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    METHOD OF PREVENTING BOTH CARIES AND PERIODONTAL DISEASE SIMULTANEOUSLY IN ONE PROCEDURE
    1.
    发明申请
    METHOD OF PREVENTING BOTH CARIES AND PERIODONTAL DISEASE SIMULTANEOUSLY IN ONE PROCEDURE 审中-公开

    公开(公告)号：WO2020049365A2

    公开(公告)日：2020-03-12

    申请号：PCT/IB2019/001066

    申请日：2019-08-13

    Applicant: CHX TECHNOLOGIES, INC., A CORPORATION CREATED AND EXISTING UNDER THE LAWS OF CANADA

    Inventor： DI NARDO, Julie ,  TENENBAUM, Howard

    Abstract: The use of PREVORA brand topical dental solution (100 mg/ml chlorhexidine) sold by CHX Technologies, Inc., Toronto, Canada, to treat and/or prevent the advance of both dental decay (caries) and periodontal disease, simultaneously and in one procedure, that can easily be accomplished by a dental professional or a medical assistant. Chronic periodontitis and/or caries, the result of an imbalance of the microbial composition of the biofilm on the teeth, at the gum line or under the gum line, can be treated by the application of PREVORA, following standard oral cleaning and debriding of plaque at or below the gum line, to restore the balance of the biofilm to more normal, symbiotic composition. This treatment method is particularly useful in conjunction with the medical management of chronic diseases, such as type 2 diabetes, chronic obstructive pulmonary disease, cardiovascular disease, and the like, which have been associated with periodontopathogens. As an example, the topical dental solution is applied to the teeth of an adult diabetic patient every 3 months for the first year, fol lowed by semi-annual single applications for as long as the patient remains at risk for either periodontal disease or caries.

    METHOD OF PREVENTING BOTH CARIES AND PERIODONTAL DISEASE SIMULTANEOUSLY IN ONE PROCEDURE
    2.
    发明申请
    METHOD OF PREVENTING BOTH CARIES AND PERIODONTAL DISEASE SIMULTANEOUSLY IN ONE PROCEDURE 审中-公开

    公开(公告)号：WO2020049365A3

    公开(公告)日：2020-03-12

    申请号：PCT/IB2019/001066

    申请日：2019-08-13

    Applicant: CHX TECHNOLOGIES, INC., A CORPORATION CREATED AND EXISTING UNDER THE LAWS OF CANADA

    Inventor： DI NARDO, Julie ,  TENENBAUM, Howard

    IPC: A61K31/155 ,  A61P1/02 ,  C07C279/26

    Abstract: The use of PREVORA brand topical dental solution (100 mg/ml chlorhexidine) sold by CHX Technologies, Inc., Toronto, Canada, to treat and/or prevent the advance of both dental decay (caries) and periodontal disease, simultaneously and in one procedure, that can easily be accomplished by a dental professional or a medical assistant. Chronic periodontitis and/or caries, the result of an imbalance of the microbial composition of the biofilm on the teeth, at the gum line or under the gum line, can be treated by the application of PREVORA, following standard oral cleaning and debriding of plaque at or below the gum line, to restore the balance of the biofilm to more normal, symbiotic composition. This treatment method is particularly useful in conjunction with the medical management of chronic diseases, such as type 2 diabetes, chronic obstructive pulmonary disease, cardiovascular disease, and the like, which have been associated with periodontopathogens. As an example, the topical dental solution is applied to the teeth of an adult diabetic patient every 3 months for the first year, fol lowed by semi-annual single applications for as long as the patient remains at risk for either periodontal disease or caries.

    TEMPORARY, PHARMACOLOGICALLY-INACTIVE DENTAL COATING FOR THE IN SITU PROTECTION OF DENTAL THERAPEUTIC AGENTS FROM SALIVA AND ABRASION FROM CHEWING
    5.
    发明申请
    TEMPORARY, PHARMACOLOGICALLY-INACTIVE DENTAL COATING FOR THE IN SITU PROTECTION OF DENTAL THERAPEUTIC AGENTS FROM SALIVA AND ABRASION FROM CHEWING 审中-公开
    临床上用于治疗牙科治疗药物的药物治疗和药物治疗从牙科治疗开始的药物灭活牙科涂料

    公开(公告)号：WO2004054518A1

    公开(公告)日：2004-07-01

    申请号：PCT/CA2003/001943

    申请日：2003-12-16

    Applicant: CHX TECHNOLOGIES, INC. ,  SYMINGTON, John, Marston ,  TURGEON, Brenda ,  PERRY, Oliver, Ross

