公开(公告)号：WO2008017001A2

公开(公告)日：2008-02-07

申请号：PCT/US2007/075009

申请日：2007-08-01

Applicant: MOKA5, INC. ,  LAM, Monica Sin-ling ,  BERKHEIMER, Andy ,  SAPUNTZAKIS, Constantine P. ,  WHALEY, John ,  CHANDRA, Ramesh ,  CHEN, Michael ,  CHUN, Won-Suk ,  YUE, Kelvin

Inventor： LAM, Monica Sin-ling ,  BERKHEIMER, Andy ,  SAPUNTZAKIS, Constantine P. ,  WHALEY, John ,  CHANDRA, Ramesh ,  CHEN, Michael ,  CHUN, Won-Suk ,  YUE, Kelvin

IPC: G06F9/455

CPC classification number: G06F8/63 ,  G06F8/658 ,  G06F9/44505 ,  G06F9/45533 ,  G06F17/30233

Abstract: Methods, systems, and apparatus, including computer program apparatus, implementing techniques for publishing, subscribing to, or playing live appliances. A live appliance includes a current virtual machine image. In publishing, a proxy file of a live appliance file type is provided to the publisher. The type is mapped to a live appliance player; so that when a proxy file is opened, the current virtual machine image is run. The player automatically binds a writeable file system external to the virtual machine image to the image to provide file storage that is accessible from within the virtual machine image and from a host operating system. The player also creates a subscription to the live appliance on the host computer if one does not exist when the proxy file is run. With the subscription, the player runs the then-current virtual machine image whenever the live appliance is run.

Abstract translation: 方法，系统和装置，包括计算机程序装置，用于发布，订阅或播放活
动电器的技术。 活动设备包括当前的虚拟机映像。 在发布时，会向发布商提供活动家电文件类型的代理文件。 该类型映射到活动家电播放器; 以便当代理文件打开时，将运行当前的虚拟机映像。 播放器自动将虚拟机映像外部的可写文件系统绑定到映像，以提供可从虚拟机映像和主机操作系统访问的文件存储。 如果代理文件运行时，播放器还会在主机上创建对主机的订阅。 通过订阅，播放器将在运行live设备时运行当前的虚拟机映像。

公开(公告)号：WO2007031830A2

公开(公告)日：2007-03-22

申请号：PCT/IB2006/002462

申请日：2006-09-07

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH ,  LAKSHMI, Vijai ,  SAXENA, Ajet ,  KUMAR, Rajesh ,  PAL, Raghwendra ,  SINGH, Satyawan ,  SRIVASTAVA, Arvind, Kumar ,  TIWARI, Preeti ,  RAINA, Deepak ,  RASTOGI, Anil, Kumar ,  SRIVASTAVA, Sudhir ,  SRIVASTAVA, Mahendra, Nath ,  CHANDRA, Ramesh ,  PURI, Anju ,  RAGHUBIR, Ram ,  GUPTA, Poonam ,  TADIGOPPULA, Narender ,  TRIPATHI, Brijendra, Kumar

Inventor： LAKSHMI, Vijai ,  SAXENA, Ajet ,  KUMAR, Rajesh ,  PAL, Raghwendra ,  SINGH, Satyawan ,  SRIVASTAVA, Arvind, Kumar ,  TIWARI, Preeti ,  RAINA, Deepak ,  RASTOGI, Anil, Kumar ,  SRIVASTAVA, Sudhir ,  SRIVASTAVA, Mahendra, Nath ,  CHANDRA, Ramesh ,  PURI, Anju ,  RAGHUBIR, Ram ,  GUPTA, Poonam ,  TADIGOPPULA, Narender ,  TRIPATHI, Brijendra, Kumar

CPC classification number: A61K36/58 ,  C07D493/18

Abstract: The present invention discloses a bioactive fraction obtained from Xylocarpus useful for the treatment of diabetes and dyslipidemia. Further, it relates to a pharmaceutical composition useful as antidiabetic and antidyslipidemic agent. The current embodiment also discusses to a method of treating diabetes and dyslipidemia in a subject. Further, the present invention relates to the novel isomeric xyloccensins and use thereof.

