公开(公告)号：WO2006081331A3

公开(公告)日：2006-08-03

申请号：PCT/US2006/002717

申请日：2006-01-25

申请人： PROLEXYS PHARMACEUTICALS, INC. ,  WHITEHAED INSTITUTE FOR BIOMEDICAL RESEARCH ,  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  BECKLIN, Robert, R. ,  CHEPANOSKE, Cindy, Lou ,  PELTER, John, M. ,  QI, Longwu ,  ROBBINS, Paul, B. ,  SAHASRABUDHE, Sudhir, R. ,  SELLIAH, Robert ,  SIMMONS, Keith ,  STOCKWELL, Brent, R. ,  VENKAT, Raj, Gopal ,  VON RECHENBERG, Moritz ,  ZHEN, Eugene

发明人： BECKLIN, Robert, R. ,  CHEPANOSKE, Cindy, Lou ,  PELTER, John, M. ,  QI, Longwu ,  ROBBINS, Paul, B. ,  SAHASRABUDHE, Sudhir, R. ,  SELLIAH, Robert ,  SIMMONS, Keith ,  STOCKWELL, Brent, R. ,  VENKAT, Raj, Gopal ,  VON RECHENBERG, Moritz ,  ZHEN, Eugene

IPC分类号： C07D239/90 ,  C07D405/12 ,  C07D409/12 ,  A61K31/495 ,  A61P35/00 ,  G01N33/68 ,  G01N33/50

摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3) . The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives, such like the compounds (1).

公开(公告)号：WO2006081331A2

公开(公告)日：2006-08-03

申请号：PCT/US2006002717

申请日：2006-01-25

申请人： PROLEXYS PHARMACEUTICALS INC ,  WHITEHAED INST FOR BIOMEDICAL ,  UNIV COLUMBIA ,  BECKLIN ROBERT R ,  CHEPANOSKE CINDY LOU ,  PELTER JOHN M ,  QI LONGWU ,  ROBBINS PAUL B ,  SAHASRABUDHE SUDHIR R ,  SELLIAH ROBERT ,  SIMMONS KEITH ,  STOCKWELL BRENT R ,  VENKAT RAJ GOPAL ,  VON RECHENBERG MORITZ ,  ZHEN EUGENE

发明人： BECKLIN ROBERT R ,  CHEPANOSKE CINDY LOU ,  PELTER JOHN M ,  QI LONGWU ,  ROBBINS PAUL B ,  SAHASRABUDHE SUDHIR R ,  SELLIAH ROBERT ,  SIMMONS KEITH ,  STOCKWELL BRENT R ,  VENKAT RAJ GOPAL ,  VON RECHENBERG MORITZ ,  ZHEN EUGENE

CPC分类号： A61K31/495 ,  C07D239/90 ,  C07D405/12 ,  C07D409/12 ,  G01N33/5011 ,  G01N33/6872

摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.

摘要翻译： 本发明涉及筛选结合配偶体，特别是结合配偶体对于erastin的生物学活性（例如VDAC如VDAC3）的生物学活性的方法。 本发明还提供了有效杀死癌细胞与erastin和相关化合物或衍生物的试剂和方法。