    Inventor： SYMINGTON, John, Marston ,  TURGEON, Brenda ,  PERRY, Oliver, Ross

    IPC: A61K6/00

    CPC classification number: A61K6/0067 ,  A61K6/0017 ,  C08L33/00

    Abstract: Topical application of a pharmacologically-inactive, inert polymeric solution to teeth affords a temporary, protective barrier for pharmacologically-active compounds that have been previously applied topically to the tooth surfaces for caries reduction. In a method of use, an aqueous dispersion polymethylmethacrylate (PMMA) and a suitable plasticizer are applied topically to the tooth surface immediately after the topical application of chlorhexidine or fluoride. The inert coating thus formed is distinct from any pharmacologically-active substance, and remains on the tooth surface until abraded by the chewing of hard foods. In a composition of matter, the solution contains ammonio methacrylate copolymer, type B USP/NF of between 20% and 35% w/w; triethyl citrate USP/NF of between 1% and 10% w/w; and purified water of between 60% and 70% w/w. The ammonio methacrylate copolymer is preferably EUDRAGIT RS 30 D brand available form Rohm GmbH.

    Abstract translation: 将药理学惰性的惰性聚合物溶液局部施用于牙齿为药理学活性化合物提供临时的保护屏障，这些药物活性化合物先前已被局部应用于牙齿表面以减少龋齿。 在使用方法中，在局部施用氯己定或氟化物之后立即将牙膏表面涂覆到聚甲基丙烯酸甲酯（PMMA）和合适的增塑剂上。 如此形成的惰性涂层不同于任何药理活性物质，并且保留在牙齿表面上，直到由硬质食物咀嚼而磨损。 在物质组成中，溶液含有氨基甲基丙烯酸酯共聚物，B类USP / NF为20％至35％w / w; 柠檬酸三乙酯USP / NF为1％至10％w / w; 和纯度为60％至70％w / w的水。 氨基甲基丙烯酸酯共聚物优选为Rohm GmbH的EUDRAGIT RS 30 D品牌。

    USE OF CHLORHEXIDINE IN THE PREVENTION OF ROOT CARIES
    6.
    发明申请
    USE OF CHLORHEXIDINE IN THE PREVENTION OF ROOT CARIES 审中-公开
    氯丙嗪在预防根癌中的应用

    公开(公告)号：WO0174321A3

    公开(公告)日：2002-05-16

    申请号：PCT/IB0100794

    申请日：2001-04-03

    Applicant: CHX TECHNOLOGIES INC ,  SYMINGTON JOHN M ,  SYMINGTON ALISON ,  TEN CATE ARNOLD R ,  PERRY OLIVER R

    Inventor： SYMINGTON JOHN M ,  SYMINGTON ALISON ,  TEN CATE ARNOLD R ,  PERRY OLIVER R

    IPC: A61K6/00 ,  A61K8/43 ,  A61Q11/00 ,  A61K7/16 ,  A61K31/155

    CPC classification number: A61K6/0032 ,  A61K6/0017 ,  A61K8/43 ,  A61Q11/00 ,  C08L75/04

    Abstract: Topical application of a solution of the antimicrobial chlorhexidine to teeth, particularly including exposed root surfaces, prevents the destruction of exposed cementum and associated exposed enamel at the cementum-enamel junction on tooth root surfaces (root caries) and the inflammation of the gingival tissue. In a method of use, a topical solution containing 10% (w/v) chlorhexidine, 20% (w/v) Sumatra benzoin, and 70% (w/v) ethanol is applied to the appropriate area of the tooth surface, followed immediately by application of a sealant which is a solution containing 29% (w/v) medical-grade polyurethane in 49% (w/v) acetone and 22% (w/v) ethyl acetate. Application of the chlorhexidine and sealant to the tooth cementum and gingival margin of "at risk" older adult patients has significantly reduced the prevalence and incidence of root caries and gingival inflammation.

    Abstract translation: 将抗微生物氯己定溶液局部应用于牙齿，特别是包括暴露的根表面，可防止在牙根表面（根龋齿）牙根牙釉质接合处和牙龈组织炎症时暴露的牙骨质和相关暴露牙釉质的破坏。 在使用方法中，将含有10％（w / v）氯己定，20％（w / v）苏门答腊安息香和70％（w / v）乙醇的局部溶液施加到牙齿表面的适当区域，随后 立即通过在49％（w / v）丙酮和22％（w / v）乙酸乙酯中施加含有29％（w / v）医用级聚氨酯的溶液的密封剂。 氯己定和密封剂对牙骨质质和“有风险”的老年成人患者的牙龈边缘的应用显着降低了龋齿和牙龈炎症的发病率和发病率。

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