Abstract translation: 本发明公开了可用于治疗糖尿病和血脂异常的从Xylocarpus得到的生物活性成分。 此外，其涉及可用作抗糖尿病和抗脂肪代谢剂的药物组合物。 目前的实施方案还讨论了在受试者中治疗糖尿病和血脂异常的方法。 此外，本发明涉及新型异构体的木糖蛋白及其用途。

公开(公告)号：WO2004063170A1

公开(公告)日：2004-07-29

申请号：PCT/IN2003/000301

申请日：2003-09-08

Applicant: UNIVERSITY OF DELHI ,  TANDON, Vibha ,  JAIN, Akash ,  TAWAR, Urmila ,  CHANDRA, Ramesh ,  DWARAKANATH, B.S. ,  CHAUDHURY, N., K.

Inventor： JAIN, Akash ,  TAWAR, Urmila ,  CHANDRA, Ramesh ,  DWARAKANATH, B.S. ,  CHAUDHURY, N., K.

IPC: C07D235/18

CPC classification number: C07D235/20 ,  C07D235/18

Abstract: A process for the synthesis of bisbenzimidazoles and its derivations comprising; (i) reacting 5 chloroaniline with zinc dust and acetic anhydride to produce 5 chloroacetanilide; (ii) reacting 5 chloroacetanilide with HN0 3 to produce 2-nitro-5-chloroacetanilide; (ix) adding sodium methoxide to 2-nitro-5-ch1oroaniline; (x) heating 2-nitro-5-chloroaniline, methyl piperazine, anhydrous K 2 CO 3 and Dimethyl formamide at 100-120°C produce a mixture which is cooled by pouring ice and is filtered to obtain 5-(4'-methylpiperazin-1'-yl)-2-nitroaniline; (xi) treating 5-(4'-methylpiperazin-l'yl)-2-nitroaniline with Pd/C to produce 2-amino-4-(4'-methylpiperazin-1'-yl) aniline; (xii) refluxing a mixture of 2-amino-4-(4'-methylpiperazin-1'yl) aniline and ethyl-4-amino-3-nitrobenzenecarboximidate hydrochloride in presence of ethanol/glacial acetic acid to produce 4-[5'-(4"-methylpiperazin-1"-yl) 15 benzimidazol-2'-yl)-2-nitroaniline; (xiii) treating a solution of 4-[5'-(4"-methylpiperazin-1"-yi) benzimidazol-2'-yl)-2-nitroaniline with palladium on carbon to yield 2-amino-4-[5'-(4"-Methylpiperazin-1"-yl)benzimidazol-2'-yl]aniline; (xiv) heating 2-amino-4-[5'-(4"-Methylpiperazin-1"-yl)benzimidazol-2'-yl]aniline and 3-4-dimethoxy benzaldehyde using nitrobenzene as a solvent at 110-150°C to produce (DMA) i.e 5-(4-methylpiperazin-1-yl)-2-[2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl] benzimidazole; (ix) heating 2-amino-4-[5'-(4"-Methylpiperazin-1"-yl) benzimidazol-2'-YI] aniline and 5-Formyl-[3-methoxy-4-hydroxy benzimidazole] using nitrobenzene at 110°C to 150°C in presence of argon to produce (TBZ) i.e 5-(4-methylpiperazine-1-yl)-2-[2' (2"-(4-hydroxy-3methoxyphenyl)5"benzimidazolyl) -5'- benzimidazolyl] benzimidazole.

