公开(公告)号：WO2016180859A1

公开(公告)日：2016-11-17

申请号：PCT/EP2016/060517

申请日：2016-05-11

Applicant: BASF SE

Inventor： NAVE, Barbara ,  DICKHAUT, Joachim ,  NESVADBA, Peter ,  SISAY, Mihiret Tekeste ,  WISSEMEIER, Alexander ,  ZERULLA, Wolfram ,  PASDA, Gregor ,  WALLQUIST, Olof ,  CUNNINGHAM, Alan Francis

IPC: C05G3/08 ,  C07C321/08 ,  C07C321/18 ,  C07C323/45

CPC classification number: C05G3/08 ,  C05C3/00 ,  C05C9/00 ,  C05F11/00 ,  C07C317/08 ,  C07C317/10 ,  C07C317/18 ,  C07C321/20 ,  C07C321/28 ,  C07C323/07 ,  C07C323/47 ,  C07C323/48 ,  C07C337/08 ,  C07D221/04 ,  C07D233/42 ,  C07D235/28 ,  C07D239/38 ,  C07D241/18 ,  C07D241/44 ,  C07D249/12 ,  C07D277/74 ,  C07D285/125 ,  C07D285/135 ,  C07D401/04 ,  C07D405/04 ,  C07D417/04 ,  C07D495/04 ,  Y02P60/218

Abstract: The invention concerns the use of thioether compounds of formula Ias nitrification inhibitors, and agricultural mixtures and compositions comprising said thioether compounds.

Abstract translation: 本发明涉及使用式I的硫醚化合物作为硝化抑制剂，以及包含所述硫醚化合物的农业混合物和组合物。

公开(公告)号：WO2010083625A1

公开(公告)日：2010-07-29

申请号：PCT/CN2009/000098

申请日：2009-01-23

Applicant: ACEA BIOSCIENCES INC. ,  AN, Haoyun ,  MO, Xiaopeng

Inventor： AN, Haoyun ,  MO, Xiaopeng

IPC: C07C321/16

CPC classification number: C07C319/24 ,  C07C319/28 ,  C07C323/07

Abstract: The invention provides a synthetic and manufacturing process for the preparation of the anticancer drug, fluorapacin, bis(4-fluorobenzyl)trisulfide, and related trisulfide derivatives on large scale. Also provided are processes for the purification and isolation of fluorapacin having high purity and improved stability.

Abstract translation: 本发明提供了大规模制备抗癌药物，氟卡宾，双（4-氟苄基）三硫化物和相关三硫​​化物衍生物的合成和制备方法。 还提供了用于纯化和分离具有高纯度和改善的稳定性的氟卡朋的方法。

公开(公告)号：WO2010045582A2

公开(公告)日：2010-04-22

申请号：PCT/US2009/061046

申请日：2009-10-16

Applicant: IKARIA, INC. ,  WINTNER, Edward, Aurel ,  RUAN, Fuqiang

Inventor： WINTNER, Edward, Aurel ,  RUAN, Fuqiang

IPC: A61K31/10 ,  A61K31/105 ,  A61P39/00 ,  A61P9/10 ,  A61P1/16 ,  C07C321/00

CPC classification number: A61K31/10 ,  A61K31/105 ,  C07C321/20 ,  C07C323/07 ,  C07C323/29 ,  C07C323/31 ,  C07C323/56 ,  C07C323/62 ,  C07D213/34 ,  C07D233/20 ,  C07D257/04 ,  C07D263/32

Abstract: A method for treating or preventing injury of a biological material exposed to hypoxic or ischemic conditions comprising contacting the biological material with an effective amount of a compound is disclosed. The compound has the following structure (I): R 1_ (S) n -R 2 or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof, wherein R 1 , R 2 , and n are as defined herein. Compounds, methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了一种治疗或预​​防暴露于缺氧或局部缺血症状的生物材料损伤的方法，其包括使生物材料与有效量的化合物接触。 该化合物具有以下结构（I）：其中R 1为（S）n -R 2或其立体异构体，药学上可接受的盐或前药 其中R 1，R 2和n如本文所定义。 还公开了化合物，与这些化合物的制备和使用有关的方法，以及包含这些化合物的药物组合物。

公开(公告)号：WO2014047110A3

公开(公告)日：2014-06-26

申请号：PCT/US2013060294

申请日：2013-09-18

Applicant: UNIV TEMPLE

Inventor： REDDY M V RAMANA ,  REDDY E PREMKUMAR

IPC: A61K31/10

CPC classification number: C07D207/337 ,  C07C231/12 ,  C07C235/38 ,  C07C311/27 ,  C07C315/04 ,  C07C317/10 ,  C07C317/18 ,  C07C317/24 ,  C07C317/28 ,  C07C319/20 ,  C07C323/07 ,  C07C2601/02

Abstract: Compounds according to Formula I are provided: and salts thereof, wherein Q1, Q2, R3, R4, X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I).

