  A61K31/495 ,  A61P9/10

Abstract: Disclosed is ranolazine, or a composition containing ranolazine, which is free, or substantially free, of potential genotoxicity wherein 2-(2-methoxyphenoxy)- methyloxirane is present in an amount equal to or less than 750 ppb (w/w) relative to ranolazine, and provides a process for preparing the same. Also disclosed is a method for determining the purity of ranolazine, wherein 2-(2-methoxyphenoxy)- methyloxirane is employed as a reference marker and/or standard.

公开(公告)号：WO2009153651A1

公开(公告)日：2009-12-23

申请号：PCT/IB2009/005994

申请日：2009-06-19

Applicant: MEDICHEM, S.A. ,  CHAMORRO GUTIÉRREZ, Iolanda ,  XIFRA GARCIA, Raül

Inventor： CHAMORRO GUTIÉRREZ, Iolanda ,  XIFRA GARCIA, Raül

IPC: C07D295/14

CPC classification number: C07D295/14

Abstract: Disclosed is a process for preparing purified ranolazine of formula (I), which is indicated for the chronic treatment of angina, comprising reacting l-[(2,6- dimethylphenyl)aminocarbonyl]piperazine with l-phenoxy-2,3-epoxypropane in an inert solvent followed by precipitating the ranolazine.

Abstract translation: 公开了制备用于慢性治疗心绞痛的式（I）的精氨酸拉诺嗪的方法，其包括使1 - [（2,6-二甲基苯基）氨基羰基]哌嗪与1-苯氧基-2,3-环氧丙烷反应 惰性溶剂，然后沉淀雷诺嗪。

公开(公告)号：WO2008015584A2

公开(公告)日：2008-02-07

申请号：PCT/IB2007/003574

申请日：2007-08-03

Applicant: MEDICHEM, S.A. ,  BOSCH I LLADÓ, Jordi ,  CHAMORRO GUTIÉRREZ, Iolanda

Inventor： BOSCH I LLADÓ, Jordi ,  CHAMORRO GUTIÉRREZ, Iolanda

CPC classification number: C07C213/08 ,  C07C2601/14 ,  C07C215/64

Abstract: The invention relates generally to an improved process for manufacturing desvenlafaxine free base and salts or solvates thereof.

Abstract translation: 本发明一般涉及一种制备去甲文拉法辛游离碱及其盐或溶剂化物的改进方法。