-
公开(公告)号：WO2010015586A3
公开(公告)日：2010-02-11
申请号：PCT/EP2009/059999
申请日：2009-08-03
申请人： NYCOMED GMBH , BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
发明人： BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , A61P11/00 , A61P15/00 , A61P25/00 , A61P29/00
摘要： The present invention pertains to 2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds, as well as the resulting pharmaceutical compositions, and their use in the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterases. Furthermore, the present invention pertains to the methods of manufacturing these 2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds.
-
公开(公告)号：WO2010015588A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/060001
申请日：2009-08-03
申请人： NYCOMED GMBH , BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
发明人： BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D471/14 , C07D491/14 , C07D515/14
摘要： The present invention pertains to Benzyl-substituted tetracyclic heterocyclic compounds of formula (I), as well as the resulting pharmaceutical compositions, and their use in the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterases. Furthermore, the present invention pertains to the methods of manufacturing these Benzyl -substituted tetracyclic heterocyclic compounds.
摘要翻译： 本发明涉及式（I）的苄基取代的四环杂环化合物，以及所得药物组合物及其在治疗或预防通过抑制5型磷酸二酯酶而减轻的疾病中的用途。 此外，本发明涉及制造这些苄基取代的四环杂环化合物的方法。
-
3.发明申请4,5-DIHYDRO-IMIDAZO[4,5,1-II]QUINOLIN-6-ONES AS PARP INHIBITORS 审中-公开4,5-二氢咪唑并[4,5,1-II]喹啉-6-酮作为PARP抑制剂
公开(公告)号：WO2004108723A1
公开(公告)日：2004-12-16
申请号：PCT/EP2004/051019
申请日：2004-06-03
发明人： CHRISTIAANS, Johannes A. M. , WEINBRENNER, Steffen , KLEIN, Thomas , FLOCKERZI, Dieter , STERK, Geert Jan , MENGE, Wiro M. P. B. , BRUNDEL, Paulus Johannes Gaurerius
IPC分类号： C07D471/06
CPC分类号： C07D471/06
摘要： Compounds of the formula 1, in which R1 and R2 have the meanings indicated in the description, are novel active PARP inhibitors.
摘要翻译： 其中R1和R2具有说明书中所示含义的式1化合物是新的活性PARP抑制剂。
-
公开(公告)号：WO2011015523A1
公开(公告)日：2011-02-10
申请号：PCT/EP2010/061081
申请日：2010-07-30
申请人： NYCOMED GMBH , BARTELS, Björn , STAVER, Ruslan , WEINBRENNER, Steffen , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
发明人： BARTELS, Björn , STAVER, Ruslan , WEINBRENNER, Steffen , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
IPC分类号： C07D471/14 , A61K31/4375 , A61P15/00
CPC分类号： C07D471/14
摘要： The present invention pertains to Benzyl-substituted tetracyclic heterocyclic compounds, as well as the resulting pharmaceutical compositions, and their use in the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterases. Furthermore, the present invention pertains to the methods of manufacturing these Benzyl-substituted tetracyclic heterocyclic compounds.
摘要翻译： 本发明涉及苄基取代的四环杂环化合物，以及所得药物组合物及其在治疗或预防通过抑制5型磷酸二酯酶而减轻的疾病中的用途。 此外，本发明涉及制造这些苄基取代的四环杂环化合物的方法。
-
5.发明申请BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS AS PDE5 INHIBITORS 审中-公开苄基取代的四环杂环化合物作为PDE5抑制剂
公开(公告)号：WO2010015589A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/060002
申请日：2009-08-03
申请人： NYCOMED GMBH , BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
发明人： BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
IPC分类号： C07D471/04 , C07D471/14 , A61K31/437 , A61K31/4375 , A61P15/00
CPC分类号： C07D471/04 , C07D471/14
摘要： The present invention pertains to Benzyl-substituted tetracyclic heterocyclic compounds, as well as the resulting pharmaceutical compositions, and their use in the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterases. Furthermore, the present invention pertains to the methods of manufacturing these Benzyl-substituted tetracyclic heterocyclic compounds.
摘要翻译： 本发明涉及苄基取代的四环杂环化合物，以及所得药物组合物及其在治疗或预防通过抑制5型磷酸二酯酶而减轻的疾病中的用途。 此外，本发明涉及制造这些苄基取代的四环杂环化合物的方法。
-
公开(公告)号：WO2008138939A1
公开(公告)日：2008-11-20
申请号：PCT/EP2008/055867
申请日：2008-05-14
申请人： NYCOMED GMBH , SCHMIDT, Beate , SCHEUFLER, Christian , VOLZ, Jürgen , FETH, Martin P. , HUMMEL, Rolf-Peter , HATZELMANN, Armin , ZITT, Christof , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-Peter , OCKERT, Deborah , HEUSER, Anke , CHRISTIAANS, Johannes A. M. , STERK, Geert Jan , MENGE, Wiro M. P. B.
发明人： SCHMIDT, Beate , SCHEUFLER, Christian , VOLZ, Jürgen , FETH, Martin P. , HUMMEL, Rolf-Peter , HATZELMANN, Armin , ZITT, Christof , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-Peter , OCKERT, Deborah , HEUSER, Anke , CHRISTIAANS, Johannes A. M. , STERK, Geert Jan , MENGE, Wiro M. P. B.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/444 , A61K31/4155 , A61P1/00 , A61P11/00 , A61P17/00
CPC分类号： C07D401/14 , A61K31/4152
摘要： The compounds of a certain formula (1), in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.