Abstract translation: 一种合成双苯并咪唑及其衍生物的方法，包括： （i）使5氯苯胺与锌粉和乙酸酐反应生成5氯乙酰苯胺; （ii）使5氯乙酰苯胺与HNO 3反应，生成2-硝基-5-氯乙酰苯胺; （ix）向2-硝基-5-氯苯胺中加入甲醇钠; （x）在100-120℃加热2-硝基-5-氯苯胺，甲基哌嗪，无水K 2 CO 3和二甲基甲酰胺，产生混合物，将其通过倒入冰冷却并过滤，得到5-（4'-甲基哌嗪-1' 基）-2-硝基苯胺; （i）用Pd / C处理5-（4'-甲基哌嗪-1-基）-2-硝基苯胺，得到2-氨基-4-（4'-甲基哌嗪-1-基）苯胺; （xii）在乙醇/冰醋酸存在下回流2-氨基-4-（4'-甲基哌嗪-1'-基）苯胺和4-氨基-3-硝基苯甲酰亚胺乙酯的混合物，得到4- [5' - （4“ - 甲基哌嗪-1” - 基）15苯并咪唑-2'-基）-2-硝基苯胺; （xiii）用钯碳处理4- [5' - （4“ - 甲基哌嗪-1” - ）苯并咪唑-2'-基）-2-硝基苯胺的溶液，得到2-氨基-4- [5' - （4 “-Methylpiperazin-1” - 基）苯并咪唑-2'-基]苯胺; （xiv）使用硝基苯作为溶剂在110-150℃下加热2-氨基-4- [5' - （4“ - 甲基哌嗪-1” - 基）苯并咪唑-2'-基]苯胺和3,4-二甲氧基苯甲醛 （DMA），即5-（4-甲基哌嗪-1-基）-2- [2' - （3,4-二甲氧基苯基）-5'-苯并咪唑基]苯并咪唑; （ix）使用硝基苯加热2-氨基-4- [5' - （4“ - 甲基哌嗪-1” - 基）苯并咪唑-2'-Y]苯胺和5-甲酰基 - [3-甲氧基-4-羟基苯并咪唑] 在氩气存在下，在110℃至150℃下生成（TBZ）即5-（4-甲基哌嗪-1-基）-2- [2'（2“ - （4-羟基-3-甲氧基苯基）5”苯并咪唑基） -5'-苯并咪唑基]苯并咪唑。

公开(公告)号：WO2004060383A1

公开(公告)日：2004-07-22

申请号：PCT/IN2003/000228

申请日：2003-06-20

Applicant: UNIVERSITY OF DELHI ,  TANDON, Vibha ,  WATAL, Geeta ,  CHANDRA, Ramesh ,  GUPTA, Kumar, Rajesh ,  KASHARI, Narayan, Achyut

Inventor： TANDON, Vibha ,  WATAL, Geeta ,  CHANDRA, Ramesh ,  GUPTA, Kumar, Rajesh ,  KASHARI, Narayan, Achyut

IPC: A61K35/78

CPC classification number: A61K36/185

Abstract: A process of preparing an extract of annona squamosa comprising collecting leaves of annona squamosa; drying the said leaves, preparing an aqueous extract of the leaves at a temperature of 80-100°C; filtering the extract to remove the solid material concentrating the extract at temperature range of 30 to 40°C under reduced pressure; subjecting the concentrated extract to the step of liquid-liquid extraction; subjecting the eluted fractions to thin layer chromatography to obtain semi purified extract.

Abstract translation: 一种制备ann藜提取物的方法，包括收集ann叶的叶片; 干燥所述叶子，在80-100℃的温度下制备叶子的水提取物; 过滤提取物以除去在减压下在30至40℃的温度范围浓缩提取物的固体物质; 浓缩提取液经液液提取步骤; 将洗脱的级分进行薄层色谱以获得半纯化的提取物。

公开(公告)号：WO2007031830A3

公开(公告)日：2007-07-12

申请号：PCT/IB2006002462

申请日：2006-09-07

Applicant: COUNCIL SCIENT IND RES ,  LAKSHMI VIJAI ,  SAXENA AJET ,  KUMAR RAJESH ,  PAL RAGHWENDRA ,  SINGH SATYAWAN ,  SRIVASTAVA ARVIND KUMAR ,  TIWARI PREETI ,  RAINA DEEPAK ,  RASTOGI ANIL KUMAR ,  SRIVASTAVA SUDHIR ,  SRIVASTAVA MAHENDRA NATH ,  CHANDRA RAMESH ,  PURI ANJU ,  RAGHUBIR RAM ,  GUPTA POONAM ,  TADIGOPPULA NARENDER ,  TRIPATHI BRIJENDRA KUMAR

Inventor： LAKSHMI VIJAI ,  SAXENA AJET ,  KUMAR RAJESH ,  PAL RAGHWENDRA ,  SINGH SATYAWAN ,  SRIVASTAVA ARVIND KUMAR ,  TIWARI PREETI ,  RAINA DEEPAK ,  RASTOGI ANIL KUMAR ,  SRIVASTAVA SUDHIR ,  SRIVASTAVA MAHENDRA NATH ,  CHANDRA RAMESH ,  PURI ANJU ,  RAGHUBIR RAM ,  GUPTA POONAM ,  TADIGOPPULA NARENDER ,  TRIPATHI BRIJENDRA KUMAR

IPC: A61K36/58 ,  A61P3/06 ,  A61P3/10

CPC classification number: A61K36/58 ,  C07D493/18

Abstract: The present invention discloses a bioactive fraction obtained from Xylocarpus useful for the treatment of diabetes and dyslipidemia. Further, it relates to a pharmaceutical composition useful as antidiabetic and antidyslipidemic agent. The current embodiment also discusses to a method of treating diabetes and dyslipidemia in a subject. Further, the present invention relates to the novel isomeric xyloccensins and use thereof.