Abstract translation: 提供了根据式I的化合物及其盐，其中Q 1，Q 2，R 3，R 4，X和Y如本文所定义。 还提供了制备式I化合物的方法，以及使用式（I）化合物治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：WO2006091870A3

公开(公告)日：2007-01-18

申请号：PCT/US2006006698

申请日：2006-02-24

Applicant: UNIV TEMPLE ,  ONCONOVA THERAPEUTICS INC ,  REDDY M V RAMANA ,  REDDY E PREMKUMAR ,  BELL STANLEY C

Inventor： REDDY M V RAMANA ,  REDDY E PREMKUMAR ,  BELL STANLEY C

IPC: C07C303/00 ,  C07C307/00 ,  C07C309/00 ,  C07C311/00

CPC classification number: C07C323/29 ,  C07B2200/07 ,  C07C315/02 ,  C07C315/04 ,  C07C317/10 ,  C07C317/18 ,  C07C317/28 ,  C07C319/14 ,  C07C323/07 ,  C07C323/16 ,  C07C323/22 ,  C07C317/24

Abstract: a,ß-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula (I): wherein Ar1, Ar2, X, n, * and R are as defined herein, are prepared by dehydration of ß-hydroxy sulfides, sulfones, sulfoxides or sulfonamides.

Abstract translation: a，根据式（I）的β-不饱和硫化物，砜，亚砜和磺酰胺：其中Ar1，Ar2，X，n，*和R如本文所定义，是通过将β-羟基硫化物，砜，亚砜或 磺胺类药物。

公开(公告)号：WO2006006154A2

公开(公告)日：2006-01-19

申请号：PCT/IL2005/000722

申请日：2005-07-07

Applicant: BROMINE COMPOUNDS LTD. ,  TITELMAN, Grigory I. ,  ZILBERMAN, Joseph ,  ANTEBI, Shlomo ,  BRON, Samuel ,  PELED, Michael

Inventor： TITELMAN, Grigory I. ,  ZILBERMAN, Joseph ,  ANTEBI, Shlomo ,  BRON, Samuel ,  PELED, Michael

IPC: C07C20060101 ,  C07C323/07 ,  C08K3/22 ,  C08K5/06 ,  C08K5/372

CPC classification number: C08K5/372 ,  C07C43/1742 ,  C07C323/07 ,  C08K3/2279 ,  C08K5/06

Abstract: A bis-polyhalobenzyl compound of the formula: (C 6 H (5-m) Y m )CH 2 XCH 2 (C 6 H (5-n) Y n ) wherein X is oxygen or sulphur, Y is bromine or chlorine, m, n is an integer from 3 to 5 inclusive, for use as a flame retardant, and a process for producing it.

Abstract translation: 下式的双 - 多卤苄基化合物：（C <

公开(公告)号：WO2005112933A2

公开(公告)日：2005-12-01

申请号：PCT/US2005/013474

申请日：2005-04-20

Applicant: ACEA BIOSCIENCES INC. ,  XU, Xiao ,  AN, Haoyun ,  WANG, Xiaobo

Inventor： XU, Xiao ,  AN, Haoyun ,  WANG, Xiaobo

IPC: A61K31/513

CPC classification number: C07C323/07 ,  C07C321/20 ,  C07C323/16 ,  C07C323/20

Abstract: The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.

Abstract translation: 本发明提供取代的二，三，四和五硫化物化合物和组合物，及其用于治疗和/或预防细胞增殖性疾病的方法。 本发明还提供了制备三硫化物和组合物的方法。

公开(公告)号：WO1994008978A1

公开(公告)日：1994-04-28

申请号：PCT/US1993009248

申请日：1993-09-29

Applicant: UNIROYAL CHEMICAL COMPANY, INC. ,  UNIROYAL CHEMICAL LTD./UNIROYAL CHEMICAL LTEE

Inventor： UNIROYAL CHEMICAL COMPANY, INC. ,  UNIROYAL CHEMICAL LTD./UNIROYAL CHEMICAL LTEE ,  MISHRA, Anupama ,  DAVIS, Robert, A.