摘要翻译： 其中R1，R7，R8，R9和n具有如说明书中给出的含义的某种式（1）的化合物是4型磷酸二酯酶的新型有效抑制剂。
-
7.发明申请5-BENZYL-1,2,3,6-TETRAHYDRO-4,6-DIAZA-CYCLOPENTA[C]FLUORENE COMPOUNDS AND 5-BENZYL-1,2,3,6-TETRAHYDRO-4,6-DIAZA-CYCLOHEPTA[C]FLUORENE COMPOUNDS 审中-公开5-苄基-1,2,3,6-四氢-4,6-二氮杂环戊二烯并[C]氟代化合物和5-苄基-1,2,3,6-四氢-4,6-二氮杂环庚烯[C ]氟化合物
公开(公告)号：WO2010015587A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/060000
申请日：2009-08-03
申请人： NYCOMED GMBH , BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
发明人： BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention pertains to 5 -Benzyl-1, 2, 3, 6- tetrahydro-4, 6-diazacyclopenta [c] fluorene compounds and 5 -Benzyl-1, 2, 3, 6- tetrahydro-4, 6-diaza-cyclohepta [c] fluorene compounds of formula (I), as well as the resulting pharmaceutical compositions, and their use in the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterases. Furthermore, the present invention pertains to the methods of manufacturing these 5-Benzyl-1, 2, 3, 6- tetrahydro-4, 6-diaza-cyclopenta [c] fluorene compounds and 5-Benzyl-1, 2, 3, 6- tetrahydro-4, 6-diaza-cyclohepta [c] fluorene compounds.
摘要翻译： 本发明涉及5-苄基-1,2,3,6-六氢-4,6-二氮杂环戊二烯并[c]芴化合物和5-苄基-1,2,3,6-四氢-4,6-二氮杂 - 式（I）的环庚烯[c]芴化合物，以及所得药物组合物，以及它们在治疗或预防通过抑制5型磷酸二酯酶而减轻的疾病中的用途。 此外，本发明涉及制备这些5-苄基-1,2,3,6-四氢-4,6-二氮杂 - 环戊二烯并[c]芴化合物和5-苄基-1,2,3,6 - 四氢-4,6-二氮杂 - 环庚三烯并[c]芴化合物。
-
8.发明申请6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO[2,3-C]QUINOLINE COMPOUNDS 审中-公开6-苄基-2,3,4,7-四氢-1H-吲哚[2,3-C]喹啉化合物
公开(公告)号：WO2010015585A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/059998
申请日：2009-08-03
申请人： NYCOMED GMBH , BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
发明人： BARTELS, Björn , WEINBRENNER, Steffen , MARX, Degenhard , DIEFENBACH, Jörg , DUNKERN, Torsten , MENGE, Wiro M.P.B. , CHRISTIAANS, Johannes A. M.
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , A61P11/00 , A61P15/00 , A61P25/00 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention pertains to 6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds of formula (I), as well as the resulting pharmaceutical compositions, and their use in the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterases. Furthermore, the present invention pertains to the methods of manufacturing these 6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds.
摘要翻译： 本发明涉及式（I）的6-苄基-2,3,4,7-四氢 - 吲哚并[2,3-c]喹啉化合物，以及所得药物组合物及其在治疗或 预防通过抑制5型磷酸二酯酶减轻的疾病。 此外，本发明涉及制造这些6-苄基-2,3,4,7-四氢 - 吲哚并[2,3-c]喹啉化合物的方法。
-
9.发明申请6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2, 3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS 审中-公开6-BENZYL-2,3,4,7-四氢吲哚[2,3-C]喹啉化合物作为PDE5抑制剂有用
公开(公告)号：WO2008095835A1
公开(公告)日：2008-08-14
申请号：PCT/EP2008/051076
申请日：2008-01-30
申请人： NYCOMED GMBH , WEINBRENNER, Steffen , DUNKERN, Torsten , MARX, Degenhard , SCHMIDT, Beate , STENGEL, Thomas , FLOCKERZI, Dieter , KAUTZ, Ulrich , HAUSER, Daniela , DIEFENBACH, Jörg , CHRISTIAANS, Johannes A. M. , MENGE, Wiro M.P.B.
发明人： WEINBRENNER, Steffen , DUNKERN, Torsten , MARX, Degenhard , SCHMIDT, Beate , STENGEL, Thomas , FLOCKERZI, Dieter , KAUTZ, Ulrich , HAUSER, Daniela , DIEFENBACH, Jörg , CHRISTIAANS, Johannes A. M. , MENGE, Wiro M.P.B.
IPC分类号： C07D471/04 , A61K31/437 , A61P11/00 , A61P15/00 , A61P9/00 , A61P25/00 , A61P29/00
CPC分类号： C07D471/04
摘要： The compounds of Formula (I) wherein R1 to R8 and R11 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof, and the stereoisomers of the compounds, the salts, the N-oxides of the compounds and the N-oxides of the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
摘要翻译： 其中R 1至R 8和R 11具有如说明书中给出的含义的式（I）化合物，其盐，化合物的N-氧化物及其盐，以及化合物，盐，N的立体异构体 化合物的氧化物及其盐的N-氧化物是5型磷酸二酯酶的有效抑制剂。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.016 秒)