Abstract translation: 本发明公开了可用于治疗糖尿病和血脂异常的从Xylocarpus得到的生物活性成分。 此外，其涉及可用作抗糖尿病和抗脂肪代谢剂的药物组合物。 目前的实施方案还讨论了在受试者中治疗糖尿病和血脂异常的方法。 此外，本发明涉及新型异构体的木糖蛋白及其用途。

公开(公告)号：WO2004039771A1

公开(公告)日：2004-05-13

申请号：PCT/IN2003/000250

申请日：2003-07-24

Applicant: DEPARTMENT OF SCIENCE AND TECHNOLOGY ,  TIWARI, Manisha ,  SHARMA, Meenakshi ,  CHANDRA, Ramesh

Inventor： TIWARI, Manisha ,  SHARMA, Meenakshi ,  CHANDRA, Ramesh

IPC: C07C323/07

CPC classification number: C07C323/16 ,  C07C321/20 ,  C07C323/07 ,  C07C323/29 ,  C07C323/56

Abstract: The present invention relates to a novel diallyldisulphide derivative having formula I as shown herebelow and their pharmaceutically acceptable salts; R-CH = CH - CH 2 -S-S-CH 2 -CH = CH-R (Formula I)wherein R=C 6 H n X p [when n = 3 to 5, p = 2 to 0; X=H, Cl, Br, F, CF 3 , CH 3 , CN, COOH, NO 2 , NH 2 , OH, OC m H 2m+1 (m = 1 to 8)]

Abstract translation: 本发明涉及具有如下所示的式I的新型二烯丙基二硫化物衍生物及其药学上可接受的盐; R-CH = CH-CH 2 -S-S-CH 2 -CH = CH-R（式I）其中R = C6HnXp [当n = 3至5，p = 2至0; X = H，Cl，Br，F，CF 3，CH 3，CN，COOH，NO 2，NH 2，OH，OCm H 2m + 1（m = 1〜8）

公开(公告)号：WO2008017001A3

公开(公告)日：2008-10-23

申请号：PCT/US2007075009

申请日：2007-08-01

Applicant: MOKA5 INC ,  LAM MONICA SIN-LING ,  BERKHEIMER ANDY ,  SAPUNTZAKIS CONSTANTINE P ,  WHALEY JOHN ,  CHANDRA RAMESH ,  CHEN MICHAEL ,  CHUN WON-SUK ,  YUE KELVIN

Inventor： LAM MONICA SIN-LING ,  BERKHEIMER ANDY ,  SAPUNTZAKIS CONSTANTINE P ,  WHALEY JOHN ,  CHANDRA RAMESH ,  CHEN MICHAEL ,  CHUN WON-SUK ,  YUE KELVIN

IPC: G06F9/44 ,  G06F9/455

CPC classification number: G06F8/63 ,  G06F8/68 ,  G06F9/44505 ,  G06F9/45533 ,  G06F17/30233

Abstract: Methods, systems, and apparatus, including computer program apparatus, implementing techniques for publishing, subscribing to, or playing live appliances. A live appliance includes a current virtual machine image. In publishing, a proxy file of a live appliance file type is provided to the publisher. The type is mapped to a live appliance player; so that when a proxy file is opened, the current virtual machine image is run. The player automatically binds a writeable file system external to the virtual machine image to the image to provide file storage that is accessible from within the virtual machine image and from a host operating system. The player also creates a subscription to the live appliance on the host computer if one does not exist when the proxy file is run. With the subscription, the player runs the then-current virtual machine image whenever the live appliance is run.