IPC: C07D249/08

CPC classification number: C07D231/12 ,  A01N43/50 ,  A01N43/653 ,  C07C15/44 ,  C07C17/16 ,  C07C22/04 ,  C07C25/24 ,  C07C43/166 ,  C07C43/215 ,  C07C205/06 ,  C07C321/28 ,  C07C323/07 ,  C07C323/12 ,  C07C323/16 ,  C07D233/56 ,  C07D249/08

Abstract: Compounds having the structural formula (I), wherein R can be the same or different and is halogen, hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, C3-C6 cycloalkyl, C7-C9 aralkyl, phenyl, nitro, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C7-C9 aralkoxy, phenoxy, phenylthio, phenylsulfinyl, or phenylsulfonyl; m is an integer from 0 to 5; Y is CH2, oxygen, or sulfur; n is an integer from 0 to 5; R1 is C1-C5 alkyl, phenyl, C1-C5 alkyl substituted phenyl, or halogenated phenyl; X is N or CH; or physiologically acceptable salts thereof are disclosed which have fungicidal activity. Fungicidal compositions comprising the compounds and a carrier are also disclosed, as are methods for controlling the growth of phytopathogenic fungi utilizing the compounds. Methods for the preparation of such compounds are also disclosed.

Abstract translation: 具有结构式（I）的化合物，其中R可以相同或不同，为卤素，氢，C1-C8烷基，C1-C8卤代烷基，C3-C6环烷基，C7-C9芳烷基，苯基，硝基，C1-C6 烷氧基，C 1 -C 6烷硫基，C 1 -C 6烷基亚磺酰基，C 1 -C 6烷基磺酰基，C 7 -C 9芳烷氧基，苯氧基，苯硫基，苯基亚磺酰基或苯基磺酰基; m是0至5的整数; Y是CH 2，氧或硫; n为0〜5的整数， R 1是C 1 -C 5烷基，苯基，C 1 -C 5烷基取代的苯基或卤代苯基; X为N或CH; 或其生理上可接受的盐，其具有杀真菌活性。 还公开了包含化合物和载体的杀真菌组合物，以及利用该化合物控制植物病原真菌生长的方法。 还公开了制备这些化合物的方法。

公开(公告)号：WO2014107380A1

公开(公告)日：2014-07-10

申请号：PCT/US2013/077605

申请日：2013-12-23

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： HARTWIG, John ,  FIER, Patrick

IPC: C07C309/04 ,  C07C309/30 ,  C07C39/06

CPC classification number: C07C41/01 ,  C07C37/06 ,  C07C45/63 ,  C07C45/64 ,  C07C51/363 ,  C07C67/00 ,  C07C201/12 ,  C07C231/12 ,  C07C253/30 ,  C07C319/14 ,  C07C2602/10 ,  C07D215/20 ,  C07D215/26 ,  C07D263/57 ,  C07D277/66 ,  C07D311/04 ,  C07D311/30 ,  C07D311/52 ,  C07D317/46 ,  C07D317/64 ,  C07F9/5022 ,  C07J1/0059 ,  C07C39/26 ,  C07C49/84 ,  C07C235/46 ,  C07C233/20 ,  C07C255/54 ,  C07C233/25 ,  C07C205/37 ,  C07C323/03 ,  C07C323/07

Abstract: The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone- depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

Abstract translation: 描述了用简单的非消耗臭氧试剂合成二氟甲基醚和硫化物。 苯酚与该试剂的二氟甲基化在几分钟内在室温下发生，具有特殊的功能基团耐受性。 温和的条件使芳基硼酸，芳基卤化物和芳烃转化为二氟甲基醚成为可能的串联方法。 机理研究支持涉及酚盐对二氟卡宾亲核攻击的反应途径。

公开(公告)号：WO2014047110A2

公开(公告)日：2014-03-27

申请号：PCT/US2013/060294

申请日：2013-09-18

Applicant: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： REDDY, M., V., Ramana ,  REDDY, E., Premkumar

IPC: C07C317/32

CPC classification number: C07D207/337 ,  C07C231/12 ,  C07C235/38 ,  C07C311/27 ,  C07C315/04 ,  C07C317/10 ,  C07C317/18 ,  C07C317/24 ,  C07C317/28 ,  C07C319/20 ,  C07C323/07 ,  C07C2601/02

Abstract: Compounds according to Formula I are provided: and salts thereof, wherein Q 1 , Q 2 , R 3 , R 4 , X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I).

Abstract translation: 提供了根据式I的化合物及其盐，其中Q 1，Q 2，R 3，Q 3， R 4，X和Y如本文所定义。 还提供了制备式I化合物的方法，以及使用式（I）化合物治疗细胞增殖性疾病如癌症的方法。