公开(公告)号：WO2005029066A3

公开(公告)日：2005-03-31

申请号：PCT/US2004/016407

申请日：2004-05-21

Applicant: AGILENT TECHNOLOGIES, INC. ,  BEN-DOR, Amir ,  BRUHN, Laurakay ,  DENG, David ,  TSALENKO, Anya ,  ASHLEY, Euan ,  CHEN, Mary, C. ,  QUERTERMOUS, Thomas

Inventor： BEN-DOR, Amir ,  BRUHN, Laurakay ,  DENG, David ,  TSALENKO, Anya ,  ASHLEY, Euan ,  CHEN, Mary, C. ,  QUERTERMOUS, Thomas ,  YAKHINI, Zohar

IPC: G01N33/566

Abstract: The invention identifies genes whose expression is upregulated or downregulated following mechanical offloading in subjects with heart failure. The invention provides compositions comprising a targeting agent conjugated to a functional moiety, wherein the targeting agent selectively binds to a polypeptide encoded by one of these genes. The functional moiety can be an imaging agent, therapeutic agent, etc. The invention further provides methods for providing diagnostic or prognostic information related to heart failure involving detecting expression or activity of an expression product of one or more of the identified genes. The invention further provides diagnostic and therapeutic methods comprising detecting or administering an apelin peptide to a subject.

公开(公告)号：WO2005029066A2

公开(公告)日：2005-03-31

申请号：PCT/US2004016407

申请日：2004-05-21

Applicant: AGILENT TECHNOLOGIES INC ,  BEN-DOR AMIR ,  BRUHN LAURAKAY ,  DENG DAVID ,  TSALENKO ANYA ,  ASHLEY EUAN ,  CHEN MARY C ,  QUERTERMOUS THOMAS

Inventor： BEN-DOR AMIR ,  BRUHN LAURAKAY ,  DENG DAVID ,  TSALENKO ANYA ,  YAKHINI ZOHAR ,  ASHLEY EUAN ,  CHEN MARY C ,  QUERTERMOUS THOMAS

IPC: A61K38/18 ,  A61K51/00 ,  C07K16/46 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/566 ,  G01N33/567 ,  G01N33/68 ,  G01N33/00

CPC classification number: G01N33/6893 ,  A61K38/1709 ,  A61K47/6843 ,  G01N2333/912 ,  G01N2333/916 ,  G01N2800/325

Abstract: The invention identifies genes whose expression is upregulated or downregulated following mechanical offloading in subjects with heart failure. The invention provides compositions comprising a targeting agent conjugated to a functional moiety, wherein the targeting agent selectively binds to a polypeptide encoded by one of these genes. The functional moiety can be an imaging agent, therapeutic agent, etc. The invention further provides methods for providing diagnostic or prognostic information related to heart failure involving detecting expression or activity of an expression product of one or more of the identified genes. The invention further provides diagnostic and therapeutic methods comprising detecting or administering an apelin peptide to a subject.

Abstract translation: 本发明鉴定了在心力衰竭受试者中机械卸载后表达上调或下调的基因。 本发明提供了包含与功能部分缀合的靶向剂的组合物，其中靶向剂选择性结合由这些基因之一编码的多肽。 功能部分可以是成像剂，治疗剂等。本发明还提供了用于提供涉及心力衰竭的诊断或预后信息的方法，涉及检测一种或多种所鉴定的基因的表达产物的表达或活性。 本发明进一步提供了诊断和治疗方法，包括检测或给药受试者的爱帕琳肽。