Abstract translation: 包括计算机程序设备的方法，系统和装置，实现用于发布，订阅或玩现场设备的技术。 活动设备包含当前的虚拟机映像。 在发布时，会向发布者提供活动设备文件类型的代理文件。 该类型被映射到现场设备播放器; 以便在打开代理文件时运行当前虚拟机映像。 播放器自动将虚拟机映像外部的可写入文件系统绑定到映像，以提供可从虚拟机映像和主机操作系统访问的文件存储。 如果在运行代理文件时不存在播放器，则播放器还会在主机上创建一个对现场设备的订阅。 通过订阅，播放器每运行一次实时应用装置就会运行当时的虚拟机镜像。

公开(公告)号：WO2008005765A3

公开(公告)日：2008-01-10

申请号：PCT/US2007/072216

申请日：2007-06-27

Applicant: MOKA5, Inc. ,  LAM, Monica Sin-ling ,  YUE, Kelvin ,  CHANDRA, Ramesh ,  SAPUNTZAKIS, Constantine P. ,  WHALEY, John ,  MESSALEM, Guy

Inventor： LAM, Monica Sin-ling ,  YUE, Kelvin ,  CHANDRA, Ramesh ,  SAPUNTZAKIS, Constantine P. ,  WHALEY, John ,  MESSALEM, Guy

IPC: G06F15/167

Abstract: Methods and apparatus, including computer program products, for network-extended storage. A portable storage device is coupled to a host computer, and network extension code stored on the portable storage device is invoked. The network extension code is operable to detect a file system write function call generated by an application executing on the host computer, the file system write function call operable to cause data to be written to the portable storage device, and cause the data to be written to the portable storage device based upon the file system write function call. The network extension code is further operable to generate a transmit determination indicative of whether to transmit the data to a network repository, and transmit the data to the network repository based upon the transmit determination.

公开(公告)号：WO2008005765A2

公开(公告)日：2008-01-10

申请号：PCT/US2007072216

申请日：2007-06-27

Applicant: MOKA5 INC ,  LAM MONICA SIN-LING ,  YUE KELVIN ,  CHANDRA RAMESH ,  SAPUNTZAKIS CONSTANTINE P ,  WHALEY JOHN ,  MESSALEM GUY

Inventor： LAM MONICA SIN-LING ,  YUE KELVIN ,  CHANDRA RAMESH ,  SAPUNTZAKIS CONSTANTINE P ,  WHALEY JOHN ,  MESSALEM GUY

IPC: G06F17/30

CPC classification number: G06F17/30067

Abstract: Methods and apparatus, including computer program products, for network-extended storage. A portable storage device is coupled to a host computer, and network extension code stored on the portable storage device is invoked. The network extension code is operable to detect a file system write function call generated by an application executing on the host computer, the file system write function call operable to cause data to be written to the portable storage device, and cause the data to be written to the portable storage device based upon the file system write function call. The network extension code is further operable to generate a transmit determination indicative of whether to transmit the data to a network repository, and transmit the data to the network repository based upon the transmit determination.

Abstract translation: 方法和设备，包括计算机程序产品，用于网络扩展存储。 便携式存储设备耦合到主计算机，并且调用存储在便携式存储设备上的网络扩展代码。 网络扩展代码可操作以检测由在主计算机上执行的应用程序生成的文件系统写入功能调用，文件系统写入功能调用可操作以使得数据被写入便携式存储设备，并且使数据被写入 基于文件系统写入功能调用到便携式存储设备。 网络扩展码进一步可操作以产生指示是否将数据发送到网络存储库的发送确定，并且基于发送确定将数据发送到网络存储库。

公开(公告)号：WO2005008259A3

公开(公告)日：2006-01-26

申请号：PCT/US2004022163

申请日：2004-07-08

Applicant: UNIV NEW YORK ,  JENSEN JENS ,  HELPERN JOSEPH A ,  JOHNSON GLYN ,  CHANDRA RAMESH

Inventor： JENSEN JENS ,  HELPERN JOSEPH A ,  JOHNSON GLYN ,  CHANDRA RAMESH

IPC: G01R20060101 ,  G01V3/00

CPC classification number: G01R33/50 ,  G01R33/56341 ,  G01R33/56536 ,  Y10T436/24

Abstract: Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function (MCF) , and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes (figure 4,5). Asymmetric Dual Spin Sequences (EPI-ADSE) may be employed to apply multiple echoes to a sample and acquire data from which the MCF may be determined (figures 2, 3)

Abstract translation: 用于测量磁场相关函数（MCF）的方法，系统，软件布置和存储介质，更具体地说，涉及利用不对称自旋回波测量磁场相关函数的方法（图4,5）。 可以使用非对称双自旋序列（EPI-ADSE）将多个回波应用于样本并获取可以从其确定MCF的数据（图2,3）