公开(公告)号：WO2014126945A1

公开(公告)日：2014-08-21

申请号：PCT/US2014/015902

申请日：2014-02-12

Applicant: DENTSPLY INTERNATIONAL INC. ,  ANGELETAKIS, Christos

Inventor： ANGELETAKIS, Christos

IPC: A61K6/00

CPC classification number: A61K6/0017 ,  A61K6/0029 ,  A61K6/0032 ,  A61K6/0038 ,  A61K6/02

Abstract: Disclosed herein are methods of treating an intraoral surface by applying a solution comprising a proteinaceous material and an aldehyde.

Abstract translation: 本文公开了通过施加包含蛋白质材料和醛的溶液来治疗口腔内表面的方法。

公开(公告)号：WO2013029790A3

公开(公告)日：2013-05-10

申请号：PCT/EP2012003646

申请日：2012-08-30

Applicant: UNIV DUESSELDORF H HEINE ,  RITTER HELMUT ,  BURKHART ALEXANDER ,  FISCHER JULIAN ,  GINGTER SABRINA ,  MONDRZYK ADAM

Inventor： RITTER HELMUT ,  BURKHART ALEXANDER ,  FISCHER JULIAN ,  GINGTER SABRINA ,  MONDRZYK ADAM

IPC: A61K6/00

CPC classification number: A61K6/0032 ,  A61K6/0038 ,  A61K6/0047 ,  C08L63/00

Abstract: The invention relates to a dental filling material mixture, in particular to a material mixture for filling root canals, containing (a) an epoxide and (b) an amino acid or an amino acid derivative. The invention further relates to a method for producing a dental filling material by providing a dental filling material mixture and subsequently hardening the mixture, and to the filling material that can be obtained by said method. The invention also relates to a kit for preparing a dental filling material mixture in which the components (a) and (b) are present separately from each other.

Abstract translation: 本发明涉及牙科填充材料混合物，特别是用于填充根管的材料混合物，其包含（a）环氧化物和（b）氨基酸或氨基酸衍生物。 此外，本发明涉及一种通过提供牙科填充剂混合物，然后固化该混合物和通过该方法获得的牙科填充剂来生产牙科充填材料的方法。 此外，本发明包括用于提供牙科充填材料混合物的套件，其中组分（a）和（b）彼此分开存在。

公开(公告)号：WO2012012507A2

公开(公告)日：2012-01-26

申请号：PCT/US2011/044644

申请日：2011-07-20

Applicant: BIOMATRX LLC ,  GEISLER, Todd ,  GEISLER, Graham ,  GEISLER, Jamison

Inventor： GEISLER, Todd ,  GEISLER, Graham ,  GEISLER, Jamison

IPC: A61K6/08 ,  A61K6/097 ,  A61K6/02 ,  A61K9/70 ,  A61C5/00

CPC classification number: A61C5/04 ,  A61C5/50 ,  A61C5/62 ,  A61C13/0006 ,  A61K6/0032 ,  A61K6/0067 ,  A61K9/0024 ,  A61K35/19 ,  A61K38/363 ,  A61L27/225 ,  A61L27/3616 ,  A61L2430/12

Abstract: Described are devices, methods, inserts, and systems useful in endodontic treatments, involving, for example, a shaped regenerative endodontic insert comprising platelet-fibrin matrix.

Abstract translation: 描述了在牙髓治疗中有用的装置，方法，插入物和系统，涉及例如包含血小板 - 纤维蛋白基质的成形再生牙髓插入物。

公开(公告)号：WO2011003592A1

公开(公告)日：2011-01-13

申请号：PCT/EP2010/004121

申请日：2010-07-06

Applicant: DENTSPLY DE TREY GMBH ,  KLEE, Joachim E. ,  WEBER, Christoph ,  PFEFFERKORN, Frank ,  HORNUNG, Tim ,  GLANER, Anja

Inventor： KLEE, Joachim E. ,  WEBER, Christoph ,  PFEFFERKORN, Frank ,  HORNUNG, Tim ,  GLANER, Anja

IPC: A61K6/00 ,  A61C5/02

CPC classification number: A61C5/02 ,  A61C5/40 ,  A61C5/44 ,  A61C5/50 ,  A61K6/0032 ,  A61K6/0038 ,  A61K6/06 ,  A61K6/0681 ,  A61K6/09 ,  A61K6/083 ,  C08L83/04

Abstract: Dental obturator point having an obturation body containing a composite material comprising (a) a polymer and (b) a particulate filler, whereby the obturation body has a radio opacity of at least 3 mm/mm Al, characterized in that the composite material has (i) a tensile strength of from 5 to 70 MPA1 (ii) a flexural strength of from 5 to 90 MPA, (iii) a flexural module of from 0.1 to 2.5 GPa, and which has (iv) a 300 rpm drilling coefficient at 37 °C in the range of from -1 to 7.00.

Abstract translation: 具有包含复合材料的密封体的牙科闭塞体点包括（a）聚合物和（b）颗粒填料，由此所述密封体具有至少3mm / mm Al的无线电不透明度，其特征在于，所述复合材料具有 i）拉伸强度为5至70MPA1（ii）弯曲强度为5至90MPA，（iii）挠曲模量为0.1至2.5GPa，并且（iv）在37℃下具有300rpm的钻孔系数 °C在-1至7.00的范围内。

公开(公告)号：WO2006070376A1

公开(公告)日：2006-07-06

申请号：PCT/IL2006/000005

申请日：2006-01-01

Applicant: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM ,  DOMB, Abraham J. ,  WEISS, Ervin I. ,  BEYTH, Nurit ,  FARBER, Ira ,  PEREZ DAVIDI, Michael

Inventor： DOMB, Abraham J. ,  WEISS, Ervin I. ,  BEYTH, Nurit ,  FARBER, Ira ,  PEREZ DAVIDI, Michael

IPC: A01N25/12 ,  A01N33/12 ,  A01N37/12 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  A61L27/16 ,  A61Q11/00 ,  A61K6/08 ,  A61L29/04 ,  A01P1/00

CPC classification number: A61K6/083 ,  A01N25/12 ,  A01N33/12 ,  A01N37/12 ,  A61K6/0008 ,  A61K6/0023 ,  A61K6/0032 ,  A61K6/0067 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/408 ,  A61L2300/624 ,  C08L39/02 ,  C08L33/08 ,  C08L5/08

Abstract: The present invention provides a particle comprising at least one aliphatic polymer having anti-microbially active quaternary ammonium groups chemically bound thereto. The particle of the invention may be used to inhibit populations of microorganisms and biofilms. Also provided are methods for the preparation of such particles and uses thereof for the inhibition of microorganisms.

Abstract translation: 本发明提供一种包含至少一种具有与其结合的抗微生物活性季铵基团的脂族聚合物的颗粒。 本发明的颗粒可用于抑制微生物和生物膜的种群。 还提供了制备这种颗粒的方法及其用于抑制微生物的用途。

公开(公告)号：WO03061506A2

公开(公告)日：2003-07-31

申请号：PCT/US0301890

申请日：2003-01-22

Applicant: DENTSPLY INT INC

Inventor： TORABINEJAD MAHMOUD ,  JOHNSON WILLIAM B

IPC: A61K8/00 ,  A01N25/02 ,  A01N37/18 ,  A01N47/44 ,  A61K6/00 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/43 ,  A61Q11/00 ,  C11D1/68 ,  C11D1/72 ,  C11D3/20 ,  C11D3/30 ,  C11D3/48 ,  C11D17/08 ,  A61C

CPC classification number: A61K6/0029 ,  A61K6/0032 ,  Y10S514/975 ,  C08L71/02

Abstract: Methods and solutions are provided for removal of the smear layer on prepared tooth and bone surfaces, especially in endodontic environments.

Abstract translation: 提供了方法和解决方案，用于去除准备的牙齿和骨表面上的涂片，特别是在牙髓环境中。

公开(公告)号：WO2002078646A1

公开(公告)日：2002-10-10

申请号：PCT/US2001/046526

申请日：2001-12-05

Applicant: PENTRON CORPORATION

Inventor： JIA, Weitao ,  JIN, Shuhua

IPC: A61K6/083

CPC classification number: A61L27/446 ,  A61K6/0032 ,  A61K6/0038 ,  A61K6/0082 ,  A61K6/0091 ,  A61K6/083 ,  A61K6/087 ,  A61L24/04 ,  A61L27/46 ,  A61L2430/12 ,  C08L29/04 ,  C08L67/07 ,  C08L33/00 ,  C08L67/04

Abstract: Curable compositions comprising degradable macromonomers having one or more terminal acrylate or methacrylate functionality, a curing composition, a filler composition comprising bioactive particles of bioactive glass, bioactive glass-ceramics, calcium phosphates, calcium appetites, or mixtures thereof and optionally one or more polymerizable acrylate or methacrylate comonomers. Degradable macromonomers are manufactured from cyclic monomers with compounds having acrylate or methacrylate functionality. Depending on their use, the degradable macromonomer compositions further comprise one or more organic or inorganic fillers, including a calcium-based compound and/or a radiopacity-imparting agent. The compositions are particularly suitable for root canal sealants, implants, bone cements, and pulp capping materials.

Abstract translation: 包含具有一个或多个末端丙烯酸酯或甲基丙烯酸酯官能团的可降解大分子单体的固化组合物，固化组合物，包含生物活性玻璃的生物活性颗粒，生物活性玻璃 - 陶瓷，磷酸钙，钙食欲或其混合物的填料组合物和任选的一种或多种可聚合丙烯酸酯 或甲基丙烯酸酯共聚单体。 可降解的大分子单体由具有丙烯酸酯或甲基丙烯酸酯官能团的化合物的环状单体制备。 根据其用途，可降解大分子组合物还包含一种或多种有机或无机填料，包括钙基化合物和/或不透射线渗透剂。 该组合物特别适用于根管密封剂，植入物，骨水泥和纸浆覆盖材料。

公开(公告)号：WO1996013245A1

公开(公告)日：1996-05-09

申请号：PCT/US1995013864

申请日：1995-10-26

Applicant: HODOSH, Milton

IPC: A61K06/08

CPC classification number: A61Q11/00 ,  A61K6/0032 ,  A61K8/19 ,  Y10S514/817 ,  Y10S514/818

Abstract: The present invention is directed to a method for anesthetizing teeth which does not require an injection into the gum in order to anesthetize a tooth (or teeth) which requires attention. The method comprises the step of applying a composition having a high concentration of potassium to a tooth requiring caries removal or manual manipulation thereof. The composition is adapted to anesthetize the tooth so that the tooth may be drilled or manually manipulated. It has been discovered that the potassium enters the dentinal tubules and odontoblastic fibrils and penetrates the pulpal tissues of the tooth for anesthetizing the tooth without having to inject anesthetics into the gum surrounding the tooth.

Abstract translation: 本发明涉及一种用于麻醉牙齿的方法，其不需要注射到牙龈中以麻醉需要注意的牙齿（或牙齿）。 该方法包括将具有高浓度钾的组合物施用于需要龋齿去除或手动操作的牙齿的步骤。 组合物适于麻醉牙齿，使得可以钻或手动操作牙齿。 已经发现，钾进入牙质小管和成牙质细胞原纤维并穿透牙齿的牙髓组织以麻醉牙齿，而不必将麻醉剂注射到牙齿周围的牙齿中。

公开(公告)号：WO1994010203A2

公开(公告)日：1994-05-11

申请号：PCT/US1993010520

申请日：1993-11-02

Applicant: CREATIVE BIOMOLECULES, INC.

Inventor： CREATIVE BIOMOLECULES, INC. ,  OPPERMANN, Hermann ,  OZKAYNAK, Engin ,  KUBERASAMPATH, Thangavel ,  RUEGER, David, C. ,  PANG, Roy, H., L. ,  COHEN, Charles, M.

IPC: C07K15/00

CPC classification number: C07K14/51 ,  A61F2310/00365 ,  A61K6/0032 ,  A61K38/00 ,  A61K48/00 ,  A61L27/227 ,  A61L27/24 ,  C07K16/22

Abstract: Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for utilizing the protein to induce tissue morphogenesis in a mammal, including methods for increasing a progenitor cell population in a mammal, methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.

Abstract translation: 公开了（1）新型形态发生蛋白的核酸和氨基酸序列; （2）以生物活性形式生产和表达蛋白质的方法; 和（3）利用蛋白质诱导哺乳动物组织形态发生的方法，包括增加哺乳动物祖细胞群的方法，用于刺激祖细胞在体内或体外分化和维持其分化表型的方法，诱导方法 体内的组织特异性生长和体内替换患病或受损组织的方法。

公开(公告)号：WO2012010478A1

公开(公告)日：2012-01-26

申请号：PCT/EP2011/061953

申请日：2011-07-13

Applicant: BAYER INNOVATION GMBH ,  SCHULZ, Hans, H.

Inventor： SCHULZ, Hans, H.

IPC: A61K31/437 ,  A61K9/00 ,  A61K47/24 ,  A61K6/00

CPC classification number: A61K31/695 ,  A61K6/0032 ,  A61K6/0067 ,  A61K31/437 ,  A61K31/47 ,  A61K31/4709 ,  A61K45/00 ,  C08L83/04

Abstract: The invention relates to a pharmaceutical composition comprising a siloxane according to general formula (I) wherein R means -C 1 -C 6 -alkyl; R 1 and R 2 each mean independently of one another -C 1 -C 6 -alkyl, or together form a (2n)-membered ring; and n is an integer of from 2 to 8; for use in combination with a pharmacologically active ingredient in the prophylaxis or treatment of a dental disorder.

Abstract translation: 本发明涉及包含根据通式（I）的硅氧烷的药物组合物，其中R表示-C 1 -C 6 - 烷基; R 1和R 2各自独立地表示-C 1 -C 6 - 烷基，或一起形成（2n）环的环; n为2〜8的整数， 与药理活性成分组合用于预防或治疗牙齿障